Adjusting pairwise nonparametric equivalence hypothesis tests and confidence intervals for period effects in 3 × 3 crossover trials

Journal of Biopharmaceutical Statistics

Volumn 12, Issue 2, 2002, Pages 149-160

  Duchateau, Luc ^a   Janssen, Paul ^b   Straetemans, Roel ^c   Otoul, Christian ^c  

^a GHENT UNIVERSITY   (Belgium)

^b HASSELT UNIVERSITY   (Belgium)

^c UCB PHARMA   (Belgium)

Author keywords

3 3 Crossover trial; Equivalence hypotheses; Hodges Lehmann confidence interval; Noninferiority hypothesis; Pairwise comparisons

Indexed keywords

ANTIHISTAMINIC AGENT; DIPHENHYDRAMINE; LEVOCETIRIZINE; PLACEBO;

ALGORITHM; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DENSITY; DRIVING ABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; HUMAN; HYPOTHESIS; METHODOLOGY; PARAMETER; PHARMACODYNAMICS; PRIORITY JOURNAL; SAMPLE SIZE; SIDE EFFECT; STATISTICAL ANALYSIS; VALIDATION PROCESS;

CHEMISTRY, PHARMACEUTICAL; CLINICAL TRIALS; CONFIDENCE INTERVALS; CROSS-OVER STUDIES; HUMANS; MATCHED-PAIR ANALYSIS; STATISTICS, NONPARAMETRIC;

EID: 0036402352     PISSN: 10543406     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIP-120014417     Document Type: Article

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