Evaluation of barrier creams against sulphur mustard. I. In vitro studies using human skin

Skin Pharmacology and Applied Skin Physiology

Volumn 15, Issue 4, 2002, Pages 225-235

  Chilcott, Robert P ^a   Jenner, John ^a   Hotchkiss, Sharon A M ^b   Rice, Paul ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Barrier creams; Decontaminants; Human skin; In vitro; Sulphur mustard

Indexed keywords

ALCOHOL; CHEMICAL WARFARE AGENT; FOMBLIN A; FOMBLIN HCR; FOMBLIN Z; FULLER EARTH; MUSTARD GAS; SKIN PROTECTIVE AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CREAM; DIFFUSION; DOSE CALCULATION; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG SCREENING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; SKIN; SKIN ABSORPTION; SKIN DECONTAMINATION; SKIN PROTECTION; STOKODERM;

ADMINISTRATION, CUTANEOUS; ALUMINUM COMPOUNDS; BENZENESULFONATES; CHEMISTRY, PHARMACEUTICAL; DECONTAMINATION; DERMATOLOGIC AGENTS; DRUG COMBINATIONS; EPIDERMIS; FLUOROCARBONS; HUMANS; LANOLIN; MAGNESIUM COMPOUNDS; MUSTARD GAS; PERMEABILITY; POISONING; SILICATES; SKIN ABSORPTION; STEARATES;

EID: 0036380664     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065969     Document Type: Article

References (36)

1. Marrs TC, Maynard RL, Sidell FR: Chemical Warfare Agents. Toxicology and Treatment. London, Wiley, 1996, pp 139-173.
2. Yang Y-C, Baker JA, Ward JR: Decontamination of chemical warfare agents. Chem Rev 1992;92:1729-1743.
3. Goh CL: Cutting oil dermatitis on guinea pig skin. Part 1. Cutting oil dermatitis and barrier cream. Contact Dermatitis 1991;24:16-21.
4. Boman A, Mellström G: Percutaneous absorption of 3 organic solvents in the guinea pig. Part 3. Effect of barrier creams. Contact Dermatitis 1999;21:134-140.
5. Marks R, Dykes PJ, Hamami I: Two novel techniques for the evaluation of barrier creams. Br J Dermatol 1989;120:655-660.
6. Blanken R, Nater JP, Veenhoff E: Protective effect of barrier creams and spray coatings against epoxy resins. Contact Dermatitis 1987;16:79-83.
7. Grevelink SA, Murrell DF, Olsen EA: Effectiveness of various barrier preparations in preventing and/or ameliorating experimentally produced Toxicodendron dermatitis. J Am Acad Dermatol 1992;27:182-188.
8. Orchard S: Barrier creams. Dermatologic Clin 1984;2:619-629.
9. Byrne MP, Broomfield CA, Stites WE: Mustard gas crosslinking of proteins through preferential alkylation of cysteines. J Protein Chem 1996;15:131-136.
10. Wheeler GP: Studies related to the mechanisms of action of cytotoxic alkylating agents. Cancer Res 1962;22:651-688.
11. Fairhurst S, Maxwell SA, Scawin JW, Swanston DW: Skin effects of trichothecenes and their amelioration by decontamination. Toxicology 1987;46:307-319.
12. Kumar P, Sharma US, Vijayaraghavan R: Study of the efficacy of CC-2 and fuller's earth combination as a decontaminant against sulphur mustard (mustard gas) dermal intoxication in mice. Def Sci J 1991;41:363-366.
13. Frosh PJ, Kurte A, Pilz B: Efficacy of skin barrier creams. Part 3. The repetitive irritation test (RIT) in humans. Contact Dermatitis 1993;29:113-118.
14. Goh CL, Gan SL: Efficacies of a barrier cream and an afterwork emollient cream against cutting fluid dermatitis in metalworkers: A prospective study. Contact Dermatitis 1994;31:176-180.
15. Olson CT, Feder PI, Hobson DW, Kiser RC, Joiner RL: Evaluation of compounds as barriers to dermal penetration of organophosphates using acetylcholinesterase inhibition. Toxicol Lett 1991;55:325-334.
16. Howes D, Guy R, Hadgraft J, Heylings J, Hoeck U, Kemper F, Maibach H, Marty J-P, Merk H, Parra J, Rekkas D, Rondelli I, Schaefer H, Täuber U, Verbiese N: Methods for assessing percutaneous absorption. Report and recommendations of the ECVAM workshop 13. Altern Lab Anim 1996;24:81-106.
17. de Fine Olivarius, Hansen AB, Karlsmark T, Wulf HC: Water protective effect of barrier creams and moisturizing creams: A new in vivo test method. Contact Dermatitis 1996;35:219-225.
18. Zhai H, Maibach HI: Effect of barrier creams: Human skin in vivo. Contact Dermatitis 1996;35:92-96.
19. Guillemin M, Murset JC, Lob M, Riquez J: Simple method to determine the efficiency of a cream used for skin protection against solvents. Br J Ind Med 1974;31:310-316.
20. Lauwerys RR, Dath T, Lachapelle JM, Buchet JP, Roels H: The influence of two barrier creams on the percutaneous absorption of m-xylene in man. J Occup Med 1978;20:17-20.
21. Grunewald AM, Gloor M, Gehring W, Kleez P: Barrier creams. Dermatosen 1995;43:69-74.
22. Zhai H, Maibach HI: Efficacy of barrier creams (skin protective creams); in Elsner P, Merk HF, Maibach HI (eds): Cosmetics - Controlled Efficacy Studies and Regulation. Berlin, Springer, 1999, pp 156-166.
23. Reiner R, Rossmann K, Hooidonk CV, Ceulen BI, Bock J: Ointments for the protection against organophosphate poisoning. Arzneimittelforschung 1982;32:630-633.
24. Loden M: The effect of 4 barrier creams on the absorption of water, benzene, and formaldehyde into excised human skin. Contact Dermatitis 1986;14:292-296.
25. Chilcott RP, Jenner J, Carrick W, Hotchkiss SAM, Rice P: In vitro human skin absorption of Bis-2-(chloroethyl)sulphide (sulphur mustard). J Appl Toxicol 2000;20:349-355.
26. Chilcott RP, Jenner J, Hotchkiss SAM, Rice P: In vitro skin absorption and decontamination of sulphur mustard: Comparison of human and pig-ear skin. J Appl Toxicol 2001;21:279-283.
27. Nagy SM, Golumbic C, Stein WH, Fruton JS, Bergmann M: The penetration of vesicant vapours into human skin. J Gen Physiol 1946:29:441-467.
28. Renshaw B: Mechanisms in production of cutaneous injuries by sulfur and nitrogen mustards. Summary technical report of division 9, NDRC volume 1. Chemical warfare agents and related chemical problems. Washington, Office of Scientific Research and Development, 1946.
29. Franz TJ: Percutaneous absorption: On the relevance of in vitro. J Invest Dermatol 1975;64:190-195.
30. Jenner J, Saleem A, Swanston DW: Transdermal delivery of physostigmine. A pretreatment against organophosphate poisoning. J Pharm Pharmacol 1995;47:206-212.
31. Kligman AM, Christophers E: Preparation of isolated sheets of human stratum corneum. Arch Dermatol 1963;88:70-73.
32. Chilcott RP, Jenner J, Taylor C, Rice P: A rapid technique to identify structurally non-viable epidermal membranes during percutaneous penetration studies. Hum Exp Toxicol 1995;15:161.
33. Fischer T, Rystedt I: Skin protection against ionized cobalt and sodium lauryl sulphate with barrier creams. Contact Dermatitis 1983;9:125-130.
34. Bartek MJ, LaBudde JA, Maibach HI: Skin permeability in vivo: Comparison of rat, rabbit, pig and man. J Invest Dermatol 1972;58:114-123.
35. Walker M, Dugard PH, Scott RC: Absorption through human and laboratory animal skins: In vitro comparisons. Acta Pharm Suec 1983;20:52-53.
36. Chilcott RP, Brown RFR, Rice P: Non-invasive quantification of skin injury resulting from exposure to sulphur mustard and Lewisite vapours. Burns 2000;26:245-250.