Influence of type and level of water-soluble additives on drug release and surface and mechanical properties of Surelease® films

Pharmaceutical Development and Technology

Volumn 7, Issue 4, 2002, Pages 421-432

  Rohera, Bhagwan D ^a   Parikh, Nilesh H ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Aqueous ethylcellulose dispersion; Brinell hardness; Coat reflectivity; Elastic modulus; Gloss; Ibuprofen; Maltodextrins; Mechanical properties; Polyethylene glycols; Porosity modifiers; Surelease; Xylitol

Indexed keywords

CARBOWAX 3350; CARBOWAX 8000; DRUG ADDITIVE; ETHYL CELLULOSE; GLUCOSE; IBUPROFEN; MACROGOL 3350; MACROGOL 400; MACROGOL 8000; MALTODEXTRIN; MALTRIN M040; MALTRIN M100; MALTRIN M150; TRIOCTANOIN; XYLITOL; CELLULOSE; DRUG DERIVATIVE; WATER;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DOSAGE FORM; DRUG RELEASE; FILM COATING; FLUIDIZED BED; HARDNESS; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; SURFACE PROPERTY; TABLET; YOUNG MODULUS; CHEMISTRY; ENTERIC COATED TABLET; MECHANICS; SOLUBILITY;

CELLULOSE; MECHANICS; SOLUBILITY; SURFACE PROPERTIES; TABLETS, ENTERIC-COATED; WATER;

EID: 0036457680     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120015044     Document Type: Article

References (31)

1. Porter, S.C. Controlled release film coatings based on ethylcellulose. Drug Dev. Ind. Pharm. 1989, 15, 1495-1521.
2. Aquacoat® - Aqueous Polymeric Dispersion, FMC Corp., Technical Literature.
3. Surelease® - The Aqueous Sustained Release Coating System, Colorcon, Technical Literature.
4. Shah, N.B.; Sheth, B.B. A method for study of timed-release films. J. Pharm. Sci. 1972, 61, 412-416.
5. Donbrow, M.; Friedman, M. Enhancement of permeability of ethylcellulose films for drug penetration. J. Pharm. Pharmacol. 1975, 27, 633-646.
6. Donbrow, M.; Samuelov, Y. Zero-order drug delivery from double-layered porous films: Release rate profiles from ethylcellulose, hydroxypropyl cellulose and polyethylene glycol mixtures. J. Pharm. Pharmacol. 1980, 32, 463-470.
7. Rowe, R.C. The effect of the molecular weight of ethylcellulose on the drug release properties of mixed films of ethylcellulose and hydroxypropyl methylcellulose. Int. J. Pharm. 1986, 29, 37-41.
8. Lindholm, T.; Lindholm, B.A.; Niskanen, M.; Koskiniemi, J. Polysorbate 20 as a drug release regulator in ethylcellulose film coatings. J. Pharm. Pharmacol. 1986, 38 (9), 686-688.
9. Gilligan, C.A.; Po, A.W. Factors affecting drug release from a pellet system coated with an aqueous colloidal dispersion. Int. J. Pharm. 1991, 73, 51-68.
10. Appel, L.; Zentner, G.M. Use of modified ethylcellulose lattices for microporous coating of osmotic tablets. Pharm. Res. 1991, 8, 603-604.
11. Wesseling, M.; Bodmeier, R. Drug release from beads coated with an aqueous colloidal ethylcellulose dispersion, aquacoat, or an organic ethylcellulose solution. Eur. J. Pharm. Biopharm. 1999, 47 (1), 33-38.
12. Tang, L.; Schwartz, J.B.; Porter, S.C.; Schnaare, R.L.; Wigent, R.J. Drug release from film-coated chlorpheniramine maleate nonpareil beads: Effect of water-soluble polymer, coating level, and soluble core material. Pharm. Dev. Technol. 2000, 5 (3), 383-390.
13. Sadeghi, F.; Ford, J.L.; Rubinstein, M.H.; Rajabi-Siahboomi, A.R. Study of drug release from pellets coated with surelease containing hydroxypropyl methylcellulose. Drug Dev. Ind. Pharm. 2001, 27 (5), 419-430.
14. Muhammad, N.A.; Boisvert, B.; Harris, M.R.; Weiss, J. Modifying the release properties of eudragit L30D. Drug Dev. Ind. Pharm. 1991, 17, 2497-2509.
15. Li, L.C.; Peck, G.C. Water-based silicone elastomer controlled release tablet film coating: II. Formulation considerations and coating evaluation. Drug Dev. Ind. Pharm. 1989, 15, 499-531.
16. Kelbert, M.; Bechard, S.R. Evaluation of a cellulose acetate latex as coating material for controlled release products. Drug Dev. Ind. Pharm. 1992, 18, 519-538.
17. Maltrin® - Carbohydrates for Pharmaceutical Formulations. Grain Processing Corporation, Technical Literature.
18. Parikh, N.H.; Porter, S.C.; Rohera, B.D. Aqueous ethylcellulose dispersion: I. Evaluation of coating process variables. Pharm. Res. 1993, 10 (4), 525-534.
19. Rohera, B.D.; Parikh, N.H. Study of effect of plasticizer type and coat level on film properties of surelease. Pharm. Dev. Technol. 2002, 7 (4), 407-420.
20. Jenquin, M.R.; Sarabia, R.E.; Liebowitz, S.M.; McGinity, J.W. Relationship of film properties to drug release from monolithic films containing additives. J. Pharm. Sci. 1992, 81, 983-989.
21. Sakellariou, P.; Rowe, R.C.; White, J.D. An evaluation of the interaction and plasticizing efficiency of the polyethylene glycols in ethylcellulose and hydroxypropyl methylcellulose films using the torsional braid pendulum. Int. J. Pharm. 1986, 31, 55-64.
22. Johnson, K.; Hathaway, R.; Leung, P.; Franz, R. Effect of triacetin and polyethylene glycol 400 on some physical properties of hydroxypropyl methylcellulose free films. Int. J. Pharm. 1991, 73, 197-208.
23. Sakellariou, P.; Rowe, R.C.; White, E.F.T. A study of the leaching/retention of water-soluble polymers in blends with ethylcellulose using torsional braid analysis. Int. J. Pharm. 1988, 7, 147-157.
24. Corrigan, O.I. Retardation of polymeric carrier dissolution. In Pharmaceutical Technology: Controlled Drug Release; Rubinstein, M.H., Ed.; John Wiley & Sons: New York, NY, 1989; Vol. 1, 88-98.
25. Sakellariou, P.; Rowe, R.C.; White, E.F.T. Polymer/polymer interaction in blends of ethylcellulose with both cellulose derivatives and polyethylene glycol 6000. Int. J. Pharm. 1986, 34, 93-103.
26. van Bommel, E.M.G.; Fokkens, J.G.; Crommelin, D.J.A. A gradient matrix system as a controlled release device - Release from a slab model system. J. Control Release 1989, 10, 283-292.
27. Ridgeway, K.; Aulton, M.E.; Rosser, P.H. The surface hardness of tablets. J. Pharm. Pharmacol. 1970, 22 (Suppl.), 70S-78S.
28. Rowe, R.C. Microindentation - A Method for Measuring the Elastic Properties and Hardness of Films on Conventionally Coated Tablets. J. Pharm. Pharmacol. 1976, 28, 310-311.
29. Okhamafe, A.O.; York, P. Mechanical properties of some pigmented and unpigmented aqueous-based film coating formulations applied to aspirin tablets. J. Pharm. Pharmacol. 1986, 38, 414-419.
30. Entwistle, C.A.; Rowe, R.C. Plasticization of cellulose ethers used in the film coating of tablets. J. Pharm. Pharmacol. 1979, 31, 269-272.
31. Rowe, R.C. The effect of molecular weight on properties of films prepared from hydroxypropyl methylcellulose. Pharm. Acta Helv. 1976, 51, 330-334.