Statistical parametric mapping of 99mTc-HMPAO-SPECT images for the diagnosis of Alzheimer's disease: Normalizing to cerebellar tracer uptake

NeuroImage

Volumn 17, Issue 3, 2002, Pages 1193-1202

  Soonawala, Darius ^a,b   Amin, Tania ^a   Ebmeier, Klaus P ^a   Steele, J Douglas ^a   Dougall, Nadine J ^a   Best, Jonathan ^a   Migneco, Octave ^c   Nobili, Flavio ^d   Scheidhauer, Klemens ^e  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITÉ CÔTE D'AZUR   (France)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Alzheimer's disease; Cerebellum; Reference region; Semiquantification; SPECT; SPM

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN MAPPING; CEREBELLUM; COMPUTER PROGRAM; ELECTROENCEPHALOGRAM; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 0036432598     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1006/nimg.2002.1259     Document Type: Article

References (19)

1. Altrocchi, P. H., Brin, M., Ferguson, J. H., Goldstein, M. L., Gorelick, P. B., Hanley, D. F., Lange, D. J., Nuwer, M. R., and Van den Noort, S. 1996. Assessment of brain SPECT-Report of the Therapeutics and Technology-Assessment Subcommittee of the American Academy of Neurology. Neurology 46: 278-285.
2. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. American sychiatric Press, Washington, DC.
3. Chang, L. T. 1978. A method for attenuation correction in radionu-clide computed tomography. IEEE Trans. Nuclear Sci. NS-25: 638-643.
4. Ebmeier, K. P., Dougall, N. J., Austin, M.-P., Murray, C. L., Curran, S. M., O'Carroll, R., Moffoot, A., Hannan, J., and Goodwin, G. M. 1991. The split-dose technique for the study of psychological and pharmacological activation with the cerebral blood flow marker exametazime and single photon emission tomography: Repeatability and rater reliability. Int. J. Methods Psychiatr. Res. 1: 27-38.
5. Ebmeier, K. P., Glabus, M. F., Prentice, N., Ryman, A., and Goodwin, G. M. 1998. A voxel-based analysis of cerebral perfusion in dementia and depression of old age. NeuroImage 7: 199-208.
6. Ebmeier, K. P., Lawrie, S. M., Blackwood, D. H. R, Johnstone, E. C., and Goodwin, G. M. 1995. Hypofrontality revisited: A high resolution single photon emission tomography study in schizophrenia. J. Neurol. Neurosurg. Psychiatry 58: 452-456.
7. 99mTc-HMPAO-SPECT and dementia of the alzheimer type: Influence of the selection of reconstruction-filter and reference-region. Nuklearmedizin 35: 243-250.
8. Folstein, M. F., Folstein, S. E., and McHugh, P. R. 1975. Minimental-state: A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12: 189-198.
9. Friston, K. J. 1994. Statistical parametric mapping. In Functional Neuroimaging (R. W. Thatcher, M. Hallet, T. Zeffiro, E. R. John, and M. Huerta, Eds.), pp. 79-93. Academic Press, San Diego.
10. Friston. K. J., Ashburner, J., Frith, C. D., Poline, J. B., Heather, J. D., and Frackowiak, R. S. J. 1995. Spatial registration and normalization of images. Hum. Brain Maps 2: 165-189.
11. Friston, K. J., Holmes, A., Poline, J. B., Price, C. J., and Frith, C. D. 1996. Detecting activations in PET and fMRI: Levels of inference and power. NeuroImage 4: 223-235.
12. Kumakura, Y., Momose, T., Oku, S., Ohtake, T., Nishikawa, J., and Sasaki, Y. 1998. Analysis of cerebral blood flow SPECT imaging on standard brain atlas in patients with dementia of Alzheimer type. Kaku Igaku 35(1): 29-32.
13. Lancaster, J. L., Summerlin, J. L., Rainey, L., Freitas, C. S., and Fox, P. T. 1997. The Talairach Daemon, a database server for Talairach Atlas labels. NeuroImage 5: S633.
14. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., and Stadlan, E. M. 1984. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34: 939-944.
15. Pickut, B. A., Dierckx, R. A., Dobbeleir, A., Audenaert, K., Van Laere, K., Vervaet, A., and De Deyn, P. P. 1999. Validation of the cerebellum as a reference region for SPECT quantification in patients suffering from dementia of the Alzheimer type. Psychiatry Res. Neuroimaging 90: 103-112.
16. Sjobeck, M., and Englund, E. 2001. Alzheimer's disease and the cerebellum: A morphologic study on neuronal and glial changes. Dement. Geriatr. Cognit. Disord. 12: 211-218.
17. m-HMPAO and SPECT: Choice of the reference region. Nuclear Med. Commun. 13: 811-816.
18. Talairach, J., and Tournoux, P. 1988. Co-planar Stereotaxic Atlas of the Human Brain. Thieme, New York.
19. Talbot, P. R., Lloyd, J. J., Snowden, J. S., Neary, D., and Testa, H. J. 1994. Choice of reference region in the quantification of single-photon emission tomography in primary degenerative dementia. Eur. J. Nuclear Med. 21: 503-508.