Peptide washout and permeability from glyceryl monooleate buccal delivery systems

Drug Development and Industrial Pharmacy

Volumn 28, Issue 9, 2002, Pages 1155-1162

  Lee, Jaehwi ^a   Kellaway, Ian W ^b  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Diffusion cell; Glyceryl monooleate; Mucoadhesive liquid crystalline phases; Peptide buccal delivery; Washout

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; GLYCEROL OLEATE; PEPTIDE; ACYLGLYCEROL; DRUG CARRIER; ENKEPHALIN[2 ALANINE 5 LEUCINE];

ADHESION; ANIMAL TISSUE; ARTICLE; BUCCAL DRUG ADMINISTRATION; CHEEK MUCOSA; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; NONHUMAN; SALIVATION; ANIMAL; BIOAVAILABILITY; BIOLOGICAL MODEL; CHEMISTRY; CRYSTALLIZATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PERMEABILITY; SALIVA; SWINE; TIME;

ADHESIVENESS; ADMINISTRATION, BUCCAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DIFFUSION; DRUG CARRIERS; DRUG STABILITY; ENKEPHALIN, LEUCINE-2-ALANINE; GLYCERIDES; MODELS, BIOLOGICAL; PERMEABILITY; SALIVA; SWINE; TIME FACTORS;

EID: 0036411670     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120014582     Document Type: Article

References (16)

1. Veuillez, F.; Kalia, Y.N.; Jacques, Y.; Deshusses, J.; Buri, P. Factors and strategies for improving buccal absorption of peptides. Eur. J. Pharm. Biopharm. 2001, 51, 93-109.
2. Rathbone, M.J.; Drummond, B.K.; Tucker, I.G. The oral cavity as a site for systemic drug delivery. Adv. Drug Del. Rev. 1994, 13, 1-22.
3. Robinson, J.R. Rationale of bioadhesion/mucoadhesion. In Bioadhesion - Possibilities and Future Trends; Gurny, R., Junginger, H.E., Eds.; Wissenschaftliche Verlagsgesellschaft: Stuttgart, 1990; 13-15.
4. Lee, J.; Young, S.A.; Kellaway, I.W. Water quantitatively induces the mucoadhesion of liquid crystalline phases of glyceryl monooleate. J. Pharm. Pharmacol. 2001, 53, 629-636.
5. Lee, J.; Kellaway, I.W. In vitro peptide release from liquid crystalline buccal delivery systems. Int. J. Pharm. 2000, 195, 29-33.
6. 5]enkephalin from liquid crystalline phases of glyceryl monooleate. Int. J. Pharm. 2000, 195, 35-38.
7. 5]enkephalin from a cubic phase of glyceryl monooleate. Int. J. Pharm. 2000, 204, 137-144.
8. Dubocovich, M.L.; Langer, S.Z. Pharmacological differentiation of presynaptic inhibitory α-adrenoceptors and opiate receptors in the cat nictitating membrane. Br. J. Pharmacol. 1980, 70, 383-393.
9. Schulteis, G.; Weinberger, S.B.; Martinez, J.L., Jr. Plasma uptake and in vivo metabolism of [leu]enkephalin following its intraperitoneal administration to rats. Peptides 1989, 10, 913-919.
10. 5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res. 1985, 336, 125-132.
11. 5]enkephalin in the rat intestine: Comparison with leucine enkephalin. J. Pharm. Sci. 1998, 87, 448-452.
12. Hansen, L.B.; Christrup, L.L.; Bundgaard, H. Saliva-catalyzed hydrolysis of a ketobemidone ester prodrug: Factors influencing human salivary esterase activity. Int. J. Pharm. 1992, 88, 221-227.
13. Veuillez, F.; Kalia, Y.N.; Jacques, Y.; Deshusses, J.; Buri, P. Factors and strategies for improving buccal absorption of peptides. Eur. J. Pharm. Biopharm. 2001, 51, 93-109.
14. Le Brun, P.P.H.; Fox, P.L.A.; de Vries, M.E.; Boddé, H.E. In vitro penetration of some β-adrenoreceptor blocking drugs through porcine buccal mucosa. Int. J. Pharm. 1989, 49, 141-145.
15. Zhou, X.H. Overcoming enzymatic and absorption barriers to non-parenterally administered protein and peptide drugs. J. Contr. Rel. 1994, 29, 239-252.
16. Engström, S. Drug delivery from cubic and other lipid-water phases. Lipid Technol. 1990, 2, 42-45.