Chemoreceptor activity is normal in mice lacking the NK1 receptor

European Journal of Neuroscience

Volumn 16, Issue 11, 2002, Pages 2078-2084

  Rigual, Ricardo ^a   Rico, Alberto J ^a   Prieto Lloret, Jesus ^a   De Felipe, Carmen ^b   González, Constancio ^a   Donnelly, David F ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b CSIC   (Spain)

Author keywords

Carotid body; Chemoreception; Dopamine release; Hypoxia; Sensory transduction; Substance P

Indexed keywords

DOPAMINE; NEUROKININ 1 RECEPTOR; NORADRENALIN;

ANIMAL BEHAVIOR; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CAROTID BODY; CATECHOLAMINE RELEASE; CERVICAL GANGLION; CHEMORECEPTOR; CONTROLLED STUDY; FEMALE; HYPOXIA; IN VITRO STUDY; MEASUREMENT; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROMOTER REGION;

ANIMALS; ANOXIA; CAROTID BODY; CATECHOLAMINES; DOPAMINE; FEMALE; MICE; MICE, KNOCKOUT; NEURONS, AFFERENT; NOREPINEPHRINE; RECEPTORS, NEUROKININ-1; RECEPTORS, SENSORY; SIGNAL TRANSDUCTION; SUBSTANCE P; SUPERIOR CERVICAL GANGLION; SYNAPTIC TRANSMISSION; VISCERAL AFFERENTS;

EID: 0036454902     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02293.x     Document Type: Article

References (27)

1. Caeser, M., Seabrook, G.R. & Kemp, J.A. (1993) Block of voltage-dependent sodium currents by the substance P receptor antagonist CP-96,345 in neurones cultured from rat cortex. Br. J. Pharmacol., 109, 918-924.
2. Cragg, P.A., Runold, M., Kou, Y.R. & Prabhakar, N.R. (1994) Tachykininas antagonists in carotid body responses to hypoxia and substance P in the rat. Respir. Physiol., 95, 295-313.
3. Cuello, M.J. & McQueen, D. (1980) Substance P: A carotid body peptide. Neurosci. Lett., 17, 215-219.
4. De Felipe, C., Herrero, J.F., O'Brien, J.A., Palmer, J.A., Doyle, C.A., Smith, A.J., Laird, J.M., Belmonte, C., Cervero, F. & Hunt, S.P. (1998) Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature, 392, 394-397.
5. Donnelly, D.F., Panisello, J.M. & Boggs, D. (1998) Effect of sodium perturbations on rat chemoreceptor spike generation: Implications for a Poisson model. J. Physiol. (London), 511, 301-311.
6. Donnelly, D.F. & Rigual, R. (2000) Single-unit recordings of arterial chemoreceptors from mouse petrosal ganglia in vitro. J. Appl. Physiol., 88, 1489-1495.
7. Dreshaj, I.A., Agani, F.H., Krause, J.E., Richer, E., Martin, R.J. & Haxhiu, M.A. (1999) NK-1 receptors (R.) are not required for changes in respiratory output induced by hypoxia or cyanide administration in mice. Am. J. Resp. Crit. Care Med. (Abstract), 159, A45.
8. Eyzaguirre, C., Monti-Bloch, L. & Woodbury, J.W. (1990) Effects of putative neurotransmitters of the carotid body on its own glomus cells. Eur J. Neurosci., 2, 77-88.
9. 2-dopamine receptor and substance P genes in the carotid body of the rat. Neurosci., 75, 969-977.
10. Gauda, E.B., Bamford, O.S. & Northington, F.J. (1998) Lack of induction of substance P gene expression by hypoxia and absence of neurokinin-1 receptor mRNAs in the rat carotid body. J. Auto. Nervous System, 74, 100-108.
11. González, C., Almaraz, L., Obeso, A. & Rigual, R. (1994) Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiol. Rev., 74, 1768-1993.
12. González, C., Dinger, B. & Fidone, S.J. (1997) Functional significance of chemoreceptor cell neurotransmitters. In: The Carotid Body Chemoreceptors. González, C., ed, Landes Bioscience. Austin, Texas, pp. 47-58.
13. Kumar, G., Runold, M., Ghai, A.R., Cherniack, N.S. & Prabhakar, N.R. (1990) Occurrence of neutral endopeptidase activity in the cat carotid body and its significance in chemoreception. Brain Res., 517, 341-343.
14. Kusakabe, T., Hayashida, Y., Matsuda, H., Gono, Y., Powell, F.L., Ellisman, M.H., Kawakami, T. & Takenaka, T. (1998) Hypoxic adaptation of the peptidergic innervation in the rat carotid body. Brain. Res., 806, 165-174.
15. Kusakabe, T., Kawakami, T., Tanabe, Y., Fujii, S. & Takenata, T. (1994) Distribution of substance P-containing and catecholaminergic nerve fibers inn the rabbit carotid body: An immunohistochemically study in combination with catecholamine fluorescent histochemistry. Arch. Histol. Cytol., 57, 193-199.
16. Livett, B.G. & Marley, P.D. (1993) Noncholinergic control of adrenal catecholamine secretion. J. Anat., 183, 277-289.
17. McQueen, D.S. (1980) Effects of substance P on carotid chemoreceptor activity in the cat. J. Physiol. (London), 302, 31-47.
18. McQueen, D.S. & Evrard, Y. (1990) Use of selective antagonist for studying the role of putative transmitters in chemoreception. In:. Arterial Chemoreception. Eyzaguirre, C., Fidone, S.J., Fitzgerald, R.S., Lahiry, S. & McDonald, D.M., eds, Springer-Verlag, New York, pp. 168-173.
19. Monti-Bloch, L. & Eyzaguirre, C. (1985) Effects of methionine-enkephalin and substance P on the chemosensory discharge of the cat carotid body. Brain. Res., 338, 297-307.
20. Pizarro, J., Ryan, M.L., Hedrick, M.S., Xue, D.H., Keith, I.M. & Bisgard, G.E. (1995) Intracarotid substance P infusion inhibits ventilation in the goat. Respir. Physiol., 101, 11-22.
21. Prabhakar, N.R., Cao, H., Lowe, J.A. & Snider, R.M. (1993) Selective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345. Proc. Natl. Acad. Sci., 90, 10041-10045.
22. 2. Brain Res., 481, 205-214.
23. Prabhakar, N., Runold, M., Kumar, G.K., Cherniack, N.S. & scarpa, A. (1989b) Substance P and mitochondrial oxygen consumption: Evidence for a direct intracellular role for the peptide. Peptides, 10, 1003-1006.
24. Prabhakar, N., Runold, M., Yamamoto, Y., Lagercrantz, H. & vonEuler, C. (1984) Effect of substance P antagonist on the hypoxia-induced carotid chemoreceptor activity. Acta Physiol. Scand., 121, 301-303.
25. 2+ currents. Pflugers Arch. - Eur. J. Physiol., 439, 463-470.
26. 2+ chanels. Eur. J. Pharmacol., 219, 491-492.
27. Wharton, J., Polak, J.M., Pearse, A.G., McGregor, G.P., Bryant, M.G., Bloom, S.R., Emson, P.C., Bisgard, G.E. & Will, J.A. (1980) Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body. Nature, 284, 269-271.