Mechanisms of dexamethasone-mediated inhibition of cAMP-induced tPA expression in rat mesangial cells

Kidney International

Volumn 62, Issue 3, 2002, Pages 809-821

  Eberhardt, Wolfgang ^a   Engels, Christina ^a   Müller, Roswitha ^a   Pfeilschifter, Josef ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Crescent glomerulonephritis; Extracellular matrix; Glomerulosclerosis; Glucocorticoids; Immunosuppression; Tissue plasminogen activator; Transcription factors

Indexed keywords

CYCLIC AMP; DEXAMETHASONE; DNA; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DNA BINDING; DNA FLANKING REGION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; GEL MOBILITY SHIFT ASSAY; MESANGIUM CELL; MOLECULAR BIOLOGY; MUTATIONAL ANALYSIS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; STEADY STATE;

EID: 0036425957     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00538.x     Document Type: Article

References (49)

1. Dano K, Andreasen PA, Grondahl-Hansen J, et al: Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res 44:139266, 1985
2. Yoshiko B, Yamabe H, Osawa H, et al: Regulation of tissue plasminogen activator production in cultured human fetal mesangial cells. Exp Nephrol 16:508-513, 1998
3. Davies M, Martin J, Thomas GJ, et al: Proteinases and glomerular matrix turnover. Kidney Int 41:671-678, 1992
4. Rondeau E, Mougenot B, Lacave R, et al: Plasminogen activator inhibitor 1 in renal fibrin deposits of human nephropathies. Clin Nephrol 33:55-60, 1990
5. Hong SY, Yang DH: Fibrinolytic activity in end-stage renal disease. Nephron 63:188-192, 1993
6. Lorrermoser K, Petras S, Poge U, et al: The fibrinolytic system in chronic renal failure. Eur J Med Res 6:372-376, 2001
7. Kitching AR, Holdsworth SR, Ploplis VA, et al: Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis. J Exp Med 185:963-968, 1997
8. Eberhardt W, Beeg T, Beck KF, et al: Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells. Kidney Int 57:59-69, 2000
9. Eberhardt W, Beck KF, Pfeilschifter J: Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells. Kidney Int 61:20-30, 2002
10. Meulders Q, He CJ, Adida C, et al: Tumor necrosis factor et increases antifibrinolytic activity of cultured human mesangial cells. Kidney Int 42:327-334, 1996
11. Yokoo T, Kitamura M: Dual regulation of IL-1β-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-κB and AP-1. Am J Physiol 270:F123-F130, 1996
12. Heaton JH, Gelehrter TD: Cyclic nucleotide regulation of plasminogen activator and plasminogen activator-inhibitor messenger RNAs in rat hepatoma cells. Mol Endocrinol 4:171-178, 1990
13. Heaton JH, Kathju S, Gelehrter TD: Transcriptional and posttranscriptional regulation of type 1 plasminogen activator inhibitor and tissue-type plasminogen activator gene expression in HTC rat hepatoma cells by glucocorticoids and cyclic nucleotides. Mol Endocrinol 6:53-60, 1992
14. Holmberg M, Leonardsson G, Ny T: The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters. Eur J Biochem 231:466-474, 1995
15. Kathju S, Heaton JH, Bruzdzinski CJ, et al: Synergistic induction of tissue-type plasminogen activator gene expression by glucocorticolds and cyclic nucleotides in rat HTC-hepatoma cells. Endocrinology 135:1195-1204, 1994
16. Peraldi MN, Rondeau E, Medcalf RL, et al: Cell-specific regulation of plasminogen activator inhibitor 1 and tissue type plasminogen activator release by human kidney mesangial cells. Biochim Biophys Acta 1134:189-196, 1992
17. Götrlicher M, Heck S, Doucas V, et al: Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor. Steroids 61:257-262, 1996
18. Auphan N, DiDonato JA, Rosette C, et al: Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286-290, 1995
19. Caldenhoven E, Liden J, Wissink S, et al: Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 9:401-412, 1995
20. Göttlicher M, Heck S, Herrlich P: Transcriptional cross-talk, the second mode of steroid hormone receptor action. J Mol Med 76:480-489, 1998
21. Akerblom IE, Slater EP, Beato M, et al: Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science 241:350-353, 1988
22. Pfeilschifter J, Vosbeck K: Transforming growth factor β 2 inhibits interleukin 1β- and tumour necrosis factor alpha-induction of nitric oxide synthase in rat renal mesangial cells. Biochem Biophys Res Commun 175:372-379, 1991
23. Beck KF, Eberhardt W, Walpen S, et al: Potentiation of nitric oxide synthase expression by superoxide in interleukin 1β-stimulated rat mesangial cells. FEBS Lett 435:35-38, 1998
24. Eberhardt W, Plüss C, Hummel R, et al: Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1β and cAMP in rat mesangial cells. J Immunol 160:4961-4969, 1998
25. Bruzdzinski CJ, Johnson MR, Goble CA, et al: Mechanism of glucocorticoid induction of the rat plasminogen activator inhibitor-1 gene in HTC rat hepatoma cells: Identification of cis-acting regulatory elements. Mol Endocrinol 7:1169-1177, 1993
26. Roesler WJ, Graham JG, Kolen R, et al: The cAMP response element binding protein synergizes with other transcription factors to mediate cAMP responsiveness. J Biol Chem 270:8225-8232, 1995
27. Ray A, Ray BK: Serum amyloid A gene expression under acutephase conditions involves participation of inducible C/EBPβ and C/EBPδ and their activation by phosphorylation. Mol Cell Biol 14:4324-4332, 1994
28. Metz R, Ziff E: cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev 5:1754-1766, 1991
29. Gotoh T, Chowhuury S, Takiguchi M, et al: The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPβ. J Biol Chem 272:3694-3698, 1997
30. Cwikel BJ, Barouski-Miller PA, Coleman PL, Gelehrter TD: Dexamethasone induction of an inhibitor of plasminogen activator in HTC hepatoma cells. J Biol Chem 259:6847-6851, 1984
31. Bator JM, Cohen RL, Chambers DA: Hydrocortisone regulates the dynamics of plasminogen activator and plasminogen activator inhibitor expression in cultured murine keratinocytes. Exp Cell Res 242:110-119, 1998
32. Jia XC, Ny T, Hsueh AJ: Synergistic effect of glucocorticoids and androgens on the hormonal induction of tissue plasminogen activator activity and messenger ribonucleic acid levels in granulosa cells. Mol Cell Endocrinol 68:143-151, 1990
33. Tsantarliotou M, Taitzoglou I, Kokolis N: The effect of dexamethasone on tissue fibrinolytic system in male and female rats. In Vivo 13:119-124, 1999
34. Bator JM, Cohen RL, Chambers DA: Hydrocortisone regulates the dynamics of plasminogen activator and plasminogen activator inhibitor expression in cultured murine keratinocytes. Exp Cell Res 242:110-119, 1998
35. Frank S, Kampfer H, Wetzler C, Pfeilschifter J: Nitric oxide drives skin repair: Novel functions of an established mediator. Kidney Int 61:882-888, 2002
36. Uno S, Nakamura M, Ohomagari Y, et al: Regulation of tissue-type plasminogen activator (tPA) and type-1 plasminogen activator inhibitor (PAI-1) gene expression in rat hepatocytes in primary culture. J Biochem 123:806-812, 1998
37. Schalkwijk C, Vervoordeldonk M, Pfeilscihfter J, et al: Cytokine- and forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by dexamethasone. Biochem Biophys Res Commun 180:46-52, 1991
38. Vervoordeldonk MJ, Schalkwijk CG, Pfeilschifter J, et al: Effects of dexamethasone and transforming growth factor-β 2 on group II phospholipase A2 mRNA and activity levels in interleukin 1 β- and forskolin-stimulated mesangial cells. Biochem J 315:435-441, 1996
39. Mohl H, Geiger T, Pignat W, et al: Transforming growth factors type-beta and dexamethasone attenuate group II phospholipase A2 gene expression by interleukin-1 and forskolin in rat mesangial cells. FEBS Lett 301:190-194, 1992
40. Pfeilschifter J, Schwarzenbach H: Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells. FEBS Lett 273:185-187, 1990
41. Pfeilschifter J: Anti-inflammatory steroids inhibit cytokine induction of nitric oxide synthase in rat renal mesangial cells. Eur J Pharmacol 195:179-180, 1991
42. Kunz D, Walker G, Eberhardt W, et al: Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1β-stimulated mesangial cells: Evidence for the involvement of transcriptional and posttranscriptional regulation. Proc Natl Acad Sci USA 93:255-259, 1996
43. Plüss C, Werner ER, Wachter H, et al: Differential effect of dexamethasone on interleukin 1β- and cyclic AMP-triggered expression of GTP cyclohydrolase I in rat renal mesangial cells. Br J Pharmacol 122:534-538, 1997
44. Falkenstein E, Tillmann HC, Christ M, et al: Multiple actions of steroid hormones-A focus on rapid, nongenomic effects. Pharmacol Rev 52:513-556, 2000
45. Whitehead D, Carter DA: cAMP-response element-binding protein phosphorylation and DNA-binding activity are increased in the anterior pituitary gland following glucocorticoid depletion. J Mol Endocrinol 19:291-297, 1997
46. Weih F, Stewart AF, Boshart M, et al: In vivo monitoring of a cAMP-stimulated DNA-binding activity. Genes Dev 4:1437-1449, 1990
47. Boshart M, Weih F, nichols M, et al: The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell 66:849-859, 1991
48. Park EA, Gurney AL, Nizielski SE, et al: Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP). J Biol Chem 268:613-619, 1993
49. Yamada K, Duong DT, Scow DK, et al: CCAAT/enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem 274:5880-5887, 1999