Planning of pharmacodynamic trials: I. Specificity and possible solutions. II. Stability considerations under placebo and interpretation of drug effects on EEG

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 24, Issue SUPPL. C, 2002, Pages 17-26

  Boeijinga, Peter H ^a   Calvi Gries, F ^a   Demazieres A ^a   Luthringer, R ^a  

^a FORENAP   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PSYCHOTROPIC AGENT;

CONFERENCE PAPER; DRUG EFFECT; DRUG INDICATION; DRUG RESEARCH; ELECTROENCEPHALOGRAM; HUMAN; HUMAN EXPERIMENT; METHODOLOGY; NORMAL HUMAN; PHARMACODYNAMICS; VALIDATION PROCESS; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; ELECTROENCEPHALOGRAPHY; VALIDATION STUDY;

ANALYSIS OF VARIANCE; CLINICAL TRIALS; CROSS-OVER STUDIES; ELECTROENCEPHALOGRAPHY; HUMANS; PSYCHOTROPIC DRUGS;

EID: 0036448346     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (15)

1. Luthringer, R., Lincker, T., Calvi-Gries, F., Boeijinga, P.H., Stepien, S., Martin, C. Planning of pharmacodynamic trials: Specificities and possible solutions. In: Electrophysiological Brain Research in Preclinical and Clinical Pharmacology and Related Fields: An Update. Saletu, B., Krijzer, F., Ferber, G., Anderer, P. (Eds.). Facultas: Vienna 2000, 8-15.
2. Cooley, J.W., Tuckey, J.W. An algorithm for the machine calculation of complex Fourier series. Math Comp 1965, 19: 297-301.
3. Kondacs, A., Szabo, M. Long-term intra-individual variability of the background EEG in normals. Clin Neurophysiol 1999, 110: 1708-16.
4. McEvoy, L.K., Smith, M.E., Gevins, A. Test-retest reliability of cognitive EEG. Clin Neurophysiol 2000, 111: 457-63.
5. Salinsky, M.C., Oken, B.S., Morehead, L. Test-retest reliability in EEG frequency analysis. Electroenceph Clin Neurophysiol 1991, 79: 382-92.
6. Barbanoj, M.J., Antonijoan, R.M., Garcia-Gea, C., Lorenzo, J.L., Jané, F. Vigilance research and drug effects: Focus on EEG methods. In: Electrophysiological Brain Research in Preclinical and Clinical Pharmacology and Related Fields: An Update. Saletu, B., Krijzer, F., Ferber, G., Anderer, P. (Eds.). Facultas: Vienna 2000, 104-13.
7. Ott, H., Becker, E., Rohloff, A., Roeske, W., Boesel, R., Fichte, K. Vigilance regulation after Lormetazepam (2 mg) in rest periods and activation phases: Power spectra (pharmaco-EEG) at rest and under video-tracking activity in trained and untrained subjects with reference to topographical aspects. IPEG International Pharmaco EEG-Group, Symposium, 1990, June 28-30, Göteborg, Sweden.
8. Dago, K.T., Luthringer, R., Lengellé, R., Rinaudo, G., Macher, J.P. Statistical decision tree: A tool for studying pharmaco-EEG effects of CNS-active drugs. Neuropsychobiol 1994, 29: 91-6.
9. Abt, K. Significance testing of many variables, problems and solutions. Neuropsychobiol 1983, 9: 47-51.
10. Abt, K. Planning controlled clinical trials on the basis of descriptive data analysis. Stat Med 1991, 10: 777-95.
11. Boeijinga, P.H., Gendre, I., Muzet, M. et al. Effects of acamprosate in alcohol withdrawal measured by cerebral mapping. Drug Ther Perspec 2002, 1: 8-12.
12. Herrmann, W.M. Development and critical evaluation of an objective procedure for the electroencephalographic classification of psychotropic drugs. In: EEG in Drug Research. Herrmann, W.M. (Ed.). Gustav Fischer: Stuttgart 1982, 249-351.
13. Macher, J.P., Luthringer, R., Toussaint, M., Minot, R. Brain mapping and psychoactive drugs. In: Human Psychopharmacology, Methods and Measures. Vol 3. Hindmarch, I., Stonier, P.D. (Eds.). 1990, 1-20.
14. Saletu, B. The use of pharmaco-EEG in drug profiling. In: Human Psychopharmacology. Measures and Methods. Vol I. Hindmarch, I., Stonier, P.D. (Eds.). John Wiley & Sons: Chichester 1987, 173-200.
15. Saletu, B., Anderer, P., Kinsperger, K., Grünenberger, J. Topographic brain mapping of EEG in psychopharmacology. Part II: Clinical applications (pharmaco EEG imaging). Methods Find Exp Clin Pharmacol 1987, 9: 385-408.