Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent

Biochemical and Biophysical Research Communications

Volumn 295, Issue 4, 2002, Pages 985-991

  Bürkert, Eva ^a   Rådmark, Olof ^b   Steinhilber, Dieter ^a   Werz, Oliver ^a  

^a GOETHE UNIVERSITY   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

5 Lipoxygenase; Arachidonic acid; Calcium; Leukotriene; Mono Mac 6; Phosphatidylcholine; Polymorphonuclear leukocyte

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CALCIUM ION; ENZYME INHIBITOR;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PURIFICATION; GENETIC RECOMBINATION; HEAT SENSITIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; MOLECULAR WEIGHT; MONOCYTE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; RAT; SOLUBILITY; THERMOSTABILITY;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; CALCIUM; CATALYSIS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IONOMYCIN; IONOPHORES; LEUKOTRIENES; MONOCYTES; NEUTROPHILS; PHOSPHATIDYLCHOLINES; PROTEIN BINDING; RATS;

SIGANUS;

EID: 0036377460     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00791-X     Document Type: Article

References (31)

1. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects
2. The molecular biology and regulation of 5-lipoxygenase
3. Identification and isolation of a membrane protein necessary for leukotriene production
4. 5-Lipoxygenase is phosphorylated by p38 kinase dependent MAPKAP kinases
5. Human 5-lipoxygenase associates with phosphatidylcholine liposomes and modulates LTA(4) synthetase activity
6. Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase
7. Regulation of the human leukocyte 5-lipoxygenase: Stimulation by micromolar calcium levels and phosphatidylcholine vesicles
8. The involvement of extracellular calcium in the formation of 5-lipoxygenase metabolites by human polymorphonuclear leukocytes
9. Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis
10. 5-Lipoxygenase binds calcium
11. The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity
12. Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase
13. Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187
14. Interactions of 5-lipoxygenase with membranes: Studies on the association of soluble enzyme with membranes and alterations in enzyme activity
15. Intracellular compartmentalization of leukotriene synthesis: Unexpected nuclear secrets
16. The N-terminal "β-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation
17. A molecular basis of specific subcellular localization of the C2-like domain of 5-lipoxygenase
18. Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase
19. 2+ activates 5-lipoxygenase in vitro: Dependency on concentrations of phosphatidylcholine and arachidonic acid
20. Characterization of leukotriene A4 synthase from murine mast cells: Evidence for its identity to arachidonate 5-lipoxygenase
21. Calcium is not required for 5-lipoxygenase activity at high phosphatidyl choline vesicle concentrations
22. Activation of 5-lipoxygenase by cell stress is calcium-independent in human polymorphonuclear leukocytes
23. A calcium-independent 5-lipoxygenase system in mast/basophil PT-18 cells
24. Purification of transforming growth factor beta1 from human platelets
25. Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor-beta and 1,25-dihydroxyvitamin D3
26. Isolation of mononuclear cells and granulocytes from human blood
27. Separation of lipoxins and leukotrienes from human granulocytes by high-performance liquid chromatography with a Radial-Pak cartridge after extraction with an octadecyl reversed-phase column
28. 2+ indicators with greatly improved fluorescence properties
29. 5-Lipoxygenase and leukotriene synthesis: Effects of calcium ions and of inhibitors
30. Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type- specific activation of mitogen-activated protein kinases
31. Interfacial catalysis and production of a high ratio of leukotriene A4 to 5-HPETE by 5-lipoxygenase in a coupled assay with phospholipase A2