Causes of gynaecomastia in young adult males and factors associated with idiopathic gynaecomastia

International Journal of Andrology

Volumn 25, Issue 5, 2002, Pages 312-316

  Ersöz, Halil Önder ^a,c   Önde, Mehmet Emin ^b   Terekeci, Hakan ^b   Kurtoglu, Soner ^b   Tor, Hayati ^b  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^b GATA HAYDARPASA TRAINING HOSPITAL   (Turkey)

^c KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Gynaecomastia; Hypogonadism; Luteinizing hormone; Obesity; Testosterone

Indexed keywords

LUTEINIZING HORMONE; TESTOSTERONE;

ADIPOSE TISSUE; ANTHROPOMETRY; ARTICLE; BODY FAT; CHRONIC LIVER DISEASE; CONTROLLED STUDY; CORRELATION FUNCTION; ECHOMAMMOGRAPHY; GYNECOMASTIA; HUMAN; HYPERPROLACTINEMIA; HYPOGONADISM; MALE; MEDICAL ASSESSMENT; OBESITY; ONSET AGE; PALPATION; PRIORITY JOURNAL; REDUCTION; SKINFOLD THICKNESS; TESTOSTERONE BLOOD LEVEL;

ADULT; ANTHROPOMETRY; CASE-CONTROL STUDIES; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FOLLICLE STIMULATING HORMONE; GYNECOMASTIA; HUMANS; LUTEINIZING HORMONE; MALE; PROLACTIN; TESTOSTERONE;

EID: 0036378193     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2605.2002.00374.x     Document Type: Article

References (26)

1. Andersen, J. A. & Gram, J. B. (1982) Male breast at autopsy. Acta Pathologica Microbiologica Immunologica Scandinavica (a) 90, 191-197.
2. Bauduceau, B., Reboul, P., Le Guyadec, T., Legrelle, M., Mayaudon, H. & Gautier, D. (1993) Hormonal profile of idiopathic gynecomastia in young adults. Apropos of 488 cases. Annales d' Endocrinologie 54, 163-167.
3. Bidlingmaier, F. & Knorr, D. (1973) Plasma testosterone and estrogens in pubertal gynecomastia. Zeitscrift für Kinderheilkd 115, 89-94.
4. Biro, F. M., Lucky, A. W., Huster, G. A. & Morrison, J. A. (1990) Hormonal studies and physical maturation in adolescent gynecomastia. Journal of Pediatrics 116, 450-455.
5. Braunstein, G. D. (1993a) Gynecomastia. New England Journal of Medicine 328, 490-495.
6. Braunstein, G. D. (1993b) Diagnosis and treatment of gynecomastia. Hospital Practice 28, 37-46.
7. Bulun, S. E., Noble, L. S., Takayama, K., Michael, M. D., Agarwal, V., Fisher, C., Zhao, Y., Hinshelwood, M. M., Ito, Y. & Simpson, E. R. (1997) Endocrine disorders associated with inappropriately high aromatase expression. Journal of Steroid Biochemistry and Molecular Biology 61, 133-139.
8. Edmondson, H. A., Glass, S. J. & Soll, S. N. (1939) Gynecomastia associated with cirrhosis of the liver. Proceedings of the Society of Experimental Biological Medicine 42, 97-99.
9. Fara, G. M., Del Corvo, G., Bernuzzi, S., Bigatello, A., Di Pietro, C., Scaglioni, S. & Chiumello, G. (1979) Epidemic of breast enlargement in an Italian school. Lancet 2, 295-297.
10. Finkelstein, J. S., O'Dea, L. S. T. L., Whitcomb, R. W. & Crowley, W. F. (1991) Sex steroid control of gonadotropin secretion in the human male. II. Effects of estradiol administration in normal and gonadotropin-releasing hormone deficient men. Journal of Clinical Endocrinological Metabolism 73, 621-628.
11. Georgiadis, E., Papandreou, L., Evangelopoulou, C., Aliferis, C., Lymberis, C., Panitsa, C. & Batrinos, M. (1994) Incidence of gynecomastia in 954 young males and its relationship to somatometric parameters. Annals of Human Biology 21, 579-587.
12. Harlan, W. R., Grillo, G. P., Cornoni-Huntley, J. & Leaverton, P. E. (1979) Secondary sex characteristics of boys 12-17 years of age: The US Health Examination Survey. Journal of Pediatrics 95, 293-297.
13. Jones, T. M., Fang, V. S., Landau, R. L. & Rosenfield, R. (1978) Direct inhibition of Leydig cell function by estradiol. Journal of Clinical Endocrinological Metabolism 47, 1368-1373.
14. Lee, P. A. (1975) The relationship of concentrations of serum hormones to pubertal gynecomastia. Journal of Pediatrics 86, 212-215.
15. MacDonald, P. C., Madden, J. D., Brenner, P. F., Wilson, J. D. & Siiteri, P. K. (1979) Origin of estrogen in normal men and in women with testicular feminization. Journal of Clinical Endocrinological Metabolism 49, 905-916.
16. Moore, D. C., Schlaepfer, L. V., Paunier, L. & Sizenenko, P. C. (1984) Hormonal changes during puberty. V. Transient pubertal gynecomastia: abnormal androgen-estrogen ratios. Journal of Clinical Endocrinological Metabolism 58, 492-499.
17. Neyzi, O., Alp, H., Yalcindag, A., Yakacikli, S. & Orhon, A. (1975) Sexual maturation in Turkish boys. Annals of Human Biology 2, 251-259.
18. Niewoehner, C. B. & Nuttall, F. Q. (1984) Gynecomastia in a hospitalized male population. American Journal of Medicine 77, 633-638.
19. Nuttall, F. Q. (1979) Gynecomastia as a physical finding in normal men. Journal of Clinical Endocrinological Metabolism 48, 338-340.
20. Nydick, M., Bustos, J., Dale, J. H. & Rawson, R. W. (1961) Gynecomastia in adolescent boys. Journal of the American Medical Association 178, 449-454.
21. Rochefort, H. & Garcia, M. (1983) The estrogenic and antiestrogenic activities of androgens in female target tissues. Pharmacological Therapy 23, 193-216.
22. Sultan, C., Bressot, N., Garandeau, P., Descomps, B. & Jean, R. (1980) Persistant pubertal gynecomastia. Biological study. La Semaine des Hopitaux 56, 1923-1930.
23. Veldhuis, J. D., Sowers, J. R., Rogol, A. D., Klein, F. A., Miller, N. & Dufau, M. L. (1985) Pathophysiology of male hypogonadism associated with endogenous hyperestrogenism: evidence for dual defects in the gonadal axis. New England Journal of Medicine 312, 1371-1375.
24. Villalpando, S., Mondragon, L., Barron, C., Perez-Pasten, E., Castaneda, G., Alonso-Uriarte, R. & Cortes-Gallegos, V. (1992) Role of testosterone and dihydrotestosterone in spontaneous gynecomastia of adolescents. Archives of Andrology 28, 171-176.
25. Voors, A. W., Harsha, D. W., Webber, L. S. & Berenson, G. S. (1981) Obesity and external sexual maturation. The Bogalusa heart study. Preventive Medicine 10, 50-61.
26. Williams, M. J. (1963) Gynecomastia: its incidence, recognition and host characteristics in 447 autopsy cases. American Journal of Medicine 34, 103-112.