Clinical characteristics and predictors of severe ketoacidosis at onset of type 1 diabetes mellitus in children in a North Rhine-Westphalian Region, Germany

Journal of Pediatric Endocrinology and Metabolism

Volumn 15, Issue 8, 2002, Pages 1137-1145

  Rosenbauer, J ^a   Icks, A ^a   Giani, G ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Children; Clinical characteristics at onset; Dibetes ketoacidosis; Social status; Type 1 diabetes mellitus

Indexed keywords

GLUCOSE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL FEATURE; CONSCIOUSNESS DISORDER; CONTROLLED STUDY; DIABETIC COMA; DIABETIC KETOACIDOSIS; DISEASE SEVERITY; FAMILY STUDY; FATIGUE; FEMALE; FREQUENCY ANALYSIS; GERMANY; GLUCOSE BLOOD LEVEL; HUMAN; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; JUVENILE DIABETES MELLITUS; MALE; MEDICAL RECORD; METABOLIC DISORDER; PATIENT INFORMATION; PH; POLYURIA; POPULATION RESEARCH; QUESTIONNAIRE; RISK ASSESSMENT; SOCIAL STATUS; SYMPTOMATOLOGY; WEIGHT REDUCTION;

EID: 0036394286     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2002.15.8.1137     Document Type: Article

References (33)

1. Hamilton DV, Mundia SS, Lister J. Mode of presentation of juvenile diabetes. Br Med J 1976; 2: 211-212.
2. Daneman D, Knip M, Kaar ML, Sochett E. Comparison of children with type 1 (insulin-dependent) diabetes in northern Finland and southern Ontario: differences at disease onset. Diabetes Res 1990; 14: 123-126.
3. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M. A comparison of childhood and adult type I diabetes mellitus. N Engl J Med 1989; 320: 881-886.
4. Samuelsson U, Ludvigsson J, Bottazzo GF, Shattock M, Adolfsson S, Becker D, Cacciari E, Chiarelli F, Chiumello G, Deschamps I. Indications for a more aggressive disease process in newly diagnosed insulin-dependent diabetic children in northern than in southern Europe. Acta Diabetol 1994; 31: 107-115.
5. Knip M, Säkkinen A, Huttunen NP, Kaar ML, Lankela S, Mustonen A, Åkerblom HK. Postinitial remission in diabetic children - an analysis of 178 cases. Acta Paediatr Scand 1982; 71: 901-908.
6. Ludvigsson J, Heding LG, Larsson Y, Leander E. C-peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control. Acta Paediatr Scand 1977; 66: 177-184.
7. Sochett EB, Daneman D, Clarson C, Ehrlich RM. Factors affecting and patterns of residual insulin secretion during the first year of type 1 (insulin-dependent) diabetes mellitus in children. Diabetologia 1987; 30: 453-459.
8. Green A, Anderson PK. Epidemiological studies of diabetes mellitus in Denmark: 3. Clinical characteristics and incidence of diabetes among males aged 0 to 19 years. Diabetologia 1983; 25: 226-230.
9. Lévy-Marchal C, Papoz L, de Beaufort C, Doutreix J, Froment V, Voirin J, Czernichow P. Clinical and laboratory features in diabetic children at the time of diagnosis: results from the French incidence study. In: Lévy-Marchal C, Czernichow P, eds. Epidemiology and Etiology of Insulin-dependent Diabetes in the Young. Basel: Karger, Pediatric and Adolescent Endocrinology 1992; 21: 77-89.
10. Soltész G. IDDM in Hungarian children: population-based clinical characteristics and their possible implication for diabetic health care. Hungarian Childhood Diabetes Epidemiology Study Group. Padiatr Padol 1992; 27: 63-66.
11. Jefferson JG, Smith MA, Baum JD. Insulin dependent diabetes in under 5 year olds. Arch Dis Child 1985; 60: 1144-1148.
12. Pinkney JH, Bingley PJ, Sawtell PA, Dunger DB, Gale EA. Presentation and progress of childhood diabetes mellitus: a prospective population-based study. The Bart's-Oxford Study Group. Diabetologia 1994; 37: 70-74.
13. Pocecco M, Nassimbeni G. Distribution of new cases of insulin-dependent diabetes mellitus (IDDM) by age, sex, seasonality, and clinical characteristics at onset in youngsters from the Friuli Venezia Giulia region from 1987 to 1990. Pediatr Med Chir 1993; 15: 489-492.
14. Pozzilli P, Visalli N, Buzzetti R, Cavallo MG, Marietti G, Hawa M, Leslie RD. Metabolic and immune parameters at clinical onset of insulin-dependent diabetes: a population-based study. Metabolism 1998; 47: 1205-1210.
15. Rosenbauer J, Icks A, Giani G. Typ-1-Diabetes bei Kindern und Jugendlichen - prospektive Inzidenzstudie in der Region Düsseldorf. Kinderärztliche Praxis 1998; 1: 15-25.
16. Green A, Gale EA, Patterson CC. Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE Study. Lancet 1992; 339: 905-909.
17. Hochberg Y, Tamhane AC. Multiple Comparison Procedures. New York: Wiley, 1987.
18. Soltész G, Gyorko BJ, Lévy-Marchal C. Clinical diagnosis of childhood insulin dependent diabetes mellitus. Hungarian Epidemiological Group for Childhood Diabetes. Orv Hetil 1997; 138: 7-9.
19. Savova R, Popova G, Koprivarova K, Konstantinova M, Angelova B, Atanasova M, Goranova S, Christov V, Kalinov K. Clinical and laboratory characteristics of type I (insulin dependent) diabetes mellitus at presentation among Bulgarian children. Diabetes Res Clin Pract 1996; 34 (Suppl): S159-S163.
20. Proos LA, Kobbah M, Tuvemo T. Clinical characteristics of insulin-dependent diabetes mellitus in children at diagnosis. Ups J Med Sci 1997; 102: 121-131.
21. Reeser HM, Hirasing RA, van Buuren S, Verloove-Vanhorick SP, Wit JM, Bruining GJ. Initial clinical approach of childhood type 1 diabetes mellitus in the Netherlands. Diabetes Res Clin Pract 1999; 44 (Suppl): S37 (abst).
22. Lévy-Marchal C, Czernichow P. Heterogeneity of type 1 diabetes at onset in children: results from the French Incidence Study. Diabete Metab 1993; 19: 296-303.
23. Komulainen J, Knip M, Sabbah E, Vahasalo P, Lounamaa R, Åkerblom HK, Reijonen H, Ilonen J. Autoimmune and clinical characteristics of type I diabetes in children with different genetic risk loads defined by HLA-DQB1 alleles. Childhood Diabetes in Finland Study Group. Clin Sci Colch 1998; 94: 263-269.
24. Komulainen J, Lounamaa R, Knip M, Kaprio EA, Akerblom HK. Ketoacidosis at diagnosis of type 1 (insulin dependent) diabetes mellitus is related to poor residual β cell function. Arch Dis Child 1996; 75: 410-415.
25. O'Leary LA, Dorman JS, LaPorte RE, Orchard TJ, Becker DJ, Kuller LH, Eberhardt MS, Cavender DE, Rabin BS, Drash AL. Familial and sporadic insulin-dependent diabetes: evidence for heterogeneous etiologies? Diabetes Res Clin Pract 1991; 14: 183-190.
26. Veijola R, Reijonen H, Vahasalo P, Sabbah E, Kulmala P, Ilonen J, Åkerblom HK, Knip M. HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group. J Clin Invest 1996; 98: 2489-2495.
27. Lessing DN, Swift PG, Metcalfe MA, Baum JD. Newly diagnosed diabetes: a study of parental satisfaction. Arch Dis Child 1992; 67: 1011-1013.
28. Komulainen J, Knip M, Lounamaa R, Vahasalo P, Karjalainen J, Sabbah E, Åkerblom HK. Poor beta-cell function after the clinical manifestation of type 1 diabetes in children initially positive for islet cell specific autoantibodies. The Childhood Diabetes in Finland Study Group. Diabet Med 1997; 14: 532-537.
29. Charron-Prochownik D, Maihle T, Siminerio L, Songer T. Outpatient versus inpatient care of children newly diagnosed with IDDM. Diabetes Care 1997; 20: 657-660.
30. Sabbah E, Savola K, Kulmala P, Veijola R, Vahasalo P, Karjalainen J, Åkerblom HK, Knip M. Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group. J Clin Endocrinol Metab 1999; 84: 1534-1539.
31. Gardner SG, Bingley PJ, Sawtell PA, Weeks S, Gale EA. Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis. The Bart's-Oxford Study Group. Br Med J 1997; 315: 713-717.
32. Rosenbauer J, Herzig P, von Kries R, Neu A, Giani G. Temporal, seasonal, and geographical incidence patterns of type I diabetes mellitus in children under 5 years of age in Germany. Diabetologia 1999; 42: 1055-1059.
33. Vanelli M, Chiari G, Ghizzoni L, Costi G, Giacalone T, Chiarelli F. Effectiveness of a prevention program for diabetic ketoacidosis in children. An 8-year study in schools and private practices. Diabetes Care 1999; 22: 7-9.