Do occasional brief seizures cause detectable clinical consequences?

Progress in Brain Research

Volumn 135, Issue , 2002, Pages 221-235

  Shinnar, Shlomo ^a   Hauser, W Allen ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT;

ABSENCE; ANIMAL MODEL; COGNITIVE DEFECT; CONFERENCE PAPER; ELECTROENCEPHALOGRAM; EPIDEMIOLOGICAL DATA; EPILEPSY; EPILEPTIC DISCHARGE; EPILEPTIC STATE; FEBRILE CONVULSION; HUMAN; LANDAU KLEFFNER SYNDROME; MYOCLONUS EPILEPSY; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK; RISK BENEFIT ANALYSIS; ROLANDIC EPILEPSY; SEIZURE; SLOW WAVE SLEEP; SPIKE WAVE; TEMPORAL LOBE EPILEPSY; WEST SYNDROME;

EID: 0036454603     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(02)35022-2     Document Type: Conference Paper

References (121)

1. Ambrosetto, G. and Tassinari, C.A. (1990) Antiepileptic drug treatment of benign childhood epilepsy with rolandic spikes: Is it necessary?. Epilepsia, 31: 802-805.
2. Annegers, J.F., Hauser, W.A. and Elveback, L.R. (1979a) Remission of seizures and relapse in patients with epilepsy. Epilepsia, 20: 729-737.
3. Annegers, J.F., Hauser, W.A., Elveback, L.R. and Kurland, L.T. (1979b) The risk of epilepsy following febrile convulsions. Neurology, 29: 297-303.
4. Annegers, J.F., Grabow, J.D., Groover, R.V., Laws Jr., E.R., Elveback, L.R. and Kurland, L.T. (1980) Seizures after head trauma: A population study. Neurology, 30: 683-689.
5. Annegers, J.F., Shirts, S.B., Hauser, W.A. and Kurland, L.T. (1986) Risk of recurrence after an initial unprovoked seizure. Epilepsia, 27: 43-50.
6. Annegers, J.F., Hauser, W.A., Shirts, S.B. and Kurland, L.T. (1987) Factors prognostic of unprovoked seizures after febrile convulsions. New Engl. J. Med., 316: 493-498.
7. Annegers, J.F., Blakely, S.A., Hauser, W.A. and Kurland, L.T. (1990) Recurrence of febrile convulsions in a population-based cohort. Epilepsy Res., 66: 1009-1012.
8. Annegers, J.F., Hauser, W.A., Coan, S. and Rocca, W.A. (1998) A population-based study of seizures after traumatic brain injuries. New Engl. J. Med., 338: 20-24.
9. Baram, T.Z., Mitchell, W.G., Toumay, A., Snead, O.C., Hanson, R.A. and Horton, E.J. (1996) High-dose corticotropin (ACTH) versus prednisone for infantile spasms: A prospective, randomized, blinded study. Pediatrics, 97: 375-379.
10. Beaumanoir, A. (1992) The Landau-Kleffner syndrome. In: J. Roger, M. Bureau, C. Dravet, F.E. Dreifuss et al. (Eds.), Epileptic Syndromes in Infancy, Childhood and Adolescence, 2nd Edn. John Libbey, London, pp. 231-243.
11. Bell, B. and Davies, K. (1998) Hippocampal sclerosis and memory: Recent neuropsychological findings. Neuropsychol. Rev., 8: 25-41.
12. Berg, A.T. and Shinnar, S. (1991) The risk of seizure recurrence following a first unprovoked seizure: a quantitative review. Neurology, 41: 965-972.
13. Berg, A.T. and Shinnar, S. (1996a) Unprovoked seizures in children with febrile seizures: Short term outcomes. Neurology, 47: 562-568.
14. Berg, A.T. and Shinnar, S. (1996b) Complex febrile seizures. Epilepsia, 37: 126-133.
15. Berg, A.T. and Shinnar, S. (1997) Do seizures beget seizures? An assessment of the clinical evidence in humans. J. Clin. Neurophysiol., 14: 102-110.
16. Berg, A.T., Shinnar, S., Hauser, W.A. and Leventhal, J.M. (1990) Predictors of recurrent febrile seizures: A meta-analytic review. J. Pediatr., 116: 329-337.
17. Berg, A.T., Shinnar, S., Hauser, W.A., Alemany, M., Shapiro, E.D., Salomon, M.E. and Crain, E.F. (1992) A prospective study of recurrent febrile seizures. New Engl. J. Med., 327: 1122-1127.
18. Berg, A.T., Shinnar, S., Darefsky, A.S., Holford, T.R., Shapiro, E.D., Salomon, M.E., Crain, E.F. and Hauser, W.A. (1997) Predictors of recurrent febrile seizures. Arch. Pediatr. Adolesc. Med., 151: 371-378.
19. Berg, A.T., Shinnar, S., Levy, S.R. and Testa, F.M. (1999) Status epilepticus in children with newly diagnosed epilepsy. Ann. Neurol., 45: 618-623.
20. Berg, A.T., Shinnar, S., Levy, S.R., Testa, F.M., Smith-Rapaport, S. and Beckerman, B. (2001) Early development of intractable epilepsy in children: A prospective study. Neurology, 56: 1445-1452.
21. Bishop, D.V.M. (1985) Age of onset and outcome in 'acquired aphasia with convulsive disorder' (Landau-Kleffner syndrome). Dev. Med. Child Neurol., 27: 705-712.
22. Camfield, P.R., Camfield, C.S., Dooley, J.M., Tibbles, J.A.R., Fung, T. and Garner, B. (1985) Epilepsy after a first unprovoked seizure in childhood. Neurology, 35: 1657-1660.
23. Camfield, P., Camfield, C., Dooley, J., Smith, E. and Garner, B. (1989) A randomized study of carbamazepine versus no medication following a first unprovoked seizure in childhood. Neurology, 39: 851-852.
24. Camfield, C., Camfield, P., Gordon, K. and Dooley, J. (1996) Does the number of seizures before treatment influence ease of control or remission of childhood epilepsy? Not if the number is 10 or less. Neurology, 464: 41-44.
25. Chadwick, D. (1995) Do anticonvulsants alter the natural course of epilepsy? Case for early treatment is not established. Br. Med. J., 310: 177-178.
26. Chandra, B. (1992) First seizure in adults: To treat or not to treat. Clin. Neurol. Neurosurg., 94(Suppl.): S61-S63.
27. Chang, Y.-C., Guo, N.-W., Huang, C.-C., Wang, S.-T. and Tsai, J.-J. (2000) Neurocognitive attention and behavior outcome of school-age children with a history of febrile convulsions: A population study. Epilepsia, 41: 412-420.
28. Chang, Y.C., Guo, N.W., Wang, S.T., Huang, C.C. and Tsai, J.J. (2001) Working memory of school-aged children with a history of febrile convulsions: A population study. Neurology, in press.
29. Chen, K., Baram, T.Z. and Soltesz, I. (1999) Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nat. Med., 5: 888-894.
30. Cockerell, O.C., Johnson, A.L., Sander, J.W. and Shorvon, S.D. (1997) Prognosis of epilepsy: A review and further analysis of the first nine years of the British National General Practice Study of Epilepsy, a prospective population-based study. Epilepsia, 38: 31-46.
31. Collaborative Group for the Study of Epilepsy (1992) Prognosis of epilepsy in newly referred patients: A multicenter prospective study of the effects of monotherapy on the long-term course of epilepsy. Epilepsia, 33: 45-51.
32. Committee on Drugs (1995) American Academy of Pediatrics. Behavioral and cognitive effects of anticonvulsant therapy. Pediatrics, 96: 538-540.
33. Commission on Epidemiology and Prognosis (1993) International League Against Epilepsy. Guidelines for epidemiologic studies on epilepsy. Epilepsia, 34: 592-596.
34. Corey, L.A., Pellock, J.M., Boggs, J.G., Miller, L.L. and DeLorenzo, R.J. (1998) Evidence for a genetic predisposition for status epilepticus. Neurology, 50: 558-560.
35. Dube, C. (2002) Do prolonged 'febrile' seizures in an immature rat model cause epilepsy? In: T.Z. Baram and S. Shinnar (Eds.), Febrile Seizures. Academic Press, San Diego, CA, pp. 215-229.
36. Dube, C., Chen, K., Eghbal-Ahmadi, M., Brunson, K., Soltesz, I. and Baram, T.Z. (2000) Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann. Neurol., 47: 336-344.
37. Duchowny, M. (2000) Seizure recurrence in childhood epilepsy: "The future ain't what it used to be". Ann. Neurol., 48: 137-139.
38. Dugas, M., Gerard, C.L., Franc, S. et al. (1991) Natural history, course and prognosis of the Landau and Kleffner syndrome. In: I.P. Martins, A. Castro-Caldas, H.R. Van Dongen and A. van Hout (Eds.), Acquired Aphasia in Children: Acquisition and Breakdown of Language in the Developing Brain. Kluwer Academic, Dordrecht, pp. 263-277.
39. Ellenberg, J.H. and Nelson, K.B. (1978) Febrile seizures and later intellectual performance. Arch. Neurol., 35: 17-21.
40. Elwes, R.D., Johnson, A.L., Shorvon, S.D. and Reynolds, E.H. (1984) The prognosis for seizure control in newly diagnosed epilepsy. New Engl. J. Med., 311: 944-947.
41. Elwes, R.D., Johnson, A.L. and Reynolds, E.H. (1988) The course of untreated epilepsy. Br. Med. J., 297: 948-950.
42. Engel Jr., J. (2001) Finally, a randomized, controlled trial of epilepsy surgery. New Engl. J. Med., 345: 365-367.
43. Engel, J. and Shewmon, D.A. (1991) The impact of the kindling phenomenon on clinical epileptology. In: F. Morrell (Ed.), Kindling and Synaptic Plasticity: The Legacy of Graham Goddard. Birkhauser, Boston, MA, pp. 195-210.
44. Feksi, A.T., Kaamugisha, J., Sander, J.W., Gatiti, S. and Shorvon, S.D. (1991) Comprehensive primary health care antiepileptic drug treatment in rural and semi-urban Kenya. Lancet, 337: 406-407.
45. First Seizure Trial Group (1993) Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic-clonic seizure. Neurology, 43: 478-483.
46. Foy, P.M., Chadwick, D.W., Rajgopalan, N., Johnson, A.L. and Shaw, M.D. (1992) Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?. J. Neurol. Neurosurg. Psychiatry, 55: 753-757.
47. Freeman, J.M., Tibbles, J., Camfield, C. and Camfield, P. (1987) Benign epilepsy of childhood: A speculation and its ramifications. Pediatrics, 79: 864-868.
48. Fuerst, D., Shah, J., Kupsky, W.J., Johnson, R., Shah, A., Hayman-Abello, B., Ergh, T., Poore, Q., Canady, A. and Watson, C. (2001) Volumetric MRI, pathological, and neuropsychological progression in hippocampal sclerosis. Neurology, 57: 184-188.
49. Gilad, R., Lampl, Y., Gabbay, U., Eshel, Y. and Sarova-Pinhas, I. (1996) Early treatment of a single generalized tonic-clonic seizure of prevent recurrence. Arch. Neurol., 53: 1149-1152.
50. Goldensohn, E.S. (1984) The relevance of secondary epileptogenesis to the treatment of epilepsy: Kindling and the mirror focus. Epilepsia, 25(Suppl. 2): S156-S168.
51. Gowers, W.R. (1881) Epilepsy and Other Chronic Convulsive Disorders. Churchill, London.
52. Hauser, W.A. and Lee, J.R. (2002) Do seizures beget seizures? In: T. Sutula and A. Pitkänen (Eds.), Do Seizures Damage the Brain. Progress in Brain Research, Vol. 135. Elsevier, Amsterdam, pp. 215-219.
53. Hauser, W.A., Anderson, V.E., Loewenson, R.B. and McRoberts, S.M. (1982) Seizure recurrence after a first unprovoked seizure. New Engl. J. Med., 307: 522-528.
54. Hauser, W.A., Tabaddor, K., Factor, P. and Feiner, C. (1984) Seizures and head injury in an urban community. Neurology, 34: 746-758.
55. Hauser, W.A., Rich, S.S., Annegers, J.F. and Anderson, V.E. (1990) Seizure recurrence after a 1st unprovoked seizure: An extended followup. Neurology, 40: 1163-1170.
56. Hauser, W.A., Rich, S.S., Lee, J.R., Annegers, J.F. and Anderson, V.E. (1998) Risk of recurrent seizures after two unprovoked seizures. New Engl. J. Med., 338: 429-434.
57. Hesdorffer, D.C. and Hauser, W.A. (2002) Febrile seizures and the risk for epilepsy. In: T.Z. Baram and S. Shinnar (Eds.), Febrile Seizures. Academic Press, San Diego, CA, pp. 63-76.
58. Hirtz, D. (2002) Cognitive outcome of febrile seizures. In: T.Z. Baram and S. Shinnar (Eds.), Febrile Seizures. Academic Press, San Diego, CA, pp. 53-61.
59. Hirtz, D., Ashwal, S., Berg, A., Bettis, D., Camfield, C., Camfield, P., Crumrine, P., Elterman, R., Schneider, S. and Shinnar, S. (2000) Practice Parameter: Evaluating a first nonfebrile seizure in children: Report of the Quality Standards Subcommittee of the American Academy of Neurology, the Child Neurology Society and the American Epilepsy Society. Neurology, 55: 616-623.
60. Hopkins, A., Garman, A. and Clarke, C. (1988) The first seizure in adult life: Value of clinical features electroencephalography and computerized tomographic scanning in prediction of seizure recurrence. Lancet, 1: 721-726.
61. Jeavons, P.M. and Livet, M.O. (1992) West syndrome: Infantile spasms. In: J. Roger, M. Bureau, C. Dravet et al. (Eds.), Epileptic Syndromes in Infancy, Childhood and Adolescence, 2nd Edn. John Libbey, London, pp. 53-65.
62. Kim, W.J., Park, S.C. and Lee, S.J. et al. (1999) The prognosis for control of seizures with medications in patients with MRI evidence for mesial temporal sclerosis. Epilepsia, 40: 290-293.
63. Knudsen, F.U. (2002) Treatment of febrile seizures: Practical management approaches to simple and complex febrile seizures. In: T.Z. Baram and S. Shinnar (Eds.), Febrile Seizures. Academic Press, San Diego, CA, pp. 273-304.
64. Knudsen, F.U. and Vestermark, S. (1985) Recurrence risk after first febrile seizure and effect of short-term diazepam prophylaxis. Arch. Dis. Child., 60: 1045-1049.
65. Knudsen, F.U., Paerregaard, A., Andersen, R. and Andresen, J. (1996) Long term outcome of prophylaxis for febrile convulsions. Arch. Dis. Child., 74: 13-18.
66. Kobayashi, E., Lopes-Cendes, I., Guerreiro, C.A.M., Sousa, S.C., Guerreiro, M.M. and Cendes, F. (2001) Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy. Neurology, 56: 166-172.
67. Lerman, P. (1992) Benign partial epilepsy with centro-temporal spikes. In: J. Roger, M. Bureau, C. Dravet et al. (Eds.), Epileptic Syndromes in Infancy, Childhood and Adolescence. 2nd Edn. John Libbey, London, pp. 189-200.
68. Lerman, P., Lerman-Sagie, T. and Kivity, S. (1991) Effect of early steroid therapy for Landau-Kleffner syndrome. Dev. Med. Child Neurol., 33: 257-266.
69. Loiseau, P. (1992) Childhood absence epilepsy. In: J. Roger, M. Bureau, C. Dravet et al. (Eds.), Epileptic Syndromes in Infancy, Childhood and Adolescence, 2nd Edn. John Libbey, London, pp. 135-150.
70. Ludvigsson, P., Ólafsson, E., Siguroardottir, S. and Hauser, W.A. (1994) Epidemiologic features of infantile spasms in Iceland. Epilepsia, 35: 802-805.
71. MacDonald, B.K., Johnson, A.L., Goodridge, D.M., Cockrell, O.C., Sander, J.W.A.S. and Shorvon, S.D. (2000) Factors predicting prognosis of epilepsy after presentation with seizures. Ann. Neurol., 48: 833-841.
72. Marescaux, C., Hirsch, E. and Finck, S. et al. (1990) Landau-Kleffner syndrome. A pharmacologic study of five cases. Epilepsia, 31: 768-777.
73. Maytal, J. and Shinnar, S. (1990) Febrile status epilepticus. Pediatrics, 86: 611-616.
74. Mitchell, T.V. and Lewis, D.V. (2002) Do prolonged febrile seizures injure the hippocampus? Human MRI studies. In: T.Z. Baram and S. Shinnar (Eds.), Febrile Seizures. Academic Press, San Diego, CA, pp. 103-126.
75. Morrell, F., Whisler, W.W. and Smith, M.C. et al. (1995) Landau-Kleffner syndrome: Treatment with subpial intracortical transection. Brain, 118: 1529-1546.
76. Moshe, S.L. and Shinnar, S. (1993) Early intervention. In: J. Engel Jr. (Ed.), Surgical Treatment of the Epilepsies, 2nd Edn. Raven Press, New York, NY, pp. 123-132.
77. Musicco, M., Beghi, E., Solari, A. and Viani, F. (1997) Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy. Neurology, 49: 991-998.
78. National Institutes of Health (1980) Febrile Seizures: Consensus Development Conference Summary. Vol. 3, no. 2. National Institutes of Health, Bethesda, MD.
79. Nelson, K.B. and Ellenberg, J.H. (1978) Prognosis in children with febrile seizures. Pediatrics, 61: 720-727.
80. O'Dell, C. and Shinnar, S. (2001) Initiation and discontinuation of antiepileptic drugs. Neurol. Clin., 19: 289-311.
81. Offringa, M., Derksen-Lubsen, G., Bossuyt, P.M.M. and Lubsen, J. (1992) Seizure recurrence after a first febrile seizure: A multivariate approach. Dev. Med. Child Neurol., 34: 15-24.
82. Offringa, M., Bossuyt, P.M.M. and Lubsen, J. et al. (1994) Risk factors for seizure recurrence in children with febrile seizures: A pooled analysis of individual patient data from five studies. J. Pediatr., 124: 574-584.
83. Ohtsuka, Y., Yoshinaga, H., Kobayashi, K., Murakami, N., Yamatogi, Y. Oka, E. and Tsuda, T. (2001) Predictors and underlying causes of medically intractable localization-related epilepsy in childhood. Pediatr. Neurol., 24: 209-213.
84. Reynolds, E.H. (1995) Do anticonvulsants alter the natural course of epilepsy? Treatment should be started as early as possible. Br. Med. J., 310: 176-177.
85. Reynolds, E.H., Elwes, R.D.C. and Shorvon, S. (1983) Why does epilepsy become intractable? Prevention of chronic epilepsy. Lancet, 2(356): 952-954.
86. Riikonen, R.S. (2000) Steroids or vigabatrin in the treatment of infantile spasms?. Pediatr Neurol., 23: 403-408.
87. Rintahaka, P.J., Chugani, H.T. and Sankar, R. (1995) Landau-Kleffner syndrome with continuous spikes and waves during slow-wave sleep. J. Child Neurol., 10: 127-133.
88. Rosman, N.P., Colton, T. and Labazzo, J. et al. (1993a) A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures. New Engl. J. Med., 329: 79-84.
89. Rosman, N.P., Labazzo, J.L. and Colton, T. (1993b) Factors predisposing to afebrile seizures after febrile convulsions and preventive treatment. Ann. Neurol., 34: 452.
90. Sander, J.W.A.S. (1993) Some aspects of prognosis in the epilepsies: A review. Epilepsia, 34: 1007-1016.
91. Sass, K., Sass, A. and Westerveld, M. et al. (1992) Specificity in the correlation of verbal memory and hippocampal neuron loss: Dissociation of memory, language, and verbal intellectual ability. J. Clin. Exp. Neuropsychol., 14: 662-672.
92. Shafer, S., Hauser, W.A., Annegers, J.F. and Klass, D.W. (1988) EEG and other early predictors of later epilepsy remission: A community study. Epilepsia, 29: 590-600.
93. Shinnar, S. (1998) Prolonged febrile seizures and mesial temporal sclerosis. Ann. Neurol., 43: 411-412.
94. Shinnar, S. and Berg, A.T. (1996) Does antiepileptic drug therapy prevent the development of 'chronic' epilepsy. Epilepsia, 37: 701-708.
95. Shinnar, S., Berg, A.T., Moshe, S.L., Petix, M., Maytal, J., Kang, H., Goldensohn, E.S. and Hauser, W.A. (1990) Risk of seizure recurrence following a first unprovoked seizure in childhood: A prospective study. Pediatrics, 85: 1076-1085.
96. Shinnar, S., Berg, A.T. and Moshe, S.L. (1995) The effect of status epilepticus on the long term outcome of a cohort of children prospectively followed from the time of their first idiopathic unprovoked seizure. Dev. Med. Child Neurol., 37(Suppl. 72): 116.
97. Shinnar, S., Berg, A.T., Moshe, S.L., O'Dell, C., Newstein, D., Kang, H., Goldensohn, H. and Hauser, W.A. (1996) The risk of seizure recurrence following a first unprovoked afebrile seizure in childhood: An extended follow-up. Pediatrics, 98: 216-225.
98. Shinnar, S., Berg, A.T., O'Dell, C., Newstein, D., Moshe, S.L. and Hauser, W.A. (2000) Predictors of multiple seizures in a cohort of children prospectively followed from the time of their first unprovoked seizure. Ann. Neurol., 48: 140-147.
99. Shinnar, S., Pellock, J.M., Berg, A.T., O'Dell, C., Driscoll, S.M., Maytal, J., Moshe, S.L. and DeLorenzo, R.J. (2001a) Short-term outcomes of children with febrile status epilepticus. Epilepsia, 42: 47-53.
100. Shinnar, S., Berg, A.T., Moshe, S.L. and Shinnar, R. (2001b) How long do new-onset seizures in children last?. Ann. Neurol., 49: 659-664.
101. Shorvon, S.D. and Reynolds, E.H. (1982) Early prognosis of epilepsy. Br. Med. J., 285: 1699-1701.
102. Sillanpaa, M., Jalava, M., Kaleva, O. and Shinnar, S. (1998a) Long-term prognosis of seizures with onset in childhood. New Engl. J. Med., 338: 1715-1722.
103. Sillanpaa, M., Jalava, M. and Shinnar, S. (1998b) Status epilepticus in a population based cohort with childhood onset epilepsy in Finland. Epilepsia, 39(Suppl. 6): 219-220.
104. Stroink, H., Brouwer, O.F., Arts, W.F., Geerts, A.T., Peters, A.C. and van Donselaar, C.A. (1998) The first unprovoked seizure in childhood: a hospital based study of the accuracy of the diagnosis, rate of recurrence, and long term outcome after recurrence. Dutch study of epilepsy in childhood. J. Neurol. Neurosurg. Psychiatry, 64: 595-600.
105. Sutula, T.P. and Pitkanen, A. (2001) More evidence for seizureinduced neuron loss: Is hippocampal sclerosis both cause and effect of epilepsy?. Neurology, 57(2): 169-170.
106. Tassinari, C.A., Bureau, M., Dravet, C., Dallla Bernardina, B. and Roger, J. (1992) Epilepsy with continuous spikes and waves during slow wave sleep - Otherwise described as ESES (epilepsy with electrical status epilepticus in slow wave sleep. In: J. Roger, M. Bureau, C. Dravet et al. (Eds.), Epileptic Syndromes in Infancy, Childhood and Adolescence, 2nd Edn. John Libbey, London, pp. 245-256.
107. Taylor, D.C. and Ounsted, C. (1971) Biological mechanisms influencing the outcome of seizures in response to fever. Epilepsia, 12: 33-45.
108. Temkin, N.R., Dikmen, S.S., Wilensky, A.J., Keihm, J., Chabal, S. and Winn, H.R. (1990) A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. New Engl. J. Med., 323: 497-502.
109. Toth, Z., Yan, X.X., Haftoglou, S., Ribak, C.E. and Baram, T.Z. (1998) Seizure-induced neuronal injury: Vulnerability to febrile seizures in immature rat model. J. Neurosci., 18: 4285-4294.
110. Van Donselaar, C.E., Schimsheimer, R.J., Geerts, A.T. and Declerck, A.C. (1992) Value of the electroencephalogram in adult patients with untreated idiopathic first seizures. Arch. Neurol., 49: 231-237.
111. Van Donselaar, C.A., Brouwer, O.F., Geerts, A.T., Arts, W.F., Stroink, H. and Peters, A.C. (1997) Clinical course of untreated tonic-clonic seizures in childhood: Prospective, hospital based study. Br. Med. J., 314: 401-404.
112. VanLandingham, K.E., Heinz, E.R., Cavazos, J.E. and Lewis, D.V. (1998) MRI evidence of hippocampal injury after prolonged, focal febrile convulsions. Ann. Neurol., 43: 413-426.
113. Verity, C.M. and Golding, J. (1991) Risk of epilepsy after febrile convulsions: A national cohort study. Br. Med. J., 303: 1373-1376.
114. Verity, C.M., Greenwood, R. and Golding, J. (1998) Long-term intellectual and behavioral outcomes of children with febrile convulsions. New Engl. J. Med., 338: 1723-1728.
115. Vining, E.P.G., Mellits, E.D., Dorsen, M.M., Cataldo, M.F., Quaskey, S.A., Spielberg, S.P. and Freeman, J.M. (1987) Psychologic and behavioral effects of antiepileptic drugs in children: A double-blind comparison between phenobarbital and valproic acid. Pediatrics, 80: 165-174.
116. Wallace, S.J. (1980) They don't do very well. Pediatrics, 65: 678-679.
117. Wiebe, S., Blume, W.T., Girvin, J.P. and Eliasziw, M. (2001) Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy. New Engl. J. Med., 345: 311-318.
118. Wirrell, E.C., Camfield, C.S., Camfield, P.R., Dooley, J.M., Gordon, K.E. and Smith, B. (1997) Long-term psychosocial outcome in typical absence epilepsy. Sometimes a wolf in sheeps' clothing. Arch. Pediatr. Adolesc. Med., 151: 152-158.
119. Wolf, P. (1992) Juvenile myoclonic epilepsy. In: J. Roger, M., Bureau, C. Dravet et al. (Eds.), Epileptic Syndromes in Infancy, Childhood and Adolescence, 2nd Edn. John Libbey, London, pp. 313-328.
120. Wolf, S.M. and Forsythe, A. (1989) Epilepsy and mental retardation following febrile seizures in childhood. Acta Paediatr. Scand., 78: 291-295.
121. Wolf, S.M., Carr, A. and Davis, D.C. et al. (1977) The value of phenobarbital in the child who has had a single febrile seizure: A controlled prospective study. Pediatrics, 59: 378-385.