Cocaine downregulates cardiac SERCA2a and depresses myocardial function in the murine model

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 10, 2002, Pages 1015-1021

  Wang, Ju Feng ^a   Yan, Xinhua ^a   Min, Jiangyong ^a   Sullivan, Matthew F ^a   Hampton, Thomas G ^a   Morgan, James P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cocaine; Mouse; Phospholamban; SERCA2a; Ventricular function

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; CELL MEMBRANE PROTEIN; COCAINE; MUSCLE ENZYME; MUSCLE PROTEIN; PHOSPHOLAMBAN; CALCIUM; CALCIUM BINDING PROTEIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; ENZYME REPRESSION; EXTRACELLULAR CALCIUM; HEART FUNCTION; HEMODYNAMIC MONITORING; ISOLATED HEART; MALE; MOUSE; MOUSE STRAIN; MUSCLE FUNCTION; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; RELAXATION TIME; SARCOPLASMIC RETICULUM; STATISTICAL DISTRIBUTION; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION; TOXICITY; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEMODYNAMICS; IN VITRO STUDY; METABOLISM; MUSCLE ISOMETRIC CONTRACTION;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; COCAINE; DOWN-REGULATION; HEMODYNAMIC PROCESSES; ISOMETRIC CONTRACTION; MALE; MICE; MICE, INBRED BALB C; MYOCARDIUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; VENTRICULAR FUNCTION, LEFT;

EID: 0036442961     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-128     Document Type: Article

References (26)

1. Bermards, C.M., Cullen, B.F., and Powers, K.M. 1997. Effect of chronic cocaine exposure on the hemodynamic response to vasopressors in sheep. J. Trauma Inj. Infect. Crit. Care, 43: 680-686.
2. Cain, B.S., Meldrum, D.R., Joo, K.S., Wang, J.F., Meng, X., Cleveland, J.C., Banerjee, A., and Harken, A. 1998. Human SERCA2a levels correlate inversely with age in senescent human myocardium. J. Am. Coll. Cardiol. 32: 458-67.
3. Colucci, W.S. 1997. Molecular and cellular mechanisms of myocardial failure. Am. J. Cardiol. 80(11A): 15L-25L.
4. Edes, I., Sato, Y., Luo, W., Liggett, S.B., and Kranias, E.G. 1997. β-Adrenergic regulation of cAMP and protein phosphorylation in phospolamban-knockout mouse hearts. Am. J. Physiol. 273: H785-H790.
5. Hampton, T.G., Kranias, E.G., and Morgan, J.P. 1996. Simultaneous measurement of intracellular calcium and ventricular function in the phospholamban-deficient mouse heart. Biochem. Biophys. Res. Commun. 226: 836-841.
6. Hampton, T.G., Amende, I., Travers, K.E., and Morgan, J.P. 1998. Intracellular calcium dynamics in mouse model of myocardial stunning. Am. J. Physiol. 274: H1821-H1827.
7. 2+-ATPase in failing and nonfailing human myocardium. Circ. Res. 75: 434-442.
8. 2+ and myocardial contraction in cardiac myocytes. Am. J. Physiol. 273: H893-H901.
9. Ji, Y., Loukianov, E., Loukianova, T., Jones, L.R., and Periasamy, M. 1999. SERCA1a can functionally substitute for SERCA2a in the heart. Am. J. Physiol. 276: H89-H97.
10. Kiss, E., Brittsan, A.G., Edes, I., Grupp, L.L., Grupp, G., and Kranias, E.G. 1998. Thyroid hormone-induced alterations in phospholamban-deficient mouse hearts. Circ. Res. 83: 608-613.
11. Kloner, R.A., Hale, S., Alker, K., and Rezkalla, S. 1992. The effects of acute and chronic cocaine use on the heart. Circulation, 85: 407-419.
12. Li, L., Chu, G., Kranias, E.G., and Bers, D.M. 1998. Cardiac myocyte calcium transport in phospholamban knockout mouse: Relaxation and endogenous CaMKII effects. Am. J. Physiol. 274: H1335-H1347.
13. 2+-handling proteins and effects of isoproterenol. Am. J. Physiol. 274: H2083-H2090.
14. Mehta, P.M., Grainger, T.A., Lust, R.M., Movahed, A., Terry, J., Gilliland, M.G.F., and Jolly, S.R. 1995. Effect of cocaine on left ventricular function. Circulation, 91: 3002-2009.
15. Meyer, M., Bluhm, W.F., He, H., Post, S.R., Giordano, F.J., Lew, W.Y.W., and Dillmann, W.H. 1999. Phospholamban-to-SERCA2 ratio controls the force-frequency relationship. Am. J. Physiol. 276: H779-H785.
16. Miyamoto, M.I., del Monte, F., Schmidt, U., DiSalvo, T.S., Kang, Z.B., Matsui, T., Guerrero, J.L., Gwathmey, J.K., Rosenzweig, A., and Hajjar, R.J. 2000. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. U.S.A. 97: 793-798.
17. Munch, G., Bolck, B., Brixius, K., Reuter, H., Mehlhorn, U., Bloch, W., and Schwinger, R.H.G. 2000. SERCA2a activity correlates with the force-frequency relationship in human myocardium. Am. J. Physiol. 278: H1924-H1932.
18. Nunez, B.D., Miao, L., Klein, M.A., and Morgan, J.P. 1997. Acute and chronic cocaine exposure can produce myocardial ischemia and infarction in Yucatan swine. J. Cardiovasc. Pharmacol. 29: 145-155.
19. O'Rourke, B., Kass, D.A., Tomaselli, G.F., Kaab, S., Tunin, R., and Marban, E. 1999. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. I. Experimental studies. Circ. Res. 84: 562-570.
20. Piano, M.R., Bondmass, M., and Schwertz, D.W. 1998. The molecular and cellular Pathophysiology of heart failure. Heart Lung, 27: 3-19.
21. Stambler, B.S., Komamura, K., Ihara, T., and Shannon, R.P. 1993. Acute intravenous cocaine causes transient depression followed by enhanced left ventricular function in conscious dogs. Circulation, 87: 1687-1697.
22. Takasago, T., Imagawa, T., Furukawa, K., Orgurusu, T., and Shigekawa, M. 1991. Regulation of the cardiac ryanodine receptor by protein kinase-dependent phosphorylation. J. Biochem. 109: 163-170.
23. Tomita, F., Bassett, A.L., Myerburg, R.J., and Kimura, S. 1993. Effects of cocaine on sarcoplasmic reticulum in skinned rat heart muscle. Am. J. Physiol. 264: H845-H850.
24. 2+/calmodulin-dependent protein kinase. J. Biol. Chem. 269: 26 492 - 26 496.
25. Wang, J.F., Hampton, T.G., DeAngelis, J., Travers, K.E., and Morgan, J.P. 1999. Differential depressant effects of general anesthetics on the cardiovascular response to cocaine in mice. Proc. Soc. Exp. Biol. Med. 221: 253-259.
26. Wang, J.F., Ren, X., DeAngelis, J., Min, J., Zhang, Y., Hampton, T.G., Amende, I., and Morgan, J.P. 2001. Differential patterns of cocaine-induced organ toxicity in murine heart versus liver. Exp. Biol. Med. 226: 52-60.