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Volumn 16, Issue 4, 2002, Pages 261-281

Potential of interferon-α in solid tumours: Part 1

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; BETA INTERFERON; CARMUSTINE; CISPLATIN; DACARBAZINE; FLUOROURACIL; GAMMA INTERFERON; INTERLEUKIN 2; RETINOID; TAMOXIFEN; VINBLASTINE;

EID: 0036385657     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200216040-00003     Document Type: Review
Times cited : (56)

References (258)
  • 2
    • 70449242194 scopus 로고
    • Inhibition de l'infection vaccinale par un facteur liquide dans le tissu infecte par le virus homologue
    • Nagano Y, Kojima Y. Inhibition de l'infection vaccinale par un facteur liquide dans le tissu infecte par le virus homologue. C R Soc Biol 1958; 152: 1627-9
    • (1958) C R Soc Biol , vol.152 , pp. 1627-1629
    • Nagano, Y.1    Kojima, Y.2
  • 3
    • 0030945648 scopus 로고    scopus 로고
    • The human interferon-alpha species and hybrid proteins
    • Pestka S. The human interferon-alpha species and hybrid proteins. Semin Oncol 1997; 24 3 Suppl. 9: S9-4-S9-17
    • (1997) Semin Oncol , vol.24 , Issue.SUPPL. 9
    • Pestka, S.1
  • 4
    • 7344221471 scopus 로고    scopus 로고
    • Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferon
    • Walter MR, Bordens R, Nagabhushan TL, et al. Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferon. Cancer Biother Radiopharm 1998; 13 (3): 143-54
    • (1998) Cancer Biother Radiopharm , vol.13 , Issue.3 , pp. 143-154
    • Walter, M.R.1    Bordens, R.2    Nagabhushan, T.L.3
  • 5
    • 0030948056 scopus 로고    scopus 로고
    • Interferons α/β and their receptors: Place in the hierarchy of cytokines
    • Zav'yalov V, Zav'yalova GA. Interferons α/β and their receptors: place in the hierarchy of cytokines. APMIS 1997; 105: 161-86
    • (1997) APMIS , vol.105 , pp. 161-186
    • Zav'yalov, V.1    Zav'yalova, G.A.2
  • 6
    • 0031324016 scopus 로고    scopus 로고
    • Interferons in dermatology: Biology, pharmacology, and clinical applications
    • Ruszczak Z, Schwartz RA. Interferons in dermatology: biology, pharmacology, and clinical applications. Adv Dermatol 1997; 13: 235-88
    • (1997) Adv Dermatol , vol.13 , pp. 235-288
    • Ruszczak, Z.1    Schwartz, R.A.2
  • 7
    • 0031846102 scopus 로고    scopus 로고
    • The biology of interferon-alpha and the clinical significance of anti-interferon antibodies
    • Hanley JP, Haydon GH. The biology of interferon-alpha and the clinical significance of anti-interferon antibodies. Leuk Lymphoma 1998; 29 (3-4): 257-68
    • (1998) Leuk Lymphoma , vol.29 , Issue.3-4 , pp. 257-268
    • Hanley, J.P.1    Haydon, G.H.2
  • 8
    • 0035134688 scopus 로고    scopus 로고
    • Interferon in oncological practice: Review of interferon biology, clinical applications and toxicities
    • Jonasch E, Haluska FG. Interferon in oncological practice: review of interferon biology, clinical applications and toxicities. Oncologist 2001; 6 (1): 34-55
    • (2001) Oncologist , vol.6 , Issue.1 , pp. 34-55
    • Jonasch, E.1    Haluska, F.G.2
  • 9
    • 0035961708 scopus 로고    scopus 로고
    • New developments in interferon therapy
    • Tossing G. New developments in interferon therapy. Eur J Med Res 2001; 6 (2): 47-65
    • (2001) Eur J Med Res , vol.6 , Issue.2 , pp. 47-65
    • Tossing, G.1
  • 10
    • 84909456681 scopus 로고
    • Human leucocyte interactions: Production, purification and stability experiments. The production and use of interferon for the treatment of human virus infections
    • Rockville (MD): Tissue Culture Association
    • Cantell H, Hirovonen S, Mogensen KE, et al. Human leucocyte interactions: production, purification and stability experiments. The production and use of interferon for the treatment of human virus infections. In vitro monograph 3. Rockville (MD): Tissue Culture Association, 1984: 35-8
    • (1984) In Vitro Monograph , vol.3 , pp. 35-38
    • Cantell, H.1    Hirovonen, S.2    Mogensen, K.E.3
  • 11
    • 0018771427 scopus 로고
    • Human leucocyte interferon: Production, purification to homogeneity and initial characterization
    • Rubinstein M, Rubinstein S, Familletti PC, et al. Human leucocyte interferon: production, purification to homogeneity and initial characterization. Proc Natl Acad Sci U S A 1979; 76: 640-4
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 640-644
    • Rubinstein, M.1    Rubinstein, S.2    Familletti, P.C.3
  • 13
    • 0020531790 scopus 로고
    • The human interferons: From protein purification and sequence to cloning and expression in bacteria: Before, between and beyond
    • Pestka S. The human interferons: from protein purification and sequence to cloning and expression in bacteria: before, between and beyond. Arch Biochem Biophys 1983; 221 (1): 307-18
    • (1983) Arch Biochem Biophys , vol.221 , Issue.1 , pp. 307-318
    • Pestka, S.1
  • 14
    • 0033546053 scopus 로고    scopus 로고
    • The nature of the principal type 1 interferon producing cells in human blood
    • Siegal FP, Kadowaki N, Shodell M, et al. The nature of the principal type 1 interferon producing cells in human blood. Science 1999; 284 (5421): 1835-7
    • (1999) Science , vol.284 , Issue.5421 , pp. 1835-1837
    • Siegal, F.P.1    Kadowaki, N.2    Shodell, M.3
  • 15
    • 0019831076 scopus 로고
    • The structure of eight distinct human cloned human leucocyte interferon cDNAs
    • Goeddel DV, Leung DW, Dull TJ, et al. The structure of eight distinct human cloned human leucocyte interferon cDNAs. Nature 1981; 290 (5801): 20-6
    • (1981) Nature , vol.290 , Issue.5801 , pp. 20-26
    • Goeddel, D.V.1    Leung, D.W.2    Dull, T.J.3
  • 16
    • 0019122738 scopus 로고
    • At least three human type a interferons: Structure of α 2
    • Streuli M, Nagata S, Weissman C. At least three human type a interferons: structure of α 2. Science 1980; 209: 1343-7
    • (1980) Science , vol.209 , pp. 1343-1347
    • Streuli, M.1    Nagata, S.2    Weissman, C.3
  • 17
    • 0019122475 scopus 로고
    • Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon
    • Maeda S, McCandliss R, Gross M, et al. Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Proc Natl Acad Sci U S A 1980; 77 (12): 7010-3
    • (1980) Proc Natl Acad Sci U S A , vol.77 , Issue.12 , pp. 7010-7013
    • Maeda, S.1    McCandliss, R.2    Gross, M.3
  • 18
    • 0019222419 scopus 로고
    • Synthesis in E. coli of a polypeptide with human leukocyte interferon activity
    • Nagata S, Taira H, Hall A, et al. Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature 1980; 284 (5754): 316-20
    • (1980) Nature , vol.284 , Issue.5754 , pp. 316-320
    • Nagata, S.1    Taira, H.2    Hall, A.3
  • 19
    • 0031158354 scopus 로고    scopus 로고
    • Biologic activities of natural and synthetic type I interferons
    • Pfeffer LM. Biologic activities of natural and synthetic type I interferons. Semin Oncol 1997; 24 3 Suppl. 4: S-9-63-9
    • (1997) Semin Oncol , vol.24 , Issue.3 SUPPL. 9
    • Pfeffer, L.M.1
  • 20
    • 0031158419 scopus 로고    scopus 로고
    • The interferon receptors
    • Pestka S. The interferon receptors. Semin Oncol 1997; 24 3 Suppl. 9: S9-18-40
    • (1997) Semin Oncol , vol.24 , Issue.3 SUPPL. 9
    • Pestka, S.1
  • 21
    • 0030957010 scopus 로고    scopus 로고
    • Interacting pathways of interferon signalling
    • Williams BRG, Haque SJ. Interacting pathways of interferon signalling. Semin Oncol 1997; 24 3 Suppl. 9: S9-70-7
    • (1997) Semin Oncol , vol.24 , Issue.3 SUPPL. 9
    • Williams, B.R.G.1    Haque, S.J.2
  • 22
    • 0031158441 scopus 로고    scopus 로고
    • Recombinant alfa-interferons from naturally occurring genes: Introduction
    • Pestka S, Trotta PP. Recombinant alfa-interferons from naturally occurring genes: introduction. Semin Oncol 1997; 24 3 Suppl. 9: S9-1-3
    • (1997) Semin Oncol , vol.24 , Issue.3 SUPPL. 9
    • Pestka, S.1    Trotta, P.P.2
  • 23
    • 0031156122 scopus 로고    scopus 로고
    • Effects of α-interferons on immune function
    • Herberman RB. Effects of α-interferons on immune function. Semin Oncol 1997; 24 3 Suppl. 9: S9-78-80
    • (1997) Semin Oncol , vol.24 , Issue.3 SUPPL. 9
    • Herberman, R.B.1
  • 24
    • 0032417696 scopus 로고    scopus 로고
    • Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays
    • Der SD, Zhou A, Williams BR, et al. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A 1998; 95: 15623-8
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15623-15628
    • Der, S.D.1    Zhou, A.2    Williams, B.R.3
  • 25
    • 0033624161 scopus 로고    scopus 로고
    • Introduction: Interferons' connection to cancer
    • Pitha PM. Introduction: interferons' connection to cancer. Semin Cancer Biol 2000; 10 (2): 69-72
    • (2000) Semin Cancer Biol , vol.10 , Issue.2 , pp. 69-72
    • Pitha, P.M.1
  • 26
    • 0033926041 scopus 로고    scopus 로고
    • The interferons and cell death: Guardians of the cell or accomplices of apoptosis?
    • Barber GN. The interferons and cell death: guardians of the cell or accomplices of apoptosis? Semin Cancer Biol 2000; 10 (2): 103-11
    • (2000) Semin Cancer Biol , vol.10 , Issue.2 , pp. 103-111
    • Barber, G.N.1
  • 27
    • 0022413260 scopus 로고
    • Expression of the 2-5A system during the cell cycle
    • Wells V, Mallucci L. Expression of the 2-5A system during the cell cycle. Exp Cell Res 1985; 159: 27-36
    • (1985) Exp Cell Res , vol.159 , pp. 27-36
    • Wells, V.1    Mallucci, L.2
  • 28
    • 0020563176 scopus 로고
    • Inhibition of ornithine decarboxylase in human fibroblast cells by type I and type II interferons
    • Sekar V, Atmar VJ, Joshi AR, et al. Inhibition of ornithine decarboxylase in human fibroblast cells by type I and type II interferons. Biochem Biophys Res Commun 1983; 114: 950-4
    • (1983) Biochem Biophys Res Commun , vol.114 , pp. 950-954
    • Sekar, V.1    Atmar, V.J.2    Joshi, A.R.3
  • 29
    • 0025073054 scopus 로고
    • Expression of gene rrg is associated with reversion of NIH3T3 transformed by LTR-c-H-ras
    • Contente S, Kenyon K, Rimoldi D, et al. Expression of gene rrg is associated with reversion of NIH3T3 transformed by LTR-c-H-ras. Science 1990; 249: 796-8
    • (1990) Science , vol.249 , pp. 796-798
    • Contente, S.1    Kenyon, K.2    Rimoldi, D.3
  • 30
    • 0021592459 scopus 로고
    • Discrimination between non-malignant and malignant cells by combinations by IFN γ and IFN α/β
    • Fleischmann WRJ, Newton RC, Fleischmann CM, et al. Discrimination between non-malignant and malignant cells by combinations by IFN γ and IFN α/β. J Biol Response Mod 1984; 3: 397-405
    • (1984) J Biol Response Mod , vol.3 , pp. 397-405
    • Fleischmann, W.R.J.1    Newton, R.C.2    Fleischmann, C.M.3
  • 31
    • 0021213970 scopus 로고
    • Modulation by recombinant DNA leukocyte (alpha) and fibroblast (beta) interferons of the expression and shedding of HLA- and tumour-associated antigens by human melanoma cells
    • Giacomini P, Aguzzi A, Pestka S, et al. Modulation by recombinant DNA leukocyte (alpha) and fibroblast (beta) interferons of the expression and shedding of HLA- and tumour-associated antigens by human melanoma cells. J Immunol 1984; 133 (3): 1649-55
    • (1984) J Immunol , vol.133 , Issue.3 , pp. 1649-1655
    • Giacomini, P.1    Aguzzi, A.2    Pestka, S.3
  • 32
    • 0025766427 scopus 로고
    • The interferons: Mechanisms of action and clinical applications
    • Baron S, Tyring SK, Fleischmann RJ, et al. The interferons: mechanisms of action and clinical applications. JAMA 1991; 266 (10): 1375-83
    • (1991) JAMA , vol.266 , Issue.10 , pp. 1375-1383
    • Baron, S.1    Tyring, S.K.2    Fleischmann, R.J.3
  • 33
    • 0002342341 scopus 로고
    • Interferons-α, Β, γ: Basic principles and preclinical studies
    • DeVita VT, Hellman S, Rosenberg SA, editors. Philadelphia (PA): JB Lippincott
    • Kurzrock R, Gutterman JU, Talpaz M. Interferons-α, β, γ: basic principles and preclinical studies. In: DeVita VT, Hellman S, Rosenberg SA, editors. Biologic therapy of cancer. Philadelphia (PA): JB Lippincott, 1991: 247-74
    • (1991) Biologic Therapy of Cancer , pp. 247-274
    • Kurzrock, R.1    Gutterman, J.U.2    Talpaz, M.3
  • 34
    • 0022497020 scopus 로고
    • Interferon: A cytotoxic T-lymphocyte differentiation signal
    • Chen L, Tourvielle B, Burns GF. Interferon: a cytotoxic T-lymphocyte differentiation signal. Eur J Immunol 1986; 16: 767-70
    • (1986) Eur J Immunol , vol.16 , pp. 767-770
    • Chen, L.1    Tourvielle, B.2    Burns, G.F.3
  • 35
    • 0002501771 scopus 로고    scopus 로고
    • Antiangiogenic therapy
    • de Vita Jr VT, Hellman S, Rosenberg SA, editors. Philadelphia (PA): Lippincott-Raven
    • Folkman J. Antiangiogenic therapy. In: de Vita Jr VT, Hellman S, Rosenberg SA, editors. Principles and practice of oncology. 5th ed. Philadelphia (PA): Lippincott-Raven, 1997: 3075-85
    • (1997) Principles and Practice of Oncology. 5th Ed. , pp. 3075-3085
    • Folkman, J.1
  • 36
    • 0023160237 scopus 로고
    • Inhibition of angiogenesis by interferons: Effects on tumor- and lymphocyte-induced vascular responses
    • Sidky YA, Borden EC. Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Res 1987; 47: 5155-61
    • (1987) Cancer Res , vol.47 , pp. 5155-5161
    • Sidky, Y.A.1    Borden, E.C.2
  • 37
    • 0024517730 scopus 로고
    • Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a
    • White CW, Sondheimer HM, Crouch EC, et al. Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a. N Engl J Med 1989; 320: 1197-200
    • (1989) N Engl J Med , vol.320 , pp. 1197-1200
    • White, C.W.1    Sondheimer, H.M.2    Crouch, E.C.3
  • 38
    • 0024343441 scopus 로고
    • Treatment of haemangioendotheliomas with alpha interferon
    • Orchard PJ, Smith CM, Woods WG, et al. Treatment of haemangioendotheliomas with alpha interferon. Lancet 1989; II: 565-7
    • (1989) Lancet , vol.2 , pp. 565-567
    • Orchard, P.J.1    Smith, C.M.2    Woods, W.G.3
  • 39
    • 0024547916 scopus 로고
    • Successful treatment of an angiogenic disease
    • Folkman J. Successful treatment of an angiogenic disease. N Engl J Med 1989; 320: 1211-2
    • (1989) N Engl J Med , vol.320 , pp. 1211-1212
    • Folkman, J.1
  • 40
    • 0026525407 scopus 로고
    • Interferon alfa-2a therapy for life-threatening hemangiomas of infancy
    • Ezekowitz RAB, Mulliken JB, Folkman J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 1992; 326 (22): 1455-63
    • (1992) N Engl J Med , vol.326 , Issue.22 , pp. 1455-1463
    • Ezekowitz, R.A.B.1    Mulliken, J.B.2    Folkman, J.3
  • 41
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136 (7): 2348-57
    • (1986) J Immunol , vol.136 , Issue.7 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3
  • 42
    • 0032818247 scopus 로고    scopus 로고
    • Immunomodulation and therapeutic effects of oral use of interferon-alpha: Mechanism of action
    • Tompkins WA. Immunomodulation and therapeutic effects of oral use of interferon-alpha: mechanism of action. J Interferon Cytokine Res 1999; 19 (8): 817-28
    • (1999) J Interferon Cytokine Res , vol.19 , Issue.8 , pp. 817-828
    • Tompkins, W.A.1
  • 43
    • 0018770807 scopus 로고
    • Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity
    • Herberman RB, Ortaldo JR, Bonnard GD. Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature 1979; 277: 221-3
    • (1979) Nature , vol.277 , pp. 221-223
    • Herberman, R.B.1    Ortaldo, J.R.2    Bonnard, G.D.3
  • 44
    • 0010587237 scopus 로고
    • Exogenous interferon therapy of osteogenic sarcoma
    • Strander H, Cantell K, Jakobson PA, et al. Exogenous interferon therapy of osteogenic sarcoma. Acta Orthop Scand 1974; 45: 958-67
    • (1974) Acta Orthop Scand , vol.45 , pp. 958-967
    • Strander, H.1    Cantell, K.2    Jakobson, P.A.3
  • 45
    • 0017688821 scopus 로고
    • Interferons: Antineoplastic drugs?
    • Strander H. Interferons: antineoplastic drugs? Blut 1977; 35: 279-99
    • (1977) Blut , vol.35 , pp. 279-299
    • Strander, H.1
  • 46
    • 0018389750 scopus 로고
    • War on cancer -interferon
    • Culliton BJ, Waterfall WK. War on cancer -interferon. BMJ 1979; 2: 195-6
    • (1979) BMJ , vol.2 , pp. 195-196
    • Culliton, B.J.1    Waterfall, W.K.2
  • 47
    • 0010623060 scopus 로고
    • The use of human leukocytic interferon in patients with cervical cancer and baseocellular cancer of the skin
    • Yugoslav Academy of Sciences and Arts; Oct 1-2; Zagreb
    • Ikic D, Krusic J, Cupak K, et al. The use of human leukocytic interferon in patients with cervical cancer and baseocellular cancer of the skin. Proceedings of the Symposium on Clinical Use of Interferon, Yugoslav Academy of Sciences and Arts; 1975 Oct 1-2; Zagreb, 239-44
    • (1975) Proceedings of the Symposium on Clinical Use of Interferon , pp. 239-244
    • Ikic, D.1    Krusic, J.2    Cupak, K.3
  • 48
    • 0018247867 scopus 로고
    • Preliminary observations on the effect of human leukocyte interferon in human non-Hodgkin's lymphoma
    • Merigan TC, Sikora K, Breeden JH, et al. Preliminary observations on the effect of human leukocyte interferon in human non-Hodgkin's lymphoma. N Engl J Med 1978; 299: 1449-53
    • (1978) N Engl J Med , vol.299 , pp. 1449-1453
    • Merigan, T.C.1    Sikora, K.2    Breeden, J.H.3
  • 49
    • 0010620669 scopus 로고
    • Phase I-II study of leucocyte interferon for recurrent breast cancer
    • National Institutes of Health; Mar 21-23; Bethesda
    • Gutterman J. Phase I-II study of leucocyte interferon for recurrent breast cancer. NIAID/NCI workshop on clinical trials with exogenous interferon, National Institutes of Health; 1978 Mar 21-23; Bethesda
    • (1978) NIAID/NCI Workshop on Clinical Trials with Exogenous Interferon
    • Gutterman, J.1
  • 50
    • 0018824574 scopus 로고
    • Leucocyte interferon-induced tumour regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma
    • Gutterman JU, Blumenschein GR, Alexanian R, et al. Leucocyte interferon-induced tumour regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma. Ann Intern Med 1980; 93 (3): 399-406
    • (1980) Ann Intern Med , vol.93 , Issue.3 , pp. 399-406
    • Gutterman, J.U.1    Blumenschein, G.R.2    Alexanian, R.3
  • 51
    • 0019865114 scopus 로고
    • Human leukocyte interferon in therapy of patients with urinary bladder papillomatosis, breast cancer, and melanoma
    • Maricic Z, Nola P, Ikic D, et al. Human leukocyte interferon in therapy of patients with urinary bladder papillomatosis, breast cancer, and melanoma. J Cancer Res Clin Oncol 1981; 10 (3): 317-23
    • (1981) J Cancer Res Clin Oncol , vol.10 , Issue.3 , pp. 317-323
    • Maricic, Z.1    Nola, P.2    Ikic, D.3
  • 52
    • 0019475983 scopus 로고
    • Application of human leucocyte interferon in patients with carcinoma of the uterine cervix
    • Ikic D, Krusic J, Kirhmajer V, et al. Application of human leucocyte interferon in patients with carcinoma of the uterine cervix. Lancet 1981; I (8228): 1027-30
    • (1981) Lancet , vol.1 , Issue.8228 , pp. 1027-1030
    • Ikic, D.1    Krusic, J.2    Kirhmajer, V.3
  • 53
    • 0019965549 scopus 로고
    • Leucocyte-derived interferon (alpha) in human breast carcinoma
    • Borden EC, Holland JF, Dao TL, et al. Leucocyte-derived interferon (alpha) in human breast carcinoma. Ann Intern Med 1982; 97 (1): 1-6
    • (1982) Ann Intern Med , vol.97 , Issue.1 , pp. 1-6
    • Borden, E.C.1    Holland, J.F.2    Dao, T.L.3
  • 54
    • 0023099032 scopus 로고
    • Clinical overview of alpha interferon: Studies and future directions
    • Spiegel RJ. Clinical overview of alpha interferon: studies and future directions. Cancer 1987; 59: 626-31
    • (1987) Cancer , vol.59 , pp. 626-631
    • Spiegel, R.J.1
  • 55
    • 16344381572 scopus 로고
    • Interferons: Clinical applications
    • DeVita VT, Hellman S, Rosenberg SA. editors. Philadelphia: JB Lippincott
    • Kurzrock R, Talpaz M, Gutterman JU. Interferons: clinical applications. In: DeVita VT, Hellman S, Rosenberg SA. editors. Biologic therapy of cancer. Philadelphia: JB Lippincott, 1991: 334-45
    • (1991) Biologic Therapy of Cancer , pp. 334-345
    • Kurzrock, R.1    Talpaz, M.2    Gutterman, J.U.3
  • 56
    • 0031632226 scopus 로고    scopus 로고
    • Interferon use in solid tumors
    • John WJ, Foon KA. Interferon use in solid tumors. Cancer Treat Res 1998; 94: 23-33
    • (1998) Cancer Treat Res , vol.94 , pp. 23-33
    • John, W.J.1    Foon, K.A.2
  • 57
    • 0033926042 scopus 로고    scopus 로고
    • Second-generation interferons for cancer: Clinical targets
    • Borden EC, Lindner D, Dreicer R, et al. Second-generation interferons for cancer: clinical targets. Semin Cancer Biol 2000; 10: 125-44
    • (2000) Semin Cancer Biol , vol.10 , pp. 125-144
    • Borden, E.C.1    Lindner, D.2    Dreicer, R.3
  • 58
    • 0034109334 scopus 로고    scopus 로고
    • Adjuvant interferon-alpha in malignant melanoma: Current status
    • Hancock BW, Harris S, Wheatley K, et al. Adjuvant interferon-alpha in malignant melanoma: current status. Cancer Treat Rev 2000; 26 (2): 81-9
    • (2000) Cancer Treat Rev , vol.26 , Issue.2 , pp. 81-89
    • Hancock, B.W.1    Harris, S.2    Wheatley, K.3
  • 59
    • 0010586641 scopus 로고    scopus 로고
    • Therapeutic advances in melanoma: Cutaneous melanoma, current status: Melanoma Congress Report Series
    • Mar 19-20: London
    • Cascinelli N. Therapeutic advances in melanoma: cutaneous melanoma, current status: Melanoma Congress Report Series. 3rd International Conference on the Adjuvant Therapy of Malignant Melanoma; 1999 Mar 19-20: London, 2-6
    • (1999) 3rd International Conference on the Adjuvant Therapy of Malignant Melanoma , pp. 2-6
    • Cascinelli, N.1
  • 60
    • 0021707134 scopus 로고
    • Phase II study of recombinant leukocyte A interferon (r-IFN A) in disseminated malignant melanoma
    • Creagan ET, Ahman DL, Green SJ, et al. Phase II study of recombinant leukocyte A interferon (r-IFN A) in disseminated malignant melanoma. Cancer 1984; 54: 2844-9
    • (1984) Cancer , vol.54 , pp. 2844-2849
    • Creagan, E.T.1    Ahman, D.L.2    Green, S.J.3
  • 61
    • 0021133667 scopus 로고
    • Phase II study of low-dose recombinant leukocyte A interferon in disseminated malignant melanoma
    • Creagan ET, Ahman DL, Green SJ, et al. Phase II study of low-dose recombinant leukocyte A interferon in disseminated malignant melanoma. J Clin Oncol 1984; 2: 1002-5
    • (1984) J Clin Oncol , vol.2 , pp. 1002-1005
    • Creagan, E.T.1    Ahman, D.L.2    Green, S.J.3
  • 62
    • 0021848512 scopus 로고
    • Effects of recombinant leucocyte interferon (rIFN-alpha A) on tumour growth and immune responses in patients with metastatic melanoma
    • Hersey P, Hasic E, MacDonald M, et al. Effects of recombinant leucocyte interferon (rIFN-alpha A) on tumour growth and immune responses in patients with metastatic melanoma. Br J Cancer 1985; 51 (6): 815-26
    • (1985) Br J Cancer , vol.51 , Issue.6 , pp. 815-826
    • Hersey, P.1    Hasic, E.2    MacDonald, M.3
  • 63
    • 0022509610 scopus 로고
    • Phase II study of recombinant alpha 2-interferon in advanced malignant melanoma
    • Coates A, Rallings M, Hersey P, et al. Phase II study of recombinant alpha 2-interferon in advanced malignant melanoma. J Interferon Res 1986; 6: 1-4
    • (1986) J Interferon Res , vol.6 , pp. 1-4
    • Coates, A.1    Rallings, M.2    Hersey, P.3
  • 64
    • 0022444726 scopus 로고
    • Clinical phase II trial of recombinant DNA interferon (interferon alpha 2b) in patients with metastatic malignant melanoma
    • Dorval T, Palangie T, Jouve M, et al. Clinical phase II trial of recombinant DNA interferon (interferon alpha 2b) in patients with metastatic malignant melanoma. Cancer 1986; 58 (2): 215-8
    • (1986) Cancer , vol.58 , Issue.2 , pp. 215-218
    • Dorval, T.1    Palangie, T.2    Jouve, M.3
  • 65
    • 0023574823 scopus 로고
    • Clinical evaluation of recombinant interferon alpha-2a (Roferon A) in metastatic melanoma using two different schedules
    • Legha SS, Papadopoulos NE, Plager C, et al. Clinical evaluation of recombinant interferon alpha-2a (Roferon A) in metastatic melanoma using two different schedules. J Clin Oncol 1987; 5 (11): 1240-6
    • (1987) J Clin Oncol , vol.5 , Issue.11 , pp. 1240-1246
    • Legha, S.S.1    Papadopoulos, N.E.2    Plager, C.3
  • 66
    • 0001751536 scopus 로고
    • Role of recombinant interferon-alpha-2 in treatment of advanced malignant melanoma
    • Mughal JE, Robinson WA, Thomas MR, et al. Role of recombinant interferon-alpha-2 in treatment of advanced malignant melanoma [abstract]. Proc Am Soc Clin Oncol 1988; 7: 25
    • (1988) Proc Am Soc Clin Oncol , vol.7 , pp. 25
    • Mughal, J.E.1    Robinson, W.A.2    Thomas, M.R.3
  • 67
    • 0025241447 scopus 로고
    • Phase II study of recombinant alpha-interferon in malignant melanoma
    • Neefe JR, Legha SS, Markowitz A, et al. Phase II study of recombinant alpha-interferon in malignant melanoma. Am J Clin Oncol 1990; 13 (6): 472-6
    • (1990) Am J Clin Oncol , vol.13 , Issue.6 , pp. 472-476
    • Neefe, J.R.1    Legha, S.S.2    Markowitz, A.3
  • 68
    • 0001428586 scopus 로고
    • Interferon-alpha-2b (rIFN-alpha-2b) alone or in combination with DTIC in metastatic melanoma (MM): Compiled data
    • Mickiewicz E, Estevez R, Rao F, et al. Interferon-alpha-2b (rIFN-alpha-2b) alone or in combination with DTIC in metastatic melanoma (MM): compiled data [abstract]. Proc Am Soc Clin Oncol 1990; 9: 281
    • (1990) Proc Am Soc Clin Oncol , vol.9 , pp. 281
    • Mickiewicz, E.1    Estevez, R.2    Rao, F.3
  • 69
    • 0031064517 scopus 로고    scopus 로고
    • The role of interferon alfa in the treatment of metastatic melanoma
    • Legha SS. The role of interferon alfa in the treatment of metastatic melanoma. Semin Oncol 1997; 24 1 Suppl. 4: 24-31
    • (1997) Semin Oncol , vol.24 , Issue.1 SUPPL. 4 , pp. 24-31
    • Legha, S.S.1
  • 70
    • 0028167560 scopus 로고
    • Results of adjuvant interferon study in WHO melanoma programme
    • Cascinelli N, Bufalino R, Morabito A, et al. Results of adjuvant interferon study in WHO melanoma programme. Lancet 1994; 343: 1287-93
    • (1994) Lancet , vol.343 , pp. 1287-1293
    • Cascinelli, N.1    Bufalino, R.2    Morabito, A.3
  • 71
    • 0001353534 scopus 로고
    • Evaluation of efficacy of adjuvant rIFNa2a in melanoma patients with regional node metastases
    • Cascinelli N. Evaluation of efficacy of adjuvant rIFNa2a in melanoma patients with regional node metastases [abstract]. Proc Am Soc Clin Oncol 1995; 14: 410
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 410
    • Cascinelli, N.1
  • 72
    • 0028872887 scopus 로고
    • Randomized surgical adjuvant trial of recombinant interferon-alfa-2a in selected patients with malignant melanoma
    • Creagan ET, Dalton RJ, Ahmann DL, et al. Randomized surgical adjuvant trial of recombinant interferon-alfa-2a in selected patients with malignant melanoma. J Clin Oncol 1995; 13 (11): 2776-83
    • (1995) J Clin Oncol , vol.13 , Issue.11 , pp. 2776-2783
    • Creagan, E.T.1    Dalton, R.J.2    Ahmann, D.L.3
  • 73
    • 0030030347 scopus 로고    scopus 로고
    • Interferonα-2b adjuvant therapy of high-risk resected cutaneous melanoma: The Eastern Co-operative Oncology Group trial EST 1684
    • Kirkwood JM, Strawderman MH, Ernstoff MS, et al. Interferonα-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Co-operative Oncology Group trial EST 1684. J Clin Oncol 1996; 14 (1): 7-17
    • (1996) J Clin Oncol , vol.14 , Issue.1 , pp. 7-17
    • Kirkwood, J.M.1    Strawderman, M.H.2    Ernstoff, M.S.3
  • 74
    • 7144228601 scopus 로고    scopus 로고
    • Randomised trial of interferonα-2a as adjuvant therapy in resected primary melanoma thicker than 1-5mm without clinically detectable nodal metastases
    • Grob JJ, Dreno B, de la Salmoniere P, et al. Randomised trial of interferonα-2a as adjuvant therapy in resected primary melanoma thicker than 1-5mm without clinically detectable nodal metastases. Lancet 1998; 351 (9120): 1905-10
    • (1998) Lancet , vol.351 , Issue.9120 , pp. 1905-1910
    • Grob, J.J.1    Dreno, B.2    De la Salmoniere, P.3
  • 75
    • 7144264391 scopus 로고    scopus 로고
    • Adjuvant interferon alpha-2a treatment in resected primary stage II cutaneous melanoma
    • Pehamberger H, Sayer HP, Steiner A, et al. Adjuvant interferon alpha-2a treatment in resected primary stage II cutaneous melanoma. J Clin Oncol 1998; 16 (4): 1425-9
    • (1998) J Clin Oncol , vol.16 , Issue.4 , pp. 1425-1429
    • Pehamberger, H.1    Sayer, H.P.2    Steiner, A.3
  • 76
    • 0000091434 scopus 로고    scopus 로고
    • Preliminary analysis of the E1690/S9111/C9190 intergroup postoperative adjuvant trial of high- and low-dose IFNα2b (HDI and LDI) in high-risk primary or lymph node metastatic melanoma
    • Kirkwood JM, Ibrahim J, Sondak V, et al. Preliminary analysis of the E1690/S9111/C9190 intergroup postoperative adjuvant trial of high- and low-dose IFNα2b (HDI and LDI) in high-risk primary or lymph node metastatic melanoma [abstract]. Proc Am Soc Clin Oncol 1999; 18: 537a
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Kirkwood, J.M.1    Ibrahim, J.2    Sondak, V.3
  • 77
    • 0002021261 scopus 로고    scopus 로고
    • Adjuvant trial in melanoma patients comparing rIFN-α to rIFN-γ to Iscador to a control group after curative resection of high risk primary (>3mm) or regional lymph node metastasis (EORTC 18871)
    • abstract 264
    • Kleeberg UR, Brocker FB, Lejeune F, et al. Adjuvant trial in melanoma patients comparing rIFN-α to rIFN-γ to Iscador to a control group after curative resection of high risk primary (>3mm) or regional lymph node metastasis (EORTC 18871) [abstract 264]. Eur J Cancer 1999; 35 Suppl. 4: S82
    • (1999) Eur J Cancer , vol.35 , Issue.SUPPL. 4
    • Kleeberg, U.R.1    Brocker, F.B.2    Lejeune, F.3
  • 78
    • 0035700212 scopus 로고    scopus 로고
    • Adjuvant interferon-alpha for melanoma revisited
    • Punt CJA, Eggermont AMM. Adjuvant interferon-alpha for melanoma revisited. Ann Oncol 2001; 12: 1663-6
    • (2001) Ann Oncol , vol.12 , pp. 1663-1666
    • Punt, C.J.A.1    Eggermont, A.M.M.2
  • 79
    • 0035281923 scopus 로고    scopus 로고
    • High-dose interferon alfa-2b does not diminish antibody response to GM2 vaccination in patients with resected melanoma: Results of the multicenter Eastern Cooperative Oncology Group phase II trial E2696
    • Kirkwood JM, Ibrahim J, Lawson DH, et al. High-dose interferon alfa-2b does not diminish antibody response to GM2 vaccination in patients with resected melanoma: results of the multicenter Eastern Cooperative Oncology Group phase II trial E2696. J Clin Oncol 2001; 19 (5): 1430-6
    • (2001) J Clin Oncol , vol.19 , Issue.5 , pp. 1430-1436
    • Kirkwood, J.M.1    Ibrahim, J.2    Lawson, D.H.3
  • 80
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801
    • Kirkwood JM, Ibrahim JG, Sosman JA, et al. High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. J Clin Oncol 2001; 19 (9): 2370-80
    • (2001) J Clin Oncol , vol.19 , Issue.9 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3
  • 81
    • 0001574741 scopus 로고    scopus 로고
    • Aim High-adjuvant interferon in melanoma (high risk), A United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) randomised study of observation versus adjuvant low close extended duration interferon alpha-2a in high risk resected malignant melanoma
    • Hancock BW, Wheatley K, Harrison G, et al. Aim High-adjuvant interferon in melanoma (high risk), A United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) randomised study of observation versus adjuvant low close extended duration interferon alpha-2a in high risk resected malignant melanoma [abstract]. Proc Am Soc Clin Oncol 2001; 20: 349a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Hancock, B.W.1    Wheatley, K.2    Harrison, G.3
  • 82
    • 0001574743 scopus 로고    scopus 로고
    • Interferon-a as adjuvant therapy for melanoma: A meta-analysis of the randomised trials
    • Wheatley K, Hancock B, Gore M, et al. Interferon-a as adjuvant therapy for melanoma: a meta-analysis of the randomised trials [abstract]. Proc Am Soc Clin Oncol 2001; 20: 349a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Wheatley, K.1    Hancock, B.2    Gore, M.3
  • 83
    • 0035805053 scopus 로고    scopus 로고
    • Adjuvant interferon alpha 2b in high risk melanoma: The Scottish study
    • Cameron DA, Combleet MC, Mackie RM, et al. Adjuvant interferon alpha 2b in high risk melanoma: the Scottish study. Br J Cancer 2001; 84 (9): 1146-9
    • (2001) Br J Cancer , vol.84 , Issue.9 , pp. 1146-1149
    • Cameron, D.A.1    Combleet, M.C.2    Mackie, R.M.3
  • 84
    • 0029739081 scopus 로고    scopus 로고
    • Quality-of-life-adjusted survival analysis of interferon alfa-2b adjuvant treatment of high-risk resected cutaneous melanoma: An Eastern Cooperative Oncology Group study
    • Cole BF, Gelber RD, Kirkwood JM, et al. Quality-of-life-adjusted survival analysis of interferon alfa-2b adjuvant treatment of high-risk resected cutaneous melanoma: an Eastern Cooperative Oncology Group study. J Clin Oncol 1996; 14 (10): 2666-73
    • (1996) J Clin Oncol , vol.14 , Issue.10 , pp. 2666-2673
    • Cole, B.F.1    Gelber, R.D.2    Kirkwood, J.M.3
  • 87
    • 0002426157 scopus 로고    scopus 로고
    • Adjuvant therapy of high-risk resected melanoma: Relapse-free and overall survival effects of high-dose interferon alpha-2b in randomized controlled multicenter trials E1684 and E2696 and intergroup trials E1690 and E1694
    • May 12-15; San Francisco
    • Kirkwood JM. Adjuvant therapy of high-risk resected melanoma: relapse-free and overall survival effects of high-dose interferon alpha-2b in randomized controlled multicenter trials E1684 and E2696 and intergroup trials E1690 and E1694. Proceedings of the 37th Annual Meeting of the American Society of Clinical Oncology; 2001 May 12-15; San Francisco, 94-101
    • (2001) Proceedings of the 37th Annual Meeting of the American Society of Clinical Oncology , pp. 94-101
    • Kirkwood, J.M.1
  • 88
    • 0034531435 scopus 로고    scopus 로고
    • Update on the role of adjuvant interferon for high risk melanoma
    • Agarwala SS, Kirkwood JM. Update on the role of adjuvant interferon for high risk melanoma. FORUM Trends Exp Clin Med 2000; 10 (3): 230-9
    • (2000) FORUM Trends Exp Clin Med , vol.10 , Issue.3 , pp. 230-239
    • Agarwala, S.S.1    Kirkwood, J.M.2
  • 89
    • 0002827483 scopus 로고    scopus 로고
    • European Organization for the Research and Treatment of Cancer melanoma group trial experience with more than 2000 patients evaluating adjuvant treatment with low or intermediate doses of interferon alpha-2b
    • May 12-15; San Francisco
    • Eggermont AMM, Kleeberg UR, Ruiter DJ, et al. European Organization for the Research and Treatment of Cancer melanoma group trial experience with more than 2000 patients evaluating adjuvant treatment with low or intermediate doses of interferon alpha-2b. Proceedings of the 37th Annual Meeting American Society of Clinical Oncology; 2001 May 12-15; San Francisco, 88-93
    • (2001) Proceedings of the 37th Annual Meeting American Society of Clinical Oncology , pp. 88-93
    • Eggermont, A.M.M.1    Kleeberg, U.R.2    Ruiter, D.J.3
  • 90
    • 0035883950 scopus 로고    scopus 로고
    • Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: A randomised trial
    • Cascinelli N, Belli F, MacKie R, et al. Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: a randomised trial. Lancet 2001; 358 (9285): 866-9
    • (2001) Lancet , vol.358 , Issue.9285 , pp. 866-869
    • Cascinelli, N.1    Belli, F.2    MacKie, R.3
  • 91
    • 0034777045 scopus 로고    scopus 로고
    • The role of interferon-alpha in malignant melanoma remains to be defined
    • Eggermont AMM. The role of interferon-alpha in malignant melanoma remains to be defined. Eur J Cancer 2001; 37: 2147-53
    • (2001) Eur J Cancer , vol.37 , pp. 2147-2153
    • Eggermont, A.M.M.1
  • 92
    • 0032858487 scopus 로고    scopus 로고
    • Phase III multicenter randomised trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma
    • Chapman PB, Einhorn LH, Meyers ML, et al. Phase III multicenter randomised trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol 1999; 17 (9): 2745-51
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2745-2751
    • Chapman, P.B.1    Einhorn, L.H.2    Meyers, M.L.3
  • 93
    • 0001954471 scopus 로고
    • Chemotherapy for metastatic melanoma
    • 2nd ed. Balch CM, Houghton AN, Milton GW, et al., editors. Philadelphia (PA): JB Lippincott
    • Houghton AN, Legha S, Bajorin DF. Chemotherapy for metastatic melanoma. 2nd ed. In: Balch CM, Houghton AN, Milton GW, et al., editors. Cutaneous melanoma. Philadelphia (PA): JB Lippincott, 1992: 499-508
    • (1992) Cutaneous Melanoma , pp. 499-508
    • Houghton, A.N.1    Legha, S.2    Bajorin, D.F.3
  • 94
    • 0021876972 scopus 로고
    • Comparison of intramuscular and intravenous recombinant alpha-2 interferon in melanoma and other cancers
    • Kirkwood JM, Ernstoff MS, Davis CA, et al. Comparison of intramuscular and intravenous recombinant alpha-2 interferon in melanoma and other cancers. Ann Intern Med 1985; 103 (1): 32-6
    • (1985) Ann Intern Med , vol.103 , Issue.1 , pp. 32-36
    • Kirkwood, J.M.1    Ernstoff, M.S.2    Davis, C.A.3
  • 95
    • 0022547088 scopus 로고
    • Treatment of metastatic malignant melanoma with recombinant interferon alpha 2
    • Robinson WA, Mughal TI, Thomas MR, et al. Treatment of metastatic malignant melanoma with recombinant interferon alpha 2. Immunobiology 1986; 172. (3-5): 275-82
    • (1986) Immunobiology , vol.172 , Issue.3-5 , pp. 275-282
    • Robinson, W.A.1    Mughal, T.I.2    Thomas, M.R.3
  • 96
    • 0023296167 scopus 로고
    • Three consecutive phase II studies of recombinant interferon alpha-2a in advanced malignant melanoma
    • Creagan ET, Ahman DL, Frytak S, et al. Three consecutive phase II studies of recombinant interferon alpha-2a in advanced malignant melanoma. Cancer 1987; 59 Suppl. 3: 638-46
    • (1987) Cancer , vol.59 , Issue.SUPPL. 3 , pp. 638-646
    • Creagan, E.T.1    Ahman, D.L.2    Frytak, S.3
  • 97
    • 0023179915 scopus 로고
    • Comparison of the effects of three different treatment regimens of recombinant interferons (r-IFN alpha, r-IFN-gamma and r-IFN alpha + cimetidine) in disseminated malignant melanoma
    • Steiner A, Wolf C, Pehamberger H. Comparison of the effects of three different treatment regimens of recombinant interferons (r-IFN alpha, r-IFN-gamma and r-IFN alpha + cimetidine) in disseminated malignant melanoma. J Cancer Res Clin Oncol 1987; 113: 459-65
    • (1987) J Cancer Res Clin Oncol , vol.113 , pp. 459-465
    • Steiner, A.1    Wolf, C.2    Pehamberger, H.3
  • 98
    • 0024520360 scopus 로고
    • Phase II trial of recombinant alpha-2b interferon in the treatment of metastatic skin melanoma
    • Sertoli MR, Bernengo MG, Ardizzoni A, et al. Phase II trial of recombinant alpha-2b interferon in the treatment of metastatic skin melanoma. Oncology 1989; 46 (2): 96-8
    • (1989) Oncology , vol.46 , Issue.2 , pp. 96-98
    • Sertoli, M.R.1    Bernengo, M.G.2    Ardizzoni, A.3
  • 99
    • 0002825205 scopus 로고
    • Systemic treatment of metastatic malignant melanoma
    • Kirkham N, Cotton DWK, Lallemand RC. et al., editors. London: Springer-Verlag
    • Sheridan E, Hancock BW. Systemic treatment of metastatic malignant melanoma. In: Kirkham N, Cotton DWK, Lallemand RC, et al., editors. Diagnosis and management of melanoma in clinical practice. London: Springer-Verlag, 1992: 135-56
    • (1992) Diagnosis and Management of Melanoma in Clinical Practice , pp. 135-156
    • Sheridan, E.1    Hancock, B.W.2
  • 100
    • 0031909884 scopus 로고    scopus 로고
    • Adjuvant therapy for melanoma: How should we respond to high-dose interferon?
    • de Takats PG, Williams MV, Hawkins R. Adjuvant therapy for melanoma: how should we respond to high-dose interferon? Cancer 1998; 77: 1287-93
    • (1998) Cancer , vol.77 , pp. 1287-1293
    • De Takats, P.G.1    Williams, M.V.2    Hawkins, R.3
  • 101
    • 0002262637 scopus 로고
    • Melanoma
    • DeVita VTJ, Hellman S, Rosenberg SA, editors. Philadelphia (PA): JB Lippincott
    • Kirkwood JM. Melanoma. In: DeVita VTJ, Hellman S, Rosenberg SA, editors. Biologic therapy of cancer. 2nd ed. Philadelphia (PA): JB Lippincott, 1995: 388-411
    • (1995) Biologic Therapy of Cancer. 2nd Ed. , pp. 388-411
    • Kirkwood, J.M.1
  • 103
    • 0025988834 scopus 로고
    • Studies of interferons in the therapy of melanoma
    • Kirkwood JM. Studies of interferons in the therapy of melanoma. Semin Oncol 1991; 18 5 Suppl. 7: 83-90
    • (1991) Semin Oncol , vol.18 , Issue.5 SUPPL. 7 , pp. 83-90
    • Kirkwood, J.M.1
  • 104
    • 0024543677 scopus 로고
    • Current therapy for melanoma
    • Legha S. Current therapy for melanoma. Semin Oncol 1989; 16 1 Suppl. 1: 34-44
    • (1989) Semin Oncol , vol.16 , Issue.1 SUPPL. 1 , pp. 34-44
    • Legha, S.1
  • 105
    • 0022612308 scopus 로고
    • Phase II trials of recombinant leucocyte A interferon in disseminated malignant melanoma: Results in 96 patients
    • Creagan ET, Ahmann DL, Frytak S, et al. Phase II trials of recombinant leucocyte A interferon in disseminated malignant melanoma: results in 96 patients. Cancer Treat Rep 1986; 70 (5): 619-24
    • (1986) Cancer Treat Rep , vol.70 , Issue.5 , pp. 619-624
    • Creagan, E.T.1    Ahmann, D.L.2    Frytak, S.3
  • 106
    • 0031946511 scopus 로고    scopus 로고
    • The use of interferon-α in the treatment of cutaneous melanoma: A review
    • Punt CJA. The use of interferon-α in the treatment of cutaneous melanoma: a review. Melanoma Res 1998; 8 (2): 95-104
    • (1998) Melanoma Res , vol.8 , Issue.2 , pp. 95-104
    • Punt, C.J.A.1
  • 107
    • 17744388962 scopus 로고    scopus 로고
    • Dacarbazine and interferon-alpha with or without interleukin-2 in metastatic melanoma: A randomized phase III multicentre trial of the Dermatologic Cooperative Oncology Group (DeCOG)
    • Hauschild A, Garbe C, Stolz W, et al. Dacarbazine and interferon-alpha with or without interleukin-2 in metastatic melanoma: a randomized phase III multicentre trial of the Dermatologic Cooperative Oncology Group (DeCOG). Br J Cancer 2001; 84 (8): 1036-42
    • (2001) Br J Cancer , vol.84 , Issue.8 , pp. 1036-1042
    • Hauschild, A.1    Garbe, C.2    Stolz, W.3
  • 108
    • 0034000545 scopus 로고    scopus 로고
    • The emerging role of cytokines in the treatment of advanced melanoma
    • EORTC Melanoma Co-operative Group
    • Keilholz U, Eggermont AMM, EORTC Melanoma Co-operative Group. The emerging role of cytokines in the treatment of advanced melanoma. Oncology 2000; 58 (2): 89-95
    • (2000) Oncology , vol.58 , Issue.2 , pp. 89-95
    • Keilholz, U.1    Eggermont, A.M.M.2
  • 109
    • 0024849183 scopus 로고
    • Combination therapy with interleukin-2 and alpha-interferon for the treatment of patients with advanced cancer
    • Rosenberg SA, Lotze MT, Yang JC, et al. Combination therapy with interleukin-2 and alpha-interferon for the treatment of patients with advanced cancer. J Clin Oncol 1989; 7 (12): 1863-74
    • (1989) J Clin Oncol , vol.7 , Issue.12 , pp. 1863-1874
    • Rosenberg, S.A.1    Lotze, M.T.2    Yang, J.C.3
  • 110
    • 0029775131 scopus 로고    scopus 로고
    • Dose efficacy study of two schedules of high-dose bolus administration of interleukin-2 and interferon alpha in metastatic melanoma
    • Kruit WHJ, Punt CJA, Goey SH, et al. Dose efficacy study of two schedules of high-dose bolus administration of interleukin-2 and interferon alpha in metastatic melanoma. Br J Cancer 1996; 74 (6): 951-5
    • (1996) Br J Cancer , vol.74 , Issue.6 , pp. 951-955
    • Kruit, W.H.J.1    Punt, C.J.A.2    Goey, S.H.3
  • 111
    • 0027315222 scopus 로고
    • Interferon-a and interleukin-2 in the treatment of metastatic melanoma: Comparison of two phase II trials
    • Keilholz U, Scheibenbogen C, Tilgen W, et al. Interferon-a and interleukin-2 in the treatment of metastatic melanoma: comparison of two phase II trials. Cancer 1993; 72 (2): 607-14
    • (1993) Cancer , vol.72 , Issue.2 , pp. 607-614
    • Keilholz, U.1    Scheibenbogen, C.2    Tilgen, W.3
  • 112
    • 0027524697 scopus 로고
    • Randomised phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon alfa-2a in patients with advanced melanoma
    • Sparano JA, Fisher RI, Sunderland M, et al. Randomised phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon alfa-2a in patients with advanced melanoma. J Clin Oncol 1993; 11 (10): 1969-77
    • (1993) J Clin Oncol , vol.11 , Issue.10 , pp. 1969-1977
    • Sparano, J.A.1    Fisher, R.I.2    Sunderland, M.3
  • 113
    • 0024203369 scopus 로고
    • A phase I-II trial of recombinant leucocyte A interferon and recombinant interferon-gamma in patients with disseminated malignant melanoma
    • Creagan ET, Loprinzi CL, Ahmann DL, et al. A phase I-II trial of recombinant leucocyte A interferon and recombinant interferon-gamma in patients with disseminated malignant melanoma. Cancer 1988; 62 (12): 2472-4
    • (1988) Cancer , vol.62 , Issue.12 , pp. 2472-2474
    • Creagan, E.T.1    Loprinzi, C.L.2    Ahmann, D.L.3
  • 114
    • 0024433613 scopus 로고
    • Concomitant administration of recombinant human interleukin-2 and recombinant interferon alpha-2A in cancer patients: A phase I study
    • Lee KH, Talpaz M, Rothberg JM, et al. Concomitant administration of recombinant human interleukin-2 and recombinant interferon alpha-2A in cancer patients: a phase I study. J Clin Oncol 1989; 7: 1726-32
    • (1989) J Clin Oncol , vol.7 , pp. 1726-1732
    • Lee, K.H.1    Talpaz, M.2    Rothberg, J.M.3
  • 115
    • 0026703622 scopus 로고
    • Phase I trial of high-dose bolus interleukin-2 and interferon alfa-2a in patients with metastatic malignancy
    • Budd GT, Murthy S, Finke J, et al. Phase I trial of high-dose bolus interleukin-2 and interferon alfa-2a in patients with metastatic malignancy. J Clin Oncol 1992; 10: 804-9
    • (1992) J Clin Oncol , vol.10 , pp. 804-809
    • Budd, G.T.1    Murthy, S.2    Finke, J.3
  • 116
    • 0027411909 scopus 로고
    • A phase II trial of concomitant interleukin-2 and interferon-alpha-2a in patients with disseminated malignant melanoma
    • Whitehead RP, Figlin R, Citron ML, et al. A phase II trial of concomitant interleukin-2 and interferon-alpha-2a in patients with disseminated malignant melanoma. J Immunother 1993; 13: 117-21
    • (1993) J Immunother , vol.13 , pp. 117-121
    • Whitehead, R.P.1    Figlin, R.2    Citron, M.L.3
  • 117
    • 0029022329 scopus 로고
    • Final report of a phase II study of interleukin 2 and interferon alpha in patients with metastatic melanoma
    • Kruit WHJ, Goey SH, Calabresi F, et al. Final report of a phase II study of interleukin 2 and interferon alpha in patients with metastatic melanoma. Br J Cancer 1995; 71: 1319-21
    • (1995) Br J Cancer , vol.71 , pp. 1319-1321
    • Kruit, W.H.J.1    Goey, S.H.2    Calabresi, F.3
  • 119
    • 0025837770 scopus 로고
    • Improved results with the addition of interferon alfa-2b to dacarbazine in the treatment of patients with metastatic malignant melanoma
    • Falkson CI, Falkson G, Falkson HC. Improved results with the addition of interferon alfa-2b to dacarbazine in the treatment of patients with metastatic malignant melanoma. J Clin Oncol 1991; 9 (8): 1403-8
    • (1991) J Clin Oncol , vol.9 , Issue.8 , pp. 1403-1408
    • Falkson, C.I.1    Falkson, G.2    Falkson, H.C.3
  • 120
    • 17944398659 scopus 로고
    • Interferon-alpha 2a does not improve response or survival when combined with dacarbazine in metastatic malignant melanoma: Results of a multi-institutional Australian randomized trial
    • Thomson DB, Adena M, McLeod GR, et al. Interferon-alpha 2a does not improve response or survival when combined with dacarbazine in metastatic malignant melanoma: results of a multi-institutional Australian randomized trial. Melanoma Res 1993; 3 (2): 133-8
    • (1993) Melanoma Res , vol.3 , Issue.2 , pp. 133-138
    • Thomson, D.B.1    Adena, M.2    McLeod, G.R.3
  • 121
    • 0028218050 scopus 로고
    • Multicenter randomized trial of dacarbazine alone or in combination with two different doses and schedules of interferon alfa-2a in the treatment of advanced melanoma
    • Bajetta E, Di Leo A, Zampino MG, et al. Multicenter randomized trial of dacarbazine alone or in combination with two different doses and schedules of interferon alfa-2a in the treatment of advanced melanoma. J Clin Oncol 1994; 12 (4): 806-11
    • (1994) J Clin Oncol , vol.12 , Issue.4 , pp. 806-811
    • Bajetta, E.1    Di Leo, A.2    Zampino, M.G.3
  • 122
    • 0031805725 scopus 로고    scopus 로고
    • Phase III trial of dacarbazine vs dacarbazine with interferon alpha2b vs dacarbazine with tamoxifen vs dacarbazine with interferon alpha2b with tamoxifen in patients with metastatic malignant melanoma
    • Falkson CI, Ibrahim J, Kirkwood JM, et al. Phase III trial of dacarbazine vs dacarbazine with interferon alpha2b vs dacarbazine with tamoxifen vs dacarbazine with interferon alpha2b with tamoxifen in patients with metastatic malignant melanoma. J Clin Oncol 1998; 16: 1743-51
    • (1998) J Clin Oncol , vol.16 , pp. 1743-1751
    • Falkson, C.I.1    Ibrahim, J.2    Kirkwood, J.M.3
  • 123
    • 0027052002 scopus 로고
    • Phase II trial of cisplatinum and alpha-interferon in advanced malignant melanoma
    • Margolin KA, Doroshow JH, Akman SA, et al. Phase II trial of cisplatinum and alpha-interferon in advanced malignant melanoma. J Clin Oncol 1992; 10 (10): 1574-8
    • (1992) J Clin Oncol , vol.10 , Issue.10 , pp. 1574-1578
    • Margolin, K.A.1    Doroshow, J.H.2    Akman, S.A.3
  • 124
    • 0026636096 scopus 로고
    • Phase II study of continuous subcutaneous interferon-alfa combined with cisplatin in advanced malignant melanoma
    • Richner J, Joss RA, Goldhirsch A, et al. Phase II study of continuous subcutaneous interferon-alfa combined with cisplatin in advanced malignant melanoma. Eur J Cancer 1992; 28A (6/7): 1044-7
    • (1992) Eur J Cancer , vol.28 A , Issue.6-7 , pp. 1044-1047
    • Richner, J.1    Joss, R.A.2    Goldhirsch, A.3
  • 125
    • 0027082482 scopus 로고
    • A promising interferon plus four-drug chemotherapy regimen for metastatic melanoma
    • Pyrhonen S, Hahka-Kempinnen M, Muhonen T. A promising interferon plus four-drug chemotherapy regimen for metastatic melanoma. J Clin Oncol 1992; 10 (12): 1919-26
    • (1992) J Clin Oncol , vol.10 , Issue.12 , pp. 1919-1926
    • Pyrhonen, S.1    Hahka-Kempinnen, M.2    Muhonen, T.3
  • 126
    • 0029061079 scopus 로고
    • Response of subcutaneous and cutaneous metastases of malignant melanoma to combined cytostatic plus interferon therapy
    • Hahka-Kemppinen M, Muhonen T, Virolainen M, et al. Response of subcutaneous and cutaneous metastases of malignant melanoma to combined cytostatic plus interferon therapy. Br J Dermatol 1995; 132: 973-7
    • (1995) Br J Dermatol , vol.132 , pp. 973-977
    • Hahka-Kemppinen, M.1    Muhonen, T.2    Virolainen, M.3
  • 128
    • 0010552593 scopus 로고
    • Alpha interferon and chemo-hormonal therapy in advanced melanoma: A phase I-II NBSG/MAOP study
    • Stark JJ, Schulof R, Wiemann M, et al. Alpha interferon and chemo-hormonal therapy in advanced melanoma: a phase I-II NBSG/MAOP study [abstract]. Proc Am Soc Clin Oncol 1993; 12: 392a
    • (1993) Proc Am Soc Clin Oncol , vol.12
    • Stark, J.J.1    Schulof, R.2    Wiemann, M.3
  • 129
    • 0343658057 scopus 로고
    • A phase II study of cisplatin (CDDP), dacarbazine (DTIC), carmustine (BCNU), tamoxifen (TM), and interferon-alpha 2B (alpha-rIFN) in metastatic melanoma
    • Schultz M, Poo WJ, Buzaid AC. A phase II study of cisplatin (CDDP), dacarbazine (DTIC), carmustine (BCNU), tamoxifen (TM), and interferon-alpha 2B (alpha-rIFN) in metastatic melanoma [abstract]. Proc Am Soc Clin Oncol 1993; 12: 390a
    • (1993) Proc Am Soc Clin Oncol , vol.12
    • Schultz, M.1    Poo, W.J.2    Buzaid, A.C.3
  • 130
    • 0028030755 scopus 로고
    • Immunotherapy of metastatic melanoma with interferon-alpha and interleukin-2: Pattern of progression in responders and patients with stable disease with or without resection of residual lesions
    • Keilholz U, Scheibenbogen C, Stoelben E, et al. Immunotherapy of metastatic melanoma with interferon-alpha and interleukin-2: pattern of progression in responders and patients with stable disease with or without resection of residual lesions. Eur J Cancer 1994; 30A: 955-8
    • (1994) Eur J Cancer , vol.30 A , pp. 955-958
    • Keilholz, U.1    Scheibenbogen, C.2    Stoelben, E.3
  • 131
    • 0344187668 scopus 로고
    • Lack of benefit from tamoxifen (T) added to a regimen of cisplatin (C), vinblastine (V), DTIC (D), and alfa interferon (rIFN) in patients (pts) with metastatic melanoma (MM)
    • Legha S, Ring S, Bedikian A, et al. Lack of benefit from tamoxifen (T) added to a regimen of cisplatin (C), vinblastine (V), DTIC (D), and alfa interferon (rIFN) in patients (pts) with metastatic melanoma (MM) [abstract]. Proc Am Soc Clin Oncol 1993; 12: 388a
    • (1993) Proc Am Soc Clin Oncol , vol.12
    • Legha, S.1    Ring, S.2    Bedikian, A.3
  • 132
    • 0026584461 scopus 로고
    • Dacarbazine (DTIC), human recombinant interferon alpha 2a (roferon) and 5-fluorouracil for disseminated malignant melanoma
    • Mulder NH, de Vries EGE, Sleijfer DT, et al. Dacarbazine (DTIC), human recombinant interferon alpha 2a (roferon) and 5-fluorouracil for disseminated malignant melanoma. Br J Cancer 1992; 65 (2): 303-4
    • (1992) Br J Cancer , vol.65 , Issue.2 , pp. 303-304
    • Mulder, N.H.1    De Vries, E.G.E.2    Sleijfer, D.T.3
  • 133
    • 0030959126 scopus 로고    scopus 로고
    • Chemoimmunotherapy with bleomycin, vincristine, lomustine, dacarbazine (BOLD) plus interferon-α for metastatic melanoma: A multicentre phase II study
    • Punt CJA, van Herpen CML, Jansen RLH, et al. Chemoimmunotherapy with bleomycin, vincristine, lomustine, dacarbazine (BOLD) plus interferon-α for metastatic melanoma: a multicentre phase II study. Br J Cancer 1997; 76: 266-9
    • (1997) Br J Cancer , vol.76 , pp. 266-269
    • Punt, C.J.A.1    Van Herpen, C.M.L.2    Jansen, R.L.H.3
  • 134
    • 0027486041 scopus 로고
    • Sequential chemoimmunotherapy with cisplatin, interleukin-2 and interferon alfa-2a for metastatic melanoma
    • Khayat D, Borel C, Tourani JM, et al. Sequential chemoimmunotherapy with cisplatin, interleukin-2 and interferon alfa-2a for metastatic melanoma. J Clin Oncol 1993; 11 (11): 2173-80
    • (1993) J Clin Oncol , vol.11 , Issue.11 , pp. 2173-2180
    • Khayat, D.1    Borel, C.2    Tourani, J.M.3
  • 135
    • 0028594033 scopus 로고
    • Combination of chemotherapy with interleukin-2 and interferon-alfa for the treatment of advanced melanoma
    • Buzaid AC, Legha SS. Combination of chemotherapy with interleukin-2 and interferon-alfa for the treatment of advanced melanoma. Semin Oncol 1994; 21 6 Suppl. 14: 23-8
    • (1994) Semin Oncol , vol.21 , Issue.6 SUPPL. 14 , pp. 23-28
    • Buzaid, A.C.1    Legha, S.S.2
  • 136
    • 0030217981 scopus 로고    scopus 로고
    • A phase II study of dacarbazine, cisplatin, interferon and high-dose interleukin-2 in 'poor-risk' metastatic melanoma
    • Proebstle TM, Scheibenbogen C, Sterry W, et al. A phase II study of dacarbazine, cisplatin, interferon and high-dose interleukin-2 in 'poor-risk' metastatic melanoma. Eur J Cancer 1996; 32A (9): 1530-3
    • (1996) Eur J Cancer , vol.32 A , Issue.9 , pp. 1530-1533
    • Proebstle, T.M.1    Scheibenbogen, C.2    Sterry, W.3
  • 137
    • 4243900425 scopus 로고    scopus 로고
    • Biochemotherapy studies in the treatment of advanced melanoma
    • Legha SS, Bedikian A, Plager C, et al. Biochemotherapy studies in the treatment of advanced melanoma [abstract]. Melanoma Res 1997; 7 Suppl. 1: S24
    • (1997) Melanoma Res , vol.7 , Issue.SUPPL. 1
    • Legha, S.S.1    Bedikian, A.2    Plager, C.3
  • 138
    • 0000170219 scopus 로고
    • Results of a French multicentric randomized trial of chemoimmunotherapy with or without interferon in metastatic malignant melanoma
    • Dorval T, Negrier S, Chevreau C, et al. Results of a French multicentric randomized trial of chemoimmunotherapy with or without interferon in metastatic malignant melanoma [abstract]. Proc Am Soc Clin Oncol 1994; 13: 1347a
    • (1994) Proc Am Soc Clin Oncol , vol.13
    • Dorval, T.1    Negrier, S.2    Chevreau, C.3
  • 139
    • 0342894822 scopus 로고    scopus 로고
    • Interferon alfa-2a and interleukin-2 with or without cisplatinum in metastatic melanoma: A randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group
    • Keilholz U, Goey SH, Punt CJ, et al. Interferon alfa-2a and interleukin-2 with or without cisplatinum in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group. J Clin Oncol 1997; 15 (7): 2579-88
    • (1997) J Clin Oncol , vol.15 , Issue.7 , pp. 2579-2588
    • Keilholz, U.1    Goey, S.H.2    Punt, C.J.3
  • 140
    • 0001521008 scopus 로고    scopus 로고
    • Cisplatin and interferon alpha with or without interleukin-2 in advanced melanoma: Interim analysis of EORTC 18951
    • Keilholz U, Punt C, Gore M, et al. Cisplatin and interferon alpha with or without interleukin-2 in advanced melanoma: interim analysis of EORTC 18951 [abstract]. Proc Am Soc Clin Oncol 1999; 18: 530a
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Keilholz, U.1    Punt, C.2    Gore, M.3
  • 141
    • 0032976897 scopus 로고    scopus 로고
    • Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b
    • Rosenberg SA, Yang JC, Schwartzentruber DJ, et al. Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b. J Clin Oncol 1999; 17 (3): 968-75
    • (1999) J Clin Oncol , vol.17 , Issue.3 , pp. 968-975
    • Rosenberg, S.A.1    Yang, J.C.2    Schwartzentruber, D.J.3
  • 142
    • 0000557793 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin, vinblastine and dacarbazine (CVD) plus interleukin-2 (IL-2) and interferon-alpha-2b (INF) vs CVD in patients (Pts) with metastatic melanoma
    • Eton O, Legha S, Bedikian A, et al. Phase III randomized trial of cisplatin. vinblastine and dacarbazine (CVD) plus interleukin-2 (IL-2) and interferon-alpha-2b (INF) vs CVD in patients (Pts) with metastatic melanoma [abstract]. Proc Am Soc Clin Oncol 2000; 19: 2174a
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Eton, O.1    Legha, S.2    Bedikian, A.3
  • 143
    • 0021888582 scopus 로고
    • Phase II study of recombinant leukocyte A interferon (IFN-rA) plus cimetidine in disseminated malignant melanoma
    • Creagan ET, Ahman DL, Green SJ, et al. Phase II study of recombinant leukocyte A interferon (IFN-rA) plus cimetidine in disseminated malignant melanoma. J Clin Oncol 1985; 3 (7): 977-81
    • (1985) J Clin Oncol , vol.3 , Issue.7 , pp. 977-981
    • Creagan, E.T.1    Ahman, D.L.2    Green, S.J.3
  • 144
    • 0025040117 scopus 로고
    • Phase II assessment of recombinant leukocyte A interferon with difluoromethylornithine in disseminated malignant melanoma
    • Creagan ET, Long HJ, Ahman DL, et al. Phase II assessment of recombinant leukocyte A interferon with difluoromethylornithine in disseminated malignant melanoma. Am J Clin Oncol 1990; 13 (3): 218-20
    • (1990) Am J Clin Oncol , vol.13 , Issue.3 , pp. 218-220
    • Creagan, E.T.1    Long, H.J.2    Ahman, D.L.3
  • 145
    • 0023907013 scopus 로고
    • Phase II trial of recombinant alpha-2b-interferon and low-dose cyclophosphamide in advanced melanoma and renal cell carcinoma
    • Wadler S, Einzig AI, Dutcher JP, et al. Phase II trial of recombinant alpha-2b-interferon and low-dose cyclophosphamide in advanced melanoma and renal cell carcinoma. Am J Clin Oncol 1988; 11 (1): 55-9
    • (1988) Am J Clin Oncol , vol.11 , Issue.1 , pp. 55-59
    • Wadler, S.1    Einzig, A.I.2    Dutcher, J.P.3
  • 146
    • 0027314951 scopus 로고
    • Phase II study of alpha-interferon and 13-cisretinoic acid in metastatic melanoma
    • Dhingra K, Papadopoulos N, Lippman S, et al. Phase II study of alpha-interferon and 13-cisretinoic acid in metastatic melanoma. Invest New Drugs 1993; 11 (1): 39-43
    • (1993) Invest New Drugs , vol.11 , Issue.1 , pp. 39-43
    • Dhingra, K.1    Papadopoulos, N.2    Lippman, S.3
  • 147
    • 0023914254 scopus 로고
    • Treatment of advanced malignant melanoma with interferon alpha and etretinate
    • Rustin GJS, Dische S, De Garis ST, et al. Treatment of advanced malignant melanoma with interferon alpha and etretinate. Eur J Cancer Clin Oncol 1988; 24 (4): 783-4
    • (1988) Eur J Cancer Clin Oncol , vol.24 , Issue.4 , pp. 783-784
    • Rustin, G.J.S.1    Dische, S.2    De Garis, S.T.3
  • 148
    • 0024574011 scopus 로고
    • Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma
    • Miller RL, Steis RG, Clark JW, et al. Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. Cancer Res 1989; 49 (7): 1871-6
    • (1989) Cancer Res , vol.49 , Issue.7 , pp. 1871-1876
    • Miller, R.L.1    Steis, R.G.2    Clark, J.W.3
  • 149
    • 0005918647 scopus 로고    scopus 로고
    • Phase I study of temozolomide in combination with interferon alfa-2b in metastatic melanoma
    • Kirkwood JM, Agarwala SS, Diaz B, et al. Phase I study of temozolomide in combination with interferon alfa-2b in metastatic melanoma [abstract]. Proc Am Soc Clin Oncol 1997; 16: 491a
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Kirkwood, J.M.1    Agarwala, S.S.2    Diaz, B.3
  • 150
    • 0019802309 scopus 로고
    • Unrecognized renal cell carcinoma: Clinical and pathological aspects
    • Hellsten S, Berge T, Wehlin L. Unrecognized renal cell carcinoma: clinical and pathological aspects. Scand J Urol Nephrol 1981; 15 (3): 273-8
    • (1981) Scand J Urol Nephrol , vol.15 , Issue.3 , pp. 273-278
    • Hellsten, S.1    Berge, T.2    Wehlin, L.3
  • 151
    • 0019823840 scopus 로고
    • Unrecognized renal cell carcinoma: Clinical and diagnostic aspects
    • Hellsten S, Berge T, Wehlin L. Unrecognized renal cell carcinoma: clinical and diagnostic aspects. Scand J Urol Nephrol 1981; 15 (3): 269-72
    • (1981) Scand J Urol Nephrol , vol.15 , Issue.3 , pp. 269-272
    • Hellsten, S.1    Berge, T.2    Wehlin, L.3
  • 152
    • 0024539002 scopus 로고
    • Unexplained spontaneous regression and alpha-interferon as treatment for metastatic renal carcinoma
    • Oliver RT, Nethersell AB, Bottomley JM. Unexplained spontaneous regression and alpha-interferon as treatment for metastatic renal carcinoma. Br J Urol 1989; 63 (2): 128-31
    • (1989) Br J Urol , vol.63 , Issue.2 , pp. 128-131
    • Oliver, R.T.1    Nethersell, A.B.2    Bottomley, J.M.3
  • 153
    • 0026730325 scopus 로고
    • Spontaneous regression of histologically proved pulmonary metastases from renal cell carcinoma: A case with 5-year followup
    • Vogelzang NJ, Priest ER, Borden L. Spontaneous regression of histologically proved pulmonary metastases from renal cell carcinoma: a case with 5-year followup. J Urol 1992; 148 (4): 1247-8
    • (1992) J Urol , vol.148 , Issue.4 , pp. 1247-1248
    • Vogelzang, N.J.1    Priest, E.R.2    Borden, L.3
  • 154
    • 0018101136 scopus 로고
    • Active specific immunotherapy of advanced renal-cell carcinoma
    • Tykka H, Oravisto KJ, Lehtonen T, et al. Active specific immunotherapy of advanced renal-cell carcinoma. Eur Urol 1978; 4 (4): 250-8
    • (1978) Eur Urol , vol.4 , Issue.4 , pp. 250-258
    • Tykka, H.1    Oravisto, K.J.2    Lehtonen, T.3
  • 155
    • 0020696384 scopus 로고
    • Renal cell carcinoma: Antitumor effects of leukocyte interferon
    • Quesada JR, Swanson DA, Trindade A, et al. Renal cell carcinoma: antitumor effects of leukocyte interferon. Cancer Res 1983; 43 (2): 940-7
    • (1983) Cancer Res , vol.43 , Issue.2 , pp. 940-947
    • Quesada, J.R.1    Swanson, D.A.2    Trindade, A.3
  • 156
    • 0025360452 scopus 로고
    • Antiproliferative and antitumor effects of alpha-interferon in renal cell carcinomas: Correlation with the expression of a kidney-associated differentiation glycoprotein
    • Nanus DM, Pfeffer LM, Bander NH, et al. Antiproliferative and antitumor effects of alpha-interferon in renal cell carcinomas: correlation with the expression of a kidney-associated differentiation glycoprotein. Cancer Res 1990; 50 (14): 4190-4
    • (1990) Cancer Res , vol.50 , Issue.14 , pp. 4190-4194
    • Nanus, D.M.1    Pfeffer, L.M.2    Bander, N.H.3
  • 157
    • 0023183561 scopus 로고
    • Effect of interferon alpha, interferon beta, and interferon gamma on the in vitro growth of human renal adenocarcinoma cells
    • Kuebler JP, Oberley TD, Meisner LF, et al. Effect of interferon alpha, interferon beta, and interferon gamma on the in vitro growth of human renal adenocarcinoma cells. Invest New Drugs 1987; 5 (1): 21-9
    • (1987) Invest New Drugs , vol.5 , Issue.1 , pp. 21-29
    • Kuebler, J.P.1    Oberley, T.D.2    Meisner, L.F.3
  • 158
    • 0345040253 scopus 로고    scopus 로고
    • Regimens with or without interferon-alpha as treatment for metastatic melanoma and renal cell carcinoma: An overview of randomized trials
    • Hernberg M, Pyrhonen S, Muhonen T. Regimens with or without interferon-alpha as treatment for metastatic melanoma and renal cell carcinoma: an overview of randomized trials. J Immunother 1999; 22 (2): 145-54
    • (1999) J Immunother , vol.22 , Issue.2 , pp. 145-154
    • Hernberg, M.1    Pyrhonen, S.2    Muhonen, T.3
  • 159
    • 0023873083 scopus 로고
    • Treatment of advanced renal cell cancer with recombinant interferon alpha as a single agent and in combination with medroxyprogesterone acetate: A randomized multicenter trial
    • Porzsolt F, Messerer D, Hautmann R, et al. Treatment of advanced renal cell cancer with recombinant interferon alpha as a single agent and in combination with medroxyprogesterone acetate: a randomized multicenter trial. J Cancer Res Clin Oncol 1988; 114 (I): 95-100
    • (1988) J Cancer Res Clin Oncol , vol.114 , Issue.1 , pp. 95-100
    • Porzsolt, F.1    Messerer, D.2    Hautmann, R.3
  • 160
    • 0022359745 scopus 로고
    • Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma
    • Quesada JR, Rios A, Swanson D, et al. Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma. J Clin Oncol 1985; 3 (11): 1522-8
    • (1985) J Clin Oncol , vol.3 , Issue.11 , pp. 1522-1528
    • Quesada, J.R.1    Rios, A.2    Swanson, D.3
  • 161
    • 0021915420 scopus 로고
    • A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: The American Cancer Society collaborative trial
    • Kirkwood JM, Harris JE, Vera R, et al. A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: the American Cancer Society collaborative trial. Cancer Res 1985; 45 (2): 863-71
    • (1985) Cancer Res , vol.45 , Issue.2 , pp. 863-871
    • Kirkwood, J.M.1    Harris, J.E.2    Vera, R.3
  • 162
    • 0025247712 scopus 로고
    • Recombinant leukocyte interferon alpha-2a and medroxyprogesterone in advanced renal cell carcinoma: A randomized trial
    • Steineck G, Strander H, Carbin BE, et al. Recombinant leukocyte interferon alpha-2a and medroxyprogesterone in advanced renal cell carcinoma: a randomized trial. Acta Oncol 1990; 29 (2): 155-62
    • (1990) Acta Oncol , vol.29 , Issue.2 , pp. 155-162
    • Steineck, G.1    Strander, H.2    Carbin, B.E.3
  • 163
    • 0021049597 scopus 로고
    • The treatment of renal cell carcinoma with human leukocyte alpha-interferon
    • deKernion JB, Sarna G, Figlin R, et al. The treatment of renal cell carcinoma with human leukocyte alpha-interferon. J Urol 1983; 130 (6): 1063-6
    • (1983) J Urol , vol.130 , Issue.6 , pp. 1063-1066
    • DeKernion, J.B.1    Sarna, G.2    Figlin, R.3
  • 164
    • 0021808602 scopus 로고
    • Phase II study of interferon alpha in metastatic renal-cell carcinoma: A progress report
    • Quesada JR, Swanson DA, Gutterman JU. Phase II study of interferon alpha in metastatic renal-cell carcinoma: a progress report. J Clin Oncol 1985; 3 (8): 1086-92
    • (1985) J Clin Oncol , vol.3 , Issue.8 , pp. 1086-1092
    • Quesada, J.R.1    Swanson, D.A.2    Gutterman, J.U.3
  • 165
    • 0022455717 scopus 로고
    • Phase II study of alpha interferon on renal cell carcinoma: Summary of three collaborative trials
    • Umeda T, Niijima T. Phase II study of alpha interferon on renal cell carcinoma: summary of three collaborative trials. Cancer 1986; 58 (6): 1231-5
    • (1986) Cancer , vol.58 , Issue.6 , pp. 1231-1235
    • Umeda, T.1    Niijima, T.2
  • 166
    • 0022644616 scopus 로고
    • Recombinant interferon alpha-2 (Intron A) in a phase II study of renal cell carcinoma
    • Kempf RA, Grunberg SM, Daniels JR, et al. Recombinant interferon alpha-2 (Intron A) in a phase II study of renal cell carcinoma. J Biol Response Mod 1986; 5 (1): 27-35
    • (1986) J Biol Response Mod , vol.5 , Issue.1 , pp. 27-35
    • Kempf, R.A.1    Grunberg, S.M.2    Daniels, J.R.3
  • 167
    • 0023135868 scopus 로고
    • Recombinant alfa interferon in renal cell carcinoma: A randomized trial of two routes of administration
    • Muss HB, Costanzi JJ, Leavitt R, et al. Recombinant alfa interferon in renal cell carcinoma: a randomized trial of two routes of administration. J Clin Oncol 1987; 5 (2): 286-91
    • (1987) J Clin Oncol , vol.5 , Issue.2 , pp. 286-291
    • Muss, H.B.1    Costanzi, J.J.2    Leavitt, R.3
  • 168
    • 0023092449 scopus 로고
    • High-dose lymphoblastoid interferon in advanced renal cell carcinoma: An Eastern Cooperative Oncology Group Study
    • Trump DL, Elson PJ, Borden EC, et al. High-dose lymphoblastoid interferon in advanced renal cell carcinoma: an Eastern Cooperative Oncology Group Study. Cancer Treat Rep 1987; 71 (2): 165-9
    • (1987) Cancer Treat Rep , vol.71 , Issue.2 , pp. 165-169
    • Trump, D.L.1    Elson, P.J.2    Borden, E.C.3
  • 169
    • 0027173443 scopus 로고
    • Interferon alfa-2a in advanced renal cell carcinoma: Treatment results and survival in 159 patients with long-term follow-up
    • Minasian LM, Motzer RJ, Gluck L, et al. Interferon alfa-2a in advanced renal cell carcinoma: treatment results and survival in 159 patients with long-term follow-up. J Clin Oncol 1993; 11 (7): 1368-75
    • (1993) J Clin Oncol , vol.11 , Issue.7 , pp. 1368-1375
    • Minasian, L.M.1    Motzer, R.J.2    Gluck, L.3
  • 170
    • 0033514050 scopus 로고    scopus 로고
    • Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial
    • Medical Research Council Renal Cancer Collaborators. Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial. Lancet 1999; 353 (9146): 14-7
    • (1999) Lancet , vol.353 , Issue.9146 , pp. 14-17
  • 171
    • 0005715039 scopus 로고    scopus 로고
    • Updated results of the MRC randomised controlled trial of alpha interferon vs MPA in patients with metastatic renal cell carcinoma
    • Hancock B, Griffiths G, Ritchie A, et al. Updated results of the MRC randomised controlled trial of alpha interferon vs MPA in patients with metastatic renal cell carcinoma [abstract]. Proc Am Soc Clin Oncol 2000; 19: 340a
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Hancock, B.1    Griffiths, G.2    Ritchie, A.3
  • 172
    • 0029683637 scopus 로고    scopus 로고
    • Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo activity of interferon alfa-2a and a polyethylene glycol-modified derivative in healthy subjects
    • Nieforth KA, Nadeau R, Indravadan H, et al. Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo
    • (1996) Clin Pharmacol Ther , vol.59 , Issue.6 , pp. 636-646
    • Nieforth, K.A.1    Nadeau, R.2    Indravadan, H.3
  • 173
    • 0000017353 scopus 로고    scopus 로고
    • Phase II trial of branched pegylated (40 kDa) interferon alpha 2a for patients with advanced renal cell carcinoma
    • Motzer RJ, Thompson J, Gurney H, et al. Phase II trial of branched pegylated (40 kDa) interferon alpha 2a for patients with advanced renal cell carcinoma [abstract]. Proc Am Soc Clin Oncol 2001; 20: 180a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Motzer, R.J.1    Thompson, J.2    Gurney, H.3
  • 174
    • 0026563367 scopus 로고
    • Concomitant administration of recombinant human interleukin-2 and recombinant interferon alfa-2A: An active outpatient regimen in metastatic renal cell carcinoma
    • Figlin RA, Belldegrun A, Moldawer N, et al. Concomitant administration of recombinant human interleukin-2 and recombinant interferon alfa-2A: an active outpatient regimen in metastatic renal cell carcinoma. J Clin Oncol 1992; 10 (3): 414-21
    • (1992) J Clin Oncol , vol.10 , Issue.3 , pp. 414-421
    • Figlin, R.A.1    Belldegrun, A.2    Moldawer, N.3
  • 175
    • 0027528833 scopus 로고
    • A phase I study of subcutaneous recombinant interleukin-2 and interferon alfa-2a
    • Ratain MJ, Priest ER, Janisch L, et al. A phase I study of subcutaneous recombinant interleukin-2 and interferon alfa-2a. Cancer 1993; 71 (7): 2371-6
    • (1993) Cancer , vol.71 , Issue.7 , pp. 2371-2376
    • Ratain, M.J.1    Priest, E.R.2    Janisch, L.3
  • 176
    • 0027199879 scopus 로고
    • Subcutaneous interleukin-2 plus interferon alfa-2a in metastatic renal cancer: An outpatient multicenter trial
    • Vogelzang NJ, Lipton A, Figlin RA. Subcutaneous interleukin-2 plus interferon alfa-2a in metastatic renal cancer: an outpatient multicenter trial. J Clin Oncol 1993; 11 (9): 1809-16
    • (1993) J Clin Oncol , vol.11 , Issue.9 , pp. 1809-1816
    • Vogelzang, N.J.1    Lipton, A.2    Figlin, R.A.3
  • 177
    • 0028227443 scopus 로고
    • Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma
    • Ravaud A, Negrier S, Cany L, et al. Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma. Br J Cancer 1994; 69 (6): 1111-4
    • (1994) Br J Cancer , vol.69 , Issue.6 , pp. 1111-1114
    • Ravaud, A.1    Negrier, S.2    Cany, L.3
  • 178
    • 24244436797 scopus 로고    scopus 로고
    • Efficacy of a regimen of chronic low dose of interleukin 2 (IL-2) and Interferon alfa (IFN) in metastatic renal cell carcinoma
    • Passalacqua R, Caminiti C, Cengarle R, et al. Efficacy of a regimen of chronic low dose of interleukin 2 (IL-2) and Interferon alfa (IFN) in metastatic renal cell carcinoma [abstract]. Proc Am Soc Clin Oncol 2001; 20: 195a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Passalacqua, R.1    Caminiti, C.2    Cengarle, R.3
  • 179
    • 0027880212 scopus 로고
    • A randomized study of low-dose interleukin-2 subcutaneous immunotherapy vs interleukin-2 plus interferon-alpha as first line therapy for metastatic renal cell carcinoma
    • Lissoni P, Barni S, Ardizzoia A, et al. A randomized study of low-dose interleukin-2 subcutaneous immunotherapy vs interleukin-2 plus interferon-alpha as first line therapy for metastatic renal cell carcinoma. Tumori 1993; 79 (6): 397-400
    • (1993) Tumori , vol.79 , Issue.6 , pp. 397-400
    • Lissoni, P.1    Barni, S.2    Ardizzoia, A.3
  • 180
    • 0031674558 scopus 로고    scopus 로고
    • Interleukin-2, interferon-alpha and interleukin-2 plus interferon-alpha in renal cell carcinoma: A randomized phase II trial
    • Boccardo F, Rubagotti A, Canobbio L, et al. Interleukin-2, interferon-alpha and interleukin-2 plus interferon-alpha in renal cell carcinoma: a randomized phase II trial. Tumori 1998; 84 (5): 534-9
    • (1998) Tumori , vol.84 , Issue.5 , pp. 534-539
    • Boccardo, F.1    Rubagotti, A.2    Canobbio, L.3
  • 181
    • 0031935841 scopus 로고    scopus 로고
    • Survival in renal cell carcinoma - A randomized evaluation of tamoxifen vs interleukin 2, alpha-interferon (leucocyte) and tamoxifen
    • Henriksson R, Nilsson S, Colleen S, et al. Survival in renal cell carcinoma -a randomized evaluation of tamoxifen vs interleukin 2, alpha-interferon (leucocyte) and tamoxifen. Br J Cancer 1998; 77 (8): 1311-7
    • (1998) Br J Cancer , vol.77 , Issue.8 , pp. 1311-1317
    • Henriksson, R.1    Nilsson, S.2    Colleen, S.3
  • 182
    • 0031846011 scopus 로고    scopus 로고
    • A randomized phase II trial of interleukin 2 and interleukin 2-interferon alpha in advanced renal cancer
    • Jayson GC, Middleton M, Lee SM, et al. A randomized phase II trial of interleukin 2 and interleukin 2-interferon alpha in advanced renal cancer. Br J Cancer 1998; 78 (3): 366-9
    • (1998) Br J Cancer , vol.78 , Issue.3 , pp. 366-369
    • Jayson, G.C.1    Middleton, M.2    Lee, S.M.3
  • 183
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma
    • Groupe Francais d'Immunotherapie
    • Negrier S, Escudier B, Lasset C, et al. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N Engl J Med 1998; 338 (18): 1272-8
    • (1998) N Engl J Med , vol.338 , Issue.18 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasset, C.3
  • 184
    • 0000017355 scopus 로고    scopus 로고
    • A randomised phase III trial of high dose interleukin-2 (HD IL2) vs subcutaneous IL-2/interferon (IFN) in patients with metastatic renal cell carcinoma
    • Mcdermott D, Flaherty L, Clark J. A randomised phase III trial of high dose interleukin-2 (HD IL2) vs subcutaneous IL-2/interferon (IFN) in patients with metastatic renal cell carcinoma [abstract]. Proc Am Soc Clin Oncol 2001; 20: 172a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Mcdermott, D.1    Flaherty, L.2    Clark, J.3
  • 185
    • 0027488554 scopus 로고
    • Interleukin-2 in combination with interferon-alpha and 5-fluorouracil for metastatic renal cell cancer
    • Atzpodien J, Kirchner H, Hanninen EL, et al. Interleukin-2 in combination with interferon-alpha and 5-fluorouracil for metastatic renal cell cancer. Eur J Cancer 1993; 29A Suppl. 5: S6-8
    • (1993) Eur J Cancer , vol.29 A , Issue.SUPPL. 5
    • Atzpodien, J.1    Kirchner, H.2    Hanninen, E.L.3
  • 186
    • 0029993158 scopus 로고    scopus 로고
    • Immunochemotherapy for metastatic renal cell carcinoma using a regimen of interleukin-2, interferon-alpha and 5-fluorouracil
    • Hofmockel G, Langer W, Theiss M, et al. Immunochemotherapy for metastatic renal cell carcinoma using a regimen of interleukin-2, interferon-alpha and 5-fluorouracil. J Urol 1996; 156 (1): 18-21
    • (1996) J Urol , vol.156 , Issue.1 , pp. 18-21
    • Hofmockel, G.1    Langer, W.2    Theiss, M.3
  • 187
    • 0030420513 scopus 로고    scopus 로고
    • A phase II study of interferon-alpha, interleukin-2 and 5-fluorouracil in advanced renal carcinoma: Clinical data and laboratory evidence of protease activation
    • Joffe JK, Banks RE, Forbes MA, et al. A phase II study of interferon-alpha, interleukin-2 and 5-fluorouracil in advanced renal carcinoma: clinical data and laboratory evidence of protease activation. Br J Urol 1996; 77 (5): 638-49
    • (1996) Br J Urol , vol.77 , Issue.5 , pp. 638-649
    • Joffe, J.K.1    Banks, R.E.2    Forbes, M.A.3
  • 188
    • 0029655348 scopus 로고    scopus 로고
    • Interleukin-2 based home therapy of metastatic renal cell carcinoma: Risks and benefits in 215 consecutive single institution patients
    • Lopez Hanninen E, Kirchner H, Atzpodien J. Interleukin-2 based home therapy of metastatic renal cell carcinoma: risks and benefits in 215 consecutive single institution patients. J Urol 1996; 155 (1): 19-25
    • (1996) J Urol , vol.155 , Issue.1 , pp. 19-25
    • Lopez Hanninen, E.1    Kirchner, H.2    Atzpodien, J.3
  • 189
    • 0030712258 scopus 로고    scopus 로고
    • Phase II trial of 5-fluorouracil, interferon-alpha and continuous infusion interleukin-2 for patients with metastatic renal cell carcinoma
    • Ellerhorst JA, Sella A, Amato RJ, et al. Phase II trial of 5-fluorouracil, interferon-alpha and continuous infusion interleukin-2 for patients with metastatic renal cell carcinoma. Cancer 1997; 80 (11): 2128-32
    • (1997) Cancer , vol.80 , Issue.11 , pp. 2128-2132
    • Ellerhorst, J.A.1    Sella, A.2    Amato, R.J.3
  • 190
    • 0031904556 scopus 로고    scopus 로고
    • Subcutaneous interleukin-2, interferon alfa-2a, and continuous infusion of fluorouracil in metastatic renal cell carcinoma: A multicenter phase II trial
    • Groupe Francais d'Immunotherapie
    • Ravaud A, Audhuy B, Gomez F, et al. Subcutaneous interleukin-2, interferon alfa-2a, and continuous infusion of fluorouracil in metastatic renal cell carcinoma: a multicenter phase II trial. Groupe Francais d'Immunotherapie. J Clin Oncol 1998; 16 (8): 2728-32
    • (1998) J Clin Oncol , vol.16 , Issue.8 , pp. 2728-2732
    • Ravaud, A.1    Audhuy, B.2    Gomez, F.3
  • 191
    • 0033512367 scopus 로고    scopus 로고
    • Pilot trial of infusional 5-fluorouracil, interleukin-2, and subcutaneous interferon-alpha for advanced renal cell carcinoma
    • Elias L, Binder M, Mangalik A, et al. Pilot trial of infusional 5-fluorouracil, interleukin-2, and subcutaneous interferon-alpha for advanced renal cell carcinoma. Am J Clin Oncol 1999; 22 (2): 156-61
    • (1999) Am J Clin Oncol , vol.22 , Issue.2 , pp. 156-161
    • Elias, L.1    Binder, M.2    Mangalik, A.3
  • 192
    • 0033007699 scopus 로고    scopus 로고
    • Results of immunochemotherapy with interleukin-2, interferon-alpha2 and 5-fluorouracil in the treatment of metastatic renal cell cancer
    • Samland D, Steinbach F, Reiher F, et al. Results of immunochemotherapy with interleukin-2, interferon-alpha2 and 5-fluorouracil in the treatment of metastatic renal cell cancer. Eur Urol 1999; 35 (3): 204-9
    • (1999) Eur Urol , vol.35 , Issue.3 , pp. 204-209
    • Samland, D.1    Steinbach, F.2    Reiher, F.3
  • 193
    • 0033781708 scopus 로고    scopus 로고
    • Protracted venous infusion 5-fluorouracil in combination with subcutaneous interleukin-2 and alpha-interferon in patients with metastatic renal cell cancer: A phase II study
    • Allen MJ, Vaughan M, Webb A, et al. Protracted venous infusion 5-fluorouracil in combination with subcutaneous interleukin-2 and alpha-interferon in patients with metastatic renal cell cancer: a phase II study. Br J Cancer 2000; 83 (8): 980-5
    • (2000) Br J Cancer , vol.83 , Issue.8 , pp. 980-985
    • Allen, M.J.1    Vaughan, M.2    Webb, A.3
  • 194
    • 0033812694 scopus 로고    scopus 로고
    • Phase II trial of interleukin 2, interferon alpha, and 5-fluorouracil in metastatic renal cell cancer: A cytokine working group study
    • Dutcher JP, Logan T, Gordon M, et al. Phase II trial of interleukin 2, interferon alpha, and 5-fluorouracil in metastatic renal cell cancer: a cytokine working group study. Clin Cancer Res 2000; 6 (9): 3442-50
    • (2000) Clin Cancer Res , vol.6 , Issue.9 , pp. 3442-3450
    • Dutcher, J.P.1    Logan, T.2    Gordon, M.3
  • 195
    • 17744405819 scopus 로고    scopus 로고
    • Infusional interleukin-2 and 5-fluorouracil with subcutaneous interferon-alpha for the treatment of patients with advanced renal cell carcinoma: A Southwest Oncology Group phase II study
    • Elias L, Lew D, Figlin RA, et al. Infusional interleukin-2 and 5-fluorouracil with subcutaneous interferon-alpha for the treatment of patients with advanced renal cell carcinoma: a Southwest Oncology Group phase II study. Cancer 2000; 89 (3): 597-603
    • (2000) Cancer , vol.89 , Issue.3 , pp. 597-603
    • Elias, L.1    Lew, D.2    Figlin, R.A.3
  • 196
    • 0033965236 scopus 로고    scopus 로고
    • Immunochemotherapy with interleukin-2, interferon-alpha and 5- fluorouracil for progressive metastatic renal cell carcinoma: A multicenter phase II study
    • Dutch Immunotherapy Working Party
    • van Herpen CM, Jansen RL, Kruit WH, et al. Immunochemotherapy with interleukin-2, interferon-alpha and 5- fluorouracil for progressive metastatic renal cell carcinoma: a multicenter phase II study. Dutch Immunotherapy Working Party. Br J Cancer 2000; 82 (4): 772-6
    • (2000) Br J Cancer , vol.82 , Issue.4 , pp. 772-776
    • Van Herpen, C.M.1    Jansen, R.L.2    Kruit, W.H.3
  • 197
    • 0034671326 scopus 로고    scopus 로고
    • Treatment of patients with metastatic renal carcinoma with a combination of subcutaneous interleukin-2 and interferon alfa with or without fluorouracil
    • Groupe Francais d'Immunotherapie, Federation Nationale des Centres de Lutte contre le Cancer
    • Negrier S, Caty A, Lesimple T, et al. Treatment of patients with metastatic renal carcinoma with a combination of subcutaneous interleukin-2 and interferon alfa with or without fluorouracil. Groupe Francais d'Immunotherapie, Federation Nationale des Centres de Lutte contre le Cancer. J Clin Oncol 2000; 18 (24): 4009-15
    • (2000) J Clin Oncol , vol.18 , Issue.24 , pp. 4009-4015
    • Negrier, S.1    Caty, A.2    Lesimple, T.3
  • 198
    • 0031600196 scopus 로고    scopus 로고
    • An outpatient phase II study of subcutaneous interleukin-2 and interferon-alpha-2b in combination with intravenous vinblastine in metastatic renal cell cancer
    • Pectasides D, Varthalitis J, Kostopoulou M, et al. An outpatient phase II study of subcutaneous interleukin-2 and interferon-alpha-2b in combination with intravenous vinblastine in metastatic renal cell cancer. Oncology 1998; 55 (1): 10-5
    • (1998) Oncology , vol.55 , Issue.1 , pp. 10-15
    • Pectasides, D.1    Varthalitis, J.2    Kostopoulou, M.3
  • 199
    • 0026544875 scopus 로고
    • Recombinant interferon alfa-2a with or without vinblastine in metastatic renal cell carcinoma: Results of a European multi-center phase III study
    • Fossa SD, Martinelli G, Otto U, et al. Recombinant interferon alfa-2a with or without vinblastine in metastatic renal cell carcinoma: results of a European multi-center phase III study. Ann Oncol 1992; 3 (4): 301-5
    • (1992) Ann Oncol , vol.3 , Issue.4 , pp. 301-305
    • Fossa, S.D.1    Martinelli, G.2    Otto, U.3
  • 200
    • 2442737061 scopus 로고    scopus 로고
    • Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer
    • Pyrhonen S, Salminen E, Ruutu M, et al. Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer. J Clin Oncol 1999; 17 (9): 2859-67
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2859-2867
    • Pyrhonen, S.1    Salminen, E.2    Ruutu, M.3
  • 201
    • 0024552005 scopus 로고
    • Recombinant alpha-2a interferon plus vinblastine in the treatment of metastatic renal cell carcinoma
    • Sertoli MR, Brunetti I, Ardizzoni A, et al. Recombinant alpha-2a interferon plus vinblastine in the treatment of metastatic renal cell carcinoma. Am J Clin Oncol 1989; 12 (1): 43-5
    • (1989) Am J Clin Oncol , vol.12 , Issue.1 , pp. 43-45
    • Sertoli, M.R.1    Brunetti, I.2    Ardizzoni, A.3
  • 202
    • 0028798749 scopus 로고
    • EORTC (30885) randomised phase III study with recombinant interferon alpha and recombinant interferon alpha and gamma in patients with advanced renal cell carcinoma
    • The EORTC Genitourinary Group
    • De Mulder PH, Oosterhof G, Bouffioux C, et al. EORTC (30885) randomised phase III study with recombinant interferon alpha and recombinant interferon alpha and gamma in patients with advanced renal cell carcinoma. The EORTC Genitourinary Group. Br J Cancer 1995; 71 (2): 371-5
    • (1995) Br J Cancer , vol.71 , Issue.2 , pp. 371-375
    • De Mulder, P.H.1    Oosterhof, G.2    Bouffioux, C.3
  • 203
    • 0029417274 scopus 로고
    • Randomised study using IFN-alpha versus IFN-alpha plus coumarin and cimetidine for treatment of advanced renal cell cancer
    • Sagaster P, Micksche M, Flamm J, et al. Randomised study using IFN-alpha versus IFN-alpha plus coumarin and cimetidine for treatment of advanced renal cell cancer. Ann Oncol 1995; 6 (10): 999-1003
    • (1995) Ann Oncol , vol.6 , Issue.10 , pp. 999-1003
    • Sagaster, P.1    Micksche, M.2    Flamm, J.3
  • 204
    • 0025748695 scopus 로고
    • A randomized prospective assessment of recombinant leukocyte A human interferon with or without aspirin in advanced renal adenocarcinoma
    • Creagan ET, Twito DI, Johansson SL, et al. A randomized prospective assessment of recombinant leukocyte A human interferon with or without aspirin in advanced renal adenocarcinoma. J Clin Oncol 1991; 9 (12): 2104-9
    • (1991) J Clin Oncol , vol.9 , Issue.12 , pp. 2104-2109
    • Creagan, E.T.1    Twito, D.I.2    Johansson, S.L.3
  • 205
    • 0031450065 scopus 로고    scopus 로고
    • Treatment of renal cell carcinoma with 5-fluorouracil and alfa-interferon
    • Gebrosky NP, Koukol S, Nseyo UO, et al. Treatment of renal cell carcinoma with 5-fluorouracil and alfa-interferon. Urology 1997; 50 (6): 863-7; discussion 867-8
    • (1997) Urology , vol.50 , Issue.6 , pp. 863-867
    • Gebrosky, N.P.1    Koukol, S.2    Nseyo, U.O.3
  • 206
    • 0031804712 scopus 로고    scopus 로고
    • Multicenter phase II trial of interleukin-2, interferon-alpha, and 13-cis-retinoic acid in patients with metastatic renal-cell carcinoma
    • Stadler WM, Kuzel T, Dumas M, et al. Multicenter phase II trial of interleukin-2, interferon-alpha, and 13-cis-retinoic acid in patients with metastatic renal-cell carcinoma. J Clin Oncol 1998; 16 (5): 1820-5
    • (1998) J Clin Oncol , vol.16 , Issue.5 , pp. 1820-1825
    • Stadler, W.M.1    Kuzel, T.2    Dumas, M.3
  • 207
    • 4243921755 scopus 로고    scopus 로고
    • A multicentre phase I/II evaluation of oral bexarotene (BEX) and interferon alfa 2b combination therapy in patients with advanced renal cell carcinoma
    • Wilding G, Carducci MA, Hwu W, et al. A multicentre phase I/II evaluation of oral bexarotene (BEX) and interferon alfa 2b combination therapy in patients with advanced renal cell carcinoma [abstract]. Proc Am Soc Clin Oncol 2001; 20: 191a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Wilding, G.1    Carducci, M.A.2    Hwu, W.3
  • 208
    • 4243648219 scopus 로고    scopus 로고
    • Multicentre phase II study with the combination of histamine dihydrochloride, interferon alfa and interleukin-2 in patients with metastatic renal cell carcinoma
    • Donskov F, Von der Masse H, Henriksson R, et al. Multicentre phase II study with the combination of histamine dihydrochloride, interferon alfa and interleukin-2 in patients with metastatic renal cell carcinoma [abstract]. Proc Am Soc Clin Oncol 2001; 20: 264a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Donskov, F.1    Von der Masse, H.2    Henriksson, R.3
  • 209
    • 0027310718 scopus 로고
    • Continuous intravenous interleukin-2 infusion and subcutaneous interferon-alpha in metastatic renal cell carcinoma
    • Fossa SD, Aune H, Baggerud E, et al. Continuous intravenous interleukin-2 infusion and subcutaneous interferon-alpha in metastatic renal cell carcinoma. Eur J Cancer 1993; 29A (9): 1313-5
    • (1993) Eur J Cancer , vol.29 A , Issue.9 , pp. 1313-1315
    • Fossa, S.D.1    Aune, H.2    Baggerud, E.3
  • 210
    • 0027433629 scopus 로고
    • A comparison of 2 modes of administration of recombinant interleukin-2: Continuous intravenous infusion alone vs subcutaneous administration plus interferon alpha in patients with advanced renal cell carcinoma
    • Palmer PA, Atzpodien J, Philip T, et al. A comparison of 2 modes of administration of recombinant interleukin-2: continuous intravenous infusion alone vs subcutaneous administration plus interferon alpha in patients with advanced renal cell carcinoma. Cancer Biother 1993; 8 (2): 123-36
    • (1993) Cancer Biother , vol.8 , Issue.2 , pp. 123-136
    • Palmer, P.A.1    Atzpodien, J.2    Philip, T.3
  • 211
    • 0029042943 scopus 로고
    • Lack of efficacy of low-dose subcutaneous recombinant interleukin-2 and interferon-alpha in the treatment of metastatic renal cell carcinoma
    • Thiounn N, Mathiot C, Dorval T, et al. Lack of efficacy of low-dose subcutaneous recombinant interleukin-2 and interferon-alpha in the treatment of metastatic renal cell carcinoma. Br J Urol 1995; 75 (5): 586-9
    • (1995) Br J Urol , vol.75 , Issue.5 , pp. 586-589
    • Thiounn, N.1    Mathiot, C.2    Dorval, T.3
  • 212
    • 0034002706 scopus 로고    scopus 로고
    • Combined subcutaneous recombinant alpha-interferon and interleukin-2 in metastatic renal cell cancer: Results of the multicentre All-Ireland Immunotherapy Study Group
    • Rogers E, Bredin H, Butler M, et al. Combined subcutaneous recombinant alpha-interferon and interleukin-2 in metastatic renal cell cancer: results of the multicentre All-Ireland Immunotherapy Study Group. Eur Urol 2000; 37 (3): 261-6
    • (2000) Eur Urol , vol.37 , Issue.3 , pp. 261-266
    • Rogers, E.1    Bredin, H.2    Butler, M.3
  • 213
    • 4243718003 scopus 로고    scopus 로고
    • Subcutaneous interleukin-2 plus alpha interferon in out-patients with metastatic renal cell carcinoma. SCAPP III trial
    • Tourani JM, Pfister C, Berdah JF. Subcutaneous interleukin-2 plus alpha interferon in out-patients with metastatic renal cell carcinoma. SCAPP III trial [abstract]. Proc Am Soc Clin Oncol 2000; 19: 334a
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Tourani, J.M.1    Pfister, C.2    Berdah, J.F.3
  • 214
    • 0031833035 scopus 로고    scopus 로고
    • Outpatient treatment with subcutaneous interleukin-2 and interferon alfa administration in combination with fluorouracil in patients with metastatic renal cell carcinoma: Results of a sequential non-randomized phase II study
    • Subcutaneous administration Propeukin Program Cooperative Group
    • Tourani JM, Pfister C, Berdah JF, et al. Outpatient treatment with subcutaneous interleukin-2 and interferon alfa administration in combination with fluorouracil in patients with metastatic renal cell carcinoma: results of a sequential non-randomized phase II study. Subcutaneous administration Propeukin Program Cooperative Group. J Clin Oncol 1998; 16 (7): 2505-13
    • (1998) J Clin Oncol , vol.16 , Issue.7 , pp. 2505-2513
    • Tourani, J.M.1    Pfister, C.2    Berdah, J.F.3
  • 215
    • 0034742672 scopus 로고    scopus 로고
    • Phase I and II trials of subcutaneously administered rIL-2, interferon alfa-2a, and fluorouracil in patients with metastatic renal carcinoma
    • Olencki T, Peereboom D, Wood L, et al. Phase I and II trials of subcutaneously administered rIL-2, interferon alfa-2a, and fluorouracil in patients with metastatic renal carcinoma. J Cancer Res Clin Oncol 2001; 127 (5): 319-24
    • (2001) J Cancer Res Clin Oncol , vol.127 , Issue.5 , pp. 319-324
    • Olencki, T.1    Peereboom, D.2    Wood, L.3
  • 216
    • 0026338063 scopus 로고
    • Metastatic renal cell cancer treated with recombinant alpha 2a interferon and vinblastine
    • Massidda B, Migliari R, Padovani A, et al. Metastatic renal cell cancer treated with recombinant alpha 2a interferon and vinblastine. J Chemother 1991; 3 (6): 387-9
    • (1991) J Chemother , vol.3 , Issue.6 , pp. 387-389
    • Massidda, B.1    Migliari, R.2    Padovani, A.3
  • 217
    • 0023711151 scopus 로고
    • Recombinant alpha-interferon and vinblastine in metastatic renal cell carcinoma: Efficacy of low doses
    • Cetto GL, Franceschi T, Turrina G, et al. Recombinant alpha-interferon and vinblastine in metastatic renal cell carcinoma: efficacy of low doses. Semin Surg Oncol 1988; 4 (3): 184-90
    • (1988) Semin Surg Oncol , vol.4 , Issue.3 , pp. 184-190
    • Cetto, G.L.1    Franceschi, T.2    Turrina, G.3
  • 218
    • 0024791554 scopus 로고
    • Recombinant interferon-alpha with or without vinblastine in metastatic renal carcinoma: Results of a randomised phase II study
    • Fossa SD, Raabe N, Moe B. Recombinant interferon-alpha with or without vinblastine in metastatic renal carcinoma: results of a randomised phase II study. Br J Urol 1989; 64 (5): 468-71
    • (1989) Br J Urol , vol.64 , Issue.5 , pp. 468-471
    • Fossa, S.D.1    Raabe, N.2    Moe, B.3
  • 219
    • 0028805829 scopus 로고
    • Interferon alfa and vinblastine vs medroxyprogesterone acetate in the treatment of metastatic renal cell carcinoma
    • Kriegmair M, Oberneder R, Hofstetter A. Interferon alfa and vinblastine vs medroxyprogesterone acetate in the treatment of metastatic renal cell carcinoma. Urology 1995; 45 (5): 758-62
    • (1995) Urology , vol.45 , Issue.5 , pp. 758-762
    • Kriegmair, M.1    Oberneder, R.2    Hofstetter, A.3
  • 220
    • 0025763734 scopus 로고
    • Vinblastine fails to improve response of renal cancer to interferon alfa-nI: High response rate in patients with pulmonary metastases
    • Neidhart JA, Anderson SA, Harris JE, et al. Vinblastine fails to improve response of renal cancer to interferon alfa-nI: high response rate in patients with pulmonary metastases. J Clin Oncol 1991; 9 (5): 832-6
    • (1991) J Clin Oncol , vol.9 , Issue.5 , pp. 832-836
    • Neidhart, J.A.1    Anderson, S.A.2    Harris, J.E.3
  • 221
    • 0033795736 scopus 로고    scopus 로고
    • Interaction of retinoic acid and interferon in renal cancer cell lines
    • Nanus DM, Geng Y, Shen R, et al. Interaction of retinoic acid and interferon in renal cancer cell lines. J Interferon Cytokine Res 2000; 20 (9): 787-94
    • (2000) J Interferon Cytokine Res , vol.20 , Issue.9 , pp. 787-794
    • Nanus, D.M.1    Geng, Y.2    Shen, R.3
  • 222
    • 0029165480 scopus 로고
    • Interferon alfa-2a and 13-cis-retinoic acid in renal cell carcinoma: Antitumor activity in a phase II trial and interactions in vitro
    • Motzer RJ, Schwartz L, Law TM, et al. Interferon alfa-2a and 13-cis-retinoic acid in renal cell carcinoma: antitumor activity in a phase II trial and interactions in vitro. J Clin Oncol 1995; 13 (8): 1950-7
    • (1995) J Clin Oncol , vol.13 , Issue.8 , pp. 1950-1957
    • Motzer, R.J.1    Schwartz, L.2    Law, T.M.3
  • 223
    • 0033902999 scopus 로고    scopus 로고
    • Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma
    • Motzer RJ, Murphy BA, Bacik J, et al. Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma. J Clin Oncol 2000; 18 (16): 2972-80
    • (2000) J Clin Oncol , vol.18 , Issue.16 , pp. 2972-2980
    • Motzer, R.J.1    Murphy, B.A.2    Bacik, J.3
  • 224
    • 0035425352 scopus 로고    scopus 로고
    • Phase II evaluation of paclitaxel, alpha-interferon, and cis-retinoic acid in advanced renal cell carcinoma
    • Vaishampayan U, Flaherty L, Du W, et al. Phase II evaluation of paclitaxel, alpha-interferon, and cis-retinoic acid in advanced renal cell carcinoma. Cancer 2001; 92 (3): 519-23
    • (2001) Cancer , vol.92 , Issue.3 , pp. 519-523
    • Vaishampayan, U.1    Flaherty, L.2    Du, W.3
  • 225
    • 0033376054 scopus 로고    scopus 로고
    • Subcutaneous administration of interferon alpha and gamma in patients with metastatic renal cell carcinoma
    • Koga S, Nishikido M, Matsuya F, et al. Subcutaneous administration of interferon alpha and gamma in patients with metastatic renal cell carcinoma. Anticancer Res 1999; 19 (6C): 5547-50
    • (1999) Anticancer Res , vol.19 , Issue.6 C , pp. 5547-5550
    • Koga, S.1    Nishikido, M.2    Matsuya, F.3
  • 226
    • 0023737411 scopus 로고
    • A prospective randomized trial of alpha 2B-interferon/gamma-interferon or the combination in advanced metastatic renal cell carcinoma
    • Foon K, Doroshow J, Bonnem E, et al. A prospective randomized trial of alpha 2B-interferon/gamma-interferon or the combination in advanced metastatic renal cell carcinoma. J Biol Response Mod 1988; 7 (6): 540-5
    • (1988) J Biol Response Mod , vol.7 , Issue.6 , pp. 540-545
    • Foon, K.1    Doroshow, J.2    Bonnem, E.3
  • 227
    • 0032957392 scopus 로고    scopus 로고
    • Interferon-alpha and 5-fluorouracil therapy in patients with metastatic renal cell cancer: An open multicenter trial
    • The Japanese Study Group Against Renal Cancer
    • Igarashi T, Marumo K, Onishi T, et al. Interferon-alpha and 5-fluorouracil therapy in patients with metastatic renal cell cancer: an open multicenter trial. The Japanese Study Group Against Renal Cancer. Urology 1999; 53 (1): 53-9
    • (1999) Urology , vol.53 , Issue.1 , pp. 53-59
    • Igarashi, T.1    Marumo, K.2    Onishi, T.3
  • 228
    • 0027267811 scopus 로고
    • Phase I trial of low-dose, prolonged continuous infusion fluorouracil plus interferon-alfa: Evidence for enhanced fluorouracil toxicity without pharmacokinetic perturbation
    • Sparano JA, Wadler S, Diasio RB, et al. Phase I trial of low-dose, prolonged continuous infusion fluorouracil plus interferon-alfa: evidence for enhanced fluorouracil toxicity without pharmacokinetic perturbation. J Clin Oncol 1993; 11 (8): 1609-17
    • (1993) J Clin Oncol , vol.11 , Issue.8 , pp. 1609-1617
    • Sparano, J.A.1    Wadler, S.2    Diasio, R.B.3
  • 229
    • 0033989568 scopus 로고    scopus 로고
    • Survival in renal cell carcinoma: A randomized evaluation of tamoxifen vs interleukin-2, alpha-interferon (leucocyte) and tamoxifen-reply
    • Henriksson R. Survival in renal cell carcinoma: a randomized evaluation of tamoxifen vs interleukin-2, alpha-interferon (leucocyte) and tamoxifen-reply. Br J Cancer 2000; 82 (1): 246-7
    • (2000) Br J Cancer , vol.82 , Issue.1 , pp. 246-247
    • Henriksson, R.1
  • 230
    • 0035880761 scopus 로고    scopus 로고
    • Feasibility of prolonged use of interferon-alpha in metastatic kidney carcinoma: A phase II study
    • Kankuri M, Pelliniemi TT, Pyrhonen S, et al. Feasibility of prolonged use of interferon-alpha in metastatic kidney carcinoma: a phase II study. Cancer 2001; 92 (4): 761-7
    • (2001) Cancer , vol.92 , Issue.4 , pp. 761-767
    • Kankuri, M.1    Pelliniemi, T.T.2    Pyrhonen, S.3
  • 231
    • 0029131619 scopus 로고
    • Interferon-alpha and survival in renal cell cancer
    • Fossa S, Jones M, Johnson P, et al. Interferon-alpha and survival in renal cell cancer. Br J Urol 1995; 76 (3): 286-90
    • (1995) Br J Urol , vol.76 , Issue.3 , pp. 286-290
    • Fossa, S.1    Jones, M.2    Johnson, P.3
  • 232
    • 0031756001 scopus 로고    scopus 로고
    • A phase II study of high-dose cimetidine and the combination 5-fluorouracil, interferon alpha-2A, and leucovorin in advanced renal cell adenocarcinoma
    • Creagan ET, Veeder MH, Suman VJ, et al. A phase II study of high-dose cimetidine and the combination 5-fluorouracil, interferon alpha-2A, and leucovorin in advanced renal cell adenocarcinoma. Am J Clin Oncol 1998; 21 (5): 475-8
    • (1998) Am J Clin Oncol , vol.21 , Issue.5 , pp. 475-478
    • Creagan, E.T.1    Veeder, M.H.2    Suman, V.J.3
  • 233
    • 0035498665 scopus 로고    scopus 로고
    • Long-term immunotherapy with low-dose interleukin-2 and interferon-alpha in the treatment of patients with advanced renal cell carcinoma
    • Buzio C, Andrulli S, Santi R, et al. Long-term immunotherapy with low-dose interleukin-2 and interferon-alpha in the treatment of patients with advanced renal cell carcinoma. Cancer 2001; 92 (9): 2286-96
    • (2001) Cancer , vol.92 , Issue.9 , pp. 2286-2296
    • Buzio, C.1    Andrulli, S.2    Santi, R.3
  • 235
    • 0027459718 scopus 로고
    • Role of lymphadenectomy in the treatment of renal cell carcinoma
    • Phillips E, Messing EM. Role of lymphadenectomy in the treatment of renal cell carcinoma. Urology 1993; 41 (1): 9-15
    • (1993) Urology , vol.41 , Issue.1 , pp. 9-15
    • Phillips, E.1    Messing, E.M.2
  • 236
    • 0028084421 scopus 로고
    • Patterns of failure following surgical resection of renal cell carcinoma: Implications for adjuvant local and systemic therapy
    • Rabinovitch RA, Zelefsky MJ, Gaynor JJ, et al. Patterns of failure following surgical resection of renal cell carcinoma: implications for adjuvant local and systemic therapy. J Clin Oncol 1994; 12 (1): 206-12
    • (1994) J Clin Oncol , vol.12 , Issue.1 , pp. 206-212
    • Rabinovitch, R.A.1    Zelefsky, M.J.2    Gaynor, J.J.3
  • 237
    • 0029053184 scopus 로고
    • A new protocol for the followup of renal cell carcinoma based on pathological stage
    • Sandock DS, Seftel AD, Resnick MI. A new protocol for the followup of renal cell carcinoma based on pathological stage. J Urol 1995; 154 (1): 28-31
    • (1995) J Urol , vol.154 , Issue.1 , pp. 28-31
    • Sandock, D.S.1    Seftel, A.D.2    Resnick, M.I.3
  • 238
    • 0028260464 scopus 로고
    • Interferon as adjunctive treatment for non-metastatic renal cell carcinoma
    • Takahashi S, Tanigawa T, Imagawa M, et al. Interferon as adjunctive treatment for non-metastatic renal cell carcinoma. Br J Urol 1994; 74 (1): 11-4
    • (1994) Br J Urol , vol.74 , Issue.1 , pp. 11-14
    • Takahashi, S.1    Tanigawa, T.2    Imagawa, M.3
  • 239
    • 0000513320 scopus 로고    scopus 로고
    • Randomised controlled trial of adjuvant therapy with lymphoblastoid interferon (L-IFN) in resected, high risk renal cell carcinoma
    • Trump DL, Elson P, Propert K. Randomised controlled trial of adjuvant therapy with lymphoblastoid interferon (L-IFN) in resected, high risk renal cell carcinoma [abstract]. Proc Am Soc Clin Oncol 1996; 15: 253a
    • (1996) Proc Am Soc Clin Oncol , vol.15
    • Trump, D.L.1    Elson, P.2    Propert, K.3
  • 240
    • 0035863285 scopus 로고    scopus 로고
    • Interferon adjuvant to radical nephrectomy in Robson stages II and III renal cell carcinoma: A multicentric randomized study
    • Pizzocaro G, Piva L, Colavita M, et al. Interferon adjuvant to radical nephrectomy in Robson stages II and III renal cell carcinoma: a multicentric randomized study. J Clin Oncol 2001; 19 (2): 425-31
    • (2001) J Clin Oncol , vol.19 , Issue.2 , pp. 425-431
    • Pizzocaro, G.1    Piva, L.2    Colavita, M.3
  • 241
    • 0002733618 scopus 로고
    • Adjuvant therapy of renal cell cancer with interferon alfa-2a
    • Porzsolt F. Adjuvant therapy of renal cell cancer with interferon alfa-2a [abstract]. Proc Am Soc Clin Oncol 1992; 11: 202a
    • (1992) Proc Am Soc Clin Oncol , vol.11
    • Porzsolt, F.1
  • 242
    • 0027409257 scopus 로고
    • Interferon-alpha antibodies in patients with renal cell carcinoma treated with recombinant interferon-alpha-2A in an adjuvant multicenter trial
    • The Delta-P Study Group
    • Prummer O. Interferon-alpha antibodies in patients with renal cell carcinoma treated with recombinant interferon-alpha-2A in an adjuvant multicenter trial. The Delta-P Study Group. Cancer 1993; 71 (5): 1828-34
    • (1993) Cancer , vol.71 , Issue.5 , pp. 1828-1834
    • Prummer, O.1
  • 243
    • 0000736431 scopus 로고    scopus 로고
    • Pooled analysis of four ECOG-intergroup trials of high-dose interferon alfa-2b (HDI) in 1916 patients with high-risk resected cutaneous melanoma
    • Kirkwood JM, Manola J, Ibrahim JG, et al. Pooled analysis of four ECOG-intergroup trials of high-dose interferon alfa-2b (HDI) in 1916 patients with high-risk resected cutaneous melanoma [abstract]. Proc Am Soc Clin Oncol 2001; 20: 1395
    • (2001) Proc Am Soc Clin Oncol , vol.20 , pp. 1395
    • Kirkwood, J.M.1    Manola, J.2    Ibrahim, J.G.3
  • 244
    • 0034005275 scopus 로고    scopus 로고
    • Interferon-alpha therapy for melanoma
    • Russell-Jones R. Interferon-alpha therapy for melanoma. Clin Exp Dermatol 2000; 25 (1): 1-6
    • (2000) Clin Exp Dermatol , vol.25 , Issue.1 , pp. 1-6
    • Russell-Jones, R.1
  • 245
    • 0036534376 scopus 로고    scopus 로고
    • Interferon alfa therapy for malignant melanoma: A systematic review of randomized controlled trials
    • Lens MB, Dawes M. Interferon alfa therapy for malignant melanoma: a systematic review of randomized controlled trials. J Clin Oncol 2002; 20 (7): 1818-25
    • (2002) J Clin Oncol , vol.20 , Issue.7 , pp. 1818-1825
    • Lens, M.B.1    Dawes, M.2
  • 246
    • 0036199833 scopus 로고    scopus 로고
    • An update on adjuvant interferon for melanoma
    • Gray RJ, Pockaj BA, Kirkwood JM. An update on adjuvant interferon for melanoma. Cancer Control 2002; 9 (1): 16-21
    • (2002) Cancer Control , vol.9 , Issue.1 , pp. 16-21
    • Gray, R.J.1    Pockaj, B.A.2    Kirkwood, J.M.3
  • 247
    • 0023763999 scopus 로고
    • IFN-treatment of B166-F1 versus B16-F10: Relative impact on non-adaptive and T-cell mediated immune defense in metastatic spread
    • Zoller M. IFN-treatment of B166-F1 versus B16-F10: Relative impact on non-adaptive and T-cell mediated immune defense in metastatic spread. Clin Exp Metastasis 1988; 6 (5): 411-29
    • (1988) Clin Exp Metastasis , vol.6 , Issue.5 , pp. 411-429
    • Zoller, M.1
  • 248
    • 0029783592 scopus 로고    scopus 로고
    • Prognostic factors for response and survival in patients with metastatic melanoma receiving immunotherapy
    • Keilholz U, Scheibenbogen C, Sommer M, et al. Prognostic factors for response and survival in patients with metastatic melanoma receiving immunotherapy. Melanoma Res 1996; 6 (2): 173-8
    • (1996) Melanoma Res , vol.6 , Issue.2 , pp. 173-178
    • Keilholz, U.1    Scheibenbogen, C.2    Sommer, M.3
  • 250
    • 0010620989 scopus 로고    scopus 로고
    • Long term follow up of patients with metastatic malignant melanoma treated continuous infusion-IL2 alone or in combination
    • 1998 Feb 3-6; Paris. Paris: SOMPS
    • Maral J. Long term follow up of patients with metastatic malignant melanoma treated continuous infusion-IL2 alone or in combination. 8th International Congress Anticancer Treatment Chiron Symposium; 1998 Feb 3-6; Paris. Paris: SOMPS, 1998
    • (1998) 8th International Congress Anticancer Treatment Chiron Symposium
    • Maral, J.1
  • 251
    • 0034063272 scopus 로고    scopus 로고
    • Combined chemoimmunotherapy in metastatic melanoma: Is there a need for the double?
    • Schrader AJ. Combined chemoimmunotherapy in metastatic melanoma: is there a need for the double? Anticancer Drugs 2000; 11 (3): 143-8
    • (2000) Anticancer Drugs , vol.11 , Issue.3 , pp. 143-148
    • Schrader, A.J.1
  • 252
    • 0034113335 scopus 로고    scopus 로고
    • Effect of cytokine therapy on survival for patients with advanced renal cell carcinoma
    • Motzer RJ, Mazumdar M, Bacik J, et al. Effect of cytokine therapy on survival for patients with advanced renal cell carcinoma. J Clin Oncol 2000; 18 (9): 1928-35
    • (2000) J Clin Oncol , vol.18 , Issue.9 , pp. 1928-1935
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3
  • 253
    • 2442743842 scopus 로고    scopus 로고
    • Prognostic factors and the role of nephrectomy in metastatic renal cell carcinoma
    • Uygur MC, Usubutun A, Ozen H, et al. Prognostic factors and the role of nephrectomy in metastatic renal cell carcinoma. J Exp Clin Cancer Res 1999; 18 (3): 397-401
    • (1999) J Exp Clin Cancer Res , vol.18 , Issue.3 , pp. 397-401
    • Uygur, M.C.1    Usubutun, A.2    Ozen, H.3
  • 254
    • 0027985315 scopus 로고
    • Prognostic factors and survival in patients with metastatic renal cell carcinoma treated with chemotherapy or interferon-alpha
    • Fossa SD, Kramar A, Droz JP. Prognostic factors and survival in patients with metastatic renal cell carcinoma treated with chemotherapy or interferon-alpha. Eur J Cancer 1994: 30A (9): 1310-4
    • (1994) Eur J Cancer , vol.30 A , Issue.9 , pp. 1310-1314
    • Fossa, S.D.1    Kramar, A.2    Droz, J.P.3
  • 255
    • 0001487027 scopus 로고    scopus 로고
    • Cytoreductive tumor nephrectomy in metastatic renal cancer: The results of Southwest Oncology Group trial 8949
    • Flanigan RC, Blumenstein BA, Salmon S, et al. Cytoreductive tumor nephrectomy in metastatic renal cancer: the results of Southwest Oncology Group trial 8949 [abstract]. J Urol 2000; 163 Suppl.: 154
    • (2000) J Urol , vol.163 , Issue.SUPPL. , pp. 154
    • Flanigan, R.C.1    Blumenstein, B.A.2    Salmon, S.3
  • 256
    • 0035934596 scopus 로고    scopus 로고
    • Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal cell carcinoma: A randomised trial
    • Mickisch GHJ, Garin A, van Poppel H, et al. Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal cell carcinoma: a randomised trial. Lancet 2001; 358 (9286): 966-70
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 966-970
    • Mickisch, G.H.J.1    Garin, A.2    Van Poppel, H.3
  • 257
    • 0035934574 scopus 로고    scopus 로고
    • Back to nephrectomy for patients with metastatic renal cell cancer
    • Klotz L. Back to nephrectomy for patients with metastatic renal cell cancer. Lancet 2001; 358 (9286): 948-9
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 948-949
    • Klotz, L.1
  • 258
    • 0036439066 scopus 로고    scopus 로고
    • Potential of interferon-α in solid tumours: Part 2
    • In press
    • Santhanam S, Decatris M, O'Byrne K. Potential of interferon-α in solid tumours: part 2. Biodrugs. In press
    • Biodrugs
    • Santhanam, S.1    Decatris, M.2    O'Byrne, K.3


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