Glucocorticoids Induce Neuroendocrine Cell Differentiation and Increase Expression of N-myc in N-type Human Neuroblastoma Cells

Oncology Research

Volumn 13, Issue 2, 2002, Pages 87-94

  Ross, Robert A ^a,c   Hein, Anne M ^a   Braca III, John A ^a   Spengler, Barbara A ^a   Biedler, June L ^a   Scammell, Jonathan G ^b  

^a FORDHAM UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^c Department of Biological Sciences   (United States)

Author keywords

Chromogranins; Dexamethasone; Differentiation; Glucocorticoid; Human neuroblastoma; N myc

Indexed keywords

CHROMOGRANIN A; DEXAMETHASONE; FORSKOLIN; GLUCOCORTICOID; MIFEPRISTONE; NEUROFILAMENT PROTEIN; RETINOIC ACID; SECRETOGRANIN II; TYROSINE 3 MONOOXYGENASE; MESSENGER RNA; MYC PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL AGGREGATION; CELL DIFFERENTIATION; CELL TYPE; CHROMAFFIN CELL; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; NEURAL CREST; NEUROBLAST; NEUROBLASTOMA CELL; NEUROSECRETORY CELL; ONCOGENE C MYB; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECT; GENETICS; NEUROBLASTOMA; NEUROSECRETION; ONCOGENE MYC; PATHOLOGY; PROMOTER REGION;

CELL DIFFERENTIATION; CHROMAFFIN CELLS; DEXAMETHASONE; GENES, MYC; HUMANS; MIFEPRISTONE; NEUROBLASTOMA; NEUROSECRETORY SYSTEMS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; RNA, MESSENGER;

EID: 0036357499     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Biedler, J. L.; Spengler, B. A.; Ross, R. A. Human neuroblastoma cell differentiation. In: Raghavan, D.; Scher, H. I.; Leibel, S. A.; Lange, P. H., eds. Principles and practice of genitourinary oncology. Philadelphia: Lippincott-Raven Publishers; 1997:1053-1061.
2. Rettig, W. J.; Spengler, B. A.; Garin Chesa, P.; Old, L. J.; Biedler, J. L. Coordinate changes in neuronal phenotype and surface antigen expression in human neuroblastoma cell variants. Cancer Res. 47:1383-1389; 1987.
3. Ciccarone, V.; Spengler, B. A.; Meyers, M. B.; Biedler, J. L.; Ross, R. A. Phenotypic diversification in human neuroblastoma cells: Expression of distinct neural crest lineages. Cancer Res. 49:219-225; 1989.
4. Valent, A.; Bénard, J.; Vénuat, A-M.; Da Silva, J.; Duverger, A.; Duarte, N.; Hartmann, O.; Spengler, B. A.; Bernheim, A. Phenotypic and genotypic diversity of human neuroblastoma studied in three IGR cell line models derived from bone marrow metastases. Cancer Genet. Cytogenet. 112:124-129; 1999.
5. Mora, J.; Cheung, N.-K. V.; Juan, G.; Illei, P.; Cheung, I.; Akram, M.; Chi, S.; Ladanyi, M.; Cordon-Cardo, C.; Gerald, W. L. Neuroblastic and Schwannian cells of neuroblastoma are derived from a tumoral progenitor cell. Cancer Res. 61:6892-6898; 2001.
6. Spengler, B. A.; Lazarova, D. L.; Ross, R. A.; Biedler, J. L. Cell lineage and differentiation state are primary determinants of MYCN gene expression and malignant potential in human neuroblatoma cells. Oncol. Res. 9:467-476; 1997.
7. Ross, R. A.; Spengler, B. A.; Domènech, C.; Porubcin, M.; Rettig, W. J.; Biedler, J. L. Human neuroblastoma I-type cells are malignant neural crest stem cells. Cell Growth Differ. 6:449-456; 1995.
8. Brodeur, G. M.; Seeger, R. C.; Schwab, M.; Varmus, H. E.; Bishop, J. M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224:1121-1124; 1984.
9. Abramson, S. J. Adrenal neoplasms in children. Radiol. Clin. North Am. 35:1415-1453; 1997.
10. Hedborg, F.; Ohlsson, R.; Sandstedt, B.; Grimelius, L.; Hoehner, J. C.; Påhlman, S. IGF2 expression is a marker for paraganglionic/SIF cell differentiation in neuroblastoma. Am. J. Pathol. 146:833-847; 1995.
11. Cooper, M. J.; Hutchins, G. M.; Cohen, P. S.; Helman, L. J.; Mennie, R. J.; Israel, M. A. Human neuroblastoma tumors correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts. Cell Growth Differ. 1:149-159; 1990.
12. Ozawa, H.; Takata, K. The granin family-its role in sorting and secretory granule formation. Cell Struct. Funct. 20:415-420; 1995.
13. Hagn, C.; Schmid, K. W.; Fischer-Colbrie, R.; Winkler, H. Chromogranin A, B, and C in adrenal medulla and endocrine tissues. Lab. Invest. 55:405-411; 1986.
14. Rozansky, D. J.; Wu, H. W.; Tang, K.; Parmer, R. J.; O'Connor, D. T. Glucocorticoid activation of chromogranin A gene expression. J. Clin. Invest. 94:2357-2368; 1994.
15. Schmid, K. W.; Dockhorn-Dworniczak, B.; Fahrenkamp, A.; Kirchmair, R.; Tötsch, M.; Fischer-Colbrie, R.; Böcker, W.; Winkler, H. Chromogranin A, secretogranin II, and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas. Histopathology 22:527-533; 1993.
16. Giudici, A. M.; Sher, E.; Pelagi, M.; Clementi, F.; Zanini, A. Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating neuroblastoma cells. Eur. J. Cell Biol. 58:383-389; 1992.
17. Weiler, R.; Meyerson, G.; Fischer-Colbrie, R.; Laslop, A.; Påhlman, S.; Floor, E.; Winkler, H. Divergent changes of chromogranin A/secretogranin II in differentiating human neuroblastoma cells. FEBS Lett. 265:27-29; 1990.
18. Eder, U.; Fischer-Colbrie, R.; Kogner, P.; Leitner, B.; Bjellerup, P.; Winkler, H. Levels and molecular forms of chromogranins in human childhood neuroblastomas and ganglioneuromas. Neurosci. Lett. 253:17-20; 1998.
19. Scammell, J. G.; Reddy, S.; Valentine, D. L.; Coker, T. N.; Nikolopoulos, S. N.; Ross, R. A. Isolation and characterization of the human secretogranin II gene promoter. Mol. Brain Res. 10:8-15; 2000.
20. Rogatsky, I.; Trowbridge, J. M.; Garabedian, M. J. Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transciptional regulatory mechanisms. Mol. Cell. Biol. 17:3181-3193; 1997.
21. Ikegaki, N.; Bukovsky, J.; Kennett, R. H. Identification and characterization of the N-MYC gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities. Proc. Natl. Acad. Sci. USA 83:5929-5933; 1986.
22. Chomczynski, P.; Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-162; 1987.
23. Lazarova, D. L.; Spengler, B. A.; Biedler, J. L.; Ross, R. A. HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts. Oncogene 18:2703-2710; 1999.
24. Lewis, E. J.; Harrington, C. A.; Chikaraishi, D. M. Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. Proc. Natl. Acad. Sci. USA 84:3550-3554; 1987.
25. Ehrlich, M. E.; Evinger, M.; Regunathan, S.; Teitelman, G. Mammalian adrenal chromaffin cells coexpress the epinephrine-synthesizing enzyme and neuronal properties in vivo and in vitro. Dev. Biol. 163:480-490; 1994.
26. Thiele, C. J.; Reynolds, C. P.; Israel, M. A. Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature 313:404-406; 1985.
27. LoPresti, P.; Poluha, W.; Poluha, D. K.; Drinkwater, E.; Ross, A. H. Neuronal differentiation triggered by blocking cell proliferation. Cell Growth Differ. 3:627-635; 1992.
28. Scammell, J. G.; Sumners, C.; Reutter, M. A.; Valentine, D. L.; Jones, L. C. Regulation of secretogranin II mRNA in rat neuronal cultures. Mol. Brain Res. 33:326-332; 1995.
29. Helman, L. J.; Thiele, C. J.; Linehan, W. M.; Nelkin, B. D.; Baylin, S. B.; Israel, M. A. Molecular markers of neuroendocrine development and evidence of environmental regulation. Proc. Natl. Acad Sci. USA 84:2336-2339; 1987.
30. Ross, S.; Fischer, A.; Unsicker, K. Sympathoadrenal progenitors in embryonic chick sympathetic ganglia show distinct responses to glucocorticoid hormones. J. Neurocytol. 24:247-256; 1995.
31. Michelsohn, A. M.; Anderson, D. J. Changes in competence determine the timing of two sequential glucocorticoid effects on sympathoadrenal progenitors. Neuron 8:589-604; 1992.
32. Berthold, F. Overview: Biology of neuroblastoma. In: Pochedly, C., ed. Neuroblastoma: Tumor biology and therapy. Boca Raton: CRC Press; 1990:1-27.
33. Carlsen, N. L. T.; Christensen, I. J.; Schroeder, H.; Bro, P. V.; Erichsen, G.; Hamborg-Pedersen, B.; Jensen, K. B.; Nielsen, O. H. Prognostic factors in neuroblastoma treated in Denmark from 1943 to 1980. Cancer 58:2726-2735; 1986.