Growth factor-dependent proliferation of the pancreatic β-cell line βTC-tet: An assay for β-cell mitogenic factors

International Journal of Experimental Diabetes Research

Volumn 3, Issue 1, 2002, Pages 69-74

  Milo landesman, Dalit ^a   Efrat, Shimon ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

cell lines; Cell proliferation; Growth factors; Mitogenicity; Tetracycline regulated gene expression

Indexed keywords

GROWTH FACTOR; MITOGENIC AGENT; ONCOPROTEIN; TETRACYCLINE; VIRUS T ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL ASSAY; CELL CULTURE; CELL DIVISION; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL SPECIFICITY; CELL TRANSFORMATION; CONTROLLED STUDY; GROWTH INHIBITION; MITOGENICITY; MOUSE; NONHUMAN; OPERON; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; EPIDERMAL GROWTH FACTOR; GROWTH SUBSTANCES; INSULIN-LIKE GROWTH FACTOR II; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; KINETICS; MICE; PROLACTIN;

EID: 0036401556     PISSN: 15604284     EISSN: None     Source Type: Journal    
DOI: 10.1080/15604280212526     Document Type: Article

References (18)

1. Nielsen, J.H., Galsgaard, E.D., Moldrup, A., Friedrichsen, B.N., Billestrup, N., Hansen, J.A., Lee, Y.C. and Carlsson, C. (2001). Regulation of beta-cell mass by hormones and growth factors, Diabetes, 50, Suppl. 1, S25-S29.
2. Garcia-Ocana, A., Vasavada, R.C., Takane, K.K., Cebrian, A., Lopez-Talavera, J.C. and Stewart, A.F. (2001). Using beta-cell growth factors to enhance human pancreatic islet transplantation, J. Clin. Endocrinol. Metab., 86, 984-988.
3. Brelje, T.C., Scharp, D.W., Lacy, P.E., Orgen, L., Talamantes, F., Robertson, M., Friesen, H.G. and Sorenson, R.L. (1993). Effect of homologous placental lactogens, prolactins, and growth hormones on islet β-cell division and insulin secretion in rat, mouse and human islets: implication for placental lactogen regulation of islet function during pregnancy, Endocrinology, 132, 879-887.
4. Beattie, G.M., Rubin, J.S., Mally, M.I., Otonkoski, T. and Hayek, A. (1996). Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact, Diabetes, 45, 1223-1228.
5. Garcia-Ocana, A., Takane, K.K., Syed, M.A., Philbrick, W.M., Vasavada, R.C. and Stewart A.F. (2000). Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J. Biol. Chem., 275, 1226-1232.
6. Swenne, I., Heldin, C-H., Hill, D.J. and Hellerstrom, C. (1988). Effects of platelet-derived growth factor and somatomedin-c/insulin-like growth factor I on the deoxyribonucleic acid replication of fetal rat islets of Langerhans in tissue culture, Endocrinology, 122, 214-218.
7. Hogg, J., Han, V.K.M., Clemmons, D.R. and Hill, D.J. (1993). Interactions of nutrients, insulin-like growth factors (IGFs), and IGF-binding proteins in the regulation of DNA synthesis in isolated fetal rat islets of Langerhans, J. Endocrinol., 138, 410-412.
8. Hugl, S.R., White, M.F. and Rhodes, C.J. (1998). Insulin-like growth factor I (IGF-1)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells, J. Biol. Chem. 273, 17771-17779.
9. Petrik, J., Pell, J.M., Arany, E., McDonald, T.J., Dean, W.L., Reik, W. and Hill, D.J. (1999). Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia, Endocrinology, 140, 2353-2363.
10. Christofori, G., Naik, P. and Hanahan, D. (1994). A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis, Nature, 369, 414-418.
11. Watanabe, T., Yonemura, Y, Yonekura, H., Suzuki, Y., Miyashita, H., Sugiyama, K., Moriizumi, S., Unno, M., Tanaka, O., Kondo, H., Bone, A.J., Takasawa, S. and Okamoto, H. (1994). Pancreatic beta-cell replication and amelioration of surgical diabetes by reg protein, Proc. Natl. Acad. Sci. USA, 91, 3589-3592.
12. Houtari, M-A., Palgi, J. and Otonkoski, T. (1998). Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of beta-cellulin as a novel β-cell mitogen, Endocrinology, 139, 1494-1499.
13. Efrat, S., Fusco-DeMane, D., Lemberg, H., Emran, O.A. and Wang, S. (1995). Conditional transformation of a pancreatic β-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene, Proc. Natl. Acad. Sci. USA, 92, 3576-3580.
14. Jones, J.I. and Clemmons, D.R. (1995). Insulin-like growth factors and their binding proteins: biological actions, Endocrine Rev., 16, 3-34.
15. Fleischer, N., Chen, C., Surana, M., Leiser, M., Rossetti, L., Pralong, W., Efrat, S. (1998). Functional analysis of a conditionally-transformed pancreatic β-cell line, Diabetes, 47, 1419-1425.
16. Nielsen, J.H., Linde, S., Welinder, B.S., Billestrup, N. and Madsen, O.D. (1989) Growth hormone is a growth factor for the differentiated pancreatic b cell. Mol. Endocrinol., 3, 165-173.
17. Nielsen, J.H. (1982). Effects of growth hormone, prolactin, and placental lactogen on insulin content and release, and deoxyribonucleic acid synthesis in cultured pancreatic islets, Endocrinology, 110, 600-606.
18. Lefebvre, V.H., Otonkoski, T., Ustinov, J., Huotari, M-A., Pipeleers, D.G. and Bouwens, L. (1998). Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for β-cells, Diabetes, 47, 134-137.