Effect of low- and high-dose levothyroxine on thyroid nodule volume: A crossover placebo-controlled trial

Clinical Endocrinology

Volumn 57, Issue 5, 2002, Pages 621-628

  Koc, Mehmet ^a   Ersoz, H Onder ^a   Akpinar, Ihsan ^a   Gogas Yavuz, Dilek ^a,b   Deyneli, Oguzhan ^a   Akalin, Sema ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b MARMARA UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; THYROTROPIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; HORMONE DETERMINATION; HUMAN; MALE; PALPATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THYROID NODULE; THYROTROPIN BLOOD LEVEL; TREATMENT OUTCOME; TUMOR VOLUME;

ADULT; ANALYSIS OF VARIANCE; CROSS-OVER STUDIES; DEPRESSION, CHEMICAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; SOFTWARE DESIGN; THYROGLOBULIN; THYROID GLAND; THYROID NODULE; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 0036420552     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2002.01650.x     Document Type: Article

References (28)

1. Bennedbaek, F.N. & Hegedus, L. (2000) Management of the solitary thyroid nodule: Results of a North American survey. Journal of Clinical Endocrinology and Metabolism, 85, 2493-2498.
2. Bennedbaek, F.N., Perrild, H. & Hegedus, L. (1999) Diagnosis and treatment of the solitary thyroid nodule. Results of a European survey. Clinical Endocrinology (Oxford), 50, 357-363.
3. Berghout, A., Wiersinga, W.M., Drexhage, H.A., Smits, N.J. & Touber, J.L. (1990) Comparison of placebo with 1-thyroxine alone or with carbimazole for treatment of sporadic non-toxic goitre. Lancet, 336, 193-197.
4. Biondi, B., Fazio, S., Carella, C., Amato, G., Cittadini, A., Lupoli, G., Sacca, L., Bellastella, A. & Lombardi, G. (1993) Cardiac effects of long term thyrotropin suppressive therapy with levothyroxine. Journal of Clinical Endocrinology and Metabolism, 77, 334-338.
5. Carrol, B.A. (1982) Asymptomatic thyroid nodules: Incidental sonographic detection. American Journal of Roentgenology, 138, 499-501.
6. Celani, M.F. (1993) Levothyroxine suppressive therapy in the medical management of nontoxic benign multinodular goiter. Experimental Clinical Endocrinology, 101, 326-332.
7. Celani, M.F., Mariani, M. & Marani, G. (1990) On the usefulness of levothyroxine suppressive therapy in the medical treatment of benign solitary, solid or predominantly solid thyroid nodules. Acta Endocrinologica (Copenhagen), 123, 603-608.
8. Cheung, P.S.Y., Lee, J.M.H. & Boey, J.H. (1989) Thyroxine suppressive therapy of benign thyroid nodules: A prospective randomised study. World Journal of Surgery, 13, 818-822.
9. Csako, G., Byrd, D., Wesley, R.A., Sarlis, N.J., Skarulis, M.C., Nieman, L.K. & Pucino, F. (2000) Assessing the effects of thyroid suppression on benign solitary thyroid nodules. A model for using quantitative research synthesis. Medicine (Baltimore), 79, 9-26.
10. Diamond, T., Nery, L. & Hales, I. (1991) A therapeutic dilemma: Suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 72, 1184-1188.
11. Erdogan, G., Erdogan, M.F., Delange, F., Sav, H., Gullu, S. & Kamel, N. (2000) Moderate to severe iodine deficiency in three endemic goitre areas from the Black Sea region and the capital of Turkey. European Journal of Epidemiology, 16, 1131-1134.
12. Ezzat, S., Sarti, D.A., Cain, D.R. & Braunstein, G.D. (1994) Thyroid incidentalomas. Prevalence by palpation and ultrasonography. Archives of Internal Medicine, 154, 1838-1840.
13. Gharib, H., James, E.M., Charboneau, J.W., Naessens, J.M., Offord, K.P. & Gorman, C.A. (1987) Suppressive therapy with levothyroxine for solitary thyroid nodules. A double blind controlled clinical study. New England Journal of Medicine, 317, 70-75.
14. Gharib, H. & Mazzaferri, E.L. (1998) Thyroxine suppressive therapy in patients with nodular thyroid disease. Annals of Internal Medicine, 128, 386-394.
15. Knudsen, N., Bulow, I., Jorgensen, T., Laurberg, P., Ovesen, L. & Perrild, H. (2000) Goitre prevalence and thyroid abnormalities at ultrasonography: A comparative epidemiological study in two regions with slightly different iodine status. Clinical Endocrinology (Oxford), 53, 479-485.
16. Kuma, K., Matsuzuka, F., Kobayashi, A., Hirai, K., Morita, S., Miyauchi, A., Katayama, S. & Sugawara, M. (1992) Outcome of long standing solitary thyroid nodules. World Journal of Surgery, 16, 583-588.
17. La Rosa, G.L., Lupo, L., Giufrida, D., Gullo, D., Vigneri, R. & Belfiore, A. (1995) Levothyroxine and potassium iodide are both effective in treating benign solitary solid cold nodules of the thyroid. Annals of Internal Medicine, 122, 1-8.
18. Lima, N., Knobel, M., Cavaliere, H., Sztejnsznajd, C., Tomimori, E. & Medeiros-Neto, G. (1997) Levothyroxine suppressive therapy is partially effective in treating patients with benign, solid thyroid nodules and multinodular goiters. Thyroid, 7, 691-697.
19. Morita, T., Tamai, H., Ohshima, A., Komaki, G., Matsubayashi, S., Kuma, K. & Nagakawa, T. (1989) Changes in serum thyroid hormone, thyrotropin and thyroglobulin concentrations during thyroxine therapy in patients with solitary thyroid nodules. Journal of Clinical Endocrinology and Metabolism, 69, 227-230.
20. Papini, E., Bacci, V., Panunzi, C., Pacella, M., Fabbrini, R., Bizzzarri, G., Petrucci, L., Giammarco, V., La Medica, P., Masala, M., Pitaro, M. & Nardi, F. (1993) A prospective randomized trial of levothyroxine suppressive therapy for solitary thyroid nodules. Clinical Endocrinology (Oxford), 38, 507-513.
21. Papini, E., Petrucci, L., Guglielmi, R., Panunzi, C., Rinaldi, R., Bacci, V., Crescenzi, A., Nardi, F., Fabbrini, R. & Pacella, C.M. (1998) Long term changes in nodular goiter: A 5 year prospective randomized trial of levothyroxine suppressive therapy for benign cold thyroid nodules. Journal of Clinical Endocrinology and Metabolism, 83, 780-783.
22. Peter, H.J., Studer, H. & Groscurth, P. (1988) Autonomous growth, but not autonomous function, in embryonic human thyroids: A clue to understanding autonomous goiter growth? Journal of Clinical Endocrinology and Metabolism, 66, 968-973.
23. Reverter, J.L., Lucas, A., Salinas, I., Audi, L., Foz, M. & Sanmarti, A. (1992) Suppressive therapy with levothyroxine for solitary thyroid nodules. Clinical Endocrinology (Oxford), 36, 25-28.
24. Ridgway, E.C. (1996) Clinical evaluation of solitary thyroid nodules. In The Thyroid (eds L. E. Braverman & R. D. Utiger), pp. 966-972. Lippincott-Raven, Philadelphia.
25. Rojeski, M.T. & Gharib, H. (1985) Nodular thyroid disease. Evaluation and management. New England Journal of Medicine, 313, 428-436.
26. Studer, H., Peter, H.J. & Gerber, H. (1989) Natural heterogeneity of thyroid cells: The basis for understanding thyroid function and nodular goiter growth. Endocrine Reviews, 10, 125-135.
27. Urgancioglu, I., Hatemi, H.H., Kokoglu, E., Guven, Y., Sur, N. & Yilmaz, O. (1986) Investigation of Iodine Contents of Drinking Water in Turkey, in Relation to Endemic Goiter Problem (ed. I. Urgancioglu), pp. 63-64. Cerrahpasa Medical Faculty, Istanbul.
28. Zelmanovitz, F., Genro, S. & Gross, J.L. (1998) Suppressive therapy with levothyroxine for solitary thyroid nodules: A double-blind controlled clinical study and cumulative meta-analyses. Journal of Clinical Endocrinology and Metabolism, 83, 3881-3885.