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Volumn 141, Issue 20, 2002, Pages 630-635

Inhibition of enzymes in the pharmacological treatment in of benign prostatic hyperplasia;Inhibice enzymů ve farmakoterapii benigní hyperplazie prostaty

Author keywords

5 reductase; Aromatase; Benign prostatic hyperplasia; Enzyme inhibitors; Pharmacotherapy; Phytopharmaceuticals

Indexed keywords

ANDROGEN; ANDROSTANOLONE; AROMATASE; CHOLEST 4 EN 3 ONE; ESTROGEN; FINASTERIDE; ISOENZYME; POLYUNSATURATED FATTY ACID; PROGESTERONE; PYGEUM AFRICANUM EXTRACT; SABAL EXTRACT; STEROID; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; URTICA EXTRACT;

EID: 0036437690     PISSN: 00087335     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (2)

References (90)
  • 1
    • 0011719820 scopus 로고    scopus 로고
    • Současné farmakoterapeutické možnosti léčby benigní hyperplazie prostaty
    • Dvořáček, J.: Současné farmakoterapeutické možnosti léčby benigní hyperplazie prostaty. Remedia, 9, 1999, s. 7-12.
    • (1999) Remedia , vol.9 , pp. 7-12
    • Dvořáček, J.1
  • 2
    • 0011751262 scopus 로고    scopus 로고
    • Možnosti farmakologického ovlivnění benigní hyperplazie prostaty
    • Veselský, Z.: Možnosti farmakologického ovlivnění benigní hyperplazie prostaty. Medicína, 7, 2000, s. 17.
    • (2000) Medicína , vol.7 , pp. 17
    • Veselský, Z.1
  • 3
    • 0011752529 scopus 로고    scopus 로고
    • Léčba benigní hyperplazie prostaty
    • Anonymous: Léčba benigní hyperplazie prostaty. Farmakoterapeutické Informace, 3, 1996, s. 1-4.
    • (1996) Farmakoterapeutické Informace , vol.3 , pp. 1-4
  • 4
    • 0011719821 scopus 로고    scopus 로고
    • O medikamentózní léčbě benigní hyperplazie prostaty
    • Kawaciuk, I.: O medikamentózní léčbě benigní hyperplazie prostaty. Lege Artis, 2000, s. 26-29.
    • (2000) Lege Artis , pp. 26-29
    • Kawaciuk, I.1
  • 6
    • 0011748713 scopus 로고    scopus 로고
    • http://www.chem.qmw.ac.uk/iubmb/enzyme/
  • 7
    • 0014027114 scopus 로고
    • Studies on the biosynthesis of 5-alpha-cholestan-3-beta-ol. I. Cholestenone 5-alpha-reductase of rat liver
    • Shefer, S., Hauser, S., Mosbach, E. H.: Studies on the biosynthesis of 5-alpha-cholestan-3-beta-ol. I. Cholestenone 5-alpha-reductase of rat liver. J. Biol. Chem., 241, 1966, s. 946-952.
    • (1966) J. Biol. Chem. , vol.241 , pp. 946-952
    • Shefer, S.1    Hauser, S.2    Mosbach, E.H.3
  • 8
    • 0024792331 scopus 로고
    • Solubilization of nuclear steroid 5 alpha-reductase from rat ventral prostate
    • Enderle-Schmitt, U., Neuhaus, C., Aumüller, G.: Solubilization of nuclear steroid 5 alpha-reductase from rat ventral prostate. Biochim. Biophys. Acta, 987, 1989, s. 21-28.
    • (1989) Biochim. Biophys. Acta , vol.987 , pp. 21-28
    • Enderle-Schmitt, U.1    Neuhaus, C.2    Aumüller, G.3
  • 9
    • 0016458753 scopus 로고
    • Reduced nicotinamide adenine dinucleotide phosphate: delta4-3-ketosteroid 5alpha-oxidoreductase (rat ventral prostate)
    • Moore, R. J., Wilson, J. D.: Reduced nicotinamide adenine dinucleotide phosphate: delta4-3-ketosteroid 5alpha-oxidoreductase (rat ventral prostate). Methods Enzymol., 36A, 1975, s. 466-474.
    • (1975) Methods Enzymol. , vol.36 A , pp. 466-474
    • Moore, R.J.1    Wilson, J.D.2
  • 10
    • 0011720460 scopus 로고
    • Properties of 4-ene 5-α-reductase in porcine testicular microsomes
    • Watkins, W. J., Goldring, C. E. P., Gower, D. B.: Properties of 4-ene 5-α-reductase in porcine testicular microsomes. Biochem. Soc. Trans., 14, 1986, s. 339-340.
    • (1986) Biochem. Soc. Trans. , vol.14 , pp. 339-340
    • Watkins, W.J.1    Goldring, C.E.P.2    Gower, D.B.3
  • 11
    • 0011777364 scopus 로고
    • Δ4-Steroid 5-α-reductase activity in porcine testicular microsomes
    • Watkins, W.J., Gower, D. B.: Δ4-Steroid 5-α-reductase activity in porcine testicular microsomes. Biochem. Soc. Trans., 13, 1985, s. 187-188.
    • (1985) Biochem. Soc. Trans. , vol.13 , pp. 187-188
    • Watkins, W.J.1    Gower, D.B.2
  • 12
    • 0015239404 scopus 로고
    • Partial characterization of the nuclear reduced nicotinamide adenine dinucleotide phosphate: Delta 4-3-ketosteroid 5 alpha-oxidoreductase of rat prostate
    • Frederiksen, D. W., Wilson, J. D.: Partial characterization of the nuclear reduced nicotinamide adenine dinucleotide phosphate: Delta 4-3-ketosteroid 5 alpha-oxidoreductase of rat prostate. J. Biol. Chem., 246, 1971, s. 2484-2593.
    • (1971) J. Biol. Chem. , vol.246 , pp. 2484-2593
    • Frederiksen, D.W.1    Wilson, J.D.2
  • 13
    • 0011720461 scopus 로고
    • Solubilization of 4-ene 5-α-reductse from porcine testicular microsomes
    • Watkins, W. J., Wilson, L., Gower, D. B.: Solubilization of 4-ene 5-α-reductse from porcine testicular microsomes. Biochem. Soc. Trans., 14, 1986, s. 979.
    • (1986) Biochem. Soc. Trans. , vol.14 , pp. 979
    • Watkins, W.J.1    Wilson, L.2    Gower, D.B.3
  • 14
    • 0017170085 scopus 로고
    • Is a Schiff base involved in the mechanism of the delta4-3-oxo steroid 5alpha- or 5beta-reductases from mammalian liver?
    • Wilton, D. C.: Is a Schiff base involved in the mechanism of the delta4-3-oxo steroid 5alpha- or 5beta-reductases from mammalian liver? Biochem. J., 155, 1976, s. 487-491.
    • (1976) Biochem. J. , vol.155 , pp. 487-491
    • Wilton, D.C.1
  • 15
    • 0019817869 scopus 로고
    • 4-ene-3-oxosteroid-5 NADPH alpha-reductase and NADH: 4-ene-3-oxosteroid-5 alpha-reductase in liver microsomes of different species of animals
    • Graef, V., Golf, S. W., Tüschen, M.: NADPH: 4-ene-3-oxosteroid-5 alpha-reductase and NADH: 4-ene-3-oxosteroid-5 alpha-reductase in liver microsomes of different species of animals. J. Steroid Biochem., 14, 1981, s. 883-887.
    • (1981) J. Steroid Biochem. , vol.14 , pp. 883-887
    • Graef, V.1    Golf, S.W.2    Tüschen, M.3
  • 16
    • 0019185259 scopus 로고
    • Importance of 5 alpha-reduction for the trophic effects of androgens on rat accessory sex organs and LH control
    • Lotz, W.: Importance of 5 alpha-reduction for the trophic effects of androgens on rat accessory sex organs and LH control. J. Steroid Biochem., 13, 1980, s. 1261-1264.
    • (1980) J. Steroid Biochem. , vol.13 , pp. 1261-1264
    • Lotz, W.1
  • 17
    • 0019199272 scopus 로고
    • Rat thymic homogenates convert testosterone to androgenic metabolites
    • Sholiton, L. J., Grossman, C. J., Taylor, B. B.: Rat thymic homogenates convert testosterone to androgenic metabolites. J. Steroid Biochem., 13, 1980, s. 1365-1367.
    • (1980) J. Steroid Biochem. , vol.13 , pp. 1365-1367
    • Sholiton, L.J.1    Grossman, C.J.2    Taylor, B.B.3
  • 18
    • 0019132834 scopus 로고
    • Interferences of zearalenone, zearalanol or estradiol-17 beta with steroid-metabolizing enzymes of the human prostate gland
    • Thoubenot,D., Morfin, R. F.: Interferences of zearalenone, zearalanol or estradiol-17 beta with steroid-metabolizing enzymes of the human prostate gland. J. Steroid Biochem., 13, 1980, s. 1337-1345.
    • (1980) J. Steroid Biochem. , vol.13 , pp. 1337-1345
    • Thoubenot, D.1    Morfin, R.F.2
  • 19
    • 0019167746 scopus 로고
    • Hormonal regulation of activities of 4-ene-5 alpha-reductase and 17 beta-o1-dehydrogenase in adult androgen-sterilized rat ovaries
    • Kondo, K., Aono, T., Furubayashi, Y. et al.: Hormonal regulation of activities of 4-ene-5 alpha-reductase and 17 beta-o1-dehydrogenase in adult androgen-sterilized rat ovaries. J. Steroid Biochem., 13, 1980, s. 703-705.
    • (1980) J. Steroid Biochem. , vol.13 , pp. 703-705
    • Kondo, K.1    Aono, T.2    Furubayashi, Y.3
  • 20
    • 0019326985 scopus 로고
    • Inhibition of testosterone 5 alpha-reductase by a proposed enzyme-activated, active site-directed inhibitor
    • Blohm, T. R., Metcalf, B. W., Lauglin, M. E. et al.: Inhibition of testosterone 5 alpha-reductase by a proposed enzyme-activated, active site-directed inhibitor. Biochem. Biophys. Res. Commun., 95, 1980, s. 273-280.
    • (1980) Biochem. Biophys. Res. Commun. , vol.95 , pp. 273-280
    • Blohm, T.R.1    Metcalf, B.W.2    Lauglin, M.E.3
  • 21
    • 0018744038 scopus 로고
    • Biochemical characterization of the NADPH: 4-ene-3-ketosteroid 5 alpha-oxidoreductase in rat ovarian suspension cultures
    • Koninckx, P., Verhoeven, G., Heyns, W., De Moore, P.: Biochemical characterization of the NADPH: 4-ene-3-ketosteroid 5 alpha-oxidoreductase in rat ovarian suspension cultures. J. Steroid Biochem., 10, 1979, s. 325-333.
    • (1979) J. Steroid Biochem. , vol.10 , pp. 325-333
    • Koninckx, P.1    Verhoeven, G.2    Heyns, W.3    De Moore, P.4
  • 22
    • 0015858926 scopus 로고
    • Further studies on testosterone 5-reductase of human skin. Structures features of steroid inhibitors
    • Voigt, W., Hsia, S. I.: Further studies on testosterone 5-reductase of human skin. Structures features of steroid inhibitors. J. Biol. Chem., 248, 1973, s. 4280-4285.
    • (1973) J. Biol. Chem. , vol.248 , pp. 4280-4285
    • Voigt, W.1    Hsia, S.I.2
  • 23
    • 0017102092 scopus 로고
    • Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities
    • Moore, R. J., Wilson, J. D.: Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities. J. Biol. Chem., 251, 1976., s. 5895-5900.
    • (1976) J. Biol. Chem. , vol.251 , pp. 5895-5900
    • Moore, R.J.1    Wilson, J.D.2
  • 24
    • 0016777802 scopus 로고
    • Effect of zinc on androgen metabolism in human hyperplastic prostate
    • Wallace, A. M., Grant, J. K.: Effect of zinc on androgen metabolism in human hyperplastic prostate. Biochem. Soc. Trans., 3, 1975, s. 540-542.
    • (1975) Biochem. Soc. Trans. , vol.3 , pp. 540-542
    • Wallace, A.M.1    Grant, J.K.2
  • 25
    • 0016295039 scopus 로고
    • Extraction of the reduced nicotinamide adenine dinucleotide phosphate: Delta 4-3-ketosteroid-5-alpha oxidoreductase of rat prostate with digitonin and potassium chloride
    • Moore, R. J., Wilson, J. D.: Extraction of the reduced nicotinamide adenine dinucleotide phosphate: Delta 4-3-ketosteroid-5-alpha oxidoreductase of rat prostate with digitonin and potassium chloride. Biochemistry, 13, 1974, s. 450-456.
    • (1974) Biochemistry , vol.13 , pp. 450-456
    • Moore, R.J.1    Wilson, J.D.2
  • 26
    • 0020744925 scopus 로고
    • Solubilization and partial characterization of rat epididynal delta 4-steroid 5 alpha-reductase (cholestenone 5 alphareductase)
    • Scheer, H., Robaire, B.: Solubilization and partial characterization of rat epididynal delta 4-steroid 5 alpha-reductase (cholestenone 5 alphareductase). Biochem. J., 211, 1983, s. 65-74.
    • (1983) Biochem. J. , vol.211 , pp. 65-74
    • Scheer, H.1    Robaire, B.2
  • 27
    • 0018648825 scopus 로고
    • Testosterone 5 alphareductase and the accumulation of dihydrotestosterone in benign prostatic hyperplasia
    • Cowan, R. A., Cook, B., Cowan, S. K. et al.: Testosterone 5 alphareductase and the accumulation of dihydrotestosterone in benign prostatic hyperplasia. J. Steroid Biochem., 11, 1979, s. 609-613.
    • (1979) J. Steroid Biochem. , vol.11 , pp. 609-613
    • Cowan, R.A.1    Cook, B.2    Cowan, S.K.3
  • 28
    • 0020030755 scopus 로고
    • Testosterone 5 alpha-reductase in spinal cord of Xenopus laevis
    • Jurman, M. E., Erulkar, S. D., Krieger, N. R.: Testosterone 5 alpha-reductase in spinal cord of Xenopus laevis. J. Neurochem., 38, 1982, s. 657-661.
    • (1982) J. Neurochem. , vol.38 , pp. 657-661
    • Jurman, M.E.1    Erulkar, S.D.2    Krieger, N.R.3
  • 29
    • 0025303307 scopus 로고
    • Structural and biochemical properties of cloned and expressed human and rat steroid 5α-reductases
    • Andersson, S., Russell, D. W.: Structural and biochemical properties of cloned and expressed human and rat steroid 5α-reductases. Proc. Nat. Acad. Sci. U.S.A., 87, 1990, s. 3640-3644.
    • (1990) Proc. Nat. Acad. Sci. U.S.A. , vol.87 , pp. 3640-3644
    • Andersson, S.1    Russell, D.W.2
  • 30
    • 0026787734 scopus 로고
    • Structure of human type II 5α-reductase gene
    • Labrie, F., Sugimoto, Y., Luu-The, V. et al.: Structure of human type II 5α-reductase gene. Endocrinology, 131, 1992, s. 1571-1573.
    • (1992) Endocrinology , vol.131 , pp. 1571-1573
    • Labrie, F.1    Sugimoto, Y.2    Luu-The, V.3
  • 31
    • 0026723090 scopus 로고
    • Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions
    • Normington, K., Russell, D. W.: Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. J. Biol. Chem., 267, 1992, s. 19548 až 19554.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19548-19554
    • Normington, K.1    Russell, D.W.2
  • 32
    • 0028825864 scopus 로고
    • Human prostatic steroid 5α-reductase isoforms: A comparative study of selective inhibitors
    • Iehlé, C., Délos, S., Guirou, O. et al.: Human prostatic steroid 5α-reductase isoforms: A comparative study of selective inhibitors. J. Steroid Biochem. Mol. Biol., 54, 1995, s. 273-279.
    • (1995) J. Steroid Biochem. Mol. Biol. , vol.54 , pp. 273-279
    • Iehlé, C.1    Délos, S.2    Guirou, O.3
  • 33
    • 0011776793 scopus 로고    scopus 로고
    • http://www.brenda.umi-koeln.de/
  • 34
    • 0021750804 scopus 로고
    • Partial characterization of the microsomal and solubilized hypothalalamic progesterone 5 alpha-reductase
    • Bertics, P. J., Karavolas, H. J.: Partial characterization of the microsomal and solubilized hypothalalamic progesterone 5 alpha-reductase. J. Steroid Biochem., 21, 1984, s. 305-314.
    • (1984) J. Steroid Biochem. , vol.21 , pp. 305-314
    • Bertics, P.J.1    Karavolas, H.J.2
  • 35
    • 0021353963 scopus 로고
    • Potent inhibition of the hypotlahamic progesterone 5 alpha-reductase by a 5 alpha-dihydroprogesterone analog
    • Bertics, P. J., Edman, C. F., Karavolas, H. J.: Potent inhibition of the hypotlahamic progesterone 5 alpha-reductase by a 5 alpha-dihydroprogesterone analog. J. Biol. Chem., 259, 1984, s. 107-111.
    • (1984) J. Biol. Chem. , vol.259 , pp. 107-111
    • Bertics, P.J.1    Edman, C.F.2    Karavolas, H.J.3
  • 36
    • 0024505324 scopus 로고
    • The kinetic mechanism of the hypothalamic progesterone 5 alpha-reductase
    • Campbell, J. S., Karavolas, H. J.: The kinetic mechanism of the hypothalamic progesterone 5 alpha-reductase. J. Steroid Biochem., 32, 1989, s. 283-289.
    • (1989) J. Steroid Biochem. , vol.32 , pp. 283-289
    • Campbell, J.S.1    Karavolas, H.J.2
  • 37
    • 0016803079 scopus 로고
    • Subcellular distribution and properties of progesterone (delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus
    • Cheng, Y.-J., Karavolas, H. J.: Subcellular distribution and properties of progesterone (delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus. Biol. Chem., 250, 1975, s. 7997-8003.
    • (1975) Biol. Chem. , vol.250 , pp. 7997-8003
    • Cheng, Y.-J.1    Karavolas, H.J.2
  • 38
    • 0019303397 scopus 로고
    • Subcellular location of hypothalamic progesterone metabolizing enzymes and evidence for distinct NADH and NAHDPH-linked 3 alpha-hydroxysteroid oxidoreductase activities
    • Krause, J. E., Karavolas, H. J.: Subcellular location of hypothalamic progesterone metabolizing enzymes and evidence for distinct NADH and NAHDPH-linked 3 alpha-hydroxysteroid oxidoreductase activities. J. Steroid Biochem., 13, 1980, s. 271-280.
    • (1980) J. Steroid Biochem. , vol.13 , pp. 271-280
    • Krause, J.E.1    Karavolas, H.J.2
  • 39
    • 0021796609 scopus 로고
    • Pituitary progesterone 5 alpha-reductase: Solubilization and partial characterization
    • Bertics, P. J., Karavolas, H. J.: Pituitary progesterone 5 alpha-reductase: Solubilization and partial characterization. J. Steroid Biochem., 22, 1985, s. 795-802.
    • (1985) J. Steroid Biochem. , vol.22 , pp. 795-802
    • Bertics, P.J.1    Karavolas, H.J.2
  • 40
    • 0016772188 scopus 로고
    • Properties and subcellular distribution of delta4-steroid (progesterone) 5alpha-reductase in rat anterior pituitary
    • Cheng, Y.-J., Karavolas, H. J.: Properties and subcellular distribution of delta4-steroid (progesterone) 5alpha-reductase in rat anterior pituitary. Steroids, 26, 1975, s. 57-71.
    • (1975) Steroids , vol.26 , pp. 57-71
    • Cheng, Y.-J.1    Karavolas, H.J.2
  • 41
    • 0021271930 scopus 로고
    • Progesterone 5 alpha-reductase in mouse brain
    • Roselli, C. E., Snipes, C. A.: Progesterone 5 alpha-reductase in mouse brain. Brain Res., 305, 1984, s. 197-202.
    • (1984) Brain Res. , vol.305 , pp. 197-202
    • Roselli, C.E.1    Snipes, C.A.2
  • 42
    • 0023567918 scopus 로고
    • Specific stimulation of steroid 5 alpha-reductase solubilized from rat liver microsomes by endogenous phosphatidylserine
    • Ichihara, K., Tanaka, C.: Specific stimulation of steroid 5 alpha-reductase solubilized from rat liver microsomes by endogenous phosphatidylserine. Biochem. Biophys. Res. Commun., 149, 1987, s. 482-487.
    • (1987) Biochem. Biophys. Res. Commun. , vol.149 , pp. 482-487
    • Ichihara, K.1    Tanaka, C.2
  • 43
    • 0025257173 scopus 로고
    • Steroidal A ring aryl carboxylic acids: A new class of steroid 5 alpha-reductase inhibitors
    • Holt, D. A., Levy, M. A., Ladd, D. L. et al.: Steroidal A ring aryl carboxylic acids: A new class of steroid 5 alpha-reductase inhibitors. J. Med. Chem., 33, 1990, s. 937-942.
    • (1990) J. Med. Chem. , vol.33 , pp. 937-942
    • Holt, D.A.1    Levy, M.A.2    Ladd, D.L.3
  • 44
    • 0025240643 scopus 로고
    • Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids
    • Holt, D. A., Levy, M. A., Oh, H. J. et al.: Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids. J. Med. Chem., 33, 1990, s. 943-950.
    • (1990) J. Med. Chem. , vol.33 , pp. 943-950
    • Holt, D.A.1    Levy, M.A.2    Oh, H.J.3
  • 45
    • 0025138334 scopus 로고
    • Characterization and localization of progesterone 5 alpha-reductase from cell cultures of foxglove (Digitalis lanata EHRH)
    • Wendroth, S., Seitz, H. U.: Characterization and localization of progesterone 5 alpha-reductase from cell cultures of foxglove (Digitalis lanata EHRH). Biochem. J., 266, 1990, s. 41-46.
    • (1990) Biochem. J. , vol.266 , pp. 41-46
    • Wendroth, S.1    Seitz, H.U.2
  • 46
    • 0025366342 scopus 로고
    • Inhibition of rat liver steroid 5 alpha-reductase by 3-androstene-3-carboxylic acids: Mechanism of enzyme-inhibitor interaction
    • Levy, M. A., Brandt, M., Heys, J. R. et al.: Inhibition of rat liver steroid 5 alpha-reductase by 3-androstene-3-carboxylic acids: Mechanism of enzyme-inhibitor interaction. Biochemistry, 29, 1990, s. 2815-2824.
    • (1990) Biochemistry , vol.29 , pp. 2815-2824
    • Levy, M.A.1    Brandt, M.2    Heys, J.R.3
  • 47
    • 0028183278 scopus 로고
    • Role of 5 alpha-reductase in health and disease
    • Randall, V. A.: Role of 5 alpha-reductase in health and disease. Baillieres. Clin. Endocrinol. Metab., 8, 1994, s. 405-431.
    • (1994) Baillieres. Clin. Endocrinol. Metab. , vol.8 , pp. 405-431
    • Randall, V.A.1
  • 48
    • 0016359646 scopus 로고
    • Steroid 5alpha-reductase deficiency in man: An inherited form of male pseudohermaphroditism
    • Imperato McGinley, J., Guerrero, L., Gautier, T., Peterson, R. E.: Steroid 5alpha-reductase deficiency in man: An inherited form of male pseudohermaphroditism. Science, 186, 1974, s. 1213-1215.
    • (1974) Science , vol.186 , pp. 1213-1215
    • Imperato McGinley, J.1    Guerrero, L.2    Gautier, T.3    Peterson, R.E.4
  • 49
    • 0024463411 scopus 로고
    • Potent inhibition of human steroid 5-α-reductase (EC 1.3.1.30) by androstene-3-carboxylic acids
    • Metcalf, B. W., Holt, D. A., Levy, M. A. et al.: Potent inhibition of human steroid 5-α-reductase (EC 1.3.1.30) by androstene-3-carboxylic acids. Bioorg. Chem., 17, 1989, s. 372-376.
    • (1989) Bioorg. Chem. , vol.17 , pp. 372-376
    • Metcalf, B.W.1    Holt, D.A.2    Levy, M.A.3
  • 50
    • 0028033066 scopus 로고
    • Katalyzovaná inhibice enzymů a mechanizmus účinku farmak
    • Dršata, J.: Katalyzovaná inhibice enzymů a mechanizmus účinku farmak. Čes. Slov. Farm., 43, 1994, s. 310-314.
    • (1994) Čes. Slov. Farm. , vol.43 , pp. 310-314
    • Dršata, J.1
  • 51
    • 0018742170 scopus 로고
    • Selective inhibition by secosteroids of 5 alpha-reductase activity in human sex skin fibroblasts
    • Zerhouni, N. A., Maes, M., Sultan, C. et al.: Selective inhibition by secosteroids of 5 alpha-reductase activity in human sex skin fibroblasts. Steroids. 33, 1979, s. 277-285.
    • (1979) Steroids , vol.33 , pp. 277-285
    • Zerhouni, N.A.1    Maes, M.2    Sultan, C.3
  • 52
    • 0021245006 scopus 로고
    • Endocrine dependence of prostatic cancer upon dihydrotestosterone and not upon testosterone
    • Petrow, V., Padilla, G. M., Mukherji, S., Marths, S. A.: Endocrine dependence of prostatic cancer upon dihydrotestosterone and not upon testosterone. J. Pharm. Pharmacol., 36, 1984, s. 352-353.
    • (1984) J. Pharm. Pharmacol. , vol.36 , pp. 352-353
    • Petrow, V.1    Padilla, G.M.2    Mukherji, S.3    Marths, S.A.4
  • 53
    • 0028847625 scopus 로고
    • 6-Methylen progesterone is cytotoxic to human cancer cell lines independent of its 5-alpha-reductase activity
    • Roberson, K. M., Padilla, G. M., Schmidt, J. M. et al.: 6-Methylen progesterone is cytotoxic to human cancer cell lines independent of its 5-alpha-reductase activity. Prostate, 26, 1995, s. 28-34.
    • (1995) Prostate , vol.26 , pp. 28-34
    • Roberson, K.M.1    Padilla, G.M.2    Schmidt, J.M.3
  • 54
    • 0028212215 scopus 로고
    • Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2
    • Levy, M. A., Brandt, M., Sheedy, K. M. et al.: Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. J. Steroid Biochem. Mol. Biol., 48, 1994, s. 197-206.
    • (1994) J. Steroid Biochem. Mol. Biol. , vol.48 , pp. 197-206
    • Levy, M.A.1    Brandt, M.2    Sheedy, K.M.3
  • 55
    • 0028235751 scopus 로고
    • Effect of 5-alúha-reductase inhibition and dexamethasone administration on the growth characteristics and intratumor androgen levels of the human prostate cancer cell line PC-3
    • Tuttle, R. M., Loop, S., Jones, R. E. et al.: Effect of 5-alúha-reductase inhibition and dexamethasone administration on the growth characteristics and intratumor androgen levels of the human prostate cancer cell line PC-3. Prostate, 24, 1994, s. 229-236.
    • (1994) Prostate , vol.24 , pp. 229-236
    • Tuttle, R.M.1    Loop, S.2    Jones, R.E.3
  • 56
    • 0032589445 scopus 로고    scopus 로고
    • Steroidal antiandrogens and 5alúha-reductase inhibitors
    • Bratoeff, E., Ramírez, E., Murillo, E. et al.: Steroidal antiandrogens and 5alúha-reductase inhibitors. Curr. Med. Chem., 6, 1999, s. 1107až 1123.
    • (1999) Curr. Med. Chem. , vol.6 , pp. 1107-1123
    • Bratoeff, E.1    Ramírez, E.2    Murillo, E.3
  • 57
    • 0025605424 scopus 로고
    • Studies on the mechanism of steroid 5 alpha-reductase inhibition by 3-caroxy A-ring aryl steroids
    • Brandt, M., Greway, A. T., Holt, D. A. et al.: Studies on the mechanism of steroid 5 alpha-reductase inhibition by 3-caroxy A-ring aryl steroids. J. Steroid Biochem. Mol. Biol., 37, 1990, s. 575-579.
    • (1990) J. Steroid Biochem. Mol. Biol. , vol.37 , pp. 575-579
    • Brandt, M.1    Greway, A.T.2    Holt, D.A.3
  • 58
    • 2642697958 scopus 로고    scopus 로고
    • 19-nor-10- azasteroids: A novel class of inhibitors for human steroid 5alpha-reductases 1 and 2
    • Guarna, A., Belle, C., Machetti, F. et al.: 19-nor-10- azasteroids: A novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J. Med. Chem., 40, 1997, s. 1112-1129.
    • (1997) J. Med. Chem. , vol.40 , pp. 1112-1129
    • Guarna, A.1    Belle, C.2    Machetti, F.3
  • 59
    • 0029078027 scopus 로고
    • Randomised placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia
    • Beta-sitosterol Study Group
    • Berges, R. R., Windeler, J., Trampisch, H. J., Senge, T.: Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet, 345, 1995, s. 1529-1532.
    • (1995) Lancet , vol.345 , pp. 1529-1532
    • Berges, R.R.1    Windeler, J.2    Trampisch, H.J.3    Senge, T.4
  • 60
    • 0028269298 scopus 로고
    • Evaluation of some 4-fluoro- and 4-cyano derivatives of delta 4,3-ketosteroids as inhibitors of testosterone 5 alpha-reductase
    • Jarman, M., Barrie, S. E., Houghton, J. et al.: Evaluation of some 4-fluoro- and 4-cyano derivatives of delta 4,3-ketosteroids as inhibitors of testosterone 5 alpha-reductase. J. Enzyme Inhib., 8, 1994, s. 17-23.
    • (1994) J. Enzyme Inhib. , vol.8 , pp. 17-23
    • Jarman, M.1    Barrie, S.E.2    Houghton, J.3
  • 61
    • 0019426653 scopus 로고
    • Response of rat ventral prostate to a new and novel 5α-reductase inhibitor
    • Brooks, J. R., Baptista, E. M., Berman, C. et al.: Response of rat ventral prostate to a new and novel 5α-reductase inhibitor. Endocrinology, 109, 1981, s. 830-836.
    • (1981) Endocrinology , vol.109 , pp. 830-836
    • Brooks, J.R.1    Baptista, E.M.2    Berman, C.3
  • 62
    • 0025761220 scopus 로고
    • Effect of 5-aůúha-reductase inhibitor, 4-MAPC, on testicular descent in male rat
    • Ngyuen, M. M., Lemmi, C. A., Rajfer, J.: Effect of 5-aůúha-reductase inhibitor, 4-MAPC, on testicular descent in male rat. J. Urol., 145, 1991, s. 1096-1098.
    • (1991) J. Urol. , vol.145 , pp. 1096-1098
    • Ngyuen, M.M.1    Lemmi, C.A.2    Rajfer, J.3
  • 63
    • 0022390704 scopus 로고
    • Species differences in prostatic 5α-reductase of rat, dog and human
    • Liang, T., Cascieri, M. A., Cheung, A. H. et al.: Species differences in prostatic 5α-reductase of rat, dog and human. Endocrinology, 117, 1985, s. 571-579.
    • (1985) Endocrinology , vol.117 , pp. 571-579
    • Liang, T.1    Cascieri, M.A.2    Cheung, A.H.3
  • 64
    • 0028174647 scopus 로고
    • 17 beta-(N-tert-butylcarbamoyl)-4-aza-5-alúha-androstan-1-en-3-one is an active sitedirected slow time-dependent inhibitor of human steroid 5 alpha-reductase 1
    • Tian, G., Stuart, J. D., Moss, M. L. et al. 17 beta-(N-tert-butylcarbamoyl)-4-aza-5-alúha-androstan-1-en-3-one is an active sitedirected slow time-dependent inhibitor of human steroid 5 alpha-reductase 1. Biochemistry, 33, 1994, s. 2291-2296.
    • (1994) Biochemistry , vol.33 , pp. 2291-2296
    • Tian, G.1    Stuart, J.D.2    Moss, M.L.3
  • 65
    • 0028301655 scopus 로고
    • Inhibition of the activity of "basic" 5α-reductase (type 1) detected in DU 145 cells and expressed in inset cells
    • Délos, S., Iehlé, C., Martin, P. M., Raynaud, J. P.: Inhibition of the activity of "basic" 5α-reductase (type 1) detected in DU 145 cells and expressed in inset cells. J. Steroid Biochem. Molec. Biol., 48, 1994, s. 347-352.
    • (1994) J. Steroid Biochem. Molec. Biol. , vol.48 , pp. 347-352
    • Délos, S.1    Iehlé, C.2    Martin, P.M.3    Raynaud, J.P.4
  • 66
    • 0027363828 scopus 로고
    • Hormonal effects of turosteride, a 5α-reductase inhibitor, in the rat
    • Di Salle, E., Giudici, D., Briatico, G. et al.: Hormonal effects of turosteride, a 5α-reductase inhibitor, in the rat. J. Steroid Biochem. Molec. Biol., 46, 1993, s. 549-555.
    • (1993) J. Steroid Biochem. Molec. Biol. , vol.46 , pp. 549-555
    • Di Salle, E.1    Giudici, D.2    Briatico, G.3
  • 67
    • 0028905949 scopus 로고
    • Synthesis and biochemical evaluation of (carbamoylalenyl)phenyloxy carbocylic acid derivatives as non-steroidal 5 alpha-reductase inhibitors
    • Kattner, L., Göhring, S., Hartmann, R. W.: Synthesis and biochemical evaluation of (carbamoylalenyl)phenyloxy carbocylic acid derivatives as non-steroidal 5 alpha-reductase inhibitors. Arch. Pharm. (Weinheim), 328, 1995, s. 239-245.
    • (1995) Arch. Pharm. (Weinheim) , vol.328 , pp. 239-245
    • Kattner, L.1    Göhring, S.2    Hartmann, R.W.3
  • 68
    • 0029100066 scopus 로고
    • Novel steroid 5 alphareductase inhibitor FK143: Its dual inhibition against the two isozymes and its effect on transcription of the isozyme genes
    • Kojo, H., Nakayama, O., Hirosumi, J. et al.: Novel steroid 5 alphareductase inhibitor FK143: its dual inhibition against the two isozymes and its effect on transcription of the isozyme genes. Mol. Pharmacol., 48, 1995, s. 401-406.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 401-406
    • Kojo, H.1    Nakayama, O.2    Hirosumi, J.3
  • 69
    • 0029123736 scopus 로고
    • Inhibition of rat steroid 5 alpha-reductase (isozyme 1) by suramin
    • Taylor, M. E., Bhattacharyya, A. K., Collins, D. C.: Inhibition of rat steroid 5 alpha-reductase (isozyme 1) by suramin. Steroids, 60, 1995, s. 452-456.
    • (1995) Steroids , vol.60 , pp. 452-456
    • Taylor, M.E.1    Bhattacharyya, A.K.2    Collins, D.C.3
  • 70
    • 0034091406 scopus 로고    scopus 로고
    • New nonsteroidal steroid 5 alpha-reductase inhibitors. Syntheses and structure-activity studies on carboxamide phenylalkyl-substituted pyridones and piperidones
    • Hartmann, R. W., Reichert, M.: New nonsteroidal steroid 5 alpha-reductase inhibitors. Syntheses and structure-activity studies on carboxamide phenylalkyl-substituted pyridones and piperidones. Arch. Pharm. (Weiheim), 333, 2000, s. 145-153.
    • (2000) Arch. Pharm. (Weiheim) , vol.333 , pp. 145-153
    • Hartmann, R.W.1    Reichert, M.2
  • 71
    • 0034071149 scopus 로고    scopus 로고
    • Kinetic analysis of LY320236: Competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5alpha-reductase
    • McNulty, A. M., Audia, J. E., Bemis, K. G. et al.: Kinetic analysis of LY320236: Competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5alpha-reductase. J. Steroid Biochem. Mol. Biol., 72, 2000, s. 13-21.
    • (2000) J. Steroid Biochem. Mol. Biol. , vol.72 , pp. 13-21
    • McNulty, A.M.1    Audia, J.E.2    Bemis, K.G.3
  • 72
    • 0026721962 scopus 로고
    • Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids
    • Liang, T., Liao, S.: Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids. Biochem. J., 285, 1992, s. 557-562.
    • (1992) Biochem. J. , vol.285 , pp. 557-562
    • Liang, T.1    Liao, S.2
  • 74
    • 0021282157 scopus 로고
    • Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts
    • Sultan, C., Terraza, A., Devillier, C. et al.: Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts. J. Steroid Biochem., 20, 1984, s. 515 až 519.
    • (1984) J. Steroid Biochem. , vol.20 , pp. 515-519
    • Sultan, C.1    Terraza, A.2    Devillier, C.3
  • 75
    • 0342407561 scopus 로고
    • Selectivity of free fatty acids on 5-α-reductase inhibitory activity
    • Raynaud, J. P., Cousse, H., Martin, P. M.: Selectivity of free fatty acids on 5-α-reductase inhibitory activity (abstracts). J. Urology, 139, 1988 (Suppl. 5), s. 110.
    • (1988) J. Urology , vol.139 , Issue.SUPPL. 5 , pp. 110
    • Raynaud, J.P.1    Cousse, H.2    Martin, P.M.3
  • 77
    • 9344246314 scopus 로고    scopus 로고
    • Determination of eonothein B as the active 5-alpha-reductase-inhibiting principle of the folk medicine Epilobium parviflorum
    • Lesuisse, D., Berjonneau, J., Ciot, C. et al.: Determination of eonothein B as the active 5-alpha-reductase-inhibiting principle of the folk medicine Epilobium parviflorum. J. Nat. Prod., 59, 1996, s. 490-492.
    • (1996) J. Nat. Prod. , vol.59 , pp. 490-492
    • Lesuisse, D.1    Berjonneau, J.2    Ciot, C.3
  • 78
    • 0028844189 scopus 로고
    • Selective inhibition of steroid 5 alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate
    • Liao, S., Hiipakka, R. A.: Selective inhibition of steroid 5 alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate. Biochem. Biophys. Res. Commun., 214, 1995, s. 833-838.
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 833-838
    • Liao, S.1    Hiipakka, R.A.2
  • 82
    • 0023480779 scopus 로고
    • The potential significance of aromatase in the etiology and treatment of prostatic disease
    • Karr, J. P., Kaburagi, Y., Mann, C. F., Sandberg, A. A.: The potential significance of aromatase in the etiology and treatment of prostatic disease. Steroids, 50, 1987, s. 449-457.
    • (1987) Steroids , vol.50 , pp. 449-457
    • Karr, J.P.1    Kaburagi, Y.2    Mann, C.F.3    Sandberg, A.A.4
  • 83
    • 0031814226 scopus 로고    scopus 로고
    • A new aspect of the pharmacological and physiological significance of the aromatase/estrogen system
    • Harada, N.: A new aspect of the pharmacological and physiological significance of the aromatase/estrogen system. Nippon Yakurigaku Zasshi. 112, 1998, s. 51-58.
    • (1998) Nippon Yakurigaku Zasshi , vol.112 , pp. 51-58
    • Harada, N.1
  • 84
    • 0029841137 scopus 로고    scopus 로고
    • Aromatase mRNA levels in benign prostatic hyperplasia and prostate cancer
    • Tsugaya, M., Harada, N., Tozawa, K. et al.: Aromatase mRNA levels in benign prostatic hyperplasia and prostate cancer. Int. J. Urol., 3, 1996, s. 292-296.
    • (1996) Int. J. Urol. , vol.3 , pp. 292-296
    • Tsugaya, M.1    Harada, N.2    Tozawa, K.3
  • 85
    • 0027273898 scopus 로고
    • Effects of estrogen deprivation on human benign prostatig hyperplasia
    • Schweikert, H. U., Tunn, U. W., Habenicht, U. F. et al.: Effects of estrogen deprivation on human benign prostatig hyperplasia. J. Steroid Biochem. Mol. Biol., 44, 1993, s. 573-576.
    • (1993) J. Steroid Biochem. Mol. Biol. , vol.44 , pp. 573-576
    • Schweikert, H.U.1    Tunn, U.W.2    Habenicht, U.F.3
  • 86
    • 0029963510 scopus 로고    scopus 로고
    • Estrogen reduction by aromatase inhibition for benign prostatic hyperplasia: Result of a double-blind, placebo-controlled, randomized clinical trial using two doses of the aromatase-inhibitor atamestane
    • Atamestane Study Group
    • Radlmaier, A., Eickenberg, H. U., Fletcher, M. S. et al.: Estrogen reduction by aromatase inhibition for benign prostatic hyperplasia: Result of a double-blind, placebo-controlled, randomized clinical trial using two doses of the aromatase-inhibitor atamestane. Atamestane Study Group. Prostate, 19, 1996, s. 199-208.
    • (1996) Prostate , vol.19 , pp. 199-208
    • Radlmaier, A.1    Eickenberg, H.U.2    Fletcher, M.S.3
  • 88
    • 79961155415 scopus 로고    scopus 로고
    • Role of estrogens in human benign prostatic hyperplasia
    • Sciarra, F., Toscano, V.: Role of estrogens in human benign prostatic hyperplasia. Arch. Androl., 44, 2000, s. 213-220.
    • (2000) Arch. Androl. , vol.44 , pp. 213-220
    • Sciarra, F.1    Toscano, V.2
  • 89
    • 0034898838 scopus 로고    scopus 로고
    • The effects of phytotherapeutic agents on prostate cancer: An overview of recent clinical trials of PC spec
    • Pirani, J. F.: The effects of phytotherapeutic agents on prostate cancer: An overview of recent clinical trials of PC spec. Urology, 58, 2001 (Suppl. 1), s. 36-38.
    • (2001) Urology , vol.58 , Issue.SUPPL. 1 , pp. 36-38
    • Pirani, J.F.1
  • 90
    • 0035156598 scopus 로고    scopus 로고
    • Future concepts in the medical therapy of benign prostatic hyperplasia
    • Cuellar, D. C., Kyprianou, N.: Future concepts in the medical therapy of benign prostatic hyperplasia. Curr. Opin. Urol., 11, 2001, s. 27-33.
    • (2001) Curr. Opin. Urol. , vol.11 , pp. 27-33
    • Cuellar, D.C.1    Kyprianou, N.2


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