Estrogen effects on neuroendocrine function: The new challenge of pulsed therapy

Climacteric

Volumn 5, Issue SUPPL. 2, 2002, Pages 50-56

  Genazzani, A R ^a   Bernardi, F ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Aerodiol; Central nervous system; Estrogen replacement therapy; Postmenopause; Pulsed estrogen therapy

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; GESTAGEN;

ARTICLE; CENTRAL NERVOUS SYSTEM; CLIMACTERIUM; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; FEMININITY; GENOMICS; NEUROENDOCRINE SYSTEM; PATIENT COMPLIANCE; PRIORITY JOURNAL; PULSATILE DRUG RELEASE;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MENOPAUSE; NEUROSECRETORY SYSTEMS; PATIENT COMPLIANCE; PULSE THERAPY, DRUG;

EID: 0036392598     PISSN: 13697137     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Genazzani AR, Petraglia F, Purdy RH, eds. The Brain: Source and Target for Sex Steroid Hormones. Lancaster, UK: Parthenon Publishing, 1996
2. Alonso-Solis R, Abreu P, Lopez-Coviella I, et al. Gonadal steroid modulation of neuroendocrine transduction: a transynaptic view. Cell Mol Neurobiol 1996;16:357-82
3. Etgen AM, Karkanias GB. Estrogen regulation of noradrenergic signaling in the hypothalamus. Psychoneuroendocrinology 1994;19:603-10
4. Biegon A, Bercovitz H, Samuel D. Serotonin receptor concentration during the estrous cycle of the rat. Brain Res 1980;187:221-5
5. Luine VN, McEwen BS. Effect of estradiol on turnover of type A monoamine oxidase in the brain. J Neurochem 1977;28:1221-7
6. Panay N, Sands RH, Studd JWW. Estrogen and behaviour. In Genazzani AR, Petraglia F, Purdy RH, eds. The Brain: Source and Target for Sex Steroid Hormones. Carnforth, UK: Parthenon Publishing, 1996;257-76
7. Lapchak PA, Araujo DM, Quirion R, et al. Chronic estradiol treatment alters central cholinergic function in the female rat: effect on choline acetyltransferase activity, acetylcholine content and nicotine autoreceptor function. Brain Res 1990;525:249-55
8. Halbreich U. Role of estrogen in postmenopausal depression. Neurology 1997;48(Suppl 7):S16-20
9. Sherwin BB, Phillips S. Estrogen and cognitive functioning in surgically menopausal women. Ann NY Acad Sci 1990;592:474-5
10. Fedor-Freybergh P. The influence of oestrogen on well being and mental performance in climacteric and postmenopausal women. Acta Obstet Gynaecol Scand 1977;64:1-91
11. Henderson VW, Paganini-Hill A, Emanuel CK, Dunn ME, Buckwalter JG. Estrogen replacement therapy in older women: comparisons between Alzheimer's disease cases and non-demented control subjects. Arch Neurol 1994;51:896-900
12. Paganini-Hill A, Henderson VW. Estrogen deficiency and risk of Alzheimer's disease in women. Am J Epidemiol 1994;140:256-61
13. Sherwin BB. Estrogen effects on cognition in menopausal women. Neurology 1997;48(Suppl 7):S21-6
14. Ohkura T, Teshima Y, Isse K. Estrogen increases cerebral and cerebellar blood flows in postmenopausal women. Menopause 1995;2:13-18
15. Genazzani AR, Petraglia F, Facchinetti F, Grasso A, Alessandrini G, Volpe A. Steroid replacement increases β-endorphin and β-lipotropin plasma levels in postmenopausal women. Gynecol Obstet Invest 1988;26:153-9
16. Genazzani AR, Petraglia F, Facchinetti F, Facchini V, Volpe A, Alessandrini G. Increase of proopiomelanocortin-related peptides during subjective menopausal flushes. Am J Obstet Gynecol 1984;149:775-9
17. O'Donohue TL, Dorsa DM. The opiomelanotropinergic neuronal and endocrine systems. Peptides 1982;3:353-95
18. Stomati M, Bersi C, Rubino S, et al. Neuroendocrine effects of different oestradiol-progestin regimens in postmenopausal women. Maturitas 1997;28:127-35
19. McLoughin L, Grossman A, Tomlin S, et al. CRF-41 stimulates the release of β-lipotropin and β-endorphin in normal human subjects. Neuroendocrinology 1984;38:282-4
20. Petraglia F, Comitini G, Genazzani AR, et al. β-Endorphin in human reproduction. In Herz A, ed. Opioids. Berlin: Springer-Verlag, 1993:763-80
21. Karla SP. Gonadal steroid hormones promote interactive comunication. In Genazzani AR, Petraglia F, Purdy RH, eds. The Brain: Source and Target for Sex Steroid Hormones. Carnforth, UK: Parthenon Publishing, 1996:257-76
22. Kaplan LM, Gabriel SM, Koenig JL, et al. Galanin is an estrogen inducible secretory product of the rat anterior pituitary. Proc Natl Acad Sci USA 1988;85:7408-12
23. Baulieu EE, Robel P. Neurosteroids: a new brain function? J Steroid Biochem Mol Biol 1990;37:395-403
24. Mellon SH. Neurosteroids: biochemistry, modes of action, and clinical relevance. J Clin Endocrinol Metab 1994;78:1003-8
25. Majewska MD. Neurosteroids: endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance. Prog Neurobiol 1992;38:379-95
26. Genazzani AR, Salvestroni C, Guo A-L, et al. Neurosteroids and regulation of neuroendocrine function. In Genazzani AR, Petraglia F, Purdy RH, eds. The Brain: Source and Target for Sex Steroid Hormones. Carnforth, UK: Parthenon Publishing, 1996;83-91
27. Genazzani AR, Bernardi F, Stomati M, et al. Effects of estradiol and raloxifene analog on brain, adrenal, and serum allopregnanolone content in fertile and ovariectomized rats. Neuroendocrinology 2000;72:162-70
28. Studd J, Pornel B, Marton I, et al. Efficacy and acceptability of intranasal 17β-oestradiol for menopausal symptoms: randomized dose-response study. Lancet 1999;353:1574-8
29. Gompel A, Bergeron C, Jondet M, et al. Endometrial safety and tolerability of Aerodiol (intranasal estradiol) for 1 year. Maturitas 2000;36:209-15
30. Pelissier C, de Kervasdoue A, Chuong VT, et al. Clinical evaluation, dose-finding and acceptability of Aerodiol, the pulsed estrogen therapy for treatment of climacteric symptoms. Maturitas 2001;37:181-9
31. Lopes P, Rozenberg S, Graaf J, Fernandez-Villoria E, Marianowski L. Aerodiol versus the transdermal route: perspectives for patient preference. Maturitas 2001;38(Suppl 1):S31-9
32. Panay N, Toth K, Pelissier C, Studd J. Dose-ranging studies of a novel intranasal estrogen replacement therapy. Maturitas 2001;38(Suppl 1):S15-22