Fumaric acid esters are potent immunosuppressants: Inhibition of acute and chronic rejection in rat kidney transplantation models by methyl hydrogen fumarate

Archives of Dermatological Research

Volumn 294, Issue 9, 2002, Pages 399-404

  Lehmann, Manfred ^a   Risch, Kirsten ^a   Nizze, Horst ^a   Lutz, Jens ^b   Heemann, Uwe ^b   Volk, Hans Dieter ^c   Asadullah, Khusru ^c,d  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d BAYER PHARMA AG   (Germany)

Author keywords

Cytokines; Immunotherapy; Psoriasis; Transplantation

Indexed keywords

CALCIUM METHYL HYDROGEN FUMARATE; FUMARIC ACID DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; UNCLASSIFIED DRUG; CREATININE;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; FEMALE; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RAT; RECIPIENT; SURVIVAL TIME; ACUTE DISEASE; ANIMAL; BLOOD; CHRONIC DISEASE; DRUG EFFECT; GRAFT REJECTION; RAT STRAIN;

ACUTE DISEASE; ANIMALS; CHRONIC DISEASE; CREATININE; FUMARATES; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; RATS; RATS, INBRED STRAINS;

EID: 0036454041     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-002-0347-6     Document Type: Article

References (28)

1. Aizawa M, Natori T (1983) Transplantation immunobiology in the rat. In: Yamamura Y, Tada T (eds) Progress in Immunology. Academic Press, Tokyo, pp 1439-1448
2. Altmeyer PJ, Matthes U, Pawlak F, et al (1994) Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients. J Am Acad Dermatol 30:977-981
3. Asadullah K, Schmid H, Friedrich M, Randow F, Volk HD, Sterry W, Döcke WD (1997) Influence of monomethylfumarate on monocytic cytokine formation - Explanation for adverse and therapeutic effects in psoriasis? Arch Dermatol Res 289:623-630
4. Asadullah K, Sabat R, Wiese A, Döcke WD, Volk HD, Sterry W (1999) Interleukin-10 in cutaneous disorders: Implications for its pathophysiological importance and therapeutical use. Arch Dermatol Res 291:628-636
5. Asadullah K, Volk HD, Sterry W (2002) Novel immunotherapies for psoriasis. Trends Immunol 23:47-53
6. Bayard W, Hunziker T, Krebs A, Speiser P, Joshi R (1987) Peroral long-term treatment of psoriasis using fumaric acid derivatives. Hautarzt 38:279-285
7. Christophers E, Sterry W (1993) Psoriasis. In: Fitzpatric TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds) Dermatology in General Medicine. McGraw-Hill, New York, pp 489-515
8. De Jong R, Bezemer AC, Zomerdijk TP, van de Pouw-Kraan T, Ottenhoff TH, Nibbering PH (1996) Selective stimulation of T helper 2 cytokine responses by anti-psoriasis agent monomethylfumarate. Eur J Immunol 26:2067-2074
9. Diamond JR, Tilney NL, Frye J, Ding G, McElroy J, Pesek-Diamond I, Yang H (1992) Progressive albuminuria and glomerulosclerosis in a rat model of chronic renal allograft rejection. Transplantation 54:710-716
10. Hancock WH, Whitley WD, Tullius SG, Heemann UW, Wasowska B, Baldwin WM, Tilney NL (1993) Cytokines, adhesion molecules, and the pathogenesis of chronic rejection of rat renal allografts. Transplantation 56:643-650
11. Lebwohl M, Ali S (2001) Treatment of psoriasis. Part 2. Systemic therapies. J Am Acad Dermatol 45:649-661
12. Lee S (1967) An improved technique of renal transplantation in the rat. Surgery 61:771-773
13. Loewe R, Pillinger M, de Martin R, Mrowietz U, Groger M, Holnthoner W, Wolff K, Wiegrebe W, Jirovsky D, Petzelbauer P (2001) Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NF-kappa B-dependent manner. J Invest Dermatol 117:1363-1368
14. Loewe R, Holnthoner W, Groger M, Pillinger M, Gruber F, Mechtcheriakova D, Hofer E, Wolff K, Petzelbauer P (2002) Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells. J Immunol 168:4781-4787
15. Mrowietz U, Christophers E, Altmeyer P (1998) Treatment of psoriasis with fumaric acid esters: Results of a prospective multicentre study. German Multicentre Study. Br J Dermatol 138:456-460
16. Mrowietz U, Christophers E, Altmeyer P (1999) Treatment of severe psoriasis with fumaric acid esters: Scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference. Br J Dermatol 141:424-429
17. Nickoloff BJ (1991) The cytokine network in psoriasis. Arch Dermatol 127:871-884
18. Nieboer C, de Hoop D, Langendijk PN, van Loenen AC, Gubbels J (1990) Fumaric acid therapy in psoriasis: A double-blind comparison between fumaric acid compound therapy and monotherapy with dimethylfumaric acid ester. Dermatologica 181:33-37
19. Nugteren-Huying WM, van der Schroeff JG, Hermans J, Suurmond D (1990) Fumaric acid therapy for psoriasis: A randomized, double-blind, placebo-controlled study. J Am Acad Dermatol 22:311-312
20. Savory J, Pu PH, Sundermann FW (1968) A biuret method for determination of protein in normal urine. Clin Chem 14:1160-1171
21. Sebök B, Bonnekoh B, Geisel J, Mahrle G (1994) Antiproliferative and cytotoxic profiles of antipsoriatic fumaric acid derivatives in keratinocyte cultures. Eur J Pharmacol 270:79-87
22. Sebök B, Bonnekoh B, Geisel J, Mahrle G (1994) IL-1 alpha-induced expression of ICAM-1 on cultured hyperproliferative keratinocytes: Suppression by antipsoriatic dimethylfumarate. Int J Dermatol 33:367-370
23. Steinbruchel DA, Larsen S, Kristensen T, Starklint H, Koch C, Kemp E (1992) Survival, function, morphology and serological aspects of rat renal allografts. Effect of short-term treatment with cyclosporine A, anti-CD4 and anti-interleukin-2 receptor monoclonal antibodies. APMIS 100:682-694
24. Thio HB, van der Schroeff JG, Nugteren-Huying WM, Vermeer BJ (1995) Long-term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm®) in psoriasis. J Eur Acad Dermatol Venereol 4:35-40
25. Tilney NL, Whitley WD, Tullius SG, Heemann U, Wasowska B, Baldwin WM, Hancock WW (1993) Serial analysis of cytokines, adhesion molecule expression and humoral responses during development of chronic kidney allograft rejection in a new rat model. Transplant Proc 25:861-862
26. Valdimarsson H, Baker BS, Johnsdottir I, Fry L (1986) Psoriasis: A disease of abnormal keratinocyte proliferation induced by T lymphocytes. Immunol Today 7:256-259
27. Vandermeeren M, Janssens S, Wouters H, Borghmans I, Borgers M, Beyaert R, Geysen (2001) Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-KB1, but not Re1A in normal human dermal fibroblast cells. J Invest Dermatol 116:124-130
28. Zhu K, Mrowietz U (2001) Inhibition of dendritic cell differentiation by fumaric acid esters. J Invest Dermatol 116:203-208