Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism

Biochemical and Biophysical Research Communications

Volumn 297, Issue 3, 2002, Pages 528-536

  He, Xianghuo ^a   Di, Yujun ^b   Li, Jinjun ^a   Xie, Yihu ^a   Tang, Yuntian ^a   Zhang, Fengrui ^a   Wei, Lin ^a   Zhang, Yu ^b   Qin, Wenxin ^a   Huo, Keke ^b   Li, Yuyang ^b   Wan, Dafang ^a   Gu, Jianren ^a  

^a SHANGHAI CANCER INSTITUTE   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Amino acid transport; Chromosome 17p13.3; Glutathione; Hepatocellular carcinoma

Indexed keywords

AMINO ACID; CARRIER PROTEIN; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; ISOPROTEIN; MEMBRANE PROTEIN; PROTEIN CT120; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA LIBRARY; EUKARYOTIC CELL; GENE FUNCTION; GENE ISOLATION; GENE LOCATION; GENETIC CONSERVATION; GENOME ANALYSIS; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANOPHELES; ARABIDOPSIS; BASE SEQUENCE; BLOTTING, NORTHERN; CELL LINE; CLONING, MOLECULAR; DROSOPHILA; EXONS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA; EUKARYOTA;

EID: 0036389794     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02227-1     Document Type: Article

References (25)

1. M. Fujimori, T. Tokino, T. Kitagawa, T. Imamura, E. Okamoto, M. Mitsunobu, T. Ishikawa, H. Nakagawa, H. Harada, Allelo-type study of primary hepatocellular carcinoma, Cancer Res. 51 (1991) 89-93.
2. V. Boige, P. Laurent-Puig, J.F. Fouchet, G. Monges, P. Bedossa, P. Bioulac-Sage, F. Capron, A. Schmitz, S. Olschwang, Concerted nonsyntenic allelic losses in hyperloid hepatocellular carcinoma as determined by a high-resolution allelotype, Cancer Res. 57 (1997) 1986-1990.
3. H. Nagai, P. Pineau, M.A. Buendia, A. Dejean, Comprehensive allelotyping of human hepatocellular carcinoma, Oncogene 14 (1997) 2927-2933.
4. Z. Piao, C. Park, J.H. Park, H. Kim, Allelotype analysis of hepatocellular carcinoma, Int. J. Cancer 75 (1998) 29-33.
5. G. Wang, Y. Zhao, X. Liu, L. Wang, C. Wu, W. Zhang, W. Liu, P. Zhang, W. Cong, Y. Zhu, L.S. Zhang, S.J. Chen, D.F. Wan, Y.T. Zhao, W. Huang, J.R. Gu, Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma, Genes Chromosomes Cancer 31 (2001) 221-227.
6. X.T. Zhao, D.F. Wan, M. He, Y. Ye, Y.H. He, L.W. Han, M.L. Guo, Y. Huang, W.X. Qin, M.H. Wang, W.M. Chong, J.G. Chen, L.S. Zhang, N.W. Yang, B.H. Xu, M.C. Wu, L. Zuo, J.R. Gu, The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis, submitted.
7. X.T. Zhao, J.J. Li, Y.H. He, F. Lan, L.L. Fu, J.Y. Guo, R.J. Zhao, Y. Ye, M. He, W.M. Chong, J.G. Chen, L.S. Zhang, N.W. Yang, B.H. Xu, M.C. Wu, D.F. Wan, J.R. Gu, A novel growth suppressor gene on chromosome 17p13.3 with a high frequency of mutation in human hepatocellular carcinoma, Cancer Res. 61 (2001) 7383-7387.
8. W.X. Qin, D.F. Wan, F.Y. Sun, P.P. Zhang, L.W. Han, Y. Huang, H.Q. Jiang, X.T. Zhao, M. He, Y. Ye, W.M. Chong, M.C. Wu, L.S. Zhang, N.W. Yang, J.R. Gu, Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocellular carcinoma, Cell Res. 11 (2001) 209-216.
9. J.J. Li, R.J. Zhao, X.T. Zhao, D.F. Wan, X.F. Cai, P. Xue, C. Ge, J.R. Gu, Di8erential expression and preliminary function study of novel tumor related cDNA clone HC90, Tumor 21 (2001) 313-317.
10. J.R. Wang, W.X. Qin, G.Y. Ren, Y. Pan, X.H. He, J. Hu, D.F. Wan, J.R. Gu, Cloning of HCAP1 and studies on its priliminary function, Tumor 22 (2002) 3-267.
11. J.A. Lumadue, A.B. GlickB, F.H. Ruddle, Cloning, sequence analysis and expression of the large subunit of the human lymphocyte activation antigen 4F2, Proc. Natl. Acad. Sci. USA 84(1987) 9204-9208.
12. E. Quackenbush, M. Clabby, K.M. Gotesdiener, J. Barbosa, N.H. Jones, J.L. Strominger, S. Speck, J.M. Leiden, Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen:a type II membrane glycoprotein involved in normal and neoplastic cell growth, Proc. Natl. Acad. Sci. USA 84 (1987) 6526-6530.
13. H.G. Dohlman, J. Thorner, M.G. Caron, R.J. Lefkowitz, Model systems for the study of seven-transmembrane-segment receptors, Annu. Rev. Biochem. 60 (1991) 653-688.
14. S.S. Tate, A. Meister, c-Glutamyl transpeptidase from kidney, Methods Enzymol. 113 (1985) 400-419.
15. A. Pawlak, O. Lahuna, F. Bulle, A. Suzuki, N. Ferry, S. Siegrist, N. Chikhi, M.N. Chobert, G. Guellaen, Y. Laperche, c-Glutamyl transpeptidase: a single copy gene in the rat and a multigene family in the human genome, J. Biol. Chem. 263 (1988) 9913-9916.
16. E. Rajpert-De Meyts, N. Heisterkamp, J. Gro8en, Cloning and nucleotide sequence of human c-glutamyl transpeptidase, Proc. Natl. Acad. Sci. USA 85 (1988) 8840-8844.
17. C.O. Harding, P. Williams, E. Wagner, D.S. Chang, K. Wild, R.E. Colwell, J.A. Wol8, Mice with genetic c-glutamyl transpep-tidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility, J. Biol. Chem. 272 (1997) 12560-12567.
18. B.Z. Carter, A.L. Wiseman, R. Orkiszewski, K.D. Ballard, C.N. Ou, M.W. Lieberman, Metabolism of leukotriene C4 in c-glutamyl transpeptidase-deficient mice, J. Biol. Chem. 272 (1997) 12305-12310.
19. P.D. Potdar, K.L. Andrews, P. Nettesheim, L.E. Ostrowski, Expression and regulation of c-glutamyl transpeptidase-related enzyme in tracheal cells, Am. J. Physiol. 273 (1997) 1082-1089.
20. D.A. Figlewicz, O. Delattre, G. Guellaen, A. Krizus, G. Thomas, J. Zucman, G.A. Rouleau, Mapping of human c-glutamyl transpeptidase genes on chromosome 22 and other human autosomes, Genomics 17 (1993) 299-305.
21. L. Mastroberardino, B. Spindler, R. Pfei8er, P.J. Skelly, J. LoVng, C.B. Shoemaker, F. Verrey, Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family, Nature 395 (1998) 288-291.
22. M. Orlowski, Possible role of glutathione in transport processes, Adv. Exp. Med. Biol. 69 (1976) 13-28.
23. S.M. Deneke, B.L. Fanburg, Regulation of cellular glutathione, Am. J. Physiol. 257 (1989) L163-73.
24. J.M. Argiles, F.J. Lopez-Soriano, Intestinal amino acids transport: an overview, Int. J. Biochem. 22 (1990) 931-937.
25. S. Wolf, H.G. Gassen, c-Glutamyl transpeptidase, a blood-brain barrier associated membrane protein. Splitting peptides to transport amino acids, Adv. Exp. Med. Biol. 421 (1997) 37-45.