Ginsenosides protect apical transporters of cultured proximal tubule cells from dysfunctions induced by H2O2

Kidney and Blood Pressure Research

Volumn 25, Issue 5, 2002, Pages 308-314

  Han, Ho Jae ^a   Yoon, Byung Cheol ^a   Park, Soo Hyun ^b   Park, Ji Yeong ^a   Oh, Young Joon ^a   Lee, Yun Jung ^a   Park, Kwon Moo ^a  

^a Chonnam National University   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Apical transporters; Ginsenosides; Kidney; Oxidative stress

Indexed keywords

ALPHA METHYLGLUCOSIDE; GINSENOSIDE; HYDROGEN PEROXIDE; LIPID PEROXIDE; PROTOPANAXADIOL; PROTOPANAXATRIOL; SAPONIN; UNCLASSIFIED DRUG; ARACHIDONIC ACID; CALCIUM; CARRIER PROTEIN; METHYLGLUCOSIDE; PHOSPHORUS; SAPOGENIN; SODIUM; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; KIDNEY TUBULE CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SODIUM TRANSPORT; TUBULAR DYSFUNCTION; ANIMAL; CYTOLOGY; DOSE RESPONSE; KIDNEY PROXIMAL TUBULE; METABOLISM; PHYSIOLOGY; RABBIT;

ANIMALS; ARACHIDONIC ACID; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GINSENOSIDES; HYDROGEN PEROXIDE; KIDNEY TUBULES, PROXIMAL; LIPID PEROXIDES; MALE; MEMBRANE TRANSPORT PROTEINS; METHYLGLUCOSIDES; OXIDATIVE STRESS; PHOSPHORUS; RABBITS; SAPOGENINS; SODIUM; TRITERPENES;

EID: 0036434138     PISSN: 14204096     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066795     Document Type: Article

References (29)

1. Haugen E, Nath KA: The involvement of oxidative stress in the progression of renal injury. Blood Purif 1999;17:58-65.
2. Sheridan AM, Fitzpatrick S, Wang C, Wheeler DC, Lieberthal W: Lipid peroxidation contributes to hydrogen peroxide induced cytotoxicity in renal epithelial cells. Kidney Int 1996;49:88-93.
3. Vercellotti GM, Severson SP, Duane P, Moldow CF: Hydrogen peroxide alters signal transduction in human endothelial cells. J Lab Clinic Med 1991;117:15-24.
4. Chatterjee PK, Cuzzocrea S, Thiemermann C: Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress. Kidney Int 1999;56:973-984.
5. Chung SD, Alavi N, Livingston D, Hiller S, Taub M: Characterization of primary rabbit kidney cultures that expresses proximal tubule functions in a hormonally defined medium. J Cell Biol 1982;95:118-126.
6. Takeda M, Hosohamada M, Cha SH, Sekine F, Endou H: Hydrogen peroxide downregulates human organic anion transporters in the basolateral membrane of the proximal tubule. Life Sci 2000;68:679-687.
7. Kim H, Chen X, Gillis N: Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochem Biophys Res Commun 1992;189:670-676.
8. Tran QL, Adnyana IK, Tezuka Y, Nagaoka T, Tran QK, Kadota S: Triterpene saponins from Vietnamese ginseng(Panax vietnamensis) and their hepatocytoprotective activity. J Nat Prod 2001;64:456-461.
9. Rudakewich M, Ba F, Benishin CG: Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1). Planta Med 2001;67:533-537.
10. Kim HE, Oh JH, Lee SK, Oh YJ: Ginsenoside RH-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway. Life Sci 1999;65:PL33-PL40.
11. Yokozawa T, Liu ZW, Dong E: A study of ginsenoside-Rd in a renal ischemia-reperfusion model. Nephron 1998;78:201-206.
12. Han HJ, Choi HJ, Park SH: High glucose inhibits glucose uptake in renal proximal tubule cells by oxidative stress and protein kinase C. Kidney Int 2000;57:918-926.
13. +/glucose cotransporter of renal proximal tubular cells following oxidant injury. Kidney Blood Press Res 2001;24:159-165.
14. 2+ uptake via PKC and cAMP pathways in renal proximal tubular cells. Kidney Blood Press Res 2001;24:84-91.
15. Sakhrani LM, Badie-Dezfooly B, Trizna W, Mikhail N, Lowe AG, Fine LG: Transport and metabolism of glucose by renal proximal tubular cells in primary culture. Am J Physiol 1984;246:F757-F764.
16. Han HJ, Park SH, Park HJ, Park KM, Kang JW, Lee JH, Lee BC, Hwang WS: Effect of various oestrogens on cell injury and alteration of apical transporters induced by tert-butyl hydroperoxide in renal proximal tubule cells. Clin Exp Pharmacol Physiol 2002;29:60-67.
17. Galle J: Oxidative stress in chronic renal failure. Nephrol Dial Transplant 2001;16:2135-2137.
18. Tariq M, Morais C, Sobki S, Al Sulaiman M, Al Khader A: N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats. Nephrol Dial Transplant 1999;14:923-929.
19. Poovala VS, Kanji VK, Tachikawa H, Salahudeen AK: Role of oxidant stress and antioxidant protection in acephate-induced renal tubular cytotoxicity. Toxicol Sci 1998;46:403-409.
20. Ha H, Endou H: Lipid peroxidation in isolated rat nephron segments. Am J Physiol 1992;263:F201-F207.
21. Moriyama T, Kawada N, Nagatoya K, Horio M, Imai E, Hori M: Oxidative stress in tubulointerstitial injury: Therapeutic potential of antioxidants towards interstitial fibrosis. Nephrol Dial Transplant 2001;15:47-49.
22. Huong NT, Matsumoto K, Kasai R, Yamasaki K, Watanabe H: In vitro antioxidant activity of Vietnamese ginseng saponin and its components. Biol Pharm Bull 1998;21:978-981.
23. Deng HL, Zhang JT: Anti-lipid peroxilative effect of ginsenoside Rb1 and Rg1. Chin Med J (Engl) 1991;104:395-398.
24. Yobimoto K, Matsumoto K, Huong NT, Kasai R, Yamasaki K, Watanabe H: Suppressive effects of Vietnamese ginseng saponin and its major component majonoside R2 on psychological stress-induced enhancement of lipid peroxidation in the mouse brain. Pharmacol Biochem Behav 2000;66:661-665.
25. Liao B, Newmark H, Zhou R: Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol 2002;173:224-234.
26. Golconda MS, Ueda N, Shah SV: Evidence suggesting that iron and calcium are interrelated in oxidant-induced DNA damage. Kidney Int 1993;44:1228-1234.
27. Shaw S, Naegeli P, Etter JD, Weidmann P: Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells. Clin Exp Pharmacol Physiol 1995;22:924-933.
28. Gillis CN: Panax ginseng pharmacology: A nitric oxide link? Biochem Pharmacol 1997;54:1-8.
29. Ha H, Kim KH: Pathogenesis of diabetic nephropathy: The role of oxidative stress and protein kinase C. Diabetes Res Clin Pract 1999;45:147-151.