Change of product specificity of hexaprenyl diphosphate synthase from sulfolobus solfataricus by introducing mimetic mutations

Biochemical and Biophysical Research Communications

Volumn 297, Issue 5, 2002, Pages 1096-1101

  Hemmi, Hisashi ^a   Noike, Motoyoshi ^a   Nakayama, Toru ^a   Nishino, Tokuzo ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Archaeal enzyme; Chain length determination; Evolution; Hexaprenyl diphosphate synthase; Isoprenoid; Mimetic mutation; Mutagenesis; Prenyl diphosphate synthase; Prenyltransferase; Terpenoid

Indexed keywords

BACTERIAL ENZYME; GERANYLTRANSFERASE; HEXAPRENYLPYROPHOSPHATE SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; EVOLUTION; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SULFOLOBUS SOLFATARICUS;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; BINDING SITES; CHROMATOGRAPHY, THIN LAYER; DIMERIZATION; DIMETHYLALLYLTRANSTRANSFERASE; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; SULFOLOBUS; TEMPERATURE;

ARCHAEA; EUKARYOTA; SULFOLOBUS; SULFOLOBUS SOLFATARICUS;

EID: 0036400595     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02348-3     Document Type: Article

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