Characterisation of the biological activity of recombinant equine eotaxin in vitro

Cytokine

Volumn 19, Issue 1, 2002, Pages 27-30

  Benarafa, Charaf ^a   Collins, Margaret E ^a   Hamblin, Anne S ^a   Sabroe, Ian ^b   Cunningham, Fiona M ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Eosinophil migration; Eotaxin; Horse; Shape change; Superoxide

Indexed keywords

CHEMOKINE RECEPTOR CCR3; EOTAXIN; HYBRID PROTEIN; MONOCLONAL ANTIBODY; RECEPTOR BLOCKING AGENT; RECOMBINANT EQUINE EOTAXIN; SUPEROXIDE; UCB 35625; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL MIGRATION; CELL SHAPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; EOSINOPHIL; GENETIC TRANSFECTION; HORSE; HUMAN; HUMAN CELL; IN VITRO STUDY; INSECT CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNTHESIS;

EQUIDAE; EQUUS CABALLUS; INSECTA;

EID: 0036384341     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2002.1052     Document Type: Article

References (13)

1. Gleich GJ (2000) Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 105:651-663.
2. Rankin SM, Conroy DM, Williams TJ (2000) Eotaxin and eosinophil recruitment: implications for human disease. Mol Med Today 6:20-27.
3. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996) Human eotaxin is a specific chemo-attractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 2:449-456.
4. Lamkhioued B, Renzi PM, Abi-Younes S, Garcia-Zepeda EA, Allakhverdi Z, Ghaffar O, Rothenberg MD, Luster AD, Hamid Q (1997) Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 159:4593-4601.
5. Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, Buckley MG, Walls AF, Askenase PW, Kay AB (1999) C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C- C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 163:3976-3984.
6. Benarafa C, Cunningham FM, Hamblin AS, Horohov DW, Collins ME (2000) Cloning of equine chemokines eotaxin, monocyte chemoattractant protein (MCP)-1, MCP-2 and MCP-4, mRNA expression in tissues and induction by IL-4 in dermal fibroblasts. Vet Immunol Immunopathol 76:283-298.
7. Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, Williams TJ, Pease JE (2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem 275:25985-25992.
8. Sabroe I, Hartnell A, Jopling LA, Bel S, Ponath PD, Pease JE, Collins PD, Williams TJ (1999) Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. J Immunol 162:2946-2955.
9. Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, Ponath PD, Mackay CR (1997) Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 99:178-184.
10. Imai T (2000) Chemokine expression in insect cells. Methods Mol Biol 138:23-32.
11. Baggiolini M, Dewald B, Moser B (1997) Human chemokines: an update. Annu Rev Immunol 15:675-705.
12. Foster AP, Cunningham FM (1998) Histamine-induced adherence and migration of equine eosinophils. Am J Vet Res 59:1153-1159.
13. Foster AP, Cunningham FM (1997) Differential superoxide anion generation by equine eosinophils and neutrophils. Vet Immunol Immunopathol 59:225-237.