PAR (protease-activated receptor) as a novel target for development of gastric mucosal cytoprotective drugs

Folia Pharmacologica Japonica

Volumn 120, Issue SUPPL. 1, 2002, Pages

  Kawabata, Atsufumi ^a   Kuroda, Ryotaro ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

G protein coupled receptor; Gastric mucosal protection; PAR (protease activated receptor; Protease; Thrombin

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; GASTROINTESTINAL AGENT; PEPSINOGEN; PROTEINASE ACTIVATED RECEPTOR 2; TACHYKININ; THROMBIN;

ARTICLE; CELL PROTECTION; MUCUS SECRETION; STOMACH ACID SECRETION; STOMACH CHIEF CELL; STOMACH MUCOSA; TISSUE DISTRIBUTION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; DRUG DESIGN; GASTRIC ACID; GASTRIC MUCOSA; GASTROINTESTINAL AGENTS; HUMANS; PEPSINOGEN A; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; TACHYKININS;

EID: 0036445743     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Kawabata A, Kuroda R: Protease-activated receptor (PAR), a novel family of G protein-coupled seven trans-membrane domain receptors: Activation mechanisms and physiological roles. Jpn J Pharmacol 82, 171-174 (2000).
2. Kawabata A: Yakugaku Zasshi 121, 1-7 (2001).
3. Kawabata A, Kinoshita M, Nishikawa H, Kuroda R, Nishida M, Araki H, Arizono N, Oda Y, Kakehi K: The protease-activated receptor-2 agonist induces gastric mucus secretin and mucosal cytoprotection. J Clin Invest 107, 1443-1450 (2001).
4. Nishikawa H, Kawai K, Nishimura S, Tanaka S, Araki H, Al-Ani B, Hollenberg MD, Kuroda R, Kawabata A: Suppression by protease-activated receptor-2 of gastric acid secretion in rats. Eur J Pharmacol 447, 87-90 (2002).
5. Kawao N, Sakaguchi Y, Tagome A, Kuroda R, Nishida S, Irimajiri K, Nishikawa H, Kawai K, Hollenberg MD, Kawabata A: Protease-activated receptor-2 in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion. Br J Pharmacol 135, 1292-1296 (2002).