The role of lactoferrin in cancer prevention

Sciences des Aliments

Volumn 22, Issue 4, 2002, Pages 461-468

  Van Belzen, Nico ^a  

^a DMV International   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0036394120     PISSN: 02408813     EISSN: None     Source Type: Journal    
DOI: 10.3166/sda.22.461-468     Document Type: Review

References (50)

1. Baker E.N., Baker H.M., Kidd R.D., 2002. Lactoferrin and transferrin: functional variations on a common structural framework. Biochem. Cell Biol., 80, 27-34.
2. Bezault J., Bhimani R., Wiprovnick J., Furmanski P., 1994. Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Res., 54, 2310-2312.
3. Brock J.H., 2002. The physiology of lactoferrin. Biochem. Cell Biol., 80, 1-6.
4. Campbell T., Skilton R.A., Coombes R.C., Shousha S., Graham M.D., Luqmani Y.A., 1992. Isolation of a lactoferrin cDNA clone and its expression in human breast cancer. Br. J. Cancer, 65, 19-26.
5. Damiens E., Mazurier J., El Y.I., Masson M., Duthille I., Spik G., Boillymarer Y., 1998. Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells. Biochim. Biophys. Acta, 1402, 277-287.
6. Damiens E., El Y.I., Mazurier J., Duthille I., Spik G., Boilly-Marer Y., 1999. Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells. J. Cell Biochem., 74, 486-498.
7. Dial E.J., Lichtenberger L.M., 2002. Effect of lactoferrin on Helicobacter felis induced gastritis. Biochem. Cell Biol., 80, 113-117.
8. Farley J., Loup D., Nelson M., Mitchell A., Esplund G., Macri C., Harrison C., Gray K., 1997. Neoplastic transformation of the endocervix associated with downregulation of lactoferrin expression. Mol. Carcinog., 20, 240-250.
9. Feldman R.A., 2001. Review article: would eradication of Helicobacter pylori infection reduce the risk of gastric cancer? Aliment. Pharmacol. Ther., 15 (Suppl 1), 2-5.
10. Fillebeen C., Descamps L., Dehouck M.P., Fenart L., Benaissa M., Spik G., Cecchelli R., Pierce A., 1999. Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier. J. Biol. Chem., 274, 7011-7017.
11. Folkman J., 1995. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1, 27-31.
12. Hoeijmakers J.H., 2001. Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-374.
13. Horwitz D.A., Bakke A.C., Abo W., Nishiya K., 1984. Monocyte and NK cell cytotoxic activity in human adherent cell preparations: discriminating effects of interferon and lactoferrin. J. Immunol., 132, 2370-2374.
14. Koike K., Tsutsumi T., Fujie H., Shintani Y., Kyoji M., 2002. Molecular mechanism of viral hepatocarcinogenesis. Oncology, 62 (Suppl 1), 29-37.
15. Kovacic P., Jacintho J.D., 2001. Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr. Med. Chem., 8, 773-796.
16. Kuhara T., Iigo M., Itoh T., Ushida Y., Sekine K., Terada N., Okamura H., Tsuda H., 2000. Orally administered lacto-ferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr. Cancer, 38, 192-199.
17. Kuwata H., Yamauchi K., Teraguchi S., Ushida Y., Shimokawa Y., Toida T., Hayasawa H., 2001. Functional fragments of ingested lactoferrin are resistant to proteolyric degradation in the gastrointestinal tract of adult rats. J. Nutr., 131, 2121-2127.
18. Lu L., Shen R.N., Zhou S.Z., Srivastava C., Harrington M., Miyazawa K., Wu B., Lin Z.H., Ruscetti S., Broxmeyer H.E., 1991. Synergistic effect of human lactoferrin and recombinant murine interferon-gamma on disease progression in mice infected with the polycythemia-inducing strain of the Friend virus complex. Int. J. Hematol., 54, 117-124.
19. Luqmani Y.A., Campbell T.A., Bennett C., Coombes R.C., Paterson I.M., 1991. Expression of lactoferrin in human stomach. Int. J. Cancer, 49, 684-687.
20. Mikogami T., Heyman M., Spik G., Desjeux J.F., 1994. Apical-to-basolateral transepithelial transport of human lactoferrin in the intestinal cell line HT-29cl.19A. Am. J. Physiol., 267, G308-G315.
21. Moretta L., Bottino C., Pende D., Mingari M.C., Biassoni R., Moretta A., 2002. Human natural killer cells: their origin, receptors and function. Eur. J. Immunol., 32, 1205-1211.
22. Nagler-Anderson C., 2001. Man the barrier! Strategic defences in the intestinal mucosa. Nature Rev. Immunol., 1, 59-67.
23. Naidu A.S., Arnold R.R., 1997. Influence of lactoferrin on host-microbe interactions. In: T.W. Hutchins, B. Lönnerdal (eds), Lactoferrin: interactions and biological functions. Humana Press, Totowa NJ. 259-275.
24. Nimmagudda R., Bagchi D., Bagchi M., Tran M.X., Steijns J., Braun S., 1999. Cytoprotection by lactoferrin in oxygen radical mediated gastrointestinal injury. Biochem. Arch., 15, 323-336.
25. Norrby K., Mattsby-Baltzer I., Innocenti M., Tuneberg S., 2001. Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat. Int. J. Cancer, 91, 236-240.
26. Okamura H., Tsutsi H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T., Torigoe K., Okura T., Nukada Y., Hattori K., 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature, 378, 88-91.
27. Opekun A.R., El Zaimaity H.M., Osato M.S., Gilger M.A., Malaty H.M., Terry M., Headon D.R., Graham D.Y., 1999. Novel therapies for Helicobacter pylori infection. Aliment. Pharmacol. Ther., 13, 35-42.
28. Penco S., Caligo M.A., Cipollini G., Bevilacqua G, Garre C., 1999. Lactoferrin expression in human breast cancer. Cancer Biochem. Biophys., 17, 163-178.
29. Satue-Gracia M.T., Frankel E.N., Rangavajhyala N., German J.B., 2000. Lactoferrin in infant formulas: effect on oxidation. J. Agric. Food Chem., 48, 4984-4990.
30. Schmidt A.M., Mora R., Cao R., Yan S.D., Brett J., Ramakrishnan R., Tsang T.C., Simionescu M., Stern D., 1994. The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide. J. Biol. Chem., 269, 9882-9888.
31. Sekine K., Watanabe E., Nakamura J., Takasuka N., KIM D.J., Asamoto M., Krutovskikh V., Baba-Toriyama H., Ota T., Moore M.A., Masuda M., Sugimoto H., Nishino H., Kakizoe T., Tsuda H., 1997. Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats. Jpn. J. Cancer Res., 88, 523-526.
32. Shau H., Kim A., Golub S.H., 1992. Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin. J. Leukoc. Biol., 51, 343-349.
33. Shimizu K., Matsuzawa H., Okada K., Tazume S., Dosako S., Kawasaki Y., Hashimoto K., Koga Y., 1996. Lactoferrin-mediated protection of the host from murine cytomegalovirus infection by a T-cell-dependent augmentation of natural killer cell activity. Arch. Virol., 141, 1875-1889.
34. Siebert P.D., Huang B.C., 1997. Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines. Proc. Natl. Acad. Sci. U.S.A, 94, 2198-2203.
35. Singh P.K., Parsek M.R., Greenberg E.P., Welsh M.J., 2002. A component of innate immunity prevents bacterial biofilm development. Nature, 417, 552-555.
36. Suzuki Y.A., Lonnerdal B., 2002. Characterization of mammalian receptors for lactoferrin. Biochem. Cell Biol., 80, 75-80.
37. Tanaka, K., Ikeda, M., Nozaki, A., Kato, N., Tsuda, H., Saito, S. & Sekihara, H., 1999. Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study. Jpn. J. Cancer Res., 90, 367-371.
38. Troost F.J., Steijns J., Saris W.H., Brummer R.J., 2001. Gastric digestion of bovine lactoferrin in vivo in adults. J. Nutr., 131, 2101-2104.
39. Tsuda H., Sekine K., Fujita K., Iigo M., 2002. Cancer prevention by bovine lactoferrin and underlying mechanismsa review of experimental and clinical studies. Biochem. Cell Biol., 80, 131-136.
40. Uchida K., Matsuse R., Tomita S., Sugi K., Saitoh O., Ohshiba S., 1994. Immunochemical detection of human lactoferrin in feces as a new marker for inflammatory gastrointestinal disorders and colon cancer. Clin. Biochem., 27, 259-264.
41. Ushida Y., Sekine K., Kuhara T., Takasuka N., Iigo M., Tsuda H., 1998. Inhibitory effects of bovine lactoferrin on intestinal polyposis in the Apc(Min) mouse. Cancer Lett., 134, 141-145.
42. Walmer D.K., Padin C.J., Wrona M.A., Healy B.E., Bentley R.C., Tsao M.S., Kohler M.F., Mclachlan J.A., Gray K.D., 1995. Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein. Cancer Res., 55, 1168-1175.
43. Wang W.P., Iigo M., Sato J., Sekine K., Adachi I., Tsuda H., 2000. Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn. J. Cancer Res., 91, 1022-1027.
44. Wang X., Hirmo S., Willen R., Wadstrom T., 2001. Inhibition of Helicobacter pylori infection by bovine milk glycoconjugates in a BAlb/cA mouse model. J. Med. Microbiol., 50, 430-435.
45. Yamauchi K., Wakabayashi H., Hashimoto S., Teraguchi S., Hayasawa H., Tomita M., 1998. Effects of orally administered bovine lactoferrin on the immune system of healthy volunteers. Adv. Exp. Med. Biol., 443, 261-265.
46. Yang Y., Kiss H., Kost-Alimova M., Kedra D., Fransson I., Seroussi E., Li J., Szeles A., Kholodnyuk I., Imreh M.P., Fodor K., Hadlaczky G., Klein G., Dumanski J.P., Imreh S., 1999. A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors. Genomics, 62, 147-155.
47. Yoo Y.C., Watanabe S., Watanabe R., Hata K., Shimazaki K., Azuma I., 1997. Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice. Jpn. J. Cancer Res., 88, 184-190.
48. Zimecki M., Wlaszczyk A., Cheneau P., Brunel A.S., Mazurier J., Spik G., Kubler A., 1998. Immunoregulatory effects of a nutritional preparation containing bovine lactoferrin taken orally by healthy individuals. Arch. Immunol. Ther. Exp. (Warsz.) 46, 231-240.
49. Zimecki M., Spiegel K., Wlaszczyk A., Kubler A., Kruzel M.L., 1999. Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells. Arch. Immunol. Ther. Exp. (Warsz.) 47, 113-118.
50. Zimecki M., Wlaszczyk A., Wojciechowski R., Dawiskiba J., Kruzel M., 2001. Lactoferrin regulates the immune responses in post-surgical patients. Arch. Immunol. Ther. Exp. (Warsz.) 49, 325-333.