Effects of the flavonoid pilloin isolated from Marrubium cylleneum on mitogen-induced lymphocyte transformation

Pharmaceutical Biology

Volumn 40, Issue 4, 2002, Pages 245-248

  Michelis, Fotios ^a   Tiligada, Ekaterini ^a   Skaltsa, Helen ^a   Lazari, Diamanto ^a   Skaltsounis, Alexios Leandros ^a   Delitheos, Andreas ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Cytotoxicity; Flavonoids; Lamiaceae; Lymphocyte; Marrubium cylleneum

Indexed keywords

CHRYSOERIOL 7 O BETA DEXTRO (3'' E 4 COUMAROYL)GLUCOPYRANOSIDE; FLAVANOID; PILLOIN; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG ISOLATION; GLYCOSYLATION; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOBLAST; LYMPHOCYTE TRANSFORMATION; NONHUMAN;

LAMIACEAE; MARRUBIUM;

EID: 0036406725     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.40.4.245.8472     Document Type: Article

References (21)

1. Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Rémésy C, Chap H, Payrastre B (1997): Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biomed Pharmacol 53: 1649-1657.
2. Baden C (1991): Marrubium L. In: Strid A, Tan K, (ed.) Mountain flora of Greece. Edinburgh: Edinburgh University Press, p. 83.
3. Bouic PJ, Lamprecht JH (1999): Plant sterols and sterolins: a review of their immuno-modulating properties. Alt Med Rev 4: 170-177.
4. Hatam NA, Porzel A, Seifert K (1995): Polyodonine, a prefuranic labdane diterpene from Marrubium polydon. Phytochemistry 40: 1575-1576.
5. Ielpo MT, Basile A, Miranda R, Moscatiello VV, Nappo C, Sorbo S, Laghi E, Ricciardi MM, Ricciardi L, Vuotto ML (2000): Immunopharmacological properties of flavonoids. Fitoterapia 71: S101-S109.
6. Jacobsen KA, Prasad VS, Sidman CL (1994): Apoptosis and macrophage-mediated deletion of precursor B cells in the bone marrow of E mu-myc transgenic mice. Blood 84: 2784-2794.
7. Mabberlay D J (1997): The Plant Book, Cambridge, Cambridge University Press.
8. Mabry TJ, Markham KR, Thomas MB (1970): The Systematic Identification of Flavonoids. New York, Springer.
9. Middleton E Jr (1998): Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol 439: 175-182.
10. Namgoong SY, Son KH, Chang HW, Kang SS, Kim HP (1993): Effects of naturally occuring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture. Life Sci 54: 313-320.
11. Nawwar MAM, El-Mousallamy AMD, Barakat HH, Buddrus J, Linscheid M (1989): Flavonoid lactates from leaves of Marrubium vulgare. Phytochemistry 28: 3201-3206.
12. Nikolic L, Topuz U, Proietti-Orlandi F (1976): With reference to a simple kit for short-term lymphocyte culture tested in experimental animals. Boll Ist Sieroterap Milan 55: 400-410.
13. Plaumann B, Fritsche M, Rimpler H, Brandner G, Hess RD (1996): Flavonoids activate wild-type p53. Oncogene 13: 1605-1614.
14. Post JF, Varma RS (1992): Growth inhibitory effects of bioflavonoids and related compounds on human leukemic CEM-C1 and CEM-C7 cells. Cancer Lett 67: 207-213.
15. Rabatic S, Dekaris D (1979): Simple phase-contrast microscopy test for human lymphocyte transformation induced by mitogens or antigens. Acta Med Jugoslav 33: 363-372.
16. Saleh MRI, Sarg TM, Metwally AM, Rakkel A (1981): Chemical constituents from Marrubium alysson. Planta Med 41: 202.
17. Savona G, Bruno M, Rodriguez B (1984): Preperegrine, a prefuranic labdane ditrepene from Marrubium friwaldskyanum. Phytochemistry 23: 191-192.
18. Sfikakis PP, Souliotis VL, Akbar A, Katsilabmbros N, Hoffbrand VA, Panayiotidis P (1996): Regulation of bcl-2 and fas expression in primary activation of human peripheral lymphocytes is not sensitive to dexamethasone or cyclosporin-A. Hum Immunol 50: 121-126.
19. Tomás-Barberán FA, Gil MI, Ferreres F, Tomás-Lorente F (1992): Flavonoid p-coumaroylglucosides and 8-hydroxyflavone allosylglucosides in some Labiatae. Phytochemistry 31: 3097-3102.
20. Yao XL, Jenkins EC, Wisniewski HM (1994): Effect of aluminum chloride on mitogenesis, mitosis, and cell cycle in human short-term whole blood cultures: lower concentrations enhance mitosis. J Cell Biochem 54: 473-477.
21. You KM, Son KH, Chang HW, Kang SS, Kim HP (1998): Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. Planta Med 64: 546-550.