Taste masking of diclofenac sodium employing four different techniques

Saudi Pharmaceutical Journal

Volumn 10, Issue 3, 2002, Pages 106-113

  Al Omran, M F ^a   Al Suwayeh, S A ^a   El Helw, A M ^a   Saleh, S I ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Diclofenac sodium; Granulation; Inclusion complexation; Microencapsulation; Pan coating; Taste evaluation; Taste masking

Indexed keywords

BETA CYCLODEXTRIN; DICLOFENAC; ETHYL CELLULOSE; MANNITOL; MICROCRYSTALLINE CELLULOSE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG GRANULATION; DRUG SOLUBILITY; HUMAN; MASKING; MICROENCAPSULATION; NORMAL HUMAN; PARTICLE SIZE; TASTE;

EID: 0036391141     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Roy GM. Taste masking in oral pharmaceuticals. Pharm Tech 1994; 18: 84-89.
2. Roy GM. The applications and future implications of bitterness reduction and inhibition in food products. Crit Rev Food Sci Nutr 1990; 29 (2): 59-71.
3. Roy G. Bitterness reduction and inhibition, in: Trends in food science & technology, Vol. 3, 1992. pp. 85-91.
4. EbyIII GA. Taste masked zinc acetate compositions for oral absorption, 992, in U. S. Pat. No.5, 095,035. Through Ref. # 1.
5. Matsubara Y, Kawajiri A, Ishiguro F. "Granules with controlled bitter taste", 1990, in JP 0256, 416. Through Ref. # 1.
6. Watabe S, Kato T, Nagata N. "Bitterness-free saponin compositions containing Aminoacids", 1992, in JP 04,207,161. Through Ref. # 1.
7. Popescu MC, Mertz ET. "Taste-Moderating Pharmaceuticals", 1991, in U. S. Pat. No. 5, 009,819.
8. Kobayashi S et al. "Vitamin B oral solutions containing sugars, aminoacids and flavors", 1993, in JP 05 04, 291. Through Ref # 1.
9. Bakan JA, Sloan FD. Microencapsulation of drugs. Drug Cosm Ind 1972; 110: (3), 34.
10. Ozer A, Hincal AA. Studies on the masking of unpleasant taste of beclamide: microencapsulation and tabletting. J Microencapsulation 1990; 7:(3), 327-339.
11. Morella AM, Lukas S. "Microcapsule compositions and process", 1992 in Can. Pat. CA 2, 068, 366. Through Ref # 1.
12. nd Ed, vol. 1, 1989:372.
13. Agarwal R, Mittal R, Singh A, Studies of ion-exchange resin complex of chloroquine phosphate. Drug Dev Ind Pharm 2000; 26 (7): 773-776.
14. Fulu M, Borodkin S, Woodward L, Li P, Diesner C, Hernandez L, Vadnere M. A polymer carrier system for taste masking of macrolide Antibiotics. Pharm Res 1991; 8(6): 706-712.
15. Yajima T, Umeki N, Itai S. Optimum spray congealing condition for masking the bitter taste of clarithromycin in wax matrix. Chem Pharm Bull 1999; 47(2): 220-225.
16. Bhalla DV, Lalla JK. Chewable tablets of acetaminophen: Prodrug Approaches. Drug Dev Ind Pharm 1990;16 (1): 115-135.
17. Higuchi T, Pitman IH. Caffeine complexes with low water solubility: Synthesis and dissolution and 1:2 caffeine-gentisic acid complexes. J Pharm Sci 1973; 62(1): 55-58.
18. Sugao H, Yamazaki S, Shiozawa H, Yano K. Taste masking of bitter drug powder without loss of bioavailability by treatment of wax-coated microcapsule. J Pharm Sci 1998; 87 (1): 96-100.
19. Abd-Elbary A, Kandil F. Formulation of chewable L-ascorbic acid tablets. Bulletin of the Faculty of Pharmacy, Cairo University, 1973; 7 (1), 1-13.
20. Luzzi LA. Microencapsulation. J Pharm Sci 1970; 59 (10): 1367-1376.
21. Remington: The Science and Practice of Pharmacy, MACK Publishing Company, Eston, Pennsylvania, 19th Ed., 1995: 1650.
22. Cwiertnia B, Hladon T, Stobiecki M. Stability of diclofenac sodium in the inclusion complex with beta-cyclodextrin in the solid state. J Pharm Pharmacol 1999; 51(11): 1213-1218.
23. Kurasumi T, Imamori K, Iwasa A. "Compositions containing Carbetapentane citrate with less bitter taste", 1991, in JP 03, 236, 316.
24. Saleh SI, Stamm A. "Composition pharmaceutique à administration perlinguale", 1994, in French Pat. FR2660195.
25. Al-Omran MF, Al-Suwayeh SA, El-Helw AM, Saleh SI. Taste masking of diclofenac sodium by microencapsulation. J Microencapsulation 2002; 19(1): 45-52.
26. Al-Omran MF. Formulation and evaluation of diclofenac sodium chewable tablets, 2001, MSc thesis, King Saud University, KSA.
27. nd ed., Chapman and Hall Ltd. London, 1975: 74.
28. rd Ed., 1987:317.
29. st Ed., 1988: 247-248.
30. nd Ed, vol. 1; 1989: 372.