-
1
-
-
0026099599
-
Synthesis of watersoluble (aminoalkyl) camptothecin analogues: Inhibition of topoisomerase I and antitumor activity
-
Kingsbury WD, Boehm JC, Jakas DR et al. Synthesis of watersoluble (aminoalkyl) camptothecin analogues: inhibition of topoisomerase I and antitumor activity. J Med Chem 1991;34:98-107.
-
(1991)
J Med Chem
, vol.34
, pp. 98-107
-
-
Kingsbury, W.D.1
Boehm, J.C.2
Jakas, D.R.3
-
2
-
-
0028012774
-
The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability
-
Burke TG, Mi Z. The structural basis of camptothecin interactions with human serum albumin: impact on drug stability. J Med Chem 1994;37:40-46.
-
(1994)
J Med Chem
, vol.37
, pp. 40-46
-
-
Burke, T.G.1
Mi, Z.2
-
3
-
-
0027454410
-
Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor
-
Verweij J, Lund B, Beijnen J et al. Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor. Ann Oncol 1993;4:673-678.
-
(1993)
Ann Oncol
, vol.4
, pp. 673-678
-
-
Verweij, J.1
Lund, B.2
Beijnen, J.3
-
4
-
-
0030826929
-
Topoisomerase I inhibitors: Review and update
-
Rothenberg ML. Topoisomerase I inhibitors: review and update. Ann Oncol 1997;8:837-855.
-
(1997)
Ann Oncol
, vol.8
, pp. 837-855
-
-
Rothenberg, M.L.1
-
5
-
-
0033995249
-
Topotecan has substantial antitumor activity as first-line salvage therapy in platinum-sensitive epithelial ovarian carcinoma: A Gynecologic Oncology Group study
-
McGuire WP, Blessing JA, Bookman MA et al. Topotecan has substantial antitumor activity as first-line salvage therapy in platinum-sensitive epithelial ovarian carcinoma: a Gynecologic Oncology Group study. J Clin Oncol 2000;18:1062-1067.
-
(2000)
J Clin Oncol
, vol.18
, pp. 1062-1067
-
-
McGuire, W.P.1
Blessing, J.A.2
Bookman, M.A.3
-
6
-
-
0031786482
-
Topotecan for the treatment of advanced epithelial ovarian cancer: An open-label phase II study in patients treated after prior chemotherapy that contained cisplatin or carboplatin and paclitaxel
-
Bookman MA, Malmström H, Bolis G et al. Topotecan for the treatment of advanced epithelial ovarian cancer: an open-label phase II study in patients treated after prior chemotherapy that contained cisplatin or carboplatin and paclitaxel. J Clin Oncol 1998;16:3345-3352.
-
(1998)
J Clin Oncol
, vol.16
, pp. 3345-3352
-
-
Bookman, M.A.1
Malmström, H.2
Bolis, G.3
-
7
-
-
10544229791
-
Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: Results of a large European phase II study
-
Creemers GJ, Bolis G, Gore M et al. Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study. J Clin Oncol 1996;14:3056-3061.
-
(1996)
J Clin Oncol
, vol.14
, pp. 3056-3061
-
-
Creemers, G.J.1
Bolis, G.2
Gore, M.3
-
8
-
-
0000695674
-
A phase II trial of topotecan for the treatment of relapsed advanced ovarian carcinoma
-
ten Bokkel Huinink W, Gore M, Bolis G et al. A phase II trial of topotecan for the treatment of relapsed advanced ovarian carcinoma. Proc Am Soc Clin Oncol 1996;15:284.
-
(1996)
Proc Am Soc Clin Oncol
, vol.15
, pp. 284
-
-
Ten Bokkel Huinink, W.1
Gore, M.2
Bolis, G.3
-
9
-
-
9244247616
-
Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma
-
Kudelka AP, Tresukosol D, Edwards CL et al. Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma. J Clin Oncol 1996;14:1552-1557.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1552-1557
-
-
Kudelka, A.P.1
Tresukosol, D.2
Edwards, C.L.3
-
10
-
-
0031239998
-
Topotecan in platinum- and paclitaxel-resistant ovarian cancer
-
Swisher EM, Mutch DG, Rader JS et al. Topotecan in platinum- and paclitaxel-resistant ovarian cancer. Gynecol Oncol 1997;66:480-486.
-
(1997)
Gynecol Oncol
, vol.66
, pp. 480-486
-
-
Swisher, E.M.1
Mutch, D.G.2
Rader, J.S.3
-
11
-
-
0031781459
-
Randomized phase II study of two schedules of topotecan in previously treated patients with ovarian cancer: A National Cancer Institute of Canada Clinical Trials Group study
-
Hoskins P, Eisenhauer E, Beare S et al. Randomized phase II study of two schedules of topotecan in previously treated patients with ovarian cancer: a National Cancer Institute of Canada Clinical Trials Group study. J Clin Oncol 1998;16:2233-2237.
-
(1998)
J Clin Oncol
, vol.16
, pp. 2233-2237
-
-
Hoskins, P.1
Eisenhauer, E.2
Beare, S.3
-
12
-
-
0036390879
-
Update on the role of topotecan in the treatment of recurrent ovarian cancer
-
Herzog TJ Update on the role of topotecan in the treatment of recurrent ovarian cancer. The Oncologist 2002;7(suppl 5):3-10.
-
(2002)
The Oncologist
, vol.7
, Issue.SUPPL. 5
, pp. 3-10
-
-
Herzog, T.J.1
-
13
-
-
0036393356
-
Management of treatment-related toxicity in advanced ovarian cancer
-
Dunton CJ. Management of treatment-related toxicity in advanced ovarian cancer. The Oncologist 2002;7(suppl 5):11-19.
-
(2002)
The Oncologist
, vol.7
, Issue.SUPPL. 5
, pp. 11-19
-
-
Dunton, C.J.1
-
14
-
-
0026468470
-
Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitro
-
Burris 3rd HA, Hanauske AR, Johnson RK et al. Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst 1992;84:1816-1820.
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1816-1820
-
-
Burris H.A. III1
Hanauske, A.R.2
Johnson, R.K.3
-
16
-
-
0028357995
-
Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen
-
Hochster H, Liebes L, Speyer J et al. Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimen. J Clin Oncol 1994;12:553-559.
-
(1994)
J Clin Oncol
, vol.12
, pp. 553-559
-
-
Hochster, H.1
Liebes, L.2
Speyer, J.3
-
17
-
-
0032795911
-
Activity and pharmacodynamics of 21-day topotecan infusion in patients with ovarian cancer previously treated with platinum-based chemotherapy
-
New York Gynecologic Oncology Group
-
Hochster H, Wadler S, Runowicz C et al. Activity and pharmacodynamics of 21-day topotecan infusion in patients with ovarian cancer previously treated with platinum-based chemotherapy. New York Gynecologic Oncology Group. J Clin Oncol 1999;17:2553-2561.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2553-2561
-
-
Hochster, H.1
Wadler, S.2
Runowicz, C.3
-
18
-
-
0035917698
-
Topotecan given as a 21-day infusion in the treatment of advanced ovarian cancer
-
Gore M, Rustin G, Schüller J et al. Topotecan given as a 21-day infusion in the treatment of advanced ovarian cancer. Br J Cancer 2001;84:1043-1046.
-
(2001)
Br J Cancer
, vol.84
, pp. 1043-1046
-
-
Gore, M.1
Rustin, G.2
Schüller, J.3
-
19
-
-
0033674914
-
A phase I trial of a 3-day topotecan Q 21 days for recurrent epithelial cancers of the ovary, fallopian tube, and peritoneum
-
Brown 3rd JV, Peters 3rd WA, Rettenmaier MA et al. A phase I trial of a 3-day topotecan Q 21 days for recurrent epithelial cancers of the ovary, fallopian tube, and peritoneum. Gynecol Oncol 2000;79:495-498.
-
(2000)
Gynecol Oncol
, vol.79
, pp. 495-498
-
-
Brown J.V. III1
Peters W.A. III2
Rettenmaier, M.A.3
-
20
-
-
0033770154
-
Phase 2 evaluation of topotecan administered on a 3-day schedule in the treatment of platinum- and paclitaxel-refractory ovarian cancer
-
Markman M, Kennedy A, Webster K et al. Phase 2 evaluation of topotecan administered on a 3-day schedule in the treatment of platinum- and paclitaxel-refractory ovarian cancer. Gynecol Oncol 2000;79:116-119.
-
(2000)
Gynecol Oncol
, vol.79
, pp. 116-119
-
-
Markman, M.1
Kennedy, A.2
Webster, K.3
-
21
-
-
4243447901
-
Phase II evaluation of three-day topotecan in recurrent platinum-sensitive ovarian or primary peritoneal cancer: A Gynecologic Oncology Group study
-
Nashville, TN
-
Miller DS, Blessing JA, Lentz SS et al. Phase II evaluation of three-day topotecan in recurrent platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group study. Society of Gynecologic Oncologists 33rd Annual Meeting, Nashville, TN, 2002:100a.
-
(2002)
Society of Gynecologic Oncologists 33rd Annual Meeting
-
-
Miller, D.S.1
Blessing, J.A.2
Lentz, S.S.3
-
22
-
-
4244068747
-
Phase II study of three-day topotecan for recurrent primary peritoneal and epithelial ovarian cancer in platinum sensitive patients
-
Nashville, TN
-
Herzog TJ, Rader JS, Gibb RK et al. Phase II study of three-day topotecan for recurrent primary peritoneal and epithelial ovarian cancer in platinum sensitive patients. Society of Gynecologic Oncologists 33rd Annual Meeting, Nashville, TN, 2002:86a.
-
(2002)
Society of Gynecologic Oncologists 33rd Annual Meeting
-
-
Herzog, T.J.1
Rader, J.S.2
Gibb, R.K.3
-
24
-
-
0003979209
-
-
GlaxoSmithKline, Philadelphia, PA
-
Data on file. GlaxoSmithKline, Philadelphia, PA:2001.
-
(2001)
Data on file
-
-
-
25
-
-
0028225686
-
Comparative activity of oral and parenteral topotecan in murine tumor models: Efficacy of oral topotecan
-
McCabe FL, Johnson RK. Comparative activity of oral and parenteral topotecan in murine tumor models: efficacy of oral topotecan. Cancer Invest 1994;12:308-313.
-
(1994)
Cancer Invest
, vol.12
, pp. 308-313
-
-
McCabe, F.L.1
Johnson, R.K.2
-
26
-
-
0033838553
-
A phase II and pharmacokinetic study of weekly 72-h topotecan infusion in patients with platinum-resistant and paclitaxel-resistant ovarian carcinoma
-
Rose PG, Gordon NH, Fusco N et al. A phase II and pharmacokinetic study of weekly 72-h topotecan infusion in patients with platinum-resistant and paclitaxel-resistant ovarian carcinoma. Gynecol Oncol 2000;78:228-234.
-
(2000)
Gynecol Oncol
, vol.78
, pp. 228-234
-
-
Rose, P.G.1
Gordon, N.H.2
Fusco, N.3
-
27
-
-
0010267346
-
Phase I/pharmacokinetic study of topotecan by 24-hour continuous infusion weekly
-
Haas NB, LaCreta FP, Walczak J et al. Phase I/pharmacokinetic study of topotecan by 24-hour continuous infusion weekly. Cancer Res 1994;54:1220-1226.
-
(1994)
Cancer Res
, vol.54
, pp. 1220-1226
-
-
Haas, N.B.1
LaCreta, F.P.2
Walczak, J.3
-
28
-
-
0034759598
-
A dose-escalating study of weekly bolus topotecan in previously treated ovarian cancer patients
-
Homesley HD, Hall DJ, Martin DA et al. A dose-escalating study of weekly bolus topotecan in previously treated ovarian cancer patients. Gynecol Oncol 2001;83:394-399.
-
(2001)
Gynecol Oncol
, vol.83
, pp. 394-399
-
-
Homesley, H.D.1
Hall, D.J.2
Martin, D.A.3
-
29
-
-
0003318986
-
Phase II trial of weekly topotecan in patients with potentially platinum sensitive relapsed ovarian and peritoneal cancer
-
Morris RT, Munkarah A, Field J et al. Phase II trial of weekly topotecan in patients with potentially platinum sensitive relapsed ovarian and peritoneal cancer. Proc Am Soc Clin Oncol 2002;21:2512a.
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Morris, R.T.1
Munkarah, A.2
Field, J.3
|