Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: A possible mechanism of protection

Journal of Biochemical and Molecular Toxicology

Volumn 16, Issue 5, 2002, Pages 254-259

  Abd Allah, Adel R A ^a   Al Majed, Abdulhakeem A ^a   Mostafa, Adel M ^a   Al Shabanah, Othman A ^a   El Din, Ayman Gamal ^a   Nagi, Mahmoud N ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Arabic gum; Cardiotoxicity; Creatine kinase; Lipid peroxidation; Mice; Reduced glutathione

Indexed keywords

CREATINE KINASE; DOXORUBICIN; GUM ARABIC; LIPID PEROXIDASE; MALONALDEHYDE; SCAVENGER; SUPEROXIDE; ANTINEOPLASTIC AGENT; GLUTATHIONE; LIPID PEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; CARDIOTOXICITY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DRUG MECHANISM; HEART PROTECTION; MALE; MOUSE; NONHUMAN; REVIEW; SINGLE DRUG DOSE; ANIMAL; ARTICLE; BLOOD; DRUG EFFECT; HEART; HEART MUSCLE; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; METABOLISM; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CREATINE KINASE; DOXORUBICIN; FREE RADICAL SCAVENGERS; GLUTATHIONE; GUM ARABIC; HEART; INJECTIONS, INTRAPERITONEAL; LIPID PEROXIDATION; LIPID PEROXIDES; MALE; MALONDIALDEHYDE; MICE; MYOCARDIUM; SUPEROXIDES;

EID: 0036453422     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.10046     Document Type: Review

References (35)

1. Arcamone F, Franceschi G, Tenco S, Selva S. Adriamycin (14-hydroxy daunorubicin), A novel antitumor antibiotic. Tetrahedron Lett 1969;13:1007-1010.
2. Singal P, Deally CMR, Weinberg IE. Subcellular effects of adriamycin in the heart: Concise review. J Mol Cell Cardiol 1987;19:817-828.
3. Buja LM, Ferrans VJ, Mayer RJ, Roberts WC, Henderson ES. Cardiac ultrastructural changes induced by daunorubicin therapy. Cancer 1973;32:771-788.
4. Tong J, Ganguly PK, Singal PK. Myocardial adrenergic changes at two stages of heart failure due to adriamycin treatment in rats. Am J Physiol 1991;260:H909-H916.
5. 2+ binding and lipid peroxidation but depresses myocardial function. Am J Physiol 1986;1250:H419-H425.
6. Myers CE, McGuire WP, Liss RH, Ifrim I, Grotzinger K, Young RC. Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response. Science 1977;19:165-167.
7. Siveski-Iliskovic N, Kaul N, Singal PK. Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 1994;89:2829-2835.
8. Morishima I, Matsui H, Mukawa H, Hayashi K, Toki Y, Okumura K, Ito T, Hayakawa T. Melatonin: A pineal hormone with antioxidant property protect against adriamycin cardiomyopathy in rats. Life Sci 1998;63:511-521.
9. Mostafa AM, Nagi MN, Al-Rikabi AC, Al-Shabanah OA, El-Kashef HA. Protective effect of aminoguanidine against cardiovascular toxicity of chronic doxorubicin treatment in rats. Mol Pathol Pharmacol Res Commun 1999;106:193-202.
10. Kotsinas A, Gorgoulis V, Zacharatos P, Zioris H, Triposkiadis F, Donta I, Kyriakidis M, Karayannacos P, Kittas C. Antioxidant agent nimesulid and beta-blocker metoprolol do not exert protective effects against rat mitochondrial DNA alterations in adriamycin-induced cardiotoxicity Biochem Biophys Res Commun 1999;254:651-656.
11. Sayed-Ahmed MM, Shouman SA, Rezk BM, Khalifa MH, Osman AM, El-Merzabani MM. Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. Pharmacol Res 2000;41:143-150.
12. Sayed-Ahmed MM, Salman TM, Gaballah HE, Abou El-Naga SA, Nicolai R, Calvani M. Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy. Pharmacol Res 2001;43:513-520.
13. Nagi MN, Mansour MA. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacol Res 2000;41:283-289.
14. Doroshow JH. Effect of anthracyclin antibiotics on oxygen radical formation in rat heart. Cancer Res 1983;43:460-472.
15. Venkatesan N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 1998;124:425-427.
16. Al-Shabanah OA, Mansour M, El-Kashef H, Al-Bekairi A. Captopril ameliorates myocardial and hematological toxicities induced by adriamycin. Biochem Mol Biol Int 1998;17:419-427.
17. Al-Harbi MM, Al-Gharably NM, Al-Shabanah OA, Al-Bekairi Am, Osman AM, Tawafik HN. Prevention of doxorubicin-induced myocardial and haematological toxicities in rats by the iron chelator desferrioxamine. Cancer Chemother Pharmacol 1992;31:200-204.
18. Yeung TK, Jaenke RS, Wilding D, Creighton AM, Hopewell FW. The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat. Cancer Chemother Pharmacol 1992;30:58-64.
19. Rossi F, Filippelli W, Russo S, Filippelli A, Berrino L. Cardiotoxicity of doxorubicin: Effects of drugs inhibiting the release of vasoactive substances. Pharmacol Toxicol 1994;75:99-107.
20. Myers CE, Chabner BA. Anthracyclines. In: Chabner BA, Collins JM, editors. Cancer Chemotherapy: Principles and Practice. Philadelphia: JB Lippincott Co.; 1990. pp 356-381.
21. Bliss DZ, Stein TP, Schleifer CR, Settle RG. Supplementation with gum arabic fiber increases fecal nitrogen excretion and lowers serum urea nitrogen concentration in chronic renal failure patients consuming a low-protein diet. Am J Clin Nutr 1996;63:392-398.
22. Phillips GO. Acacia gum (gum Arabic): A nutritional fibre; metabolism and calorific value. Food Addit Contam 1998;15:251-264.
23. Al-Majed AA, Mostafa AM, Al-Rikabi AC, Al-Shabanah OA. Protective effects of oral Arabic gum administration on gentanmicin-induced nephrotoxicity in rats. Pharmacol Res 2002;46(5):445-451.
24. 2+ and reversing effect of EDTA. Clin Chem 1978;24:177-184.
25. Ohkawa H, Ohish N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid. Anal Biochem 1979;95:351-358.
26. Ellman, GL. Tissue sulfahydryl groups. Arch Biochem Biophys 1959;82:70-77.
27. Nikishimi M, Rao NA, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 1972;46:849-854.
28. Misra HP, Fridovich I. Superoxide dismutase: A photochemical augmentation assay. Arch Biochem Biophys 1977;181:308-312.
29. Mimnaugh EG, Trush MA, Bhatangar M, Gram TE. Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin. Biochem Pharmacol 1985;34:847-856.
30. Sarvazyan NA, Askari A, Huang WH. Effects of doxorubicin on cardiomyocytes with reduced level of superoxide dismutase. Life Sci 1995;57:1003-1010.
31. Singal PK, Siveski-ILiskovic N, Hill M, Thomas T, Li T. Combination therapy with probucol prevents adriamycin-induced cardiomyopathy. J Mol Cell Cardiol 1995;27:1055-1063.
32. Geetha A, Sankar R, Marar T, Devi CS. α-Tocopherol reduces doxorubicin-induced toxicity in rats histological and biochemical evidence. Ind J Physiol Pharmacol 1990;34:94-98.
33. Al-Shabanah OA, Badary OA, Nagi MN, Al-Garably N, Al-Rikabi A, Al-Bekairi AM. Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity. J Exp Clin Cancer Res 1998;17:193-198.
34. Nishida K, Ohta Y, Kongo M, Ishiguro I. Response of endogenous reduced glutathione through hepatic glutathione redox cycle to enhancement of hepatic lipid peroxidation with the development of acute liver injury in mice intoxicated with carbon tetrachloride. Res Commun Mol Pathol Pharmacol 1996;93(2):198-218.
35. Wood JS, Ellis ME. Up-regulation of glutathione synthesis in rat kidney by methyl mercury. Relationship to mercury-induced oxidative stress. Biochem Pharmacol 1995;50:1719-1724.