Chronomodulated chemotherapy in metastatic gastrointestinal cancer combining 5-FU and sodium folinate with oxaliplatin, irinotecan or gemcitabine: The Jena experience in 79 patients

Journal of Cancer Research and Clinical Oncology

Volumn 128, Issue 9, 2002, Pages 516-524

  Kliche, Kay Oliver ^a   Kubsch, Konstantin ^a   Raida, Martin ^a   Masri Zada, Rami ^a   Höffken, Klaus ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Chronotherapy; Colorectal cancer; Irinotecan; Oxaliplatin; Sodium folinate

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; FOLINATE CALCIUM; GEMCITABINE; IRINOTECAN; OXALIPLATIN; SODIUM FOLINATE; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ARTICLE; BILE DUCT CARCINOMA; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CHRONOTHERAPY; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL CARCINOMA; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; NEUROTOXICITY; PANCREAS CARCINOMA; PRIORITY JOURNAL; SURVIVAL TIME; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BILIARY TRACT NEOPLASMS; CAMPTOTHECIN; COLORECTAL NEOPLASMS; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; FOLIC ACID; GASTROINTESTINAL NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; ORGANOPLATINUM COMPOUNDS; PANCREATIC NEOPLASMS; STOMACH NEOPLASMS;

EID: 0036379086     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-002-0363-0     Document Type: Article

References (26)

1. Adam R, et al (2001) Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal. Ann Surg Oncol 8:347-353
2. Bertheault-Cvitkovic F, et al (1996) Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer. J Clin Oncol 14:2950-2958
3. Cure H, et al (2000) Phase II trial of chronomodulated infusion of 5-fluorouracil and folinic acid in metastatic colorectal cancer. Anticancer Res 20:4649-4653
4. Extra JM, et al (1990) Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol 25:299-303
5. Focan C, et al (1999) Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion. Anticancer Drugs 10:385-392
6. Garufi C, et al (2000) Overcoming resistance to chronomodulated 5-fluorouracil and folinic acid by the addition of chronomodulated oxaliplatin in advanced colorectal cancer patients. Anticancer Drugs 11:495-501
7. Garufi C, et al (2001) Irinotecan and chronomodulated infusion of 5-fluorouracil and folinic acid in the treatment of patients with advanced colorectal carcinoma: a phase I study. Cancer 91:712-720
8. Giacchetti S, et al (1999) Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10:663-669
9. Giacchetti S, et al (2000) Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 18:136-147
10. Gornet JM, et al (2000) Dramatic tumor response of bulky liver metastases following treatment with CPT-11 and a chronomodulated 4-day infusion of 5-fluorouracil, folinic acid and oxaliplatin every 2 weeks in a colorectal cancer patient. Anticancer Drugs 11:263-268
11. Granda TG, et al (2001) Experimental chronotherapy of mouse mammary adenocarcinoma MA13/C with docetaxel and doxorubicin as single agents and in combination. Cancer Res 61:1996-2001
12. Halberg F, et al (1980) Chronotherapy of mammary cancer in rats. Int J Chronobiol 7:85-99
13. Hrushesky WJ, et al (1982) Circadian stage dependence of cis-diamminedichloroplatinum lethal toxicity in rats. Cancer Res 42:945-949
14. Levi F (1999) Cancer chronotherapy. J Pharm Pharmacol 51:891-898
15. Levi F, et al (1992) A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer. Cancer 69:893-900
16. Levi FA, et al (1994) Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial. J Natl Cancer Inst 86:1608-1617
17. Levi, F., S. Giacchetti, et al (1995a) Chronomodulation of chemotherapy against metastatic colorectal cancer. International Organization for Cancer Chronotherapy. Eur J Cancer 31A:1264-1270
18. Levi F, et al (1995b) A phase I-II trial of five-day continuous intravenous infusion of 5-fluorouracil delivered at circadian rhythm modulated rate in patients with metastatic colorectal cancer. J Infus Chemother 5 [3 Suppl 1]:153-158
19. Levi F, et al (1997) Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy. Lancet 350:681-686
20. Levi F, et al (1999) A multicenter evaluation of intensified, ambulatory, chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin as initial treatment of patients with metastatic colorectal carcinoma. International Organization for Cancer Chronotherapy. Cancer 85:2532-2540
21. Levi F, et al (2001) Chronotherapy of colorectal cancer metastases. Hepatogastroenterology 48:320-322
22. Misset JL, Levi F (2000) Chronotherapy with 5-fluorouracil and other drugs in gastrointestinal malignancies. Chronotherapy Group of the European Organization for Research and Treatment of Cancer. Semin Oncol 27 [5 Suppl 10]:78-82
23. Raida M, et al (2002) Circadian variation of dihydropyrimidine dehydrogenase mRNA expression in leukocytes and serum cortisol levels in patients with advanced gastrointestinal carcinomas compared to healthy controls. J Cancer Res Clin Oncol 128:96-102
24. Saltz LB, et al (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343:905-914
25. Sothern RB, et al (1989) Control of a murine plasmacytoma with doxorubicin-cisplatin: dependence on circadian stage of treatment. J Natl Cancer Inst 81:135-145
26. WHO (1979) WHO Handbook for Reporting Results of Cancer Treatment. WHO, Geneva, Switzerland