The prevalence of activated protein C resistance and F V Leiden in healthy population of Edirne, Turkey

Turkish Journal of Haematology

Volumn 19, Issue 2, 2002, Pages 287-291

  Vurkun, Mutlu ^a   Vural, Özden ^a   Demir, Muzaffer ^a   Turgut, Burhan ^a   Gürgey, Aytemiz ^a   Parlak, Hülya ^a   Duran, Nesrin ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

Activated protein C resistance; FV Leiden; Prevalence in healthy population; Turkey

Indexed keywords

ACTIVATED PROTEIN C; ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; DNA; PROTEIN S; PROTHROMBIN;

ACTIVATED PROTEIN C RESISTANCE; ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; ETHNIC GROUP; EUROPE; FEMALE; GENE MUTATION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PREVALENCE; PROTEIN C DEFICIENCY; RISK FACTOR; THROMBOPHILIA; TURKEY (REPUBLIC); VEIN THROMBOSIS;

EID: 0036403712     PISSN: 13007777     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Throm Diath Haemorrh 1965;13:516.
2. Dahlback B. Inherited thrombophilia: Resistance to protein C as a pathogenetic factor of venous thromboembolism. Blood 1995;85:607-14.
3. De Stefano V, Finazzi G, Manucci PM. Inherited thrombophilia: Pathogenesis, clinical syndromes and management. Blood 1996;87:3531-44.
4. Akar N, Ulutin O, Cin Ç. Trombozda Moleküler Deǧişimler: Neonatal Hemostaz ve Tromboz. Ankara: 1999:41-57.
5. De Stefano S, Leone G, Mastrangelo S, Tripodi A, Rodeghiero F, Castaman G, Barbui T, Finazzi G, Bizzi B, Manucci PM. Clinical manifestations and management of inherited thrombophilia: Retrospective analysis and follow-up after diagnosis of 238 patients with congenital deficiency of antithrombin III, protein C, protein S. Thromb Haemost 1994;72:352-8.
6. Shafer AI. Hypercoagulabl. Genetics to clinical practice. Lancet 1994;334:1739-42.
7. Demir M, Vural Ö, Sunar H, Altun A, Yorulmaz F, Özbay G. The prevalence of hereditary thrombophilia in the Trakya region of Turkey. Yonsei Med J 2000;41:436-40.
8. Bertina RM, Koeleman BPC, Koester T, Rosendaal FR, Dirven RJ, de Ronde H, von der Velden PA, Reitsma PH. Mutation in blood coagulation factor associated with resistance to activated protein C. Nature 1994;369:64-7.
9. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995;346:1133-4.
10. Özbek U, Tangün Y. Frequency of factor V Leiden (Arg 506 Gln) in Turkey (Letter). Br J Haematol 1997;97:504-5.
11. Dzimiri N, Meyer B. World distribution of factor V Leiden (Letter). Lancet 1996;347:481-2.
12. Awidi A, Shannak M, Bseiso A, Kaliani MA, Omar N, An Shasi B. Thromb Haemost 1999;81:582-4.
13. Takamiya O, Ishida F, Kodaira H, Kifano K. APC resistance and MnLI genotype (Gly 506) of coagulation factor V are rare in Japanise population (letter) Thromb Haemost 1995;74:996.
14. Yavuz As, Karalar S, Tangün Y. Aktive protein C'ye direncin normal ve venöz trombozlu kişilerde araştirilmasi. XXIV. National Congress of Hematology; 1996 April 11-14, Istanbul-Turkey. Abstract Book. pp. 221.
15. Gürgey A, Mesci L, Renda Y, Olcay L, Koçak N, Erdem G. Trombozlu çocuklarda FV Leiden mutasyonu. XXIV. National Congress of Hematology; 1996 April 11-14, Istanbul-Turkey. Abstract Book. pp. 68.
16. Ganderille S, Greengard JS, Alhenc-Gelas M, Juhan-Vague I, Abgrall JF, Jude B, Griffin JH, Aiach M, and the French Network on behalf of INSERM. Incidence of activated protein C resistance caused by the Arg506Gln mutation in factor V Leiden in 113 unrelated symptomatic protein C-deficient patients. Blood 1995;86:219-24.
17. Koeleman BPC, van Rumpt D, Halmulyak K, Reitsma PH, Bertian RM. Factor V Leiden. An additional risk factor for thrombosis in protein S deficient families? Thromb Haemost 1995;74:580-3.
18. Van Boven HH, Reitsma PH, Rosendaal FR, Bayston TA, Chowdhury V, Bauer KA, Scharre I, Conrad J, Lane DA. Factor V Leiden (FVR506Q) in families with inherited antithrombin deficiency. Thromb Haemost 1996;75:417-21.
19. Margaglione M, D'Andrea G, Colaizzo D, Cappucci G, del Popolo AM, et al. Coexistance of factor V Leiden and factor II A20210 mutations and recurrent venous thromboembolism. Thromb Haemost 1999;82:1583-7.