Uncoupled regulation of leukotriene C4 synthase in platelets from aspirin-intolerant asthmatics and healthy volunteers after aspirin treatment

Clinical and Experimental Allergy

Volumn 32, Issue 11, 2002, Pages 1566-1573

  Tornhamre, S ^a   Ehnhage, A ^b   Kolbeck K G ^b   Edenius, C ^a   Lindgren, J A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acetylsalicylic acid; Aspirin sensitive; Asthma; Cyclooxygenase; Leukotriene C4; Leukotriene C4 synthase; Platelets; Thromboxane A2

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; COLLAGEN; LEUKOTRIENE C4; LEUKOTRIENE C4 SYNTHASE; SALICYLIC ACID; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE; LEUKOTRIENE-C4 SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; THROMBOXANE A2;

ADULT; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG HYPERSENSITIVITY; ENZYME ACTIVITY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIDE EFFECT; THROMBOCYTE; ASTHMA; BLOOD; CASE CONTROL STUDY; CHEMICAL PHENOMENA; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; MIDDLE AGED;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONIC ACID; ASPIRIN; ASTHMA; BLOOD PLATELETS; CASE-CONTROL STUDIES; COLLAGEN; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MIDDLE AGED; THROMBOXANE A2;

EID: 0036434864     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2002.01531.x     Document Type: Article

References (64)

1. Claesson H-E, Dahlen S-E. Asthma and leukotrienes: Antileukotrienes as novel antiasthmatic drugs. J Int Med 1998; 245:205-27.
2. Weller PF, Lee CW, Foster DW, Corey EJ, Austen KF, Lewis RA. Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: Predominant production of leukotriene C4. Proc Natl Acad Sci USA 1983; 80:7626-30.
3. MacGlashan DWJ, Peters SP, Warner J, Lichtenstein LM. Characteristics of human basophil sulfidopeptide leukotriene release: Releasability defined as the ability of the basophil to respond to dimeric cross-links. J Immunol 1986; 136:2231-9.
4. MacGlashan DWJ, Schleimer RP, Peters SP et al. Generation of leukotrienes by purified human lung mast cells. J Clin Invest 1982; 70:747-51.
5. Du JT, Foegh M, Maddox Y, Ramwell PW. Human peritoneal macrophages synthesize leukotrienes B4 and C4. Biochim Biophys Acta 1983; 753:159-63.
6. Tornhamre S, Sjölinder M, Lindberg Å et al. Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity. Eur J Biochem 1998; 251:227-35.
7. Edenius C, Heidvall K, Lindgren JÅ. Novel transcellular interaction: Conversion of granulocyte-derived leukotriene A4 to cysteinyl-containing leukotrienes by human platelets. Eur J Biochem 1988; 178:81-86.
8. Lindgren JÅ, Edenius C. Transcellular biosynthesis of leukotrienes and lipoxins via leukotriene A4 transfer. Trends Pharmacol Sci 1993; 14:351-4.
9. Sala A, Bolla M, Zarini S, Müller-Peddinghaus R, Folco G. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. J Biol Chem 1996; 271:17944-8.
10. Hoffman R. Regulation of megakaryocytopoiesis. Blood 1989; 74:1196-2121.
11. Herd CM, Page CP. The platelet in asthma. Platelets 1994; 4:293-303.
12. Mannaioni P, Mg DB, Masini E. Platelets and inflammation: Role of platelet-derived growth factor, adhesion molecules and histamine. Inflammation Res 1997; 46:4-18.
13. Metzger WJ, Sjoerdsma K, Richerson HB et al. Platelets in bronchoalveolar lavage from asthmatic patients and allergic rabbits with allergen-induced late phase responses. Agents Actions 1987; 21:151-9.
14. Dahlén B, Dahlén S-E. Leukotrienes as mediators of airway obstruction and inflammation in asthma. Clin Exp Allergy 1995; 25:50-4.
15. Szczeklik A. Mechanism of aspirin-induced asthma. European J Allergy Clin Immunology 1997; 52:613-9.
16. Kumlin M, Dahlén B, Björck T, Zetterström O, Granström E, Dahlén SE. Urinary excretion of leukotriene-E4 and 11-dehydrothromboxane-B2 in response to bronchial provocations with allergen, aspirin, leukotriene-D4, and histamine in asthmatics. Am Rev Respir Dis 1992; 146:96-103.
17. Christie PE, Tagari P, Ford-Hutchinson AW et al. Urinary leukotriene-E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. Am Rev Respir Dis 1991; 143:1025-9.
18. Dahlén B, Margolskee DJ, Zetterström O, Dahlén S-E. Effect of the leukotriene receptor antagonist mK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. Thorax 1993; 48(12):1205-10.
19. Dahlen B, Nizankowska E, Szczeklik A et al. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. Respiratory Crit Care Med 1998; 157:1187-94.
20. Cowburn AS, Sladek K, Soja J et al. Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest 1998; 101:834-46.
21. 4 synthase promotor polymorphism and risk of aspirin-induced asthma. Lancet 1997; 350:1599-600.
22. Van Sambeek R, Stevenson D, Baldasaro M et al. 5′ flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. J Allergy Clin Immunol 2000; 106:72-6.
23. Szczeklik A, Sanak M. Genetic mechanisms in aspirin-induced asthma. Am J Respiratory Crit Care Med 2000; 161:142-6.
24. Sladek K, Dworski R, Soja J et al. Eicosanoids in bronchoalveolar lavage fluid of aspirin-intolerant patients with asthma after aspirin challenge. Am J Respir Crit Care Med 1994; 149:940-6.
25. Szczeklik A. Prostaglandin E2 and aspirin-induced asthma. Lancet 1995; 345:1056.
26. Tauber AI, Kaliner M, Stechschulte DJ, Austen KF. Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine. J Immunol 1973; 111:27-32.
27. Raud J, Dahlén S-E, Sydbom A, Lindbom L, Hedqvist P. Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: Apparent correlation with in vivo modulation of mediator release. Proc Natl Acad Sci (USA) 1988; 85:2315-9.
28. Szczeklik A, Mastalerz L, Nizankowska E, Cmiel A. Protective and bronchodilator effects of prostaglandin E and salbutamol in aspirin-induced asthma. Am J Respir Crit Care Med 1996; 153:567-71.
29. Sestini P, Armetti L, Gambaro G et al. Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma. Am J Respir Crit Care Med 1996; 153:572-5.
30. Kargman S, Ali A, Vaillancourt JP, Evans JF, Nicholson DW. Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C-4 synthase in neutrophilic HL-60 cells. Mol Pharmacol 1994; 45:1043-9.
31. Ali A, Ford-Hutchinson AW, Nicholson DW. Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells. J Immunol 1994; 153:776-88.
32. Sjölinder M, Tornhamre S, Werga P, Edenius C, Lindgren JÅ. Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocyte suspensions. FEBS Lett 1995; 377:87-91.
33. Gupta N, Nicholson DW, Ford-Nutchinson AW. Demonstration of cell-specific phosphorylation of LTC4 synthase. FEBS Lett 1999; 449:66-70.
34. Tornhamre S, Edenius C, Lindgren JÅ. Receptor-mediated regulation of leukotriene C4 synthase activity in human platelets. Eur J Biochem 1995; 234:513-20.
35. Lupinetti MD, Sheller JR, Catella F, Fitzgerald GA. Thromboxane biosynthesis in allergen-induced bronchospasm - Evidence for platelet activation. Am Rev Respir Dis 1989; 140:932-5.
36. Dahlen B, Kumlin M, Margolskee D et al. The leukotriene-receptor antagonist MK-0679 blocks airway obstruction induced by inhaled lysine-aspirin in aspirin-sensitive asthmatics. European Respiratory J 1993; 6:1018-26.
37. Knapp HR, Sladek K, Fitzgerald GA. Increased excretion of leukotriene-E4 during aspirin-induced asthma. J Laboratory Clin Med 1992; 119:48-51.
38. Sladek K, Szczeklik A. Cysteinyl leukotrienes overproduction and mast cell activation in aspirin-provoked bronchospasm in asthma. Eur Respir J 1993; 6:391-9.
39. Itoh K, Mukaiyama O, Satoh Y, Yamaguchi T, Iizuka Y. Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function. Eur J Pharmacol 1993; 239:159-69.
40. 2 in cultured vascular smooth muscle cells of rat aorta. Biochem Biophys Res Commun 1988; 150:1170-5.
41. Macchia L, Hamberg M, Kumlin M, Butterfield JH, Haeggstrom JZ. Arachidonic acid metabolism in the human mast cell line HMC-1: 5-Lipoxygenase gene expression and biosynthesis of thromboxane. Biochim Biophys Acta 1995; 1257:58-74.
42. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992; 89:958-67.
43. Maestrelli P, di Stefano A, Occari P et al. Cytokines in the airway mucosa of subjects with asthma induced by toluene diisocyanate. Am J Respir Crit Care Med 1995; 151:607-12.
44. Herschman HR. Prostaglandin synthase 2. Biochim Biophys Acta 1996; 1299:125-40.
45. Sousa A, Pfister R, Christie P et al. Enhanced expression of cyclo-oxygenase isoenzyme 2 (cox-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. Thorax 1997; 52:940-5.
46. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1994; 90:11693-7.
47. 2 and cyclooxygenase-2 expression by tracheobronchial smooth muscle cells. Eur J Biochem 1996; 235:557-63.
48. Akarasereenont P, Thiemermann C. The induction of cyclooxygenase-2 in human pulmonary epithelial cell culture (A549) activated by IL-1 beta is inhibited by tyrosine kinase inhibitors. Biochem Biophys Res Commun 1996; 220:181-5.
49. Belvisi MG, Saunders MA, Haddad el B. Induction of cyclooxygenase-2 by cytokines in human cultured airway smooth muscle cells: Novel inflammatory role of this cell type. Br J Pharmacol 1997; 120:910-6.
50. Zhang Y, Cao HJ, Graf B, Meekins H, Smith TJ, Phipps RP. Cutting edge - Cd40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E-2 production in human lung fibroblasts. J Immunol 1998; 160:1053-7.
51. Arias-Negrete S, Keller K, Chadee K. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochem Biophys Res Comms 1995; 208:582-9.
52. Otto JC, Smith WL. Prostaglandin endoperoxide synthase-1 and-2. J Lipid Med Cell Signal 1995; 12:139-56.
53. Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1993; 268:6610-4.
54. De Caterina R, Giannessi D, Bernini W et al. Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function. Eur Heart J 1985; 6:409-17.
55. Szczeklik A, Nizankowska E, Bochenek G, Nagraba K, Mejza F, Swierczynska M. Safety of a specific COX-2 inhibitor in aspirin-induced asthma. Clin Exp Allergy 2001; 31:219-25.
56. Yoshida S, Ishizaki Y, Onuma K, Shoji T, Nakagawa H, Amayasu H. Selective cyclo-oxygenase 2 inhibitor in patients with aspirin-induced asthma. J Allergy Clin Immunol 2000; 106:1201-2.
57. Dahlen B, Szczeklik A, Murray J. Celecoxib in patients with asthma and aspirin intolerance. The Celecoxib in Aspirin-Intolerant Asthma Study Group. N Engl J Med 2001; 344:142.
58. Drvota V, Vesterqvist O, Green K. Effects of non-steroidal anti-inflammatory drugs on the in vivo synthesis of thromboxane and prostacyclin in humans. Adv Prostagland Thrombox Leukot Res 1991; 21A:153-6.
59. Kowalski ML. Management of aspirin-sensitive rhinosinusitis-asthma syndrome: What role for aspirin desensitization? Allergy Proc 1992; 13:175-84.
60. Pleskow WW, Stevenson DD, Mathison DA, Simon RA, Schatz M, Zeiger RS. Aspirin desensitization in aspirin-sensitive asthmatic patients: Clinical manifestations and characterization of the refractory period. J Allergy Clin Immunol 1982; 69:11-9.
61. Szczeklik A, Nizankowska E, Splawinski J, Dworski R, Gajewski P, Splawinska B. Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma. J Allergy Clin Immunol 1987; 80:839-43.
62. Senna GE, Andri G, Dama AR, Mezzelani P, Andri L. Tolerability of imidazole salycilate in aspirin-sensitive patients. Allergy Proc 1995; 16:251-4.
63. Pagella PG, Agozzino S, Bellavite O, Donà GC. Reversible inhibition of thromboxane A2 production by imidazole 2-hydroxybenzoate (ITF 182) in the arachidonic acid injected rat. Drug Res 1984; 34:597-8.
64. Kantar A, Oggiano N, Gabbianelli R, Giorgi PL, Biraghi M. Effect of imidazole salicylate on the respiratory burst of polymorphonuclear leukocytes. Curr Ther Res 1993; 54:241-7.