Non-myeloablative stem cell transplantation for the treatment of cancer and life-threatening non-malignant disorders; past accomplishments and future goals

Transfusion and Apheresis Science

Volumn 27, Issue 2, 2002, Pages 159-166

  Slavin, Shimon ^a   Aker, Mehmet ^a   Shapira, Michael Y ^a   Panigrahi, Soumya ^a   Gabriel, Cividalli ^a   Or, Reuven ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Allogeneic cell therapy; Bone marrow or blood stem cell transplantation; Donor lymphocyte infusion; Hematologic malignancies; Mini transplant; Non malignant hematologic diseases; Non myeloablative stem cell transplantation

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; FLUDARABINE PHOSPHATE; FRESENIUS; T LYMPHOCYTE ANTIBODY;

ADOPTIVE IMMUNOTHERAPY; ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOIMMUNITY; ARTICLE; BENIGN TUMOR; BLOOD TOXICITY; CANCER CELL; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; ERADICATION THERAPY; FEASIBILITY STUDY; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOLOGIC DISEASE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HOST; HUMAN; HYPOTHESIS; IMMUNOCOMPETENT CELL; LYMPHOCYTE; MALIGNANT NEOPLASTIC DISEASE; METHODOLOGY; MYELOID LEUKEMIA; RECIPIENT; STEM CELL TRANSPLANTATION; TUMOR CELL; ALLOTRANSPLANTATION; AUTOIMMUNE DISEASE; CRITICAL ILLNESS; IMMUNOTHERAPY; NEOPLASM; REVIEW;

AUTOIMMUNE DISEASES; CRITICAL ILLNESS; HUMANS; IMMUNOTHERAPY; NEOPLASMS; STEM CELL TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS;

EID: 0036344648     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1473-0502(02)00038-1     Document Type: Article

References (24)

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2. Graft-versus-leukemia reactions after bone marrow transplantation
3. Graft-versus-leukemia reactions in humans
4. Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation
5. Total lymphoid irradiation
6. Transplantation of allogeneic bone marrow without graft vs host disease using total lymphoid irradiation
7. Cellular-mediated immunotherapy of leukemia in conjunction with autologous and allogeneic bone marrow transplantation in experimental animals and man
8. Allogeneic cell therapy for relapsed leukemia following bone marrow transplantation with donor peripheral blood lymphocytes
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10. Allogeneic cell mediated immunotherapy using donor lymphocytes for prevention of relapse in patients treated with allogeneic BMT for hematological malignancies
11. Allogeneic cell therapy of severe beta thalassemia major by displacement of host stem cells in mixed chimera by donor blood lymphocytes
12. Eradication of murine leukemia with histoincompatible marrow grafts in mice conditioned with total lymphoid irradiation (TLI)
13. Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer
14. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and non-malignant hematologic diseases
15. Fludarabine based protocol for BMT in Fanconi anemia
16. Outpatient PBSC allografts using immunosuppression with low-dose TBI before, and cyclosporine (CSP) and mycophenolate mofetil (MMF) after transplant
17. A new non-myeloablative protocol using fludarabine and low-dose TBI in preparation for allogeneic blood stem cell transplantation for high risk patients with malignant and non-malignant disorders
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19. Engraftment and induction of GVL with fludarabine based non-ablative preparative regimens in patients with chronic lymphocytic leukemia and lymphoma
20. Mini-allografts ongoing trials in humans
21. Anti-tumor effects of allogeneic bone marrow transplantation in (NZB × NZW)F1 hybrids with spontaneous lymphosarcoma
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23. Cancer immunotherapy with alloreactive lymphocytes
24. Graft vs autoimmunity following allogeneic non-myeloablative blood stem cell transplantation in a patient with chronic myelogenous leukemia and severe systemic psoriasis and psoriatic polyarthritis