Mental illness in mild PKU responds to biopterin

Molecular Genetics and Metabolism

Volumn 75, Issue 3, 2002, Pages 284-286

  Koch, Richard ^a   Guttler, Flemming ^b   Blau, Nenad ^c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b JOHN F KENNEDY INSTITUTE   (Denmark)

^c UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Mental illness; Mild hyperphenylalaninemia; Phenylketonuria; Tetrahydrobiopterin

Indexed keywords

BIOPTERIN; PHENYLALANINE 4 MONOOXYGENASE; PSYCHOTROPIC AGENT; TETRAHYDROBIOPTERIN;

ADULT; ARTICLE; CONTROLLED STUDY; DENMARK; DEPRESSION; DISEASE COURSE; FEMALE; GENE MUTATION; HUMAN; HYPERPHENYLALANINEMIA; MENTAL DISEASE; MUTATIONAL ANALYSIS; NEWBORN; PANIC; PHENYLKETONURIA; PRIORITY JOURNAL;

POMACANTHUS MACULOSUS;

EID: 0036353190     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3289     Document Type: Article

References (9)

1. Molecular basis for the phenotypic diversity of phenylketonuria
2. Disorders of tetrahydrobiopterin and related biogenic amines
3. Tetrabiopterin-responsive phenylalanine hydroxylase deficiency
4. Treatable neurotransmitter deficiency in mild phenylketonuria
5. Long term beneficial effect of the phenylalanine-restricted diet in late-diagnosed individuals with phenylketonuria
6. Treatment of mild phenylketonuria (PKU) by tetrahydrobiopterin (BH4)
7. Tetrahydrobiopterin-responsive hyperphenylalaninemia (HPA) in Dutch neonates
8. Tetrahydrobiopterin responsiveness in phenylketonuria differs between patients with the same genotype
9. Human phenylalanine hydroxylase mutations and hyperphenylalaninemia phenotypes: A metanalysis of genotype-phenotype correlations