Guaifenesin enhances the analgesic potency of paracetamol in mice

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 366, Issue 6, 2002, Pages 551-554

  Doležal, Tomas ^a   Krsiak M ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Analgesic combinations; Guaifenesin; Locomotor performance; Paracetamol; Writhing

Indexed keywords

ACETIC ACID; GUAIFENESIN; PARACETAMOL; ANALGESIC AGENT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CAGE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; LOCOMOTION; MALE; MOUSE; NONHUMAN; TASK PERFORMANCE; WRITHING TEST; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; METHODOLOGY; MOTOR ACTIVITY; PAIN ASSESSMENT; PHYSIOLOGY;

ACETAMINOPHEN; ANALGESICS; ANIMALS; DRUG SYNERGISM; GUAIFENESIN; MALE; MICE; MOTOR ACTIVITY; PAIN MEASUREMENT;

EID: 0036443905     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0642-y     Document Type: Article

References (27)

1. Beaver WT (1984) Combination analgesics. Am J Med 77:38-53
2. Carter CH (1966) Muscle relaxant properties of glyceryl guaiacolate. West Med Med J West 7:206-211
3. Courade JP, Chassaing C, Bardin L, Alloui A, Eschalier A (2001a) 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats. Eur J Pharmacol 432:1-7
4. Courade JP, Caussade F, Martin K, Besse D, Delchambre C, Hanoun N, Hamon M, Eschalier A, Cloarec A (2001b) Effects of acetaminophen on monoaminergic systems in the rat central nervous system. Naunyn Schmiedebergs Arch Pharmacol 364:534-537
5. Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240:410-411
6. Gorski R, Kuchler G (1971) [Action of guaiacol glycerol ether on isolated skeletal muscle]. Acta Biol Med Ger 26:141-150
7. Gorski R, Luther D, Rossberg F, Sinz R, Tiedt N (1970) [Resorption, distribution and excretion of guaiacol glyceryl ether and its effect on the physiological parameters]. Z Gesamte Inn Med 25:589-597
8. Haga HA, Moerch H, Soli NE (2000) Effects of intravenous infusion of guaifenesin on electroencephalographic variables in pigs. Am J Vet Res 61:1599-1601
9. Hofrichter G, Roesch A, Roesch E, Schenk G (1967) [Simple methods for the pharmacologic differentiation of central muscle relaxants]. Arzneimittelforschung 17:242-245
10. Horn W (1967) [Muscle relaxants 4]. Pharm Prax 5:124-130
11. Kozena L, Frantik E, Horvath M (1986) The effect on vigilance of an analgesic combination (Ataralgin) and its components, guaiphenesine and caffeine. Act Nerv Super (Praha) 28:153-155
12. Kršiak M, Tomašíková Z (1979) Analgetická účinnost a toxicita směsi kyseliny acetylosalicylové s guaifenesinem. [Analgesic activity and toxicity of a combination of aspirin with guaifenesin.] - abstract in Czech. Cs Fysiol 28:265-266
13. Kršiak M, Tomašíková Z, Líkařová E, Fousková H, Sajvera J, Elis J (1980) Analgetická účinnost a toxicita směsi paracetamolu s guaifenesinem. [Analgesic activity and toxicity of a combination of paracetamol with guaifenesin.] - abstract in Czech. Cs Fysiol 29-56
14. Laska EM, Sunshine A, Mueller F, Elvers WB, Siegel C, Rubin A (1984) Caffeine as an analgesic adjuvant. JAMA 251:1711-1718
15. Maier RD (1980) [The detection of guaiacol glyceryl ether, a content of many sedatives and hypnotics in the Federal Republic of Germany]. Arch Toxicol 45:130-131
16. Matthews NS, Peck KE, Mealey KL, Taylor TS, Ray AC (1997) Pharmacokinetics and cardiopulmonary effects of guaifenesin in donkeys. J Vet Pharmacol Ther 20:442-446
17. McQuay HJ, Angell K, Carroll D, Moore RA, Juniper RP (1996) Ibuprofen compared with ibuprofen and caffeine after third molar surgery. Pain 66:247-251
18. Millan MJ (1994) Serotonin and pain: Evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice. Pain 58:45-61
19. Perlik F, Janku I, Kordac V (1988) The effect of guaiphenesin on absorption and bioavailability of paracetamol from composite analgesic preparations. Int J Clin Pharmacol Ther Toxicol 26:413-416
20. Po AL, Zhang WY (1998) Analgesic efficacy of ibuprofen alone and in combination with codeine or caffeine in post-surgical pain: A meta-analysis. Eur J Clin Pharmacol 53:303-311
21. Rossberg F, Luther D (1971) [Animal experiment on the absorption, distribution and elimination of C 14- and H 3-labelled guaiacol-glyceryl-ether]. Acta Biol Med Ger 26:331-339
22. Schroeder K, Fahey T (2001) Over-the-counter medications for acute cough in children and adults in ambulatory settings (Cochrane Review). Cochrane Database Syst Rev 3:CD001831
23. Souri E, Sharifzadeh M, Farsam H, Gharavi N (1999) Muscle relaxant activity of methocarbamol enantiomers in mice. J Pharm Pharmacol 51:853-855
24. Swedberg MD, Jacobsen P, Honore T (1995) Anticonvulsant, anxiolytic and discriminative effects of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX). J Pharmacol Exp Ther 274:1113-1121
25. Tomašíková Z, Kršiak M (1980) Behavioural effects of acetylsalicylic acid, paracetamol, caffeine, guaiphenesin and their combinations. Activ Nerv Sup 22:203-205
26. Walker JS (1995) NSAID: An update on their analgesic effects. Clin Exp Pharmacol Physiol 22:855-860
27. Zhang WY, Po AL (1997) Do codeine and caffeine enhance the analgesic effect of aspirin? A systematic overview. J Clin Pharm Ther 22:79-97