Gelatin-specific cellular immune responses persist for more than 3 years after priming with gelatin containing DTaP vaccine

Clinical and Experimental Allergy

Volumn 32, Issue 10, 2002, Pages 1510-1514

  Kumagai, T ^a,c   Kamada, M ^a   Igarashi, C ^a   Yuri, K ^a   Furukawa, H ^a   Nagata, N ^a   Saito, A ^b   Okui, T ^b   Yano, S ^b  

^a Pediatric Allergy and Infectious Diseases Society of Sapporo   (Japan)

^b HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

^c Kumagai Pediatric Clinic   (Japan)

Author keywords

Allergy; Cellular immunology; Gelatin hypersensitivity; Gelatin IgE; Gelatin IgG; Lymphocyte transformation; Vaccine

Indexed keywords

DIPHTHERIA PERTUSSIS TETANUS VACCINE; GELATIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; VACCINE;

ANTIBODY SPECIFICITY; ARTICLE; CELL ACTIVITY; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG SENSITIZATION; FEMALE; FOLLOW UP; HUMAN; INFANT; INOCULATION; LABORATORY TEST; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL;

DIPHTHERIA-TETANUS-ACELLULAR PERTUSSIS VACCINES; DRUG HYPERSENSITIVITY; FEMALE; GELATIN; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFANT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 0036411717     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2745.2002.01505.x     Document Type: Article

References (9)

1. Kelso JM. The gelatin story. J Allergy Clin Immunol 1999; 103:200-2.
2. Kumagai T, Yamanaka T, Wataya Y et al. Gelatin-specific humoral and cellular immune responses in children with immediate- and nonimmediate-type reactions to live measles, mumps, rubella, and varicella vaccines. J Allergy Clin Immunol 1997; 100:1304.
3. Taniguchi K, Fujisawa T, Ihara T et al. Gelatin-induced T-cell activation in children with nonanaphylactic-type reactions to vaccines containing gelatin. J Allergy Clin Immunol 1998; 102:1028-32.
4. Ohsaki M, Tsutsumi H, Kumagai T et al. The relevance of TH1 and TH2 cells in immediate and nonimmediate reactions to gelatin-containing vaccine. J Allergy Clin Immunol 1999; 103:276-81.
5. Nakayama T, Aizawa C, Kuno-Sakai H. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allergy Clin Immunol 1999; 103:321-5.
6. Kumagai T, Ozaki T, Kamada Met al. Gelatin-containing diphtheria-tetanus-pertussis (DTP) vaccine causes sensitization to gelatin in the recipients. Vaccine 2000; 18:1555-61.
7. Sakaguchi M, Inouye S. IgE sensitization to gelatin: The probable role of gelatin-containing diphtheria-tetanus-acellular pertussis (DTaP) vaccines. Vaccine 2000; 18:2055-8.
8. Nakayama T, Aizawa C. Change in gelatin content of vaccines associated with reduction in reports of allergic reactions. J Allergy Clin Immunol 2000; 106:591-2.
9. Kumagai T, Yamanaka T, Wataya Y et al. A strong association between HLA-DR9 and gelatin allergy in the Japanese population. Vaccine 2001; 19:3273-6.