Imaging sulfur mustard lesions in human epidermal tissues and keratinocytes by confocal and multi photon microscopy

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 4620, Issue , 2002, Pages 231-241

  Werrlein, Robert J ^a   Madren Whalley, Janna S ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Adhesion complex; Alpha 6 integrin; Blisters; Human skin; Keratin 14; Laminin 5; Sulfur mustard

Indexed keywords

ADHESION; ANTIBODIES; FLUORESCENCE; IMAGE ANALYSIS; MEDICAL IMAGING; MOLECULES; MULTIPHOTON PROCESSES;

MULTI-PHOTON MICROSCOPY;

LASER TISSUE INTERACTION;

EID: 0036403262     PISSN: 0277786X     EISSN: None     Source Type: Journal    
DOI: 10.1117/12.470695     Document Type: Article

References (16)

1. W. Denk, D. Piston, and W. Webb, "Two-photon molecular excitation in laser-scanning microscopy," Handbook of Biological Confocal Microscopy, J. Pawley, pp. 445-458, Plenum Press, New York, 1995.
2. B. Papirmeister, A. Feister, S. Robinson, and R. Ford, Medical Defense Against Mustard Gas: Toxic Mechanisms and Pharmacological Implications, CRC Press, Boca Raton, 1991.
3. R. Werrlein, and J. Madren-Whalley, "Effects of sulfur mustard on the basal cell adhesion complex," J Appl Toxicol, 20, S115-S123, 2000.
4. E. Fuchs, "The cytoskeleton and disease: genetic disorders of intermediate filaments," Annu Rev Gene, 30, 197-231, 1996.
5. E. Fuchs, (Keith R. Porter Lecture, 1996), "Of mice and men: genetic disorders of the cytoskeleton," Mol Biol Cell, 8, 189-203, 1997.
6. J. Uttam, E. Hutton, P.A. Coulombe, I. Anton-Lamprecht, Q.C. Yu, T. Gedde-Dahle Jr., J.D. Fine, and E. Fuchs, "The genetic basis of epidermolysis bullosa simplex with mottled pigmentation," Proc Natl Acac Sci, USA, 93, 9079-9084, 1996.
7. 4 integrin with the cytoskeleton of the hemidesmosomes. Mol Biol Cell, 4, 871-884, 1993.
8. R. Foisner, F.E. Leichfried, H. Herrmann, J.V. Small, D. Lawson, and G. Wiche, "Cytoskeleton associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins," J Cell Biol, 105, 723-733, 1988.
9. G. Wiche, R. Krepler, U. Artlieb, R. Pytela, and W. Aberer, "Identification of plectin in different human cell types and immunolocalization at epithelial basal cell surface membranes," Exp Cell Res, 155, 43-49, 1984.
10. G. Wiche, D. Gromov, A. Donovan, M.J. Castanon, and E. Fuchs, "Expression of plectin mutant cDNA in cultured cells indicates a role of COOH-terminal domain in intermediate filament association," J Cell Biol, 121, 607-619, 1993.
11. L. Pulkkinen, and J.Uitto, "Hemidesmosomal variants of epidermolysis bullosa," Exp Dermatol, 7, 46-64, 1998.
12. R. Werrlein, T. Hamilton, J. Madren-Whalley, "Development of human keratinocyte colonies for confocal microscopy and for study of calcium effects on growth differentiation and sulfur mustard lesions," Toxicity Assessment Alternatives: Methods, Issues, Opportunities, H. Salem and S. Katz, pp. 165-174, The Humana Press Inc., 1999.
13. L. Goldfinger, S. Hopkinson, G. deHart, S. Collawn, J. Couchman, and J. Jones, "The α3 laminin subunit, α6β4 and α3β1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin," J Cell Sci, 112, 2615-2629, 1999.
14. B. Nguyen, M. Ryan, S. Gil, and W. Carter, "Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion," Curr Opin Cell Biol, 12, 554-562, 2000.
15. L. Borradori, and A. Sonnenberg, "Hemidesmosomes: roles in adhesion, signaling and human diseases," Curt Opin Cell Biol, 8, 647-656, 1996.
16. L. Borradori, and A. Sonnenberg, "Structure and function of hemidesmosomes: more than simple adhesion complexes," J Invest Dermatol, 112, 411-418, 1999.