The glucose-specific carrier of the Escherichia coli phosphotransferase system: Synthesis of selective inhibitors and inactivation studies

European Journal of Biochemistry

Volumn 269, Issue 20, 2002, Pages 4969-4980

  García Alles, Luis Fernando ^a   Navdaeva, Vera ^a   Haenni, Simon ^a   Erni, Bernhard ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Binding site; Carbohydrate chemistry; Cysteine; Glucose transporter; Irreversible inhibitor

Indexed keywords

2',3' EPOXYPROPYL BETA DEXTRO GLUCOPYRANOSIDE; BETA DEXTRO GLUCOPYRANOSYL ISOTHIOCYANATE; BETA DEXTRO GLUCOPYRANOSYLPHENYL ISOTHIOCYANATE; CHLOROACETYL BETA DEXTRO GLUCOPYRANOSIDE; GLUCOSE DERIVATIVE; GLUCOSE TRANSPORTER; METHYL (6E) 6,7 DIDEOXY ALPHA DEXTRO GLUCOOCT 6 ENOPYRANOSIDURONIC ACID; METHYL 6,7 ANHYDRO DEXTRO LEVO GLYCERO ALPHA DEXTRO GLUCOHEPTOPYRANOSIDE; METHYL ALPHA DEXTRO GLUCOPYRANOSIDE; METHYL ALPHA DEXTRO MANNOPYRANOSIDE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CYTOPLASM; DIASTEREOISOMER; DRUG EFFECT; DRUG SYNTHESIS; ESCHERICHIA COLI; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION;

BINDING SITES; BIOCHEMISTRY; BIOLOGICAL TRANSPORT; CYSTEINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; EPOXY COMPOUNDS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLUCOSE; GLUCOSIDES; MICROBIAL SENSITIVITY TESTS; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE SYSTEM; PHOSPHORYLATION; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0036410159     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03197.x     Document Type: Article

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