Regulation of fetal versus embryonic gamma globin genes: Appropriate developmental stage expression patterns in the presence of HS2 of the locus control region

Blood

Volumn 99, Issue 3, 2002, Pages 1082-1084

  Yu, Timothy ^a,b   Thomas, David M ^a,b   Zhu, Wei ^a,b   Goodman, Morris ^a,b   Gumucio, Deborah L ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GAMMA GLOBIN;

ARTICLE; DEVELOPMENTAL STAGE; DNA DETERMINATION; GENE; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; HS2 GENE; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSGENIC MOUSE;

EID: 0036464693     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.3.1082     Document Type: Article

References (10)

1. Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus): Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints
2. Molecular evolution in the β-globin gene family of mammals: Emergence of redundant genes, important new genes, and new expression patterns
3. Evolution of a fetal expression pattern via cis changes near the gamma globin gene
4. Analysis of linked human epsilon and gamma transgenes: Effect of locus control region hypersensitive sites 2 and 3 or a distal YY1 mutation on stage-specific expression patterns
5. Autonomous developmental control of human embryonic globin gene switching in transgenic mice
6. DNasel hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression
7. Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes
8. A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region
9. Position independence and proper developmental control of gamma-globin gene expression require both a 5′ locus control region and a downstream sequence element
10. Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion