An open-label, multicenter study of the combination of amorolfine nail lacquer and oral itraconazole compared with oral itraconazole alone in the treatment of severe toenail onychomycosis

Current Therapeutic Research - Clinical and Experimental

Volumn 63, Issue 6, 2002, Pages 366-379

  Lecha, Mario ^a   Alsina, Mercè ^a   Torres Rodríguez, Josep M ^b   De Erenchun, Fermín Ruiz ^c   Mirada, Alfons ^d   Rossi, Ana Beatris ^e  

^a HOSPITAL CLÍNIC   (Spain)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^c Roche Farma SA   (Spain)

^d Laboratorios Isdin   (Spain)

^e Galderma R and D   (France)

Author keywords

Amorolfine; Combination therapy; Itraconazole; Onychomycosis

Indexed keywords

AMOROLFINE; ITRACONAZOLE; PAINT;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST CONTROL; COST EFFECTIVENESS ANALYSIS; DRUG COST; DRUG EFFICACY; DRUG MIXTURE; DRUG SAFETY; DYSPEPSIA; ECONOMIC ASPECT; EPIGASTRIC PAIN; FEMALE; HEALTH CARE COST; HEARTBURN; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ONYCHOMYCOSIS; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; SPAIN; STATISTICAL ANALYSIS;

EID: 0036340818     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(02)80040-6     Document Type: Article

References (17)

1. Achilles foot screening project: Preliminary results of patients screened by dermatologists
2. Onychomycosis: Therapeutic update
3. How often does oral treatment of toenail onychomycosis produce a disease-free nail? An analysis of published data
4. Mechanism of action of antifungals and combination therapy
5. Combination of amorolfine with various antifungal drugs in dermatophytosis
6. Onychomycosis: Current treatment and future challenges
7. New developments in antifungals
8. Mode of action studies
9. Kinetics of amorolfine in human nails
10. Determination of the subungual antifungal activity of amorolfine after 1 month's treatment in patients with onychomycosis: Comparison of two nail lacquer formulations
11. Skin kinetics of azole antifungal drugs
12. Determination of terbinafine in nail samples during systemic treatment for onychomycoses
13. Combination of amorolfine with griseofulvin: In vitro activity and clinical results in onychomycosis
14. A randomized trial of amorolfine 5% solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix region
15. Antifungal pulse therapy for onychomycosis. A pharmacokinetic and pharmacodynamic investigation of monthly cycles of 1-week pulse therapy with itraconazole
16. Onychomycosis and other superficial fungal infections of the foot in the elderly: A pan-European survey