bis(trichloromethyl)carbonate, an efficient activator for the one-pot conversion of aldehydes into nitriles under mild conditions

Synthetic Communications

Volumn 32, Issue 23, 2002, Pages 3621-3624

  Bose, D Subhas ^a   Goud, P Ravinder ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Activator; Aldehydes; Nitriles; One pot; Triphosgene

Indexed keywords

ALDEHYDE; BIS(TRICHLOROMETHYL)CARBONATE; CARBONIC ACID DERIVATIVE; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; STOICHIOMETRY; SYNTHESIS;

EID: 0036408890     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120014975     Document Type: Article

References (10)

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2. (b) Mowry, D.T. Chem. Rev. 1948, 42, 250.
3. (a) Fatiadi, A.J. The Chemistry of Triple-Bonded Functional Group, Part 2; Patai, S., Rappoport, Z., Eds.; John Wiley and sons: New York, 1983; pp. 1057;
4. (b) Stevens, T.E. J. Org. Chem. 1961, 26, 2531;
5. (c) Pakusch, J.; Ruchardt, C. Chem. Ber. 1991, 124, 971.
6. (a) Bose, D.S.; Jayalakshmi, B. J. Org. Chem. 1999, 64, 1713;
7. (b) Bose, D.S.; Goud, P.R. Tetrahedron Lett. 1999, 40, 747;
8. (c) Bose, D.S.; Kiran Kumar, K. Synth. Commun. 2000, 30, 3047.
9. Cotarca, L.; Delogu, P.; Nardelli, A.; Sunjic, V. Synthesis 1996, 553.
10. Work on the similar line has been reported by Prasad Sahu, D, Ind. J. Chem. 1993, 32B, 385 in which total completion of the reaction takes place using half molar ratio of triphosgene to carboxamides instead of theoretical one third molar ratio of triphosgene at 50°C.