The effects of corticosteroids on the healing of tracheal anastomoses in a rat model

Pharmacological Research

Volumn 45, Issue 4, 2002, Pages 299-304

  Talas, Derya U ^a   Nayci, Ali ^b   Atis, Sibel ^b   Polat, Ayse ^b   Comelekoglu, Ulku ^b   Bagdatoglu, Celal ^a   Renda, Nurten ^c  

^a MERSIN UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b Department of Pediatric Surgery ^*  (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Airway; Anastomosis; Corticosteroids; Trachea; Wound healing

Indexed keywords

CORTICOSTEROID; DEKORT; DEXAMETHASONE; HYDROXYPROLINE;

ANASTOMOSIS; ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EPITHELIUM; FEMALE; FIBROBLAST; HISTOLOGY; INFLAMMATION; INFLAMMATORY CELL; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE LEVEL; TISSUE REGENERATION; TRACHEA; TRACHEA PRESSURE; TRACHEA RESECTION; WOUND HEALING;

EID: 0036446891     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2002.0964     Document Type: Article

References (23)

1. Esclamado RM, Cummings CW. In: Management of the Impaired Airway in Adults. Otolaryngology head and neck surgery, Cummings CW, ed. St. Louis, Missouri: Mosby-Year Book, 1998: 2036-54.
2. Wicke C, Halliday B, Allen D, Roche NS, Scheuenstuhl H, Spencer MM, Roberts AB, Hunt TK. Effects of steroids and retinoids on wound healing. Arch Surg 2000; 135: 1265-70.
3. Fermor B, Urban J, Murray D, Pocock A, Lim E, Francis M, Gage J. Proliferation and collagen synthesis of human anterior cruciate ligament cells in vitro: Effects of ascorbate-2-phosphate, dexamethasone and oxygen tension. Cell Biol Int 1998; 22: 635-40.
4. Campbell RB, Wiggins ME, Cannistra LM, Fadale PD, Akelman E. Influence of steroid injection on ligament healing in the rat. Clin Orthop 1996; 332: 242-53.
5. Waters RV, Gamradt SC, Asnis P, Vickery BH, Avnur Z, Hill E, Bostrom M. Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model. Acta Orthop Scand 2000; 71: 316-21.
6. Kim CS, Buchmiller TL, Fonkalsrud EW, Phillips JD. The effect of anabolic steroids on ameliorating the adverse effects of chronic corticosteroids on intestinal anastomotic healing in rabbits. Surg Gynecol Obstet 1993; 176: 73-9.
7. Brown JS, Lee N, Lowe D, Browne RM. Effect of short-term high dose steroids on the healing of microvascular anastomoses in a rabbit model: Pilot study. Br J Oral Maxillofac Surg 2000; 38: 167-72.
8. Skigen AL, Bedrock RD, Stopperich PS. Correction of the depressed, retracted, post-tracheostomy scar. Plast Reconstr Surg 1999; 103: 1703-5.
9. Bergman I, Loxly R. Two impaired and simplified methods for the spectro-photometric determination of hydroxyproline. Ann Chem 1963; 35: 1961-5.
10. Ehrlich HP, Tarver H, Hunt TK. Effects of vitamin A and glucocorticoids upon inflammation and collagen synthesis. Ann Surg 1973; 177: 222-7.
11. Loewen MS, Walner DL, Caldarelli DD. Improved airway healing using transforming growth factor beta-3 in a rabbit model. Wound Rep Reg 2001; 9: 44-9.
12. Froehlich P, Kearns DB, Seid AB, Pransky SM, Chappuis JP, Morgon A. One-stage tracheal reconstruction of congenital tracheal stenosis. Int J Pediatr Otorhinolaryngol 1996; 34: 245-52.
13. Hardillo J, Vanclooster C, Delaere PR. An investigation of airway wound healing using a novel in vivo model. Laryngoscope 2001; 111: 1174-82.
14. Dal T, Demirhan B. Reconstruction of tracheal defects with dehydrated human costal cartilage: An experimental study in rats. Otolaryngol Head Neck Surg 2000; 123: 607-12.
15. Walner DL, Heffelfinger SC, Stern Y, Abrams MJ, Miller MA, Cotton RT. Potential role of growth factors and extracellular matrix in wound healing after laryngotracheal reconstruction. Otolaryngol Head Neck Surg 2000; 122: 363-66.
16. Di Rosa M, Radomski M, Carnuccio R, Moncada S. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun 1990; 172: 1246-52.
17. Schaffer MR, Tantry U, van Wesep RA, Barbul A. Nitric oxide metabolism in wounds. J Surg Res 1997; 71: 25-31.
18. Witte MB, Barbul A. Wound healing. General principles of wound healing. Surg Clin North Am 1997; 77: 6-17.
19. Blomquist P, Jiborn H, Zederfeldt B. The effect of relative bowel rest on healing of colonic anastomoses. Breaking strength and collagen in the colonic wall following left colon resection and anastomosis in the rat. Acta Chir Scand 1984; 150: 671-5.
20. Jonsson K, Jiborn H, Zederfeldt B. Mechanical and biochemical alterations in the intestinal wall adjacent to an anastomosis. Am J Surg 1986; 151: 387-90.
21. Rolandelli RH, Koruda MJ, Settle RG, Rombeau JL. Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomoses in the rat. Surgery 1986; 100: 198-203.
22. Weiner FR, Blaner WS, Czaja MJ, Shah A, Geerts A. Ito cell expression of a nuclear retinoic acid receptor. Hepatology 1992; 15: 336-42.
23. Wahl SM, Wahl LM. Regulation of macrophage collagenase, prostaglandin and fibroblast-activating-factor production by anti-inflammatory agents: Different regulatory mechanisms for tissue injury and repair. Cell Immunol 1985; 92: 302-12.