Effects of nitric oxide donors on vascular smooth muscles depend on a type of vascular smooth-muscle preactivation

Cardiovascular Toxicology

Volumn 2, Issue 2, 2002, Pages 151-160

  Lehen'kyi, V V ^a   Zelensky, S N ^a   Stefanov, A V ^a   Soloviev, Anatoly I ^a  

^a Res Inst Pharmacol Toxicol   (Ukraine)

Author keywords

Glyceryl trinitrate (GTN); Intracellular calcium concentration ( Ca2+ i); K+ depolarization; Phenylephrine (PE); Sodium nitroprusside (SNP); Vascular smooth muscles

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; GLYCERYL TRINITRATE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; VOLTAGE GATED POTASSIUM CHANNEL; ISOTONIC SOLUTION; KREBS RINGER SOLUTION; KREBS-RINGER SOLUTION; NITRIC OXIDE DONOR; POTASSIUM CHANNEL; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; COMPARATIVE STUDY; CONTROLLED STUDY; HEART DEPOLARIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; BIOLOGICAL MODEL; DOSE RESPONSE; DRUG EFFECT; HEART CONTRACTION; PHYSIOLOGY; STIMULATION; VASCULAR PATENCY; WISTAR RAT;

ANIMALIA;

ANIMALS; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOTONIC SOLUTIONS; MALE; MODELS, ANIMAL; MODELS, CARDIOVASCULAR; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; NITRIC OXIDE DONORS; NITROGLYCERIN; NITROPRUSSIDE; PHENYLEPHRINE; POTASSIUM CHANNELS; RATS; RATS, WISTAR; STIMULATION, CHEMICAL; VASCULAR PATENCY; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0036364899     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:2:2:151     Document Type: Article

References (25)

1. Furchgott, R.F. and Zawadski, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 228:373-376.
2. Furchgott, R.F. (1983). Role of endothelium in response of vascular smooth muscle. J. Vasc. Res. 53:557-573.
3. Furchgott, R.F. and Vanhoutte, P.M. (1989). Endothelium-derived relaxing and contracting factors. FASEB J. 3:2007-2018.
4. Palmer, R.M., Feridge, A.G., and Moncada, S. (1987). Nitric oxide release accounts for the biological activity of endothelium derived relaxing factor. Nature 327:524-526.
5. Ignarro, L. (1989). Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ. Res. 65:1-21.
6. Somlyo, A.P. and Himpens, B. (1989). Cell calcium and its regulation in smooth muscle. FASEB J. 3:2266-2276.
7. 2+-homeostasis in vascular smooth muscle. J. Vasc. Res. 32:207-219.
8. Moncada, S., Palmer, R.M., and Higgs, I.A. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142.
9. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
10. Blatter, L.A. and Wier, W.G. (1990). Intracellular diffusion, binding and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2. Biophys. J. 58:1491-1499.
11. i signals from calcium-indicator dyes. News Physiol. Sci. 15:19-25.
12. Chung, S.J. and Fung, H.L. (1990). Identification of the subcellular sites for nitroglycerin metabolism to nitric oxide in bovine coronary smooth muscle cells. J. Pharmacol. Exp. Ther. 253:614-619.
13. Soloviev, A., Lehen'kyi, V., Zelensky, S., and Stefanov, A. (2001). Method for investigation of contractile activity and intracellular calcium level of vascular smooth muscles in study of myofilament calcium sensitivity and screening of cardiovascular drugs. Acta Med. Leopol. 1:29-34.
14. Karaki, H., Sato, K., Ozaki, H., and Murakami, K. (1988). Effects of sodium nitroprusside on cytosolic calcium level in vascular smooth muscle. Eur. J. Pharmacol. 156:259-266.
15. Kuriyama, H., Kitamura, K., and Nabata, H. (1995). Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol. Rev. 47:491-499.
16. 2+ sensitivity in rat tail artery independent of guanylyl cyclase activation. J. Vasc. Res. 33(Suppl. 2):43.
17. Berridge, M.J. and Irvine, R.F. (1984). Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature 312:315-321.
18. Bolton, T. (1979). Mechanisms of action of transmitters and other substances on smooth muscle. Physiol. Rev. 59:606-717.
19. Vaugh, W.H. (1962). Role of calciumin contractile excitation of vascular smooth muscle by epinephrine and potassium. Circ. Res. 11:927-940.
20. Collins, P., Griffith, T.M., Henderson A.H., and Lewis, M.J. (1986). Endothelium-derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate-mediated effect. J. Physiol. 381:427-437.
21. i in vascular smooth muscle by inhibition of the calcium current. Cell Calcium 15:122-131.
22. 2+ pump of smooth muscle via phosphorylation of phosphatidylinositol. Biochem. J. 255:855-863.
23. 2+ exchange in vascular smooth muscle cells in primary culture. J. Biol. Chem. 266:12,337-12,341.
24. Archer, S.L., Huang, J.M., Hampel, V., Nelson, D.P., Shultz, P.J., and Weir, E.K. (1994). Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 91:7583-7587.
25. +-ATPase activity by nitric oxide: a cGMP-independent effect. Am. J. Physiol. 266:2146-2151.