Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis

British Journal of Dermatology

Volumn 147, Issue 2, 2002, Pages 299-307

  Griffiths, C E M ^a   Van Leent, E J M ^b   Gilbert, M ^c   Traulsen, J ^d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c LAVAL UNIVERSITY   (Canada)

^d LEO PHARMA A S   (Denmark)

Author keywords

Atopic dermatitis; Cipamfylline; Hydrocortisone 17 butyrate

Indexed keywords

CIPAMFYLLINE; DRUG VEHICLE; HYDROCORTISONE BUTYRATE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATOPIC DERMATITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ADULT; ANTI-INFLAMMATORY AGENTS; DERMATITIS, ATOPIC; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; OINTMENTS; PHOSPHODIESTERASE INHIBITORS; PROSPECTIVE STUDIES; RECURRENCE; STATISTICS, NONPARAMETRIC; XANTHINES;

EID: 0036379509     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2002.04894.x     Document Type: Article

References (20)

1. Larsen FS, Holm NV, Henningsen K. Atopic dermatitis, a genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol 1986; 15: 487-94.
2. Rajka G. Essential Aspects of Atopic Dermatitis 1989; 5-7.
3. Taylor B, Wadsworth J, Wadsworth M, Peckham C. Changes in the reported prevalence of childhood eczema since the 1939-45 war. Lancet 1998; 2: 1255-7.
4. Lapidus CS, Schwarz DF, Honig PJ. Atopic dermatitis in children: who cares? Who pays? J Am Acad Dermatol 1993; 28: 699-703.
5. Williams HC. Is the prevalence of atopic dermatitis increasing? Dermatol Ther 1992; 17: 385-91.
6. Hanifin J, Chan SC. Diagnosis and treatment of atopic dermatitis. Dermatol Ther 1996; 1: 9-18.
7. Coleman R, Trembath RC, Harper JI. Genetic studies of atopy and atopic dermatitis. Br J Dermatol 1997; 136: 1-5.
8. Hanifin JM, Chan SC. Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis. J Invest Dermatol 1995; 105 (Suppl. 1): 84-8S.
9. Grewe SR, Chan SC, Hanifin JM. Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness. J Allergy Clin Immunol 1982; 70: 452-7.
10. Butler JM, Chan SC, Stevens S, Hanifin JM. Increased leukocyte histamine release with elevated cyclic AMP-phosphodiesterase activity in atopic dermatitis. J Allergy Clin Immunol 1983; 71: 490-7.
11. Heckel NS, Chan SC, Thiel L et al. Elevated umbilical cord blood leukocyte cyclic adenosine monophosphate-phosphodiesterase activity in children with atopic parents. J Am Acad Dermatol 1984; 11: 422-6.
12. Chan SC, Li S-H, Hanifin JM. Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition. J Invest Dermatol 1993; 100: 681-4.
13. Cooper KD, Kang K, Chan SC et al. Phosphodiesterase inhibition by Ro 20-1724 hyper-IgE synthesis by atopic dermatitis cells in vitro. J Invest Dermatol 1985; 84: 477-82.
14. Hanifin JM, Chan SC, Cheng JB et al. Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. J Invest Dermatol 1996; 107: 51-6.
15. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 92 (Suppl.): 44-7.
16. Long CC, Finlay AY. The finger-tip unit - a new practical measure. Clin Exp Dermatol 1991; 16: 444-7.
17. Cytel Software Corporation. Statxact Statistical Software for Exact Nonparametric Influence User Manual Cambridge, MA, U.S.A: Cytel Software Corp., 1992.
18. European Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis: the SCORAD Index. Dermatology 1993; 186: 23-31.
19. Oranje AP, Stadler J-F, Ta A et al. Scoring of atopic dermatitis by SCORAD using a training atlas by investigators from different disciplines. Pediatr Allergy Immunol 1997; 8: 28-34.
20. Kunz B, Oranje AP, Labrèze I et al. Clinical validation and guidelines for the SCORAD Index: Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1997; 195: 10-19.