Mechanisms of immune privilege for tumor cells by regulatory cytokines produced by innate and acquired immune cells

Seminars in Cancer Biology

Volumn 12, Issue 4, 2002, Pages 291-300

  Seo, Naohiro ^a   Hayakawa, Satoshi ^b   Tokura, Yoshiki ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

Acquired immunity; Immunosuppression; Innate immunity; Regulatory cytokines; Regulatory T cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

AUTOIMMUNITY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DOWN REGULATION; HUMAN; IMMUNOREGULATION; NATURAL KILLER CELL; NONHUMAN; REVIEW; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR IMMUNITY; TUMOR REGRESSION;

EID: 0036374997     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-579X(02)00015-9     Document Type: Short Survey

References (79)

1. Immunity to intracellular microbial pathogens
2. Polarization of Th-cell responses: A phylogenetic consequence of nonspecific immune defence?
3. Natural killer cells wear different hats: Effector cells of innate resistance and regulatory cells of adoptive immunity and of hematopoiesis
4. Activate γ/δ T lymphocytes infiltrating renal cell carcinoma
5. Evidence for extrathemic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation
6. Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses
7. T cell immunity to oral allergens
8. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
9. + T cells upon NKR-P1 cross-linking
10. + T cell subsets and induces early resistance to Leishmania major in mice
11. Cellular responses to interferon-gamma
12. b molecules expressed on Th2-type γδ T and αβ T cells co-infiltrating in early B16 melanoma lesions
13. Depletion of IL-10-and TGF-β-producing regulatory γδ T cells by administering a dounomycin-conjugated specific mAb in early tumor lesions augments the activity of CTLs and NK cells
14. Higher frequency of selective losses of HLA-A and -B allospecificities in metastasis than in primary melanoma lesions
15. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity
16. The Ly-49 and NKR-P1 gene families encoding lectin like receptors on natural killer cells: The NK gene complex
17. Stimulation of murine natural killer (NK) cells by a monoclonal antibody specific for the NK1.1 antigen. IL-2 activated NK cells possess additional specific stimulation pathways
18. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity
19. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties
20. The role of Ly-49A and 5E6 (Ly-49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts
21. Ly-49 mediates EL4 lymphoma adhesion to isolated class I major histocompatibility complex molecules
22. Recognition of major histocompatibility complex class I antigens by natural killer cells
23. b) gene transfection reduces susceptibility of YAC-1 lymphoma targets to natural killer cells
24. Interferon-induced alterations in metastatic capacity, class I antigen expression and natural killer cell sensitivity of melanoma cells
25. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells
26. Peptide specificity in the recognition of MHC class I by natural killer cell clones
27. The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation
28. IL-4 inhibits IL-2-mediated induction of human lymphocyte-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte culture
29. Invertebrate immune recognition, natural immunity and the evolution of positive selection
30. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells
31. + T cell development in CD3ζ-deficient mice
32. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
33. int liver lymphocytes: Influence of thymus, β2-microglobulin and NK1.1 expression
34. HLA class I specific inhibitory receptors
35. Natural interferon α/β-producing cells link innate and adaptive immunity
36. - TCRαβ intermediate T cells in the liver of normal adult mice: Implication for lpr pathogenesis
37. Physiological responses of extrathymic T cells in the liver
38. + T cells for concanavalin A-induced hepatic injury in mice
39. Identification of two distinct subsets of bovine γδ T cells with unique cell surface phenotype and tissue distribution
40. Biology of murine γδ T cells
41. Induction of autologous tumor killing by heat treatment of fresh human tumor cells: Involvement of γβ T cells and heat shock protein 70
42. γδ T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides
43. Antigen presentation by major histocompatibility complex class I-B molecules
44. Crucial role of TCR gamma chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells
45. Cytolytic and IFN-γ-producing activities of γδ T cells in the mouse intestinal epithelium are T cell receptor-β-chain dependent
46. Primary γδ cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation
47. Sentinel function of broadly reactive human γδ T cells
48. Suppression of cytotoxic T lymphocyte activity by γ/δ T cells in tumor-bearing mice
49. + T cells
50. Downregulation of innate and acquired antitumor immunity by bystander γδ and αβ T lymphocytes with Th2 or Tr1 cytokine profiles
51. Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes
52. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells
53. Propagation and regulation of systemic autoimmunity by γδ T cells
54. The role of T-cell receptor-positive cells in pregnancy: Part II
55. A role for γ(δ)TCR+ cells in regulation of rejection of small intestinal allografts in rats
56. Mechanisms of dendritic cell function
57. Functional skewing of bone marrow-derived dendritic cells by Th1- or Th2-inducing cytokines
58. Regulation of interferon-gamma production by IL-12 and IL-18
59. Interleukin 18 induces the sequential activation of natural killer cells and cytotoxic T lymphocytes to protect syngeneic mice from transplantation with Meth A sarcoma
60. Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells
61. Effect of interleukin-10 on dendritic cell maturation and function
62. T-cell based cancer immunotherapy: Direct or redirected tumor-cell recognition?
63. Functional heterogeneity among bone marrow-derived dendritic cells conditioned by T(h)1- and T(h)2-biasing cytokines for the generation of allogeneic cytotoxic T lymphocytes
64. Immunomodulation of experimental autoimmune diseases via oral tolerance
65. Interleukin 10 is a growth factor for a population of regulatory T cells
66. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody
67. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
68. + T regulatory cells and systemic collapse of antitumor immunity
69. Immunosuppressive network connecting innate immunity involving IL-10 and γδ T cells with acquired immunity mediated by TGF-β-producing T cells in anti-B16 immunity
70. Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection
71. TGF-β contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice
72. Lymphokine mRNA expression by transplantable murine B lymphocytic malignancies. Tumor-derived IL-10 as a possible mechanism for modulating the anti-tumor response
73. Natural selection and early changes of phenotype of tumor cells in vivo: Acquisition of new defense mechanisms
74. Coupling and uncoupling of tumor immunity and autoimmunity
75. The use of melanosomal proteins in the immunotherapy of melanoma
76. Crosstalk between α/β T cells and γ/δ T cells in vivo: Activation of α/β T-cell responses after γ/δ T-cell modulation with the monoclonal antibody GL3
77. γδ T cells from tolerized αβ T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in vivo, and their interferon-gamma production in vitro
78. + T cells
79. Activation of human γδ T cells by Mycobacterium tuberculosis and Daudi lymphoma cells: Differential regulatory effect of IL-10 and IL-12