The psychosocial consequences of short stature: A review of the evidence

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 16, Issue 3, 2002, Pages 449-463

  Sandberg, David E ^a   Voss, Linda D ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b PENINSULA MEDICAL SCHOOL   (United Kingdom)

Author keywords

Body height; Children; Growth hormone; Psychological adaptation; Short stature

Indexed keywords

ESTROGEN; GROWTH HORMONE; RECOMBINANT GROWTH HORMONE;

ADOLESCENCE; ADULTHOOD; ALGORITHM; BODY HEIGHT; CHILD; CHILD GROWTH; CHILDHOOD; CLINICAL RESEARCH; DISTRESS SYNDROME; DRUG INDICATION; DRUG SAFETY; ESTROGEN THERAPY; FAMILY; GONADAL DYSGENESIS; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HUMAN; HYPOPITUITARISM; MEDICAL DECISION MAKING; MEDICAL ETHICS; METHODOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSICIAN; PRADER WILLI SYNDROME; PSYCHOLOGIC ASSESSMENT; QUALITY OF LIFE; REVIEW; SAMPLING; SHORT STATURE; SOCIAL ADAPTATION; SOCIAL PROBLEM; SOCIAL PSYCHOLOGY; STEREOTYPY; STRESS; TURNER SYNDROME; ADAPTATION; CHILD PSYCHOLOGY; GROWTH HORMONE RELEASE; GROWTH RATE; MENTAL STRESS; PREDICTION; TREATMENT OUTCOME;

EID: 0036424524     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1053/beem.2002.0211     Document Type: Review

References (100)

1. Tanner JM & Davies PS. Clinical longitudinal standards for height and height velocity for North American children. Journal of Pediatrics 1985; 107: 317-329.
2. Tanner JM & Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Archives of Disease in Childhood 1976; 51: 170-179.
3. Freeman JV, Cole TJ, Chinn S et al. Cross sectional stature and weight reference curves for the UK, 1990. Archives of Disease in Childhood 1995; 73: 17-24.
4. Ranke MB. Towards a consensus on the definition of idiopathic short stature. Hormone Research 1996; 45 (supplement 2): 64-66.
5. Saenger P, Wikland KA, Conway GS et al. Fifth International Symposium on Turner Syndrome. Recommendations for the diagnosis and management of Turner syndrome. Journal of Clinical Endocrinology & Metabolism 2001; 86: 3061-3069.
6. Lee PDK, Allen DB, Angulo MA et al. Consensus statement - Prader-Willi syndrome: Growth hormone (GH)/insulin-like growth factor axis deficiency and GH treatment. Endocrinologist 2000; 10 (supplement 1): 71S-73S.
7. Hindmarsh P, Smith P, Brook C & Matthews D. The relationship between height velocity and 24 growth hormone secretion in children. Clinical Endocrinology 1987; 27: 581-591.
8. KIGS International Board/Pharmacia Corporation. Pharmacia International Growth Database, Report No. 18. Biannual Report, Stockholm, March 2001.
9. Vance ML & Mauras N. Growth hormone therapy in adults and children. New England Journal of Medicine 1999; 341: 1206-1216.
10. Sandberg DE. Should short children who are not deficient in growth hormone be treated? Western Journal of Medicine 2000; 172: 186-189.
11. Martel LF & Biller HB. Stature and Stigma: the Biopsychosocial Development of Short Males. Lexington, MA: DC Heath, 1987.
12. Lechelt EC. Occupational affiliation and ratings of physical height and personal esteem. Psychological Reports 1975; 36: 943-946.
13. Wilson PR. Perceptual distortion of height as a function of ascribed status. Journal of Social Psychology 1968; 74: 97-102.
14. Clopper R. Height and children's stereotypes. In Stabler B & Underwood LE (eds) Growth, Stature and Adaptation, pp 7-18. University of North Carolina at Chapel Hil Press, 1994.
15. Gillis JS. Too Tall, Too Small. Champaign, IL: Institute for Personality and Ability Testing, 1982.
16. Ekwo E, Gosselink C, Roisen N & Brazdziunas D. The effect of height on family income. American Journal of Human Biology 1991; 3: 181-188.
17. Stabler B & Gilbert MC. Psychological effects of growth delay. In Hintz R & Rosenfeld R (eds) Growth Abnormalities, pp 255-274. New York: Churchill Livingstone, 1987.
18. Lee PDK & Rosenfeld RG. Psychosocial correlates and short stature and delayed puberty. Pediatric Clinics of North America 1987; 34: 851-863.
19. Underwood LE. The social cost of being short: societal perceptions and biases. Acta Paediatrica Scandinavica 1991; 377 (supplement): 3-8.
20. Stabler B, Siegel PT, Clopper RR et al. Behaviour change after growth hormone treatment of children with short stature. Journal of Pediatrics 1998; 133: 366-373.
21. Cuttler L, Silvers JB, Singh J et al. Short stature and growth hormone therapy. A national study of physician recommended patterns. Journal of the American Medical Association 1996; 276: 531-537.
22. Sandberg DE. Short stature: intellectual and behavioral aspects. In Lifshitz F (ed.) Pediatric Endocrinology, 3rd edn, pp 149-162. New York: Marcel Dekker, 1996.
23. Lerner RM & Gellert E. Body build identification, preference and aversion in children. Developmental Psychology 1969; 1: 456-462.
24. Steinhausen HC & Stahnke N. Negative impact of growth hormone deficiency on psychological functioning in dwarfed children and adolescents. European Journal of Pediatrics 1977; 126: 263-270.
25. Meyer-Bahlburg HFL. Short stature: psychological issues. In Lifshitz F (ed.) Pediatric Endocrinology. A Clinical Guide, 2nd edn, pp 173-196. New York: Marcel Dekker, 1990.
26. Kusalic M, Fortin C & Gauthier Y. Psychodynamic aspects of dwarfism. Response to growth hormone treatment. Canadian Psychiatric Association Journal 1972; 17: 29-34.
27. Rotnem D, Genel M, Hintz RL & Cohen DJ. Personality development in children with growth hormone deficiency. Journal of the American Academy of Child Psychiatry 1977; 16: 412-426.
28. Holmes CS, Hayford JT & Thompson RG. Parents and teachers differing views of short children's behaviour. Child: Care, Health and Development 1982; 8: 327-336.
29. Olweus D. Bully/victim problems among school children: basic facts and effects of a school based intervention program. In Pepler DJ & Rubin KH (eds) The Development and Treatment of Childhood Aggression, pp 411-448. Hillsdale, NJ: Lawrence Erlbaum Associates, 1991.
30. Voss LD & Mulligan J. The short 'normal' child in school: self-esteem, behaviour and attainment before puberty (The Wessex Growth Study). In Stabler B & Underwood LE (eds) Growth, Stature and Adaptation, pp 47-64. University of North Carolina at Chapel Hill Press, 1994.
31. Sandberg DE, MacGillivray MH, Clopper RR et al. Quality of life (QOL) among formerly treated child-onset growth hormone-deficient (GHD) adults: a comparison with unaffected siblings. Journal of Clinical Endocrinology & Metabolism, 1998; 83: 1134-1142.
32. Lagrou K, Xhrouet-Heinrichs D, Heinrichs C et al. Age-related perception of stature, acceptance of therapy, and psychosocial functioning in human growth hormone-treated girls with Turner's syndrome. Journal of Clinical Endocrinology & Metabolism 1998; 83: 1494-1501.
33. Drash PW. Psychologic counselling in dwarfism. In Gardner LI (ed.) Endocrine and Genetic Diseases of Childhood, pp 1014-1022. Philadelphia: WB Saunders, 1969.
34. Gordon M, Crouthamel C, Post EM & Richman RA. Psychosocial aspects of constitutional short stature: social competence, behavior problems, self-esteem and family functioning. Journal of Pediatrics 1982; 101: 477-480.
35. Zimet GD, Cutler M, Litvene M et al. Psychological adjustment of children evaluated for short stature: a preliminary report. Journal of Developmental and Behavioral Pediatrics 1995; 16: 264-270.
36. Apter A, Galatzer A, Beth-Halachmi N & Laron Z. Self-image in adolescents with delayed puberty and growth retardation. Journal of Youth and Adolescence 1981; 10: 501-505.
37. Lewis VG, Money J & Bobrow NA. Idiopathic pubertal delay beyond age fifteen: psychologic study of twelve boys. Adolescence 1977; 12: 1-11.
38. Holmes CS, Karlsson JA & Thompson RB. Social and school competencies in children with short stature. Longitudinal patterns. Journal of Developmental and Behavioral Paediatrics 1985; 6: 263-267.
39. Sartorio A, Morabito F, Peri G et al. The social outcome of adults with constitutional growth delay. Journal of Endocrinological Investigation 1990; 13: 593-595.
40. Zimet G, Cutler M & Owens R. Psychosocial functioning of adults who were short as children. In Stabler B & Underwood LE (eds) Growth, Stature and Adaptation, pp 73-82. University of North Carolina at Chapel Hill Press, 1994.
41. Crowne EC, Shalet SM, Wallace WHB et al. Final height in boys with untreated constitutional delay in growth and puberty. Archives of Disease in Childhood 1990; 65: 1109-1112.
42. Crowne EC, Shalet SM, Wallace WHB et al. Final height in girls with untreated constitutional delay of growth and puberty. European Journal of Pediatrics 1991; 150: 708-712.
43. Sandberg DE, Kranzler J, Bukowski WM & Rosenbloom AL. Psychosocial aspects of short stature and growth hormone therapy. Journal of Pediatrics 1999; 135: 133-134.
44. Rosenthal R & Rosnow RL. The Volunteer Subject. New York: John Wiley & Sons, 1975.
45. Skuse D, Gilmour J, Tian CS, Hindmarsh P. Psychosocial assessment of children with short stature: a preliminary report. Acta Paediatrica Scandinavica 1994; 406 (supplement): 11-16.
46. Gilmour J & Skuse D. Short stature - the role of intelligence in psychosocial adjustment. Archives of Disease in Childhood 1996; 75: 25-31.
47. Sandberg DE, Brook AE & Campos SP. Short stature: a psychosocial burden requiring growth hormone therapy? Pediatrics 1994; 94: 832-840.
48. Rekers-Mombarg LTM, Busschbach JJV, Massa GG et al. Quality of life of young adults with idiopathic short stature: effect of growth hormone treatment. Acta Paediatrica 1998; 87: 865-870.
49. Reiter EO & Rosenfeld RG. Normal and aberrant growth. In Wilson JD et al (eds) Williams Textbook of Endocrinology, pp 1427-1507. Philadelphia: Saunders, 1998.
50. Blizzard RM & Bulatovic A. Syndromes of psychosocial short stature. In Lifshitz F (ed) Pediatric Endocrinology, 3rd edn, pp 83-93. New York: Marcel Dekker, 1996.
51. Stabler B, Tancer ME, Ranc J & Underwood LE. Evidence for social phobia and other psychiatric disorders in adults who were growth hormone deficient during childhood. Anxiety 1996; 2: 86-89.
52. Sandberg DE & Barrick C. Endocrine disorders in childhood: a selective review of educational sequelae. School Psychology Review 1995; 24: 144-168.
53. Meyer-Bahlburg HFL, Feinman JA, MacGillivray MH & Aceto T Jr. Growth hormone deficiency, brain development, and intelligence. American Journal of Diseases of Children 1978; 132: 565-572.
54. Galatzer A, Aran O, Beit-Halachmi N et al. The impact of long-term therapy by a multidisciplinary team on the education, occupation and marital status of growth hormone deficient patients after termination of therapy. Clinical Endocrinology 1987; 27: 191-196.
55. Siegel PT & Hopwood NJ. The relationship of academic achievement and the intellectual functioning and affective conditions of hypopituitary children. In Stabler B & Underwood LE (eds) Slow Grows the Child: Psychosocial Aspects of Growth Delay, pp 57-71. Hillsdale, NJ: Erlbaum, 1986.
56. Sandberg DE, Ognibene TC, Brook AE et al. Academic adjustment among children and adolescents receiving growth hormone therapy. Children's Health Care 1998; 27: 265-282.
57. Lippe B. Turner syndrome: a recognizable cause of adolescent short stature. Seminars in Adolescent Medicine 1987; 3: 241-253.
58. Rovet JF. The psychoeducational characteristics of children with Turner syndrome. Journal of Learning Disabilities 1993; 26: 333-341.
59. Robinson A, Bender BG, Borelli JB et al. Sex chromosome aneuploidy: prospective and longitudinal studies. In Ratcliffe S & Pauls N (eds) Prospective Studies on Children with Sex Chromosome Aneuploidy, pp 23-72. New York: Alan Liss, 1986.
60. Rovet JF. School outcome in Turner syndrome. In Stabler B & Underwood LE (eds) Growth, Stature, and Adaptation: an International Symposium on the Behavioral, Social, and Cognitive Aspects of Growth Delay, pp 165-180. Chapel Hill, NC: University of North Carolina at Chapel Hil Press, 1994.
61. McCauley E, Feuillan P, Kushner H & Ross JL. Psychosocial development in adolescents with Turner syndrome. Journal of Developmental and Behavioral Pediatrics 2001; 22: 360-365.
62. McCauley E, Kay T, Ito J & Treder R. The Turner syndrome: cognitive deficits, affective discrimination, and behavior problems. Child Development 1987; 58: 464-467.
63. Skuse DH, James RS, Bishop DV et al. Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function. Nature 1997; 387: 705-708.
64. Siegel PT, Clopper R & Stabler B. The psychological consequences of Turner syndrome and review of the National Cooperative Growth Study psychological substudy. Pediatrics 1968; 102: 488-491.
65. Ross JL, Feuillan P, Kushner H et al. Absence of growth hormone effects on cognitive function in girls with Turner syndrome. Journal of Clinical Endocrinology & Metabolism 1997; 82: 1814-1817.
66. Busshbach JJV, Rikken B, Grobbee DE et al. Quality of life in short adults. Hormone Research 1998; 490: 32-38.
67. Kranzler JH, Rosenbloom AL, Proctor B et al. Is short stature a handicap? A comparison of the psychosocial functioning of referred and non-referred children with normal short stature and children with normal stature. Journal of Pediatrics 2000; 136: 96-102.
68. Douglas JWB, Ross JM & Simpson HR. The relation between height and measured educational ability in school children of the same social class, family size and stage of sexual development. Human Biology 1965; 37: 178-186.
69. Miller FJW, Knox EG, Court SDM & Brandon S. The School Years in Newcastle-upon-Tyne 1952-1962: Being a Further Contribution to the Study of a Thousand Families. London: Oxford University Press, 1974.
70. Wilson DM, Hammer LD, Duncan PM et al. Growth and intellectual development. Pediatrics 1986; 78: 646-650.
71. Vance MD, Ingersoll GM & Golden MP. Short stature in a non-clinical sample: not a big problem. In Stabler B & Underwood LE (eds) Growth, Stature and Adaptation, pp 35-45. Chapel Hill, NC: University of North Carolina at Chapel Hill Press, 1994.
72. Voss LD, Walker JM, Lunt H et al. The Wessex Growth Study B First report. Acta Paediatrica Scandinavica 1989; 349 (supplement): 65-72.
73. Downie AB, Mulligan J, Stratford RJ et al. Are short normal children at a disadvantage? British Medical Journal 1997; 314: 97-100.
74. Voss LD. Short but normal. Archives of Disease in Childhood 1999; 81: 370-371.
75. Voss LD & Mulligan J. Bullying in school B: are short children at risk? British Medical Journal 2000; 320: 612-613.
76. Illich I. Limits to Medicine. Penguin Books UK, 1996.
77. Buchlis JG, Irizarry L, Crotzer BC et al. Comparison of final heights of hormone-treated vs. untreated children with idiopathic short stature. Journal of Clinical Endocrinology and Metabolism 1998; 83: 1075-1079.
78. Voss LD, Wilkin TJ, Bailey BJR & Betts PR. The reliability of height and height velocity in the assessment of growth. Archives of Disease in Childhood 1991; 66: 833-837.
79. Voss L & Mulligan J. Normal growth in the short normal prepubertal child. Journal of Medical Screening 1998; 5: 127-130.
80. Allen DB & Fost NC. Ethical issues in growth hormone therapy: where are we now? Endocrinologist 2001; 11 (supplement 1): 1S-2S.
81. Churchill LR. Bias, opportunity and justice in growth hormone therapy. In Stabler B & Underwood LE (eds) Growth, Stature and Adaptation, 195-202. Chapel Hill, NC: University of North Carolina at Chapel Hill Press, 1994.
82. Neely EK & Rosenfeld RG. Use and abuse of human growth hormone. Annual Review of Medicine 1994; 45: 407-420.
83. Fost N. Is the treatment/enhancement distinction useful? Endocrinologist 2001; 11 (supplement 1): 72S-77S.
84. Voss LD. Growth hormone therapy for the short normal child: who needs it and who wants it? Journal of Pediatrics 2000; 136: 103-110.
85. Lantos JD. Ethics and growth hormone: where have we been and where are we going?. In Stabler B & Underwood LE (eds) Growth, Stature and Adaptation, 213-219. Chapel Hill, NC: University of North Carolina at Chapel Hill Press, 1994.
86. Voss LD, Mulligan J, Betts PR & Wilkin TJ. Poor growth in school entrants as an index of organic disease. British Medical Journal 1992; 305: 1400-1402.
87. Underwood LE & Rieser PA. Is it ethical to treat healthy short children with growth hormone? Acta Paediatrica Scandinavica 1989; 362 (supplement): 18-23.
88. Lantos J, Siegler M & Cuttler L. Ethical issues in growth hormone therapy. Journal of the American Medical Association 1989; 261: 1020-1024.
89. Diekema DS. Is taller really better? Growth hormone therapy in short children. Perspectives in Biology and Medicine 1990; 34: 109-123.
90. Hunt L, Hazen RA & Sandberg DE. Perceived versus measured height: which is the stronger predictor of psychosocial functioning? Hormone Research 2000; 53: 129-138.
91. Rotnem D, Cohen D, Hintz R & Genel M. Psychological sequelae of relative 'treatment failure' for children receiving GH replacement. Journal of the American Academy of Child Psychiatry 1989; 18: 505-520.
92. Guyda HJ. Growth hormone therapy for non-growth hormone-deficient children with short stature. Current Opinion in Pediatrics 1998; 10: 416-421.
93. Hintz RL, Attie KM, Baptista J & Roche A. Effect of growth hormone treatment on adult height of children with idiopathic short stature. New England Journal of Medicine 1999; 340: 502-507.
94. Slyper A. The safety and effectiveness of human growth hormone using pharmacological dosing. Medical Hypotheses 1995; 45: 523-528.
95. Wilton P. Adverse events during GH treatment: 10 years' experience in KIGS, a pharmacoepidemiological survey. In Ranke MB & Wilton P (eds) Growth Hormone Therapy in KIGS - 10 Years' Experience, pp 349-364. Mannheim: Barth, 1999.
96. Clayton PE & Cowell CT. Safety issues in children and adolescents during growth hormone therapy - a review. Growth Hormone IGF Research 2000; 10: 306-317.
97. Eminson M, Powell RP & Hollis S. Cognitive behaviour interventions with short statured boys: a pilot study. In Stabler B & Underwood LE (eds) Growth, Stature and Adaptation, 135-150. Chapel Hill, NC: University of North Carolina at Chapel Hill Press, 1994.
98. Allen DB. Terminating growth promoting hormone therapy: in favor of the 'normal opportunity range'. Endocrinologist 2001; 11 (supplement 1): 56S-59S.
99. Diekema DS. Is maximizing height good parenting? Endocrinologist 2001; 11 (supplement 1): 67-71.
100. Noeker M & Haverkamp F. Adjustment in conditions with short stature: a conceptual framework. Journal of Pediatric Endocrinology 2000; 13: 1585-1594.