Effects of N-acetylcysteine on myoglobinuric-acute renal failure in rats

Renal Failure

Volumn 24, Issue 6, 2002, Pages 725-733

  Fernández Fúnez, Angel ^a,b   Polo, Francisco J ^a   Broseta, Luís ^a   Valer, Julio ^a   Zafrilla, Lucia ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^b Department of Internal Medicine ^*  (Spain)

Author keywords

Acute renal failure; Myoglobinuria; N Acetylcysteine; Rat

Indexed keywords

ACETYLCYSTEINE; GLYCEROL; MYOGLOBIN; SCAVENGER;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MYOGLOBINURIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; ANIMALS; CRYOPROTECTIVE AGENTS; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; GLYCEROL; HYPERTONIC SOLUTIONS; INJECTIONS, INTRAPERITONEAL; KIDNEY; KIDNEY FAILURE, ACUTE; MYOGLOBINURIA; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 0036440185     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.1081/JDI-120015676     Document Type: Article

References (21)

1. Better, O.S.; Stain, J.H. Early management of shock and prophylaxis of acute renal failure in traumatic rhabdomyolysis. N. Engl. J. Med. 1990, 322, 825-827.
2. Odeh, M. The role of reperfusion-induced injury in the pathogenesis of the crush syndrome. N. Engl. J. Med. 1991, 324, 1417-1422.
3. Thiel, G.; Wilson, D.R.; Arce, M.L.; Oken, D.E. Glycerol induced hemoglobinuric acute renal failure in the rat. Nephron 1967, 4, 276-297.
4. Zager, R.A. Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int. 1996, 49, 314-326.
5. Baud, L.; Ardaillou, R. Reactive oxygen species: Production and role in the kidney. Am. J. Physiol. 1986, 251, F765-F776.
6. Fantone, J.C.; Ward, P.A. Polymorphonuclear leukocyte-mediated cell and tissue injury: Oxygen metabolites and their relations to human disease. Human Pathol. 1985, 16, 973-978.
7. Weiss, S.J. Oxygen, ischemia and inflammation. Acta Physiol. Scand. 1986, 548, 9-37.
8. Weiss, S.J.; Lobuglio, A.F. Phagocyte-generated oxygen metabolites and cellular injury. Lab. Invest. 1982, 47, 5-18.
9. Olson, C.E. Glutathione modulates toxic oxygen metabolite injury of canine chief cell monolayers in primary culture. Am. J. Physiol. 1988, 254, G49-G56.
10. Thielmann, L.; Rosenblut, E. Sulfur-containing amino acids that increase renal glutathione protect the kidney against papillary necrosis induced by 2-bronothylamina. Cell. Biochem. Funct. 1990, 8, 19-24.
11. Jonuod, A.F.; Jornot, L.; Griching, G. Comparative study on the selenium and n-acetylcysteine related effects on the toxic actions of hyperoxia, paraquat and the enzyme reaction hypoxanthine-xanthine oxidase in cultured endothelial cells. Agents Actions 1987, 32, 177-183.
12. Bernard, G.R.; Lucht, W.D.; Niedermeyer, M.E.; Snapper, J.R.; Ogletree, M.L.; Brigham, K.L. Effect of n-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function. J. Clin. Invest. 1984, 73, 1772-1784.
13. Cotgreave, I.A.; Sandy, M.S.; Berggren, M.; Moldeus, P.W.; Smith, M.T. n-acetylcysteine and glutathione-dependent protective effect of PZ51 (ebselen) against diquat-induced cytotoxicity in isolated hepatocytes. Biochem. Pharmacol. 1987, 36, 2899-2904.
14. Miners, J.O.; Drew, R.; Birkett, D.J. Mechanism of action of paracetamol protective agents in mice in vivo. Biochem. Pharmacol. 1984, 33, 2995-3000.
15. Moldeus, P.; Cotgreave, I.A.; Berggren, M. Lung Protection by a Thiol-Containing Antioxidant. N-Acetylcysteine. Respiration 1986, 50(suppl. 1), 31-42.
16. Dach, J.L.; Kurtzman, N.A. A scanning electron microscopic study of the glycerol odel of acute renal failure. Lab. Invest. 1976, 34, 406-414.
17. Baliga, R.; Zhang, Z.; Baliga, M.; Shah, S. Evidence for cytochrome P-450 as a source of catalytic iron in myoglobinuric acute renal failure. Kidney Int. 1996, 49, 362-369.
18. Zager, R.A. Mitochondrial free radical production induces lipid peroxidation during myohemoglobinuria. Kidney Int. 1996, 49, 741-751.
19. Tepel, M.; van der Giet, M.; Schwarzfeld, C.; Laufer, U.; Liermann, D.; Zidek, W. Prevention of radiographic contrast agent induced reductions in renal function by acetylcysteine. N. Engl. J. Med. 2000, 343, 180-184.
20. McCoy, R.N.; Hill, K.E.; Ayon, M.A.; Stein, J.H.; Burk, R.F. Oxidant stress following renal ischemia: Changes in the glutathione redox ratio. Kidney Int. 1988, 33, 812-817.
21. Ishizuka, S.; Nagashima, Y.; Numata, M.; Yano, T.; Hagiwara, K.; Ozasa, H.; Sone, M.; Nihei, H.; Horikawa, S. Regulation and immunohistochemical analysis of stress protein hem oxygenase-1 in rat kidney with myoglobinuric acute renal failure. Biochem. Biophys. Res. Commun. 1997, 240, 93-98.