Toxins and bioactive compounds from cyanobacteria and their implications on human health

Journal of Environmental Biology

Volumn 23, Issue 3, 2002, Pages 215-224

  Lakshmana Rao, P V ^a   Gupta, Nidhi ^a   Bhaskar, A S B ^a   Jayaraj, R ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Anatoxin; Bioactive peptides; Cyanobacteria; Cyanotoxins; Microcystin

Indexed keywords

AERUGINOSIN; ANATOXIN A; BACTERIAL TOXIN; CIRCINAMIDE; CYANOGINOSIN; CYANOPEPTOLIN; CYLINDROSPERMOPSIN; DRINKING WATER; MICROPEPTIN; MICROVIRIDIN; NODULARIN; PEPTIDE; SAXITOXIN; SEA WATER; UNCLASSIFIED DRUG; CYCLOPEPTIDE; MARINE TOXIN;

CYANOBACTERIUM; HEALTH IMPACT; HEALTH RISK; TOXIN;

ANIMAL DISEASE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOASSAY; BLUE GREEN ALGA; CHEMICAL STRUCTURE; CYANOBACTERIUM; CYTOTOXICITY; DRUG ACTIVITY; GASTROENTERITIS; HEMODIALYSIS; HUMAN; INTOXICATION; LIVER CANCER; LIVER INJURY; METABOLITE; NEUROTOXICITY; NONHUMAN; PRACTICE GUIDELINE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SKIN IRRITATION; WORLD HEALTH ORGANIZATION; CHEMISTRY; EUTROPHICATION; LIVER TUMOR; PUBLIC HEALTH; RENAL REPLACEMENT THERAPY; WATER SUPPLY;

ALGAE; ANIMALIA; BACTERIA (MICROORGANISMS); CHLOROPHYTA; CYANOBACTERIA; RICKETTSIALES;

BACTERIAL TOXINS; CYANOBACTERIA; EUTROPHICATION; GASTROENTERITIS; HUMANS; LIVER NEOPLASMS; MARINE TOXINS; MICROCYSTINS; PEPTIDES, CYCLIC; PUBLIC HEALTH; RENAL DIALYSIS; WATER SUPPLY;

EID: 0036348369     PISSN: 02548704     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins
2. Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis
3. Cyanobacterial toxins and human health
4. Toxicity assessment of freshwater cyanobacterial toxins in mammalian cell cultures
5. Liver slice culture for assessing hepatotoxicity of freshwater cyanobacteria
6. Seaweed dermatitis: Structure of lyngbyatoxin A
7. Toxins of freshwater algae
8. The toxins of cyanobacteria
9. Diseases related to freshwater blue-green algal toxins and control measures
10. Pharmacology of anatoxin-a, produced by the freshwater cyanophyte Anabaena flos-aquae NRC-44-1
11. Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand
12. Health risks caused by freshwater cyanobacteria in recreational waters
13. The toxicology of microcystin
14. Anatoxin-a, a toxic alkaloid from Anabaena flos-aquae NRC-44-1
15. Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases
16. An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking water
17. Tumour promotion and liver injury caused by oral consumption of cyanobacteria
18. Tumour promotion by cyanobacterial toxins
19. Poisonous Australian lake
20. Significant marine natural products in cancer research
21. Unique features of the okadaic acid activity class of tumour promoters
22. Deriving a safe level for microcystin toxin in blue-green algae dietary supplement
23. Chemistry and detection of microcystins
24. Mass spectrometric screening method for microcystins in cyanobacteria
25. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir
26. Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice
27. Cyanobacterial toxins: Removal during drinking water treatment, and human risk assessment
28. Anatoxin-a (s), a naturally occurring organo-phosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC 3.1.1.7)
29. Micropeptins 478-A and B, plasmin inhibitors from the cyanobacterium Microcystis aeruginosa
30. Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injection of microcystin-LR
31. Liver failure and death after exposure to microcystins at a hemodialysis centre in Brazil
32. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants
33. Paralytic shellfish poisons produced by the cyanobacterium Aphanizomenon flosaquae NH-5
34. Anatoxin-a(s), an acetylcholinesterase from the cyanobacterium Anabaena flos-aquae NRC-52517
35. Lipopolysaccharides and polysaccharides of the cell envelope of toxic Microcystics aeruginosa strains
36. Aeruginosins 102-A and B, new thrombin inhibitors from the cyanobacterium Microcystis viridis (NIES-102)
37. Anatoxin-a(s), a potent anticholinesterase from Anabaena flos-aquae
38. Respiratory allergy to algae: Clinical aspects
39. Cyanobacterial toxins
40. Bioactive compounds produced by cyanobacteria
41. Liver tumour promotion by the cyanobacterial cyclic peptide toxin microcystin-LR
42. Nodularin, a potent inhibitor of protein phosphatase 1 and 2A, is a new environmental carcinogen in male F344 rat liver
43. Cylindrospermopsin: A potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii
44. Microginin, an angiotensin-converting enzyme inhibitor for the blue-green alga Microcystis aeruginosa
45. Nostopeptins A and B, elastase inhibitors from the cyanobacterium Nostoc minutum
46. Antibacterial properties of extracts from selected planktonic freshwater cyanobacteria - A comparative study of bacterial bioassays
47. Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil
48. The cyanobacterial toxin microcystin-LR induced DNA damage in mouse liver in vivo
49. Effects of nutrient media and culture duration on growth, macromolecular composition and toxicity in batch cultures of Microcystis aeruginosa (UTEX 2385)
50. Genotoxic effects of freshwater cyanobacterium Microcystis aeruginosa
51. Isolation, culture and toxicity of cyanobacterium (blue-green alga) Microcystis aeruginosa from a freshwater source in India
52. Toxicity evaluation of in vitro cultures of freshwater cyanobacterium Microcystis aeruginosa: I Hepatic and histopathological effects in rats
53. Freshwater cyanobacterium Microcystis aeruginosa (UTEX 2385) induced DNA damage in vivo and in vitro
54. Risk assessment of microcystin in dietary Aphanizomenon flos-aquae
55. Antitumour-promoting activities of various synthetic 1-O-acyl-3-o- (6-O-acyl-beta-D-galactopyranosyl) -sn-glycerols related to natural product from fresh water cyanobacterium Anabena flos-aquae
56. Cyanobacterial toxins and toxin production
57. Cyanobacterial toxins - A guide to public health significance, monitoring and management
58. Investigations of a neurotoxic oscillatorian strain (Cyanophyceae) and its toxin. Isolation and characterization of homoanatoxin-a
59. Expression of the tumour necrosis factor alpha gene and early response genes by nodularin, a liver tumour promoter, in primary cultured rat hepatocytes
60. Mutagenicity of microcystin-LR in human Rsa cells
61. Gastroenteritis epidemic in the area of the Itaparica Dam, Bahia, Brazil
62. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans
63. Development and application of highly sensitive anti-immune complex ELISAs for microcystins in tap water
64. Pneumonia associated with contact with cyanobacteria
65. Detection of microcystins, a blue green algal hepatotoxin, in drinking water samples in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay
66. Drinking water and primary liver cancer