Serological and conformational properties of E. coli K92 capsular polysaccharide and its N-propionylated derivative both illustrate that induced antibody does not recognize extended epitopes of polysialic acid: Implications for a comprehensive conjugate vaccine against groups B and C N. meningitidis

Canadian Journal of Chemistry

Volumn 80, Issue 8, 2002, Pages 1055-1063

  Pon, Robert A ^a   Khieu, Nam Huan ^a   Yang, Qing Ling ^a   Brisson, Jean Robert ^a   Jennings, Harold J ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Conjugate vaccine; Molecular dynamics; Neisseria meningitidis; NMR; Polysialic acid

Indexed keywords

ANTIBODIES; CONFORMATIONS; ESCHERICHIA COLI; IMMUNIZATION; MOLECULAR DYNAMICS; VACCINES;

HELICAL SEGMENTS;

POLYSACCHARIDES;

ACETIC ACID DERIVATIVE; BACTERIAL POLYSACCHARIDE; BACTERIUM ANTIBODY; EPITOPE; FUNCTIONAL GROUP; MENINGOCOCCUS VACCINE; POLYSIALIC ACID;

ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; BACTERICIDAL ACTIVITY; CARBOHYDRATE ANALYSIS; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; CONFORMATION; CONJUGATE; CONTROLLED STUDY; CROSS REACTION; DRUG CONJUGATION; ESCHERICHIA COLI; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; MOLECULAR DYNAMICS; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; SEROLOGY; VACCINATION;

EID: 0036434876     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/v02-141     Document Type: Article

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